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Parr, Joanna Chorostowska-Wynimko, Angelo Corsico, Cristina Esquinas, Gerard N. McElvaney, Annelot D. Sark, Maria Sucena, Hanan Tanash, Alice M. Turner, Marc Miravitlles" "autores" => array:10 [ 0 => array:2 [ "nombre" => "David G." "apellidos" => "Parr" ] 1 => array:2 [ "nombre" => "Joanna" "apellidos" => "Chorostowska-Wynimko" ] 2 => array:2 [ "nombre" => "Angelo" "apellidos" => "Corsico" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "Esquinas" ] 4 => array:2 [ "nombre" => "Gerard N." "apellidos" => "McElvaney" ] 5 => array:2 [ "nombre" => "Annelot D." "apellidos" => "Sark" ] 6 => array:2 [ "nombre" => "Maria" "apellidos" => "Sucena" ] 7 => array:2 [ "nombre" => "Hanan" "apellidos" => "Tanash" ] 8 => array:2 [ "nombre" => "Alice M." 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] 5 => array:2 [ "nombre" => "Juan Carlos" "apellidos" => "Bioque-Rivera" ] 6 => array:2 [ "nombre" => "Rocío" "apellidos" => "Jimeno- Galván" ] 7 => array:2 [ "nombre" => "Maria Soledad" "apellidos" => "Cano-Gómez" ] 8 => array:2 [ "nombre" => "Jose Luis" "apellidos" => "López-Campos" ] 9 => array:2 [ "nombre" => "Silvia" "apellidos" => "Merlos-Navarro" ] 10 => array:2 [ "nombre" => "Agustín" "apellidos" => "Valido-Morales" ] 11 => array:2 [ "nombre" => "Jose Manuel" "apellidos" => "Vaquero-Barrios" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289622003209?idApp=UINPBA00003Z" "url" => "/03002896/0000005800000012/v2_202305072241/S0300289622003209/v2_202305072241/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Increased Blood Eosinophil Count Is Related to Less Daily Physical Activity in Patients With Chronic Obstructive Pulmonary Disease" "tieneTextoCompleto" => true "saludo" => "To the Director," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "837" "paginaFinal" => "839" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Raúl Galera, Cristina Mergelina, Raquel Casitas, Elisabet Martínez-Cerón, Francisco García Río" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Raúl" "apellidos" => "Galera" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Cristina" "apellidos" => "Mergelina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Raquel" "apellidos" => "Casitas" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Elisabet" "apellidos" => "Martínez-Cerón" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:4 [ "nombre" => "Francisco" "apellidos" => "García Río" "email" => array:1 [ 0 => "fgr01m@gmail.com" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Universidad Autónoma de Madrid, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1831 "Ancho" => 3175 "Tamanyo" => 228964 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Distribution of daily physical activity patterns between COPD patients with or without increased blood eosinophils count (BEC); (B) Relationship between the number (upper panel) or percentage (lower panel) of the BEC and physical activity level (PAL) of patients with COPD. Abbreviation: <span class="elsevierStyleItalic">r</span>, Pearson correlation coefficient.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Recently, the relevant role of eosinophils as a marker of sensitivity to inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) has been recognized, particularly in patients with frequent exacerbations.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">1,2</span></a> In these subjects, peripheral eosinophils have been shown to be closely related to the rates of exacerbations<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">3,4</span></a> and mortality<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a> as well as the intensity of symptomatic limitation,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a> which is a major determinant of daily physical activity.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> Indeed, physical activity has become an important therapeutic target in COPD, with emerging evidence showing a relationship between sedentarism and disease progression<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> and even increased mortality.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite this, the information currently available about the relationship between peripheral eosinophils and daily physical activity in COPD patients is very scarce. To our knowledge, only one previous study described lower self-reported physical activity in patients with asthma-COPD overlap (ACO) than in those with other COPD phenotypes,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a> although unconventional ACO criteria and a questionnaire were used to assess physical activity. Therefore, our aim was to compare the level of daily physical activity in COPD patients according to their blood eosinophil count (BEC).</p><p id="par0015" class="elsevierStylePara elsevierViewall">We selected consecutive patients aged 40–80 years with a previous diagnosis of COPD,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> post-bronchodilator FEV<span class="elsevierStyleInf">1</span>/FVC ratio<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>lower limit of normal, and a history of smoking (>10<span class="elsevierStyleHsp" style=""></span>packs/year) who had been clinically stable in the previous 6 weeks. Exclusion criteria were: previous diagnosis of asthma or other respiratory diseases, previous treatment with systemic corticosteroids or other immunosuppressant drugs, clinical evidence of disorders associated with peripheral eosinophilia (drugs, parasitic infections, acute allergic conditions, vasculitis or hypereosinophilic syndromes), severe cardiovascular or neurological diseases, and cognitive problems or other disabling conditions that may affect physical activity. The study was performed in a single center, and it was approved by the local ethics committee, and all participants signed informed consent forms.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Data were collected for anthropometric variables, smoking history, disease duration, dyspnea level using modified Medical Research Council (mMRC) scale and Charlson comorbidity index. Post-bronchodilator spirometry was performed according to ATS/ERS recommendations<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> and using Global Lung Initiative (GLI) reference values.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> A 6-min walk test was also performed following ATS guidelines, and the BODE index was calculated. A SenseWear Pro3 accelerometer (Body Media Inc, Pittsburgh, PA, USA) was placed on the patients’ non-dominant arm for 7 consecutive days to measure daily physical activity. Recordings were considered valid if they included at least 10<span class="elsevierStyleHsp" style=""></span>h per day for a minimum of 4 days, including one weekend day. Physical activity level (PAL) was recorded, and patients were classified as: very sedentary (PAL<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>1.40), sedentary (PAL<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.40–1.69) or moderately active (PAL<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>1.70).<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> Simultaneously, a hemogram was determined in the center's laboratory, and increased BEC was defined as 300 or more cells/μL,<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> although other cut-off points were also used.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Between-group comparisons were performed using Student's <span class="elsevierStyleItalic">t</span>-test or chi-square tests. For comparison of physical activity levels between groups, general linear models were employed, using the presence or absence of increased BEC as a fixed factor and age, body mass index, dyspnea (mMRC), Charlson index and post-bronchodilator FEV<span class="elsevierStyleInf">1</span> as covariates. Relationship between variables was assessed with Pearson's rank correlation. The discriminative capacity of several eosinophil cut-off points to identify sedentary patients was analyzed using Receiver Operating Characteristic (ROC) curves and forward stepwise multiple logistic regression.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 123 COPD patients were selected, with a mean age of 63 years, mainly men (72%) who were overweight (mean body mass index [BMI]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>27.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.7<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>) and had a history of heavy smoking (47<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>18 pack-years). Mean time since COPD diagnosis was 9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>6 years, with moderate-severe airflow limitation (post-bronchodilator FEV<span class="elsevierStyleInf">1</span> 47<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>13% pred.), dyspnea (mean mMRC scale 2.4<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1) and a mean BODE index of 4<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2 points (4-year survival 67%).</p><p id="par0035" class="elsevierStylePara elsevierViewall">The frequency of increased BEC in our sample of COPD patients was 14.6% (95%CI, 8.4–20.9%). Patients with increased BEC were slightly younger than non-eosinophilic patients (59<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9 vs 64<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>8, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.026). However, both groups were homogeneous for all other anthropometric characteristics, cumulative smoking pattern and intensity, years since diagnosis, baseline dyspnea intensity, Charlson comorbidity index, severity of airflow limitation, or BODE index. No differences were identified for hemoglobin, hematocrit, or total leukocyte levels.</p><p id="par0040" class="elsevierStylePara elsevierViewall">COPD patients with increased BEC had significantly lower PAL than patients with normal BEC (1.81<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.32 vs 1.54<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.31; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). This association is also reflected in the distribution of physical activity patterns of both groups (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). The decrease in physical activity performed by patients with COPD and increased BEC remained statistically significant after adjusting for confounding variables, such as age, BMI, dyspnea, Charlson comorbidity index and post-bronchodilator FEV<span class="elsevierStyleInf">1</span> (mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard error) (1.81<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.03 vs 1.53<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.08; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001). In turn, an inversely proportional relationship between absolute or percentage BEC and PAL was observed (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.533, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001 and <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.502, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001, respectively) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The discriminative capacity of several increased BEC cut-off points to identify sedentary or very sedentary patients was also assessed. The criterion of >150<span class="elsevierStyleHsp" style=""></span>eosinophils/μL achieved the higher area under the ROC curve (0.71<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.05). Similarly, the multiple logistic regression model also retained a value of 150<span class="elsevierStyleHsp" style=""></span>eosinophils/μL as the only cut-off point independently associated with sedentarism (adjusted odds ratio<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6.2; 95%CI: 2.83–13.62; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.227).</p><p id="par0050" class="elsevierStylePara elsevierViewall">The prevalence of increased BEC found in our patients concurred with data from the BODE and CHAIN cohorts, which showed a prevalence of persistent eosinophilia (also defined as ≥300<span class="elsevierStyleHsp" style=""></span>cells/μL) of 12.3% and 15.8%, respectively.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> In turn, different studies have correlated the intensity of increased BEC with the severity of airflow limitation. Thus, an analysis of the SPIROMICS cohort indicates that patients with ≥200<span class="elsevierStyleHsp" style=""></span>eosinophils/μL have a lower FEV<span class="elsevierStyleInf">1</span>, slightly increased airway wall thickness, as well as poor health-related quality of life and increased wheezing.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">There is little information about the relationship between the physical activity of COPD patients and their inflammatory response. In COPD patients without corticosteroid treatment, increased airway eosinophils have been reported after acute exercise, with a decrease in the peripheral blood eosinophil count and serum levels of proinflammatory cytokines (IL-6, IL-8 and CCL-5), suggesting an anti-inflammatory effect of exercise.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> Moreover, in older adults from the general population, genetic markers associated with increased physical activity were related to lower levels of lymphocytes and eosinophils in peripheral blood.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">16</span></a> Although this decrease has traditionally been considered a certain level of immunosuppression, recent evidence suggests that it might represent an increased state of immune surveillance and regulation, through the transfer of cells to peripheral tissues.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">To our knowledge, this is the first study that evaluates the relationship between the number of eosinophils in peripheral blood from COPD patients and their level of physical activity, assessed by an objective measurement. Our data show that increased BEC in COPD patients is negatively related to the level of physical activity, independently of other confounding variables such as age, severity of airflow limitation or comorbidity. However, and due to its cross-sectional design, the present study does not allow us to establish a cause-effect association for said relationship or to infer a prognostic value.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1831 "Ancho" => 3175 "Tamanyo" => 228964 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Distribution of daily physical activity patterns between COPD patients with or without increased blood eosinophils count (BEC); (B) Relationship between the number (upper panel) or percentage (lower panel) of the BEC and physical activity level (PAL) of patients with COPD. Abbreviation: <span class="elsevierStyleItalic">r</span>, Pearson correlation coefficient.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0090" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global initiative for the diagnosis. Management, and prevention of chronic obstructive lung disease. The 2020 GOLD science committee report on COVID-19 and chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.M.G. Halpin" 1 => "G.J. Criner" 2 => "A. Papi" 3 => "D. Singh" 4 => "A. Anzueto" 5 => "F.J. 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Year/Month | Html | Total | |
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2024 November | 4 | 2 | 6 |
2024 October | 85 | 22 | 107 |
2024 September | 61 | 19 | 80 |
2024 August | 67 | 38 | 105 |
2024 July | 77 | 22 | 99 |
2024 June | 54 | 27 | 81 |
2024 May | 109 | 34 | 143 |
2024 April | 56 | 26 | 82 |
2024 March | 48 | 17 | 65 |
2024 February | 65 | 31 | 96 |
2024 January | 59 | 22 | 81 |
2023 December | 70 | 25 | 95 |
2023 November | 55 | 17 | 72 |
2023 October | 79 | 24 | 103 |
2023 September | 71 | 22 | 93 |
2023 August | 43 | 31 | 74 |
2023 July | 48 | 23 | 71 |
2023 June | 51 | 11 | 62 |
2023 May | 48 | 14 | 62 |
2023 April | 55 | 28 | 83 |
2023 March | 66 | 55 | 121 |
2023 February | 72 | 28 | 100 |
2023 January | 70 | 35 | 105 |
2022 December | 349 | 99 | 448 |
2022 November | 0 | 2 | 2 |
2022 October | 1 | 0 | 1 |
2022 September | 22 | 3 | 25 |
2022 July | 7 | 0 | 7 |