Review Article
Origin and Development of RUTI, a New Therapeutic Vaccine Against Mycobacterium tuberculosis Infection
P.J. Cardonaa,b,
, I. Amata,b
Corresponding author
pcardona@ns.hugtip.scs.es
Correspondence: Dr. P.J. Cardona. Unitat de Tuberculosi Experimental. Servei de Microbiologia. Hospital Universitari Germans Trias i Pujol. Ctra. del Canyet, s/n. 08916 Badalona. Barcelona. España
Correspondence: Dr. P.J. Cardona. Unitat de Tuberculosi Experimental. Servei de Microbiologia. Hospital Universitari Germans Trias i Pujol. Ctra. del Canyet, s/n. 08916 Badalona. Barcelona. España
Read
4598
Timeswas read the article
1984
Total PDF
2614
Total HTML
Share statistics
array:23 [ "pii" => "S1579212906601109" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60110-9" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "60110" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Arch Bronconeumol. 2006;42:25-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2589 "formatos" => array:3 [ "EPUB" => 100 "HTML" => 1738 "PDF" => 751 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212906601110" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60111-0" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "60111" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:33-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6821 "formatos" => array:3 [ "EPUB" => 89 "HTML" => 5405 "PDF" => 1327 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Techniques and Procedures</span>" "titulo" => "Nasal Potential Difference Test to Diagnose Cystic Fibrosis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "33" "paginaFinal" => "38" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Domingo-Ribas, M. Bosque-García" "autores" => array:2 [ 0 => array:3 [ "preGrado" => "Dr." "nombre" => "C." "apellidos" => "Domingo-Ribas" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Bosque-García" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601110?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000001/v1_201305150227/S1579212906601110/v1_201305150227/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212906601092" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60109-2" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "60109" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:21-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2545 "formatos" => array:3 [ "EPUB" => 97 "HTML" => 1869 "PDF" => 579 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Smoking Among Adolescents: Population Study on Parental and School Influences" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "21" "paginaFinal" => "24" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.M. Yáñez, R. López, J. Serra-Batlles, N. Roger, A. Arnau, P. Roura" "autores" => array:6 [ 0 => array:3 [ "preGrado" => "Dra." "nombre" => "A.M." "apellidos" => "Yáñez" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "López" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Serra-Batlles" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Roger" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Arnau" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Roura" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601092?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000001/v1_201305150227/S1579212906601092/v1_201305150227/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "Origin and Development of RUTI, a New Therapeutic Vaccine Against <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> Infection" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "25" "paginaFinal" => "32" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P.J. Cardona, I. Amat" "autores" => array:2 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "P.J." "apellidos" => "Cardona" "email" => array:1 [ 0 => "pcardona@ns.hugtip.scs.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Amat" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unitat de Tuberculosi Experimental, Servei de Microbiologia, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. P.J. Cardona. Unitat de Tuberculosi Experimental. Servei de Microbiologia. Hospital Universitari Germans Trias i Pujol. Ctra. del Canyet, s/n. 08916 Badalona. Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-01-10" "fechaAceptado" => "2005-02-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154176" "palabras" => array:9 [ 0 => "Latent bacilli" 1 => "Immunotherapy" 2 => "Mycobacterium tuberculosis" 3 => "Koch phenomenon" 4 => "Foamy macrophages" 5 => "Experimental models" 6 => "Tolerance" 7 => "Chemotherapy" 8 => "Th1/Th2" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154175" "palabras" => array:9 [ 0 => "Bacilos latentes" 1 => "Inmunoterapia" 2 => "Mycobacterium tuberculosis" 3 => "Fenómeno de Koch" 4 => "Macrófagos foamy" 5 => "Modelos experimentales" 6 => "Tolerancia" 7 => "Quimioterapia" 8 => "Th1/Th2" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">This article reviews the pathophysiology of the latent form of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> along with its natural history and progression in infected tissues. The proposed hypotheses regarding the relationship between <span class="elsevierStyleItalic">M tuberculosis</span> and the associated immune response, the cause of granuloma necrosis, the tolerance of a certain concentration of the bacillus in host tissues, the constant turnover of cells in the lung, and the effect of chemotherapy form the basis for the design of the therapeutic vaccine RUTI against latent <span class="elsevierStyleItalic">M tuberculosis</span> infection. This vaccine is generated from detoxified <span class="elsevierStyleItalic">M tuberculosis</span> cell fragments that facilitate a balanced T helper (Th) 1/Th2/Th3 response to a wide range of antigens along with intense antibody production. Treatment with RUTI following chemotherapy has been demonstrated to be effective in experimental models in mice and guinea pigs and does not exhibit toxicity.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">En este artículo se revisan la fisiopatología de la forma la-tente de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>, su naturaleza y su evo-lución en los tejidos infectados. Las hipótesis planteadas en-tre la relación de este bacilo con la respuesta inmunitaria generada, el origen de la necrosis intragranulomatosa, la to-lerancia hacia cierta concentración bacilar en los tejidos del hospedador, el constante recambio celular en los pulmona-res y el efecto inducido por el tratamiento quimioterápico permiten conocer las bases para el diseño de la vacuna terapéutica RUTI contra la infección latente por <span class="elsevierStyleItalic">M. tuberculosis.</span> Se trata de una vacuna generada a partir de fragmentos ce-lulares de <span class="elsevierStyleItalic">M. tuberculosis</span> biotransformados que permiten generar una respuesta equilibrada de tipo Th1/Th2/Th3 ante un amplio abanico de antígenos, además de una intensa producción de anticuerpos. El tratamiento con RUTI, posterior a la quimioterapia, ya ha demostrado su eficacia en mo-delos experimentales en ratones y cobayas, sin generar nin-guna respuesta tóxica.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This work was supported by grants FIS 01/0644 and 01/3104 from the Spanish Ministry of Health, and by a grant from the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) 2003.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:63 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "World Health Organization" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Global Tuberculosis Control: surveillance, planning, financing" "fecha" => "2004" "editorial" => "WHO Report" "editorialLocalizacion" => "Geneva" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeted tuberculin testing and treatment of latent tuberculosis infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Thoracic Society" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.supplement_3.ats600" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "paginaInicial" => "S221" "paginaFinal" => "SS47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10764341" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of new vaccines for tuberculosis. Recommendations of the Advisory Council for the Elimination of Tuberculosis (ACET)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Centers for Disease Control and Prevention" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "MMWR Recomm Rep" "fecha" => "1998" "volumen" => "47" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9809743" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HSV LAT and neuronal survival" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "DC Bloom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Rev Immunol" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "187" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14690860" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamics of microbial growth in the decelerating and stationary phase of batch culture" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "CA Mason" 1 => "T Egli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Starvation in bacteria" "paginaInicial" => "81" "paginaFinal" => "102" "serieFecha" => "1993" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of rpoS in early stationary-phase gene regulation in <span class="elsevierStyleItalic">Escherichia coli</span> K12" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R Hengge-Aronis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Starvation in bacteria" "paginaInicial" => "171" "paginaFinal" => "200" "serieFecha" => "1993" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deciphering the biology of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> from the complete genome sequence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "ST Cole" 1 => "R Brosch" 2 => "J Parkhill" 3 => "T Garnier" 4 => "C Churcher" 5 => "D Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/31159" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1998" "volumen" => "393" "paginaInicial" => "537" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9634230" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structure, function, and biogenesis of the cell wall of <span class="elsevierStyleItalic">Mycobacterium tuberculosis.</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "PJ Brennan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Tuberculosis (Edinb)" "fecha" => "2003" "volumen" => "83" "paginaInicial" => "91" "paginaFinal" => "97" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946–1986, with relevant subsequent publications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W Fox" 1 => "GA Ellard" 2 => "DA Mitchison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "1999" "volumen" => "3" "paginaInicial" => "S231" "paginaFinal" => "S279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10529902" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The action of antituberculosis drugs in short-course chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "DA Mitchison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tubercle" "fecha" => "1985" "volumen" => "66" "paginaInicial" => "219" "paginaFinal" => "225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3931319" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The viability and virulence of old cultures of tubercle bacilli: studies on twelve-year broth cultures maintained at incubator temperature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "HJ Corper" 1 => "ML Cohn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Rev Tuberc" "fecha" => "1933" "volumen" => "28" "paginaInicial" => "856" "paginaFinal" => "874" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exogenous reinfection: its relative impact with regard to development of pulmonary tuberculosis. A study of the pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G Canetti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tubercle" "fecha" => "1950" "volumen" => "31" "paginaInicial" => "224" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14788276" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tubercle bacilli in latent tuberculous lesions and in lung tissue without tuberculous lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "EL Opie" 1 => "JD Aronson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Arch Pathol" "fecha" => "1927" "volumen" => "4" "paginaInicial" => "121" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fate of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> in mouse tissues as determined by the microbial enumeration technique. I. The persistence of drug susceptible bacilli in the tissues despite prolonged antimicrobial therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "RM McCune" 1 => "R Tompsett" 2 => "W McDermott" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1956" "volumen" => "104" "paginaInicial" => "737" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13367341" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dormancy in non-sporulating bacteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "AS Kaprelyants" 1 => "JC Gottschal" 2 => "DB Kell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "FEMS Microbiol Rev" "fecha" => "1993" "volumen" => "10" "paginaInicial" => "271" "paginaFinal" => "285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8318260" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Formation and resuscitation of "non-culturable" cells of <span class="elsevierStyleItalic">Rhodococcus rhodochrous</span> and <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> in prolonged stationary phase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "MO Shleeva" 1 => "K Bagramyan" 2 => "MV Telkov" 3 => "GV Mukamolova" 4 => "M Young" 5 => "DB Kell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1099/00221287-148-5-1581" "Revista" => array:6 [ "tituloSerie" => "Microbiology" "fecha" => "2002" "volumen" => "148" "paginaInicial" => "1581" "paginaFinal" => "1591" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11988533" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microbial physiology and ecology of slow growth" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "AL Koch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Microbiol Mol Biol Rev" "fecha" => "1997" "volumen" => "61" "paginaInicial" => "305" "paginaFinal" => "318" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9293184" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dormancy of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> and latency of disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "LG Wayne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Microbiol Infect Dis" "fecha" => "1994" "volumen" => "13" "paginaInicial" => "908" "paginaFinal" => "914" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7698116" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glyoxylate metabolism and adaptation of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> to survival under anaerobic conditions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "LG Wayne" 1 => "KY Lin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "1982" "volumen" => "37" "paginaInicial" => "1042" "paginaFinal" => "1049" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6813266" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistence of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JD McKinney" 1 => "ZU Honer" 2 => "K Bentrup" 3 => "EJ Muñoz-Elias" 4 => "A Miczak" 5 => "B Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/35021074" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2000" "volumen" => "406" "paginaInicial" => "735" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10963599" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The latent tuberculosis bacillus (I'll let you know if I ever meet one)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "IM Orme" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2001" "volumen" => "5" "paginaInicial" => "589" "paginaFinal" => "593" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11469255" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug tolerance in <span class="elsevierStyleItalic">Mycobacterium tuberculosis.</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "RS Wallis" 1 => "S Patil" 2 => "SH Cheon" 3 => "K Edmonds" 4 => "M Phillips" 5 => "MD Perkins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "1999" "volumen" => "43" "paginaInicial" => "2600" "paginaFinal" => "2606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10543735" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "L variation in mycobacteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "KH Mattman" 1 => "KH Tunstall" 2 => "WW Mathews" 3 => "DL Gordon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1960" "volumen" => "82" "paginaInicial" => "202" "paginaFinal" => "211" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "LH Mattman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Cell wall deficient forms. Stealth pathogens" "fecha" => "2001" "editorial" => "CRC Press" "editorialLocalizacion" => "Boca Ratón" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolution of granulomas in mice infected aerogenically with <span class="elsevierStyleItalic">Mycobacterium tuberculosis.</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "R Llatjós" 2 => "S Gordillo" 3 => "J Díaz" 4 => "I Ojanguren" 5 => "A Ariza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Scan J Immunol" "fecha" => "2000" "volumen" => "52" "paginaInicial" => "156" "paginaFinal" => "163" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histopatología de la tuberculosis. Aproximación a la evolución de las lesiones pulmonares en modelos de experimentación animal inducidos mediante aerosol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "PJ Cardona" 1 => "V Ausina" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "645" "paginaFinal" => "650" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11171437" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alveolobronchiolar transport mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "GM Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1973" "volumen" => "131" "paginaInicial" => "109" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4739083" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diseases in mice and rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "MJ Lefford" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The mycobacteria: a source book" "paginaInicial" => "947" "paginaFinal" => "977" "serieFecha" => "1984" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Catalase-peroxidase activity has no influence on virulence in a murine model of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "S Gordillo" 2 => "I Amat" 3 => "J Díaz" 4 => "J Lonca" 5 => "C Vilaplana" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tuberculosis (Edinb)" "fecha" => "2003" "volumen" => "83" "paginaInicial" => "351" "paginaFinal" => "359" "itemHostRev" => array:3 [ "pii" => "S0210569110002238" "estado" => "S300" "issn" => "02105691" ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "A Cooper" 2 => "M Luquin" 3 => "A Ariza" 4 => "F Filipo" 5 => "IM Orme" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Immunol" "fecha" => "1999" "volumen" => "49" "paginaInicial" => "362" "paginaFinal" => "366" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10219760" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Virulence ranking of some Mycobacterium tuberculosis and <span class="elsevierStyleItalic">Mycobacterium bovis</span> strains according to their ability to multiply in the lungs, induce lung pathology, and cause mortality in mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "PL Dunn" 1 => "RJ North" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "1995" "volumen" => "63" "paginaInicial" => "3428" "paginaFinal" => "3437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7642273" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Host responses and antigens involved in protective immunity to <span class="elsevierStyleItalic">Mycobacterium tuberculosis.</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P Andersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Immunol" "fecha" => "1997" "volumen" => "45" "paginaInicial" => "115" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042423" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunophysiology and immunopathology of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "JM Grange" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Clinical tuberculosis" "paginaInicial" => "113" "paginaFinal" => "127" "serieFecha" => "1998" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rabbit model of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "AM Dannenberg Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "149" "paginaFinal" => "156" "serieVolumen" => "10" "serieTitulo" => "Tuberculosis: pathogenesis, protection, and control" "serieFecha" => "1994" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The correlation between the histological changes and the fate of living tubercle bacilli in the organs of tuberculous rabbits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "MB Lurie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1932" "volumen" => "55" "paginaInicial" => "31" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19869977" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokines and the Koch phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "GA Rook" 1 => "R Al Attiyah" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tubercle" "fecha" => "1991" "volumen" => "72" "paginaInicial" => "13" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1882441" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G Shwartzman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Phenomenon of local tissue reactivity and its immunological, pathological and clinical significance" "fecha" => "1937" "editorial" => "Paul B. Hober" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Towards a "human-like" model of tuberculosis: local inoculation of LPS in lungs of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> aerogenically infected mice induces intragranulomatous necrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "R Llatjós" 2 => "S Gordillo" 3 => "B Viñado" 4 => "J Díaz" 5 => "A Ariza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Immunol" "fecha" => "2001" "volumen" => "53" "paginaInicial" => "65" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11169208" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "AM Dannenberg Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0167-5699(91)90035-R" "Revista" => array:6 [ "tituloSerie" => "Immunol Today" "fecha" => "1991" "volumen" => "12" "paginaInicial" => "228" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1822092" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disseminated tuberculosis in interferon gamma gene-disrupted mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "AM Cooper" 1 => "DK Dalton" 2 => "TA Stewart" 3 => "JP Griffin" 4 => "DG Russell" 5 => "IM Orme" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1993" "volumen" => "178" "paginaInicial" => "2243" "paginaFinal" => "2247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8245795" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison in the United States of America of tuberculins PPD and RT23" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "GW Comstock" 1 => "LB Edwards" 2 => "RN Philip" 3 => "WA Winn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "WHO Bull" "fecha" => "1964" "volumen" => "31" "paginaInicial" => "2" "paginaFinal" => "45" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "SL Baldwin" 1 => "C d'Souza" 2 => "AD Roberts" 3 => "BP Kelly" 4 => "AA Frank" 5 => "MA Lui" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "1998" "volumen" => "66" "paginaInicial" => "2951" "paginaFinal" => "2959" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9596772" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does antibody to mycobacterial antigens, including lipoarabinomannan, limit dissemination in childhood tuberculosis?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "AM Costello" 1 => "A Kumar" 2 => "V Narayan" 3 => "MS Akbar" 4 => "S Ahmed" 5 => "C Abou-Zeid" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Trans R Soc Trop Med Hyg" "fecha" => "1992" "volumen" => "86" "paginaInicial" => "686" "paginaFinal" => "692" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1287946" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An IgG antibody response to the antigen 85 complex is associated with good outcome in Mexican Totonaca Indians with pulmonary tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Sánchez-Rodríguez" 1 => "C Estrada-Chávez" 2 => "J García-Vigil" 3 => "F Laredo-Sánchez" 4 => "J Halabe-Cherem" 5 => "A Pereira-Suárez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2002" "volumen" => "6" "paginaInicial" => "706" "paginaFinal" => "712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12150483" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X10004805" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-4 in tuberculosis: implications for vaccine design" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "GA Rook" 1 => "R Hernández-Pando" 2 => "K Dheda" 3 => "G Teng Seah" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.it.2004.06.005" "Revista" => array:6 [ "tituloSerie" => "Trends Immunol" "fecha" => "2004" "volumen" => "25" "paginaInicial" => "483" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15324741" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced intracellular growth of mycobacteria in human macrophages cultivated at physiologic oxygen pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "PRA Meylan" 1 => "DD Richman" 2 => "RS Konbluth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/145.4_Pt_1.947" "Revista" => array:7 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1992" "volumen" => "145" "paginaInicial" => "947" "paginaFinal" => "953" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1554224" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210569112000290" "estado" => "S300" "issn" => "02105691" ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxygen tensions and infections: modulation of microbial growth, activity of antimicrobial agents, and immunologic responses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MK Park" 1 => "RA Myers" 2 => "L Marzella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "1992" "volumen" => "14" "paginaInicial" => "720" "paginaFinal" => "740" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1562664" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of altitude on mortality from tuberculosis and pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R Pérez-Padilla" 1 => "F Franco-Marina" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2004" "volumen" => "8" "paginaInicial" => "1315" "paginaFinal" => "1320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15581198" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0163445302909783" "estado" => "S300" "issn" => "01634453" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of altitude on the frequency of pulmonary tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MH Vargas" 1 => "ME Furuya" 2 => "C Pérez-Guzmán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2004" "volumen" => "8" "paginaInicial" => "1321" "paginaFinal" => "1324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15581199" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of cell replication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "KR Harmon" 1 => "WA Marinelli" 2 => "CA Henke" 3 => "PB Bitterman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The lung: scientific foundations" "paginaInicial" => "105" "paginaFinal" => "129" "serieFecha" => "1991" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cell-wall alterations as an attribute of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> in latent infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P Seiler" 1 => "T Ulrichs" 2 => "S Bandermann" 3 => "L Pradl" 4 => "S Jorg" 5 => "V Krenn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/378563" "Revista" => array:7 [ "tituloSerie" => "J Infect Dis" "fecha" => "2003" "volumen" => "188" "paginaInicial" => "1326" "paginaFinal" => "1331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14593589" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210569110000409" "estado" => "S300" "issn" => "02105691" ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of acidification in <span class="elsevierStyleItalic">Mycobacterium phagosomes</span> produced by exclusion of the vesicular proton-ATPase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S Sturgill-Koszycki" 1 => "PH Schlesinger" 2 => "P Chakraborty" 3 => "PL Haddix" 4 => "HL Collins" 5 => "AK Fok" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1994" "volumen" => "263" "paginaInicial" => "678" "paginaFinal" => "681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8303277" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The heat resistance of tubercle bacilli in the lungs of infected mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "JG Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1961.83.6.866" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1961" "volumen" => "83" "paginaInicial" => "866" "paginaFinal" => "871" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13782801" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Processing of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L Ramachandra" 1 => "E Noss" 2 => "WH Boom" 3 => "CV Harding" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "2001" "volumen" => "194" "paginaInicial" => "1421" "paginaFinal" => "1432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11714749" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Life and death of <span class="elsevierStyleItalic">Brucella</span> within cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E Moreno" 1 => "J Pizarro-Cerdá" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracellular pathogens in membrane interactions and vacuole biogenesis" "paginaInicial" => "99" "paginaFinal" => "129" "serieFecha" => "2004" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro <span class="elsevierStyleItalic">Brucella</span> suis infection prevents the programmed cell death of human monocytic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A Gross" 1 => "A Terraza" 2 => "S Ouahrani-Bettache" 3 => "JP Liautard" 4 => "J Dornand" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "2000" "volumen" => "68" "paginaInicial" => "342" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10603407" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Widespread bronchogenic dissemination makes DBA/2 mice more susceptible than C57BL/6 mice to experimental aerosol infection with <span class="elsevierStyleItalic">Mycobacterium tuberculosis.</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "S Gordillo" 2 => "J Díaz" 3 => "G Tapia" 4 => "I Amat" 5 => "A Pallarés" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "2003" "volumen" => "71" "paginaInicial" => "5845" "paginaFinal" => "5854" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14500506" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "CA Scanga" 1 => "VP Mohan" 2 => "K Yu" 3 => "H Joseph" 4 => "K Tanaka" 5 => "J Chan" 6 => "JL Flynn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "2000" "volumen" => "192" "paginaInicial" => "347" "paginaFinal" => "358" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10934223" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Susceptibility of a panel of virulent strains of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> to reactive nitrogen intermediates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "ER Rhoades" 1 => "IM Orme" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Infect Immun" "fecha" => "1997" "volumen" => "65" "paginaInicial" => "1189" "paginaFinal" => "1195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9119450" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cells and mucosal macrophages" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "PA Stumbles" 1 => "AS McWilliam" 2 => "PG Holt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Mucosal immunology" "paginaInicial" => "397" "paginaFinal" => "412" "serieFecha" => "1999" ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Production of antibodies against glycolipids from the <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> cell wall in aerosol murine models of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "E Julián" 2 => "X Vallés" 3 => "S Gordillo" 4 => "M Muñoz" 5 => "M Luquin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Immunol" "fecha" => "2002" "volumen" => "55" "paginaInicial" => "639" "paginaFinal" => "645" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12028568" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy with fragmented <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PJ Cardona" 1 => "I Amat" 2 => "S Gordillo" 3 => "V Arcos" 4 => "E Guirado" 5 => "J Díaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vaccine.2004.09.008" "Revista" => array:6 [ "tituloSerie" => "Vaccine" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "1393" "paginaFinal" => "1398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15661388" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infection of swine with <span class="elsevierStyleItalic">Mycobacterium bovis</span> as a model of human tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "CA Bolin" 1 => "DK Whipple" 2 => "KV Khanna" 3 => "JM Risdahl" 4 => "PK Peterson" 5 => "TW Molitor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1997" "volumen" => "176" "paginaInicial" => "1559" "paginaFinal" => "1566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395368" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000001/v1_201305150227/S1579212906601109/v1_201305150227/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000001/v1_201305150227/S1579212906601109/v1_201305150227/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601109?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 2 | 5 |
| 2024 October | 38 | 14 | 52 |
| 2024 September | 25 | 12 | 37 |
| 2024 August | 51 | 36 | 87 |
| 2024 July | 32 | 28 | 60 |
| 2024 June | 34 | 21 | 55 |
| 2024 May | 36 | 30 | 66 |
| 2024 April | 16 | 20 | 36 |
| 2024 March | 25 | 14 | 39 |
| 2024 February | 26 | 27 | 53 |
| 2023 March | 3 | 2 | 5 |
| 2023 February | 21 | 15 | 36 |
| 2023 January | 21 | 28 | 49 |
| 2022 December | 26 | 31 | 57 |
| 2022 November | 22 | 26 | 48 |
| 2022 October | 26 | 39 | 65 |
| 2022 September | 24 | 30 | 54 |
| 2022 August | 20 | 38 | 58 |
| 2022 July | 22 | 43 | 65 |
| 2022 June | 26 | 30 | 56 |
| 2022 May | 23 | 26 | 49 |
| 2022 April | 23 | 29 | 52 |
| 2022 March | 21 | 33 | 54 |
| 2022 February | 18 | 30 | 48 |
| 2022 January | 25 | 41 | 66 |
| 2021 December | 10 | 45 | 55 |
| 2021 November | 16 | 45 | 61 |
| 2021 October | 19 | 52 | 71 |
| 2021 September | 16 | 48 | 64 |
| 2021 August | 14 | 40 | 54 |
| 2021 July | 12 | 34 | 46 |
| 2021 June | 15 | 32 | 47 |
| 2021 May | 10 | 28 | 38 |
| 2021 April | 15 | 28 | 43 |
| 2021 March | 13 | 37 | 50 |
| 2021 February | 14 | 13 | 27 |
| 2021 January | 9 | 28 | 37 |
| 2020 December | 8 | 16 | 24 |
| 2020 November | 9 | 20 | 29 |
| 2020 October | 6 | 16 | 22 |
| 2020 September | 6 | 8 | 14 |
| 2020 August | 8 | 14 | 22 |
| 2020 July | 8 | 11 | 19 |
| 2020 June | 4 | 7 | 11 |
| 2020 May | 18 | 24 | 42 |
| 2020 April | 15 | 20 | 35 |
| 2020 March | 17 | 12 | 29 |
| 2020 February | 16 | 26 | 42 |
| 2020 January | 23 | 16 | 39 |
| 2019 December | 15 | 17 | 32 |
| 2019 November | 15 | 9 | 24 |
| 2019 October | 9 | 21 | 30 |
| 2019 September | 7 | 23 | 30 |
| 2019 August | 16 | 10 | 26 |
| 2019 July | 15 | 22 | 37 |
| 2019 June | 12 | 10 | 22 |
| 2019 May | 20 | 19 | 39 |
| 2019 April | 42 | 19 | 61 |
| 2019 March | 21 | 32 | 53 |
| 2019 February | 19 | 17 | 36 |
| 2019 January | 8 | 27 | 35 |
| 2018 December | 19 | 19 | 38 |
| 2018 November | 14 | 21 | 35 |
| 2018 October | 9 | 19 | 28 |
| 2018 September | 11 | 10 | 21 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 9 | 9 | 18 |
| 2018 March | 2 | 5 | 7 |
| 2018 February | 5 | 4 | 9 |
| 2018 January | 5 | 6 | 11 |
| 2017 December | 10 | 8 | 18 |
| 2017 November | 3 | 3 | 6 |
| 2017 October | 5 | 10 | 15 |
| 2017 September | 2 | 12 | 14 |
| 2017 August | 7 | 11 | 18 |
| 2017 July | 4 | 2 | 6 |
| 2017 June | 7 | 16 | 23 |
| 2017 May | 7 | 9 | 16 |
| 2017 April | 1 | 2 | 3 |
| 2017 March | 4 | 8 | 12 |
| 2017 February | 4 | 6 | 10 |
| 2017 January | 1 | 1 | 2 |
| 2016 December | 5 | 9 | 14 |
| 2016 November | 6 | 5 | 11 |
| 2016 October | 7 | 3 | 10 |
| 2016 September | 13 | 9 | 22 |
| 2016 August | 7 | 4 | 11 |
| 2016 July | 7 | 0 | 7 |
| 2016 March | 4 | 0 | 4 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 52 | 1 | 53 |
| 2015 September | 44 | 12 | 56 |
| 2015 August | 42 | 6 | 48 |
| 2015 July | 57 | 11 | 68 |
| 2015 June | 43 | 6 | 49 |
| 2015 May | 50 | 5 | 55 |
| 2015 April | 32 | 12 | 44 |
| 2015 March | 35 | 9 | 44 |
| 2015 February | 36 | 10 | 46 |
| 2015 January | 45 | 4 | 49 |
| 2014 December | 25 | 6 | 31 |
| 2014 November | 31 | 8 | 39 |
| 2014 October | 64 | 10 | 74 |
| 2014 September | 32 | 7 | 39 |
| 2014 August | 52 | 11 | 63 |
| 2014 July | 30 | 5 | 35 |
| 2014 June | 54 | 11 | 65 |
| 2014 May | 47 | 12 | 59 |
| 2014 April | 52 | 15 | 67 |
| 2014 March | 72 | 14 | 86 |
| 2014 February | 34 | 8 | 42 |
| 2014 January | 37 | 5 | 42 |
| 2013 December | 39 | 9 | 48 |
| 2013 November | 42 | 7 | 49 |
| 2013 October | 40 | 11 | 51 |
| 2013 September | 35 | 11 | 46 |
| 2013 August | 55 | 21 | 76 |
| 2013 July | 54 | 11 | 65 |
| 2013 June | 37 | 9 | 46 |
| 2013 May | 31 | 3 | 34 |
| 2013 April | 18 | 10 | 28 |
| 2013 March | 6 | 2 | 8 |
Show all
