Original Article
Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis
Marcos Matabuenaa, Francisco Javier Salgadob,c, Juan José Nieto-Fontarigob,c,d,
, María J. Álvarez-Pueblae, Ebymar Arismendif,g,h,i, Pilar Barrancof,j, Irina Boboleaf,h,i,k, María L. Caballeroj, José Antonio Cañasf,l,m, Blanca Cárdabaf,m, María Jesus Cruzf,n,o, Elena Curtof,p,q,r, Javier Domínguez-Ortegaj, Juan Alberto Lunaj, Carlos Martínez-Riveraf,s, Joaquim Mullolf,h,i,t, Xavier Muñozf,n,o, Javier Rodriguez-Garciau, José María Olaguibele,f, César Picadof,g,h,i, Vicente Plazaf,p,q,r, Santiago Quircef,j, Manuel J. Rialv, Christian Romero-Mesoneso, Beatriz Sastref,l,m, Lorena Soto-Retesf,p,q,r, Antonio Valerof,g,h,i, Marcela Valverde-Mongel,m, Victoria Del Pozof,l,m,y, Joaquín Sastref,l,m,y, Francisco Javier González-Barcalac,f,w,x
Corresponding author
a Centro Singular de Investigación en Tecnoloxías Intelixentes (CiTIUS), University of Santiago of Compostela, Santiago de Compostela, Spain
b Department of Biochemistry and Molecular Biology, School of Biology-Biological Research Centre (CIBUS), University of Santiago de Compostela, Santiago de Compostela, Spain
c Translational Research in Airway Diseases Group (TRIAD) – Health Research Institute of Santiago de Compostela (IDIS), Spain
d Department of Experimental Medical Science, Lund University, Sweden
e Allergology Department, Navarre University Hospital, Pamplona, Navarra, Spain
f Biomedical Research Centre Network – Respiratory Diseases (CIBERES), Madrid, Spain
g Pneumology and Allergy Department, Hospital Clínic de Barcelona, Barcelona, Spain
h Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain
i University of Barcelona, Barcelona, Spain
j Department of Allergy, La Paz University Hospital, IdiPAZ (Research Institute), Madrid, Spain
k Allergy Unit & Severe Asthma Unit, Pneumonology and Allergy Department, Hospital Clínic de Barcelona, Barcelona, Spain
l Allergology Service, Jiménez Díaz Foundation University Hospital, Madrid, Spain
m Department of Immunology, Health Research Institute Jiménez Díaz Foundation, Madrid, Spain
n Department of Cellular Biology, Physiology and Immunology, Autonomous University of Barcelona, Barcelona, Spain
o Pneumology Department, Vall d’Hebron Hospital, Barcelona, Spain
p Department of Respiratory Medicine, Santa Creu i Sant Pau Hospital, Barcelona, Spain
q Sant Pau Biomedical Research Institute, Sant Pau, Barcelona, Spain
r Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
s Pneumology Service, Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain
t Ear, Nose and Throat (ENT) Department, Hospital Clínic de Barcelona, Barcelona, Spain
u Department of Biochemistry and Molecular Biology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
v Allergology Department, A Coruña University Hospital, A Coruña, Spain
w Department of Respiratory Medicine, University Hospital of Santiago de Compostela, Spain
x Department of Medicine, University of Santiago de Compostela, Spain
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