Original Articles
Analysis of Oxidative Stress in Exhaled Breath Condensate From Patients With Severe Pulmonary Infections
P.V. Romeroa,
, B. Rodrígueza, S. Martíneza, R. Cañizaresb, D. Sepúlvedab, F. Manresaa
Corresponding author
pvromero@csub.scs.es
Correspondence: Dr. P.V. Romero. Laboratorio de Función Pulmonar. Servicio de Neumología. Hospital Universitario de Bellvitge. IDIBELL. Feixa Llarga, s/n. 08907 L'Hospitalet de Llobregat. Barcelona. España
Correspondence: Dr. P.V. Romero. Laboratorio de Función Pulmonar. Servicio de Neumología. Hospital Universitario de Bellvitge. IDIBELL. Feixa Llarga, s/n. 08907 L'Hospitalet de Llobregat. Barcelona. España
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"apellidos" => "Romero" "email" => array:1 [ 0 => "pvromero@csub.scs.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "Cañizares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "D." "apellidos" => "Sepúlveda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "F." "apellidos" => "Manresa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Intensiva, Hospital Universitario de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. P.V. Romero. Laboratorio de Función Pulmonar. Servicio de Neumología. Hospital Universitario de Bellvitge. IDIBELL. Feixa Llarga, s/n. 08907 L'Hospitalet de Llobregat. Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-03-14" "fechaAceptado" => "2005-05-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154261" "palabras" => array:9 [ 0 => "Pneumonia" 1 => "Chronic obstructive pulmonary disease" 2 => "Reactive nitrogen species" 3 => "Reactive oxygen species" 4 => "Pulmonary inflammation" 5 => "8-isoprostane" 6 => "Myeloperoxidase" 7 => "Nitrate" 8 => "Nitrite" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154260" "palabras" => array:9 [ 0 => "Neumonía" 1 => "Enfermedad pulmonar obstructiva crónica" 2 => "Especies reactivas del nitrógeno" 3 => "Especies reactivas del oxígeno" 4 => "Inflamación pulmonar" 5 => "8-isoprostano" 6 => "Mieloperoxidasa" 7 => "Nitrato" 8 => "Nitrito" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Oxidative stress is an intrinsic part of the chain of events leading to inflammation of the airways caused by bacterial infection. The aim of this study was to determine whether analysis of exhaled breath condensate from patients with severe lung infections reveals changes in the redox state at the airway surface.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included a total of 48 subjects divided into 4 groups: individuals without respiratory disease (n=14), patients with multilobar pneumonia (n=13), patients who had chronic obstructive pulmonary disease with superinfection (n=14), and mechanically ventilated patients with severe pneumonia (n=7). A sample of exhaled breath condensate was obtained within the first 72 hours of hospital admission and the concentrations of nitrite, nitrate, 8-isoprostane, and myeloperoxidase (MPO) were determined.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Significant differences in the concentrations of nitrite, 8-isoprostane, and MPO were observed between patients and individuals without respiratory disease but no differences were found between the 3 patient groups. The concentration of MPO was correlated with the concentrations of 8-isoprostane and nitrate, which were normalized to the nitrite concentration.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Analysis of the concentrations of 8-isoprostane and MPO in exhaled breath condensate allows assessment of oxidative stress in the airways of patients with severe lung infections.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El estrés oxidativo forma parte esencial de la cadena de acontecimientos que conducen al estado inflama-torio de la vía aérea tras la agresión bacteriana. El objetivo del presente trabajo ha sido investigar si el análisis del condensado del vapor exhalado (CER) de pacientes con infección pulmonar grave refleja las alteraciones del estado oxidativo de la interfase aérea.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado a un total de 48 pacientes divididos en 4 grupos: sujetos sin enfermedad respiratoria (n = 14), pacientes con neumonía multilobular (n = 13), con enfermedad pulmonar obstructiva crónica sobreinfectados (n = 14) y con neumonía grave ventilados mecánicamente (n = 7). Se obtuvo una muestra de CER en las primeras 72 h tras el ingreso y se determinó la concentración de nitrito, nitrato, 8-isoprostano y mieloperoxidasa (MPO).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se apreciaron variaciones significativas de la concentración de nitrito, 8-isoprostano y MPO en los pacientes respecto del grupo control, pero no entre los diferentes grupos de pacientes. La concentración de MPO se rela-cionó con las concentraciones de 8-isoprostano y nitrato normalizadas para el valor de nitrito.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El análisis de la concentración de 8-isoprostano y MPO en el CER permite apreciar el estrés oxidativo en la interfase aérea de los pacientes con infección pulmonar grave.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This work was funded by grants from the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) 2002 and Red Respira (ISCiii RTIC 03/111, project CER).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of nasal and oral inhalation during exhaled breath condensate collection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G Vass" 1 => "E Huszar" 2 => "E Barat" 3 => "M Valyon" 4 => "D Kiss" 5 => "I Penzes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200207-716BC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "850" "paginaFinal" => "855" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12493648" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress as an initiator of cytokine release and cell damage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "JD Crapo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J Suppl" "fecha" => "2003" "volumen" => "44" "paginaInicial" => "4S" "paginaFinal" => "6S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14582891" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The isoprostanes: unique products of arachidonic acid oxidation-a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "SS Fam" 1 => "JD Morrow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Med Chem" "fecha" => "2003" "volumen" => "10" "paginaInicial" => "1723" "paginaFinal" => "1740" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12871112" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of <span class="elsevierStyleItalic">Staphylococcus aureus</span> by neutrophils" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MB Hampton" 1 => "AJ Kettle" 2 => "CC Winterbourn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "1996" "volumen" => "64" "paginaInicial" => "3512" "paginaFinal" => "3517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8751892" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactions of superoxide with myeloperoxidase and its products" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "CC Winterbourn" 1 => "AJ Kettle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Jpn J Infect Dis" "fecha" => "2004" "volumen" => "57" "paginaInicial" => "S31" "paginaFinal" => "S33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507767" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biomarkers in breath condensate: a promising new non-invasive technique in free radical research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I Rahman" 1 => "F Kelly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Free Radic Res" "fecha" => "2003" "volumen" => "37" "paginaInicial" => "1253" "paginaFinal" => "1266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14753750" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A simple method for estimating respiratory solute dilution in exhaled breath condensates" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "RM Effros" 1 => "J Biller" 2 => "B Foss" 3 => "K Hoagland" 4 => "MB Dunning" 5 => "D Castillo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200307-920OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "168" "paginaInicial" => "1500" "paginaFinal" => "1505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14512268" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "WA Biernacki" 1 => "SA Kharitonov" 2 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "294" "paginaFinal" => "298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12668789" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Markers of inflammation and oxidative stress during lower respiratory tract infections in COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "WJ van Beurden" 1 => "FW Smeenk" 2 => "GA Harff" 3 => "PN Dekhuijzen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Monaldi Arch Chest Dis" "fecha" => "2003" "volumen" => "59" "paginaInicial" => "273" "paginaFinal" => "280" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15148836" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E Huszar" 1 => "G Vass" 2 => "E Vizi" 3 => "Z Csoma" 4 => "E Barat" 5 => "G Molnar Vilagos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "1393" "paginaFinal" => "1398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12503694" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E Baraldi" 1 => "S Carraro" 2 => "R Alinovi" 3 => "A Pesci" 4 => "L Ghiro" 5 => "A Bodini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "505" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12775861" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased vitronectin and endothelin-1 in the breath condensate of patients with fibrosing lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "GE Carpagnano" 1 => "SA Kharitonov" 2 => "AU Wells" 3 => "P Pantelidis" 4 => "RM du Bois" 5 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "70062" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2003" "volumen" => "70" "paginaInicial" => "154" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12740512" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "GE Carpagnano" 1 => "PJ Barnes" 2 => "DM Geddes" 3 => "ME Hodson" 4 => "SA Kharitonov" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200203-179OC" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "1109" "paginaFinal" => "1112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684249" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X11700568" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utility of exhaled breath condensates in chronic obstructive pulmonary disease: a critical review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "RM Effros" 1 => "J Su" 2 => "R Casaburi" 3 => "R Shaker" 4 => "J Biller" 5 => "M Dunning" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "135" "paginaFinal" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15699785" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "NR Anthonisen" 1 => "J Manfreda" 2 => "CP Warren" 3 => "ES Hershfield" 4 => "GK Harding" 5 => "NA Nelson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1987" "volumen" => "106" "paginaInicial" => "196" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3492164" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Métodos de valoración de la inflamación de las vías respiratorias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "JB Galdiz Iturri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "numero" => "Sup 15" "paginaInicial" => "2" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16137450" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis del condensado exhalado: ¿una técnica con futuro?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N González Mangado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "540" "paginaFinal" => "541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16266665" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Condensado de aire exhalado en patología respiratoria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C Almonacid" 1 => "J Castelao" 2 => "JL Izquierdo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Patol Respir" "fecha" => "2004" "volumen" => "7" "paginaInicial" => "123" "paginaFinal" => "130" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of nasal and oral inhalation during exhaled breath condensate collection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G Vass" 1 => "E Huszar" 2 => "E Barat" 3 => "M Valyon" 4 => "D Kiss" 5 => "I Penzes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200207-716BC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "850" "paginaFinal" => "855" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12493648" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of exhaled breath condensate from nasal and oral collection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P Latzin" 1 => "J Beck" 2 => "A Bartenstein" 3 => "M Griese" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Med Res" "fecha" => "2003" "volumen" => "8" "paginaInicial" => "505" "paginaFinal" => "510" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14644706" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Condensado exhalado: estandarización de la recogida de muestras en voluntarios sanos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "JB de Lema" 1 => "M González" 2 => "L Vigil" 3 => "P Casan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "4" "paginaInicial" => "584" "paginaFinal" => "586" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "MB Schleiss" 1 => "O Holz" 2 => "M Behnke" 3 => "K Richter" 4 => "H Magnussen" 5 => "RA Jorres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "1115" "paginaFinal" => "1118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11292115" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exhaled breath condensate nitrite and its relation to tidal volume in acute lung injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Gessner" 1 => "S Hammerschmidt" 2 => "H Kuhn" 3 => "T Lange" 4 => "L Engelmann" 5 => "J Schauer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "1046" "paginaFinal" => "1052" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12970036" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "GE Carpagnano" 1 => "SA Kharitonov" 2 => "MP Foschino-Barbaro" 3 => "O Resta" 4 => "E Gramiccioni" 5 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2003.020768" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "1016" "paginaFinal" => "1019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15563698" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B Balint" 1 => "LE Donnelly" 2 => "T Hanazawa" 3 => "SA Kharitonov" 4 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "456" "paginaFinal" => "461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11359961" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nitrate in exhaled breath condensate of patients with different airway diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Corradi" 1 => "A Pesci" 2 => "R Casana" 3 => "R Alinovi" 4 => "M Goldoni" 5 => "MV Vettori" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nitric Oxide" "fecha" => "2003" "volumen" => "8" "paginaInicial" => "26" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12586538" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitative analysis of 8-isoprostane and hydrogen peroxide in exhaled breath condensate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "PG van Hoydonck" 1 => "WA Wuyts" 2 => "BM Vanaudenaerde" 3 => "EG Schouten" 4 => "LJ Dupont" 5 => "EH Temme" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "189" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14979489" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "No effect of inhaled budesonide on the response to inhaled ozone in normal subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "JA Nightingale" 1 => "DF Rogers" 2 => "KF Chung" 3 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.2.9905031" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "paginaInicial" => "479" "paginaFinal" => "486" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10673189" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacterial infection induces nitric oxide synthase in human neutrophils" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "MA Wheeler" 1 => "SD Smith" 2 => "G García-Cardena" 3 => "CF Nathan" 4 => "RM Weiss" 5 => "WC Sessa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI119121" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1997" "volumen" => "99" "paginaInicial" => "110" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9011564" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I Rahman" 1 => "SK Biswas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1179/135100004225005219" "Revista" => array:6 [ "tituloSerie" => "Redox Rep" "fecha" => "2004" "volumen" => "9" "paginaInicial" => "125" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15327743" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "JD Morrow" 1 => "LJ Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.2206011" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "166" "paginaInicial" => "S25" "paginaFinal" => "S30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12471085" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "CT Carpenter" 1 => "PV Price" 2 => "BW Christman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "114" "paginaInicial" => "1653" "paginaFinal" => "1659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872202" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000003/v1_201305150239/S1579212906601286/v1_201305150239/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000003/v1_201305150239/S1579212906601286/v1_201305150239/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601286?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 1 | 5 |
| 2024 October | 27 | 27 | 54 |
| 2024 September | 28 | 16 | 44 |
| 2024 August | 47 | 42 | 89 |
| 2024 July | 31 | 23 | 54 |
| 2024 June | 39 | 16 | 55 |
| 2024 May | 30 | 33 | 63 |
| 2024 April | 19 | 21 | 40 |
| 2024 March | 31 | 17 | 48 |
| 2024 February | 18 | 20 | 38 |
| 2023 March | 3 | 2 | 5 |
| 2023 February | 17 | 19 | 36 |
| 2023 January | 16 | 28 | 44 |
| 2022 December | 16 | 21 | 37 |
| 2022 November | 18 | 23 | 41 |
| 2022 October | 25 | 29 | 54 |
| 2022 September | 13 | 21 | 34 |
| 2022 August | 21 | 36 | 57 |
| 2022 July | 22 | 43 | 65 |
| 2022 June | 44 | 35 | 79 |
| 2022 May | 40 | 38 | 78 |
| 2022 April | 18 | 26 | 44 |
| 2022 March | 17 | 36 | 53 |
| 2022 February | 19 | 32 | 51 |
| 2022 January | 17 | 34 | 51 |
| 2021 December | 18 | 41 | 59 |
| 2021 November | 12 | 40 | 52 |
| 2021 October | 23 | 47 | 70 |
| 2021 September | 17 | 31 | 48 |
| 2021 August | 11 | 31 | 42 |
| 2021 July | 8 | 23 | 31 |
| 2021 June | 8 | 29 | 37 |
| 2021 May | 16 | 31 | 47 |
| 2021 April | 24 | 36 | 60 |
| 2021 March | 32 | 23 | 55 |
| 2021 February | 10 | 16 | 26 |
| 2021 January | 8 | 10 | 18 |
| 2020 December | 8 | 6 | 14 |
| 2020 November | 3 | 5 | 8 |
| 2020 October | 5 | 5 | 10 |
| 2020 September | 4 | 9 | 13 |
| 2020 August | 6 | 9 | 15 |
| 2020 July | 8 | 10 | 18 |
| 2020 June | 11 | 3 | 14 |
| 2020 May | 9 | 16 | 25 |
| 2020 April | 13 | 16 | 29 |
| 2020 March | 17 | 11 | 28 |
| 2020 February | 14 | 12 | 26 |
| 2020 January | 9 | 6 | 15 |
| 2019 December | 13 | 16 | 29 |
| 2019 November | 3 | 8 | 11 |
| 2019 October | 4 | 3 | 7 |
| 2019 September | 12 | 17 | 29 |
| 2019 August | 6 | 7 | 13 |
| 2019 July | 12 | 29 | 41 |
| 2019 June | 9 | 15 | 24 |
| 2019 May | 12 | 11 | 23 |
| 2019 April | 13 | 25 | 38 |
| 2019 March | 19 | 24 | 43 |
| 2019 February | 12 | 11 | 23 |
| 2019 January | 4 | 10 | 14 |
| 2018 December | 11 | 13 | 24 |
| 2018 November | 18 | 9 | 27 |
| 2018 October | 31 | 14 | 45 |
| 2018 September | 7 | 10 | 17 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 7 | 3 | 10 |
| 2018 March | 2 | 3 | 5 |
| 2018 February | 5 | 8 | 13 |
| 2018 January | 4 | 6 | 10 |
| 2017 December | 7 | 8 | 15 |
| 2017 November | 2 | 3 | 5 |
| 2017 October | 3 | 7 | 10 |
| 2017 September | 4 | 13 | 17 |
| 2017 August | 5 | 12 | 17 |
| 2017 July | 3 | 7 | 10 |
| 2017 June | 4 | 22 | 26 |
| 2017 May | 9 | 11 | 20 |
| 2017 April | 1 | 1 | 2 |
| 2017 March | 4 | 9 | 13 |
| 2017 February | 1 | 2 | 3 |
| 2017 January | 1 | 4 | 5 |
| 2016 December | 10 | 7 | 17 |
| 2016 November | 16 | 7 | 23 |
| 2016 October | 9 | 4 | 13 |
| 2016 September | 15 | 11 | 26 |
| 2016 August | 9 | 4 | 13 |
| 2016 July | 8 | 2 | 10 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 48 | 13 | 61 |
| 2015 September | 31 | 8 | 39 |
| 2015 August | 44 | 9 | 53 |
| 2015 July | 54 | 5 | 59 |
| 2015 June | 34 | 8 | 42 |
| 2015 May | 46 | 9 | 55 |
| 2015 April | 34 | 16 | 50 |
| 2015 March | 35 | 10 | 45 |
| 2015 February | 36 | 9 | 45 |
| 2015 January | 26 | 13 | 39 |
| 2014 December | 56 | 5 | 61 |
| 2014 November | 35 | 7 | 42 |
| 2014 October | 58 | 9 | 67 |
| 2014 September | 35 | 7 | 42 |
| 2014 August | 37 | 11 | 48 |
| 2014 July | 35 | 6 | 41 |
| 2014 June | 38 | 7 | 45 |
| 2014 May | 56 | 10 | 66 |
| 2014 April | 64 | 4 | 68 |
| 2014 March | 80 | 9 | 89 |
| 2014 February | 53 | 8 | 61 |
| 2014 January | 39 | 8 | 47 |
| 2013 December | 42 | 12 | 54 |
| 2013 November | 39 | 6 | 45 |
| 2013 October | 51 | 8 | 59 |
| 2013 September | 40 | 8 | 48 |
| 2013 August | 56 | 10 | 66 |
| 2013 July | 58 | 19 | 77 |
| 2013 June | 39 | 6 | 45 |
| 2013 May | 39 | 4 | 43 |
| 2013 April | 20 | 7 | 27 |
| 2013 March | 9 | 2 | 11 |
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