Case Report
Clinicopathological Features of Solitary Fibrous Tumors of the Pleura: a Case Series and Literature Review
N. Sánchez-Moraa,b,
, M. Cebollero-Presmanesa, V. Monroyc, L. Carretero-Albiñanaa, M. Herranz-Aladroa, E. Álvarez-Fernándeza
Corresponding author
histonora@yahoo.es
Correspondence: Dra. N. Sánchez-Mora. Departamento de Anatomía Patológica. Hospital General Universitario Gregorio Marañón. C/Dr. Esquerdo, 46. 28007. España
Correspondence: Dra. N. Sánchez-Mora. Departamento de Anatomía Patológica. Hospital General Universitario Gregorio Marañón. C/Dr. Esquerdo, 46. 28007. España
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Carretero-Albiñana, M. Herranz-Aladro, E. Álvarez-Fernández" "autores" => array:6 [ 0 => array:5 [ "preGrado" => "Dra." "nombre" => "N." "apellidos" => "Sánchez-Mora" "email" => array:1 [ 0 => "histonora@yahoo.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Cebollero-Presmanes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Monroy" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "L." "apellidos" => "Carretero-Albiñana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "M." "apellidos" => "Herranz-Aladro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "E." "apellidos" => "Álvarez-Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "LABIEMET, Universidad de Los Andes, Mérida, Venezuela" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Hospital de Especialidades Centro Médico Nacional La Raza, México DF, Mexico" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. N. Sánchez-Mora. Departamento de Anatomía Patológica. Hospital General Universitario Gregorio Marañón. C/Dr. Esquerdo, 46. 28007. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-05-23" "fechaAceptado" => "2005-09-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154248" "palabras" => array:3 [ 0 => "Solitary fibrous tumor" 1 => "Pleura" 2 => "Biological behavior" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154249" "palabras" => array:3 [ 0 => "Tumor fibroso solitario" 1 => "Pleura" 2 => "Comportamiento biológico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We assessed the clinicopathological features of solitary fibrous tumors of the pleura in a case series comprising 30 patients (20 women, 66.6%) with a mean age of 58.39 years. Forty-five percent of the cases were asymptomatic. In 70% of the cases the tumors arose in the visceral pleura. Twenty percent presented multiple tumors, a finding that was associated with intrapulmonary localization and malignant behavior (<span class="elsevierStyleItalic">P</span><.0001) Histology revealed low cell density in 15% of the cases, moderate density in 50%, and high density in 35%; further findings showed atypia in 45% of the cases, necrosis in 25%, and hemorrhage in 15%. More than 4 mitoses per 10 high-power fields were noted in 30% of the cases. Immunohistochemistry results were positive for vimentin in all cases; cells were CD34<span class="elsevierStyleSup">+</span> in 85% of the cases, BCL2<span class="elsevierStyleSup">+</span> in 65%, and CD99<span class="elsevierStyleSup">+</span> in 40%. Findings for keratin and protein S100 were negative in all cases. Malignant biological behavior (local recurrence and metastasis) was observed in 4 cases, 2 of which were CD34<span class="elsevierStyleSup">−</span>.</p><p class="elsevierStyleSimplePara elsevierViewall">Solitary fibrous tumors of the pleura are uncommon neoplasms with unpredictable biological behavior; follow-up should therefore be based on early detection of recurrence or metastasis.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Hemos evaluado las características clinicopatológicas del tumor fibroso solitario pleural en una serie de 30 casos. El 70% de los pacientes eran mujeres. El promedio de edad fue de 58,39 años. El 45% de los casos fueron asintomÁticos. La localización más frecuente fue la pleura visceral (70%). En el 20% de los casos se observaron tumoraciones múltiples y se asociaron a localización intrapulmonar (p < 0,0001). His-tológicamente mostraron densidad celular escasa en el 15% de los casos, moderada en el 50% e intensa en el 35%; atipia en el 45%; necrosis en el 25%; hemorragia en el 15%, y mitosis mayor de 4 por 10 campos en el 30%. La inmuhistoquí-mica mostró positividad para vimentina (100%), CD34 (85%), BCL2 (65%) y CD99 (40%), y negatividad en el 100% de los casos para queratinas y la proteína S100. Cuatro pacientes presentaron un comportamiento biológico maligno (recurrencia local y metástasis); en 2 de ellos el CD34 había sido negativo.</p><p class="elsevierStyleSimplePara elsevierViewall">El tumor fibroso solitario pleural es una neoplasia poco común de comportamiento biológico impredecible, por lo que el seguimiento debe centrarse en la detección precoz de la recurrencia o de metÁstasis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benign fibrous mesothelioma of the pleura" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A Oliaro" 1 => "PL Filosso" 2 => "C Casadio" 3 => "E Ruffini" 4 => "R Cianci" 5 => "C Porrello" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Minerva Chir" "fecha" => "1994" "volumen" => "49" "paginaInicial" => "1311" "paginaFinal" => "1316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7746454" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solitary fibrous tumor: the emerging clinicopathologic spectrum of an entity and its differential diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J Graadt van Roggen" 1 => "P Hogendoorn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Diagn Pathol" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "229" "paginaFinal" => "235" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solitary fibrous tumour of the pleura: surgical treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O Rena" 1 => "PL Filosso" 2 => "E Papalia" 3 => "M Molinatti" 4 => "P di Marzio" 5 => "G Maggi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "185" "paginaFinal" => "189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11167110" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Localized benign and malignant fibrous tumors of the pleura. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 2 | 4 |
| 2024 October | 35 | 16 | 51 |
| 2024 September | 32 | 17 | 49 |
| 2024 August | 47 | 25 | 72 |
| 2024 July | 22 | 23 | 45 |
| 2024 June | 28 | 21 | 49 |
| 2024 May | 34 | 32 | 66 |
| 2024 April | 16 | 23 | 39 |
| 2024 March | 23 | 23 | 46 |
| 2024 February | 24 | 17 | 41 |
| 2023 March | 4 | 4 | 8 |
| 2023 February | 13 | 20 | 33 |
| 2023 January | 17 | 30 | 47 |
| 2022 December | 29 | 21 | 50 |
| 2022 November | 29 | 16 | 45 |
| 2022 October | 62 | 34 | 96 |
| 2022 September | 15 | 21 | 36 |
| 2022 August | 56 | 37 | 93 |
| 2022 July | 53 | 48 | 101 |
| 2022 June | 13 | 35 | 48 |
| 2022 May | 19 | 44 | 63 |
| 2022 April | 15 | 25 | 40 |
| 2022 March | 20 | 32 | 52 |
| 2022 February | 21 | 38 | 59 |
| 2022 January | 14 | 29 | 43 |
| 2021 December | 22 | 59 | 81 |
| 2021 November | 34 | 45 | 79 |
| 2021 October | 34 | 39 | 73 |
| 2021 September | 21 | 43 | 64 |
| 2021 August | 10 | 27 | 37 |
| 2021 July | 12 | 24 | 36 |
| 2021 June | 15 | 33 | 48 |
| 2021 May | 17 | 24 | 41 |
| 2021 April | 26 | 64 | 90 |
| 2021 March | 17 | 17 | 34 |
| 2021 February | 13 | 46 | 59 |
| 2021 January | 18 | 16 | 34 |
| 2020 December | 18 | 11 | 29 |
| 2020 November | 13 | 16 | 29 |
| 2020 October | 13 | 11 | 24 |
| 2020 September | 13 | 17 | 30 |
| 2020 August | 9 | 9 | 18 |
| 2020 July | 10 | 21 | 31 |
| 2020 June | 10 | 13 | 23 |
| 2020 May | 19 | 11 | 30 |
| 2020 April | 15 | 12 | 27 |
| 2020 March | 10 | 8 | 18 |
| 2020 February | 15 | 10 | 25 |
| 2020 January | 16 | 7 | 23 |
| 2019 December | 17 | 14 | 31 |
| 2019 November | 11 | 16 | 27 |
| 2019 October | 12 | 5 | 17 |
| 2019 September | 9 | 10 | 19 |
| 2019 August | 9 | 7 | 16 |
| 2019 July | 9 | 19 | 28 |
| 2019 June | 8 | 8 | 16 |
| 2019 May | 11 | 13 | 24 |
| 2019 April | 32 | 34 | 66 |
| 2019 March | 16 | 24 | 40 |
| 2019 February | 10 | 11 | 21 |
| 2019 January | 13 | 10 | 23 |
| 2018 December | 10 | 21 | 31 |
| 2018 November | 20 | 11 | 31 |
| 2018 October | 22 | 13 | 35 |
| 2018 September | 6 | 14 | 20 |
| 2018 May | 2 | 2 | 4 |
| 2018 April | 13 | 10 | 23 |
| 2018 March | 2 | 3 | 5 |
| 2018 February | 7 | 7 | 14 |
| 2018 January | 4 | 12 | 16 |
| 2017 December | 9 | 10 | 19 |
| 2017 November | 9 | 9 | 18 |
| 2017 October | 11 | 12 | 23 |
| 2017 September | 9 | 5 | 14 |
| 2017 August | 18 | 12 | 30 |
| 2017 July | 9 | 4 | 13 |
| 2017 June | 15 | 10 | 25 |
| 2017 May | 17 | 12 | 29 |
| 2017 April | 14 | 1 | 15 |
| 2017 March | 17 | 11 | 28 |
| 2017 February | 4 | 5 | 9 |
| 2017 January | 5 | 2 | 7 |
| 2016 December | 10 | 10 | 20 |
| 2016 November | 8 | 7 | 15 |
| 2016 October | 12 | 6 | 18 |
| 2016 September | 10 | 9 | 19 |
| 2016 August | 5 | 3 | 8 |
| 2016 July | 4 | 2 | 6 |
| 2016 March | 3 | 0 | 3 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 76 | 17 | 93 |
| 2015 September | 74 | 20 | 94 |
| 2015 August | 61 | 12 | 73 |
| 2015 July | 63 | 7 | 70 |
| 2015 June | 49 | 11 | 60 |
| 2015 May | 82 | 17 | 99 |
| 2015 April | 56 | 13 | 69 |
| 2015 March | 69 | 10 | 79 |
| 2015 February | 63 | 9 | 72 |
| 2015 January | 85 | 14 | 99 |
| 2014 December | 71 | 6 | 77 |
| 2014 November | 71 | 7 | 78 |
| 2014 October | 85 | 9 | 94 |
| 2014 September | 66 | 8 | 74 |
| 2014 August | 61 | 14 | 75 |
| 2014 July | 82 | 10 | 92 |
| 2014 June | 81 | 10 | 91 |
| 2014 May | 69 | 14 | 83 |
| 2014 April | 88 | 14 | 102 |
| 2014 March | 88 | 12 | 100 |
| 2014 February | 99 | 9 | 108 |
| 2014 January | 71 | 11 | 82 |
| 2013 December | 70 | 11 | 81 |
| 2013 November | 56 | 13 | 69 |
| 2013 October | 70 | 6 | 76 |
| 2013 September | 58 | 11 | 69 |
| 2013 August | 54 | 15 | 69 |
| 2013 July | 59 | 10 | 69 |
| 2013 June | 39 | 7 | 46 |
| 2013 May | 45 | 7 | 52 |
| 2013 April | 28 | 6 | 34 |
| 2013 March | 13 | 4 | 17 |
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