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Pre-proof, online 29 July 2024
Mucus Plugs as Precursors to Exacerbation and Lung Function Decline in COPD Patients
Kwang Nam Jin1,
Corresponding author
athrunzara86@snu.ac.kr
athrunzara86@gmail.com

Corresponding author: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Republic of Korea
, Hyo Jin Lee2, Heemoon Park2, Jung-Kyu Lee2, Eun Young Heo2, Deog Kyeom Kim2, Hyun Woo Lee2
1 Department of Radiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea
2 Division of Respiratory and Critical Care, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea
Highlights

  • COPD patients with mucus plugs in chest CT scans experienced higher rates and increased hazard of moderate-to-severe and severe exacerbations, particularly non-eosinophilic types, compared to those without mucus plugs.

  • Higher mucus plug scores, especially scores of 3 or greater, were significantly associated with shorter time to exacerbation.

  • The presence of mucus plugs was associated with a faster annual decline in lung function, measured as FEV1, with those having higher mucus plug scores experiencing the most rapid declines.

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Mucus Plugs as Precursors to Exacerbation and Lung Function Decline in COPD Patients
Kwang Nam Jin1,
Corresponding author
athrunzara86@snu.ac.kr
athrunzara86@gmail.com

Corresponding author: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Republic of Korea
, Hyo Jin Lee2, Heemoon Park2, Jung-Kyu Lee2, Eun Young Heo2, Deog Kyeom Kim2, Hyun Woo Lee2
1 Department of Radiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea
2 Division of Respiratory and Critical Care, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea
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ISSN: 03002896
Original language: English
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2024 July 15 17 32

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