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CRP 2&#46;62<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and leukocytosis 15&#44;180&#47;mcL &#40;eosinophils 3&#46;990&#47;mcL&#44; 27&#37;&#41;&#46; The ANAs&#44; MPO-ANCA&#44; PR3-ANCA&#44; microbiology and serology were all negative &#40;virus&#44; bacteria and parasites&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In view of patient&#39;s poor respiratory progress&#44; we performed a diagnostic thoracentesis&#44; obtaining a yellowish non-hematic exudate with the following characteristics&#58; pH 7&#46;20&#44; protein 6<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; glucose 214<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; LDH 203<span class="elsevierStyleHsp" style=""></span>U&#47;L and leukocytes 6780&#47;mcL &#40;50&#37; eosinophils&#41;&#46; Cytology and microbiology were negative&#46; It was decided to carry out a nasal turbinate biopsy&#44; that showed eosinophilic infiltration of the corium&#46; Polyneuropathy was ruled out&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">EGPA was diagnosed classifying it as a nonsevere with a &#8220;Five Factor Score&#8221; &#40;FFS&#41; of zero&#46; Treatment was started with prednisone 50<span class="elsevierStyleHsp" style=""></span>mg and mepolizumab 100<span class="elsevierStyleHsp" style=""></span>mg per day&#44; progressively escalating to mepolizumab 300<span class="elsevierStyleHsp" style=""></span>mg per day&#46; After 6 months of full-dose treatment&#44; the patient presented an excellent clinical and radiological improvement with complete resolution of eosinophilic pleural effussion &#40;EPE&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">According to <span class="elsevierStyleItalic">the American College of Rheumatology &#40;1990</span>&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> more than 4 of the next 6 criteria are necessary for EGPA diagnosis&#58; asthma&#44; peripheral eosinophilia &#40;&#62;10&#37;&#41;&#44; neuropathy&#44; sinusitis&#44; extravascular eosinophilia and evanescent pulmonary infiltrates&#46; Eosinophilic pleural effusion is a rare complication&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> with an incidence of 29&#37; in patients with EGPA&#46; Its characteristics have not been well described&#44; having been defined by more than 10&#37; eosinophil count&#44; low pH and low glucose&#46; Differential diagnoses of EPE include rheumatoid arthritis&#44; bacterial pneumonia&#44; tuberculosis&#44; parasitosis&#44; pharmacological&#44; neoplasms&#44; hematological disorders and&#44; less frequently&#44; certain vasculitis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">There is no standard therapy for the management of EGPA&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Currently&#44; the cornerstone of treatment consist of systemic glucocorticosteroids&#44; with a relapse rate of 35&#37;&#46; In this context&#44; immunosuppressive agents are used for maintaining remission&#46; In spite of that&#44; high dose of glucocorticoids and immunosuppressants may have long-term adverse effects&#46; Recently&#44; clinical benefits of mepolizumab have been demonstrated in patients with EGPA&#46; MIRRA trial<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> included patients with refractory EGPA treated with prednisone&#44; demonstrating remission in 87&#37; of patients treated with mepolizumab versus 53&#37; in the placebo group&#46; An European Observacional Study compared mepolizumab 300<span class="elsevierStyleHsp" style=""></span>mg versus 100<span class="elsevierStyleHsp" style=""></span>mg dose&#44; showing both doses are associated with effective control of systemic EGPA manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Therefore&#44; mepolizumab is now a good therapeutic option for EGPA&#46; It should be considered as a steroid-sparing drug used for maintenance of remission and control of non-organ-threatening flares&#44; but not as a treatment for active organ-threatening disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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Case Report
Mepolizumab and Eosinophilic Pleural Effusion in Patient With Eosinophilic Granulomatosis With Polyangiitis
María del Carmen Lorenzo Martíneza,
Corresponding author
carmenlorenzomtz@gmail.com

Corresponding author.
, Oscar Clavería Garcíaa, María Dolores Herrero Mendozab, José Javier Jareño Estebana
a Pneumology Department, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain
b Internal Medicine Department, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain
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Polyneuropathy was ruled out&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">EGPA was diagnosed classifying it as a nonsevere with a &#8220;Five Factor Score&#8221; &#40;FFS&#41; of zero&#46; Treatment was started with prednisone 50<span class="elsevierStyleHsp" style=""></span>mg and mepolizumab 100<span class="elsevierStyleHsp" style=""></span>mg per day&#44; progressively escalating to mepolizumab 300<span class="elsevierStyleHsp" style=""></span>mg per day&#46; After 6 months of full-dose treatment&#44; the patient presented an excellent clinical and radiological improvement with complete resolution of eosinophilic pleural effussion &#40;EPE&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">According to <span class="elsevierStyleItalic">the American College of Rheumatology &#40;1990</span>&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> more than 4 of the next 6 criteria are necessary for EGPA diagnosis&#58; asthma&#44; peripheral eosinophilia &#40;&#62;10&#37;&#41;&#44; neuropathy&#44; sinusitis&#44; extravascular eosinophilia and evanescent pulmonary infiltrates&#46; Eosinophilic pleural effusion is a rare complication&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> with an incidence of 29&#37; in patients with EGPA&#46; Its characteristics have not been well described&#44; having been defined by more than 10&#37; eosinophil count&#44; low pH and low glucose&#46; Differential diagnoses of EPE include rheumatoid arthritis&#44; bacterial pneumonia&#44; tuberculosis&#44; parasitosis&#44; pharmacological&#44; neoplasms&#44; hematological disorders and&#44; less frequently&#44; certain vasculitis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">There is no standard therapy for the management of EGPA&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Currently&#44; the cornerstone of treatment consist of systemic glucocorticosteroids&#44; with a relapse rate of 35&#37;&#46; In this context&#44; immunosuppressive agents are used for maintaining remission&#46; In spite of that&#44; high dose of glucocorticoids and immunosuppressants may have long-term adverse effects&#46; Recently&#44; clinical benefits of mepolizumab have been demonstrated in patients with EGPA&#46; MIRRA trial<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> included patients with refractory EGPA treated with prednisone&#44; demonstrating remission in 87&#37; of patients treated with mepolizumab versus 53&#37; in the placebo group&#46; An European Observacional Study compared mepolizumab 300<span class="elsevierStyleHsp" style=""></span>mg versus 100<span class="elsevierStyleHsp" style=""></span>mg dose&#44; showing both doses are associated with effective control of systemic EGPA manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Therefore&#44; mepolizumab is now a good therapeutic option for EGPA&#46; It should be considered as a steroid-sparing drug used for maintenance of remission and control of non-organ-threatening flares&#44; but not as a treatment for active organ-threatening disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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ISSN: 03002896
Original language: English
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