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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "687" "paginaFinal" => "688" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jesus Isea de la Viña, Gema Ramírez-Rodríguez, Bernardino Alcázar-Navarrete" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Jesus" "apellidos" => "Isea de la Viña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Gema" "apellidos" => "Ramírez-Rodríguez" "email" => array:1 [ 0 => "gemaramirezrodriguez@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Bernardino" "apellidos" => "Alcázar-Navarrete" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Thoracic Surgery Unit, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Virgen de las Nieves, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Medicina, Universidad de Granada, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "IBS-Granada, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Non-small cell lung cancer (NSCLC) remains the leading cause of cancer death worldwide,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> especially in patients with chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). In recent decades, however, efforts to prevent, diagnose, and treat NSCLC have led to a decline in age-adjusted mortality rates (especially in men)<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a> and the detection of smaller tumors at the time of diagnosis.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Today, the treatment of choice for small NSCLC tumors is surgical resection by lobectomy combined with lymph node dissection,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> preferably by video-assisted thoracic surgery (VATS). NSCLC treatment practice guidelines recommend the use of sublobar resections such as segmentectomy only in patients who would not tolerate lobectomy due to poor lung function or comorbidities.</p><p id="par0015" class="elsevierStylePara elsevierViewall">However, the results of the JCOG0802 study, a multicenter randomized clinical trial in a Japanese population of patients with stage IA NSCLC<span class="elsevierStyleHsp" style=""></span>≤<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm and a consolidation-to-tumor ratio<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.5<span class="elsevierStyleHsp" style=""></span>cm have recently been published.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> In this phase III trial, the authors randomized more than 1000 participants to a segmentectomy arm or a lobectomy arm, with the primary objective of demonstrating the non-inferiority of overall survival after segmentectomy versus lobectomy. After a mean follow-up of more than 7 years, the authors found that segmentectomy was superior to lobectomy in overall 5-year survival (94.3% vs 91.1, HR 0.663, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.005), and showed a similar 5-year recurrence-free survival rate (88.0% vs 87.9%) and a higher rate of local recurrences (10.5% vs 5.4%). Surprisingly, improved survival in the segmentectomy group appeared to be due to a decrease in deaths from a second cancer and, to a lesser extent, from non-cancer diseases.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The results of this study have generated great interest among the scientific community since it was first reported in 2021, but doubts have also emerged surrounding the resulting paradigm shift in the surgical treatment of NSCLC. Is this study sufficiently robust to prompt the medical community and stakeholders to change their guidelines and recommend segmentectomy as the procedure of choice for the surgical treatment of NSCLC? Several previously published studies support the benefit of segmentectomy versus lobectomy reported by Saji and colleagues.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A retrospective study<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> of 312 patients with clinical stage IA NSCLC published in 2016 compared outcomes of patients undergoing segmentectomy or pulmonary lobectomy, and found similar 5-year and 10-year survival in both groups. Specifically, oncologic outcomes after segmentectomy were slightly better than after lobectomy, with the first group obtaining 5- and 10-year survival rates of 97.5% and 83.5%, respectively, compared with 87.75% and 75.0% in the lobectomy group.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In 2017, a systematic review based on retrospective data from 24,542 patients found that survival in patients with stage I NSCLC who underwent therapeutic segmentectomies did not vary from patients who underwent lobectomies, with a hazard ratio (relative risk) of 1.04 (95% confidence interval 0.92–1.18; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.50).<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A more recent systematic review and meta-analysis that included 16 studies concluded that lobectomy has an overall survival similar to segmentectomy and superior to wedge resection. These results led the authors to suggest that segmentectomy should be positioned as a valuable alternative for patients with NSCLC smaller than 2<span class="elsevierStyleHsp" style=""></span>cm, and that wedge resection should be avoided whenever possible.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Finally, a recently published retrospective analysis of data from a reference center in the USA concluded that there were no differences in clinical outcomes (5-year mortality, recurrence, or recurrence-free survival) between anatomic segmentectomy and lobectomy.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Based on the evidence from the above studies and from the JCOG0802 study group, it seems clear that segmentectomy should be positioned as the surgical procedure of choice for patients with early-stage NSCLC, as it offers better survival than lobectomy and greater preservation of pulmonary parenchyma, despite a greater proportion of local relapses in the follow-up. Systematic nodal dissection can be performed with segmentectomy in a manner similar to that of lobectomy.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">9–11</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The findings of this study are only applicable to peripheral NSCLC measuring less than 2<span class="elsevierStyleHsp" style=""></span>cm in diameter, but this is precisely the area where diagnostic rates are increasing, especially as a result of lung cancer screening programs in at-risk populations.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> Furthermore, as the target population for lung cancer screening consists predominantly of patients with COPD and previous emphysema, procedures of this type will be performed more frequently because patients who otherwise would not be eligible for lobectomy can be included.</p><p id="par0055" class="elsevierStylePara elsevierViewall">However, it is also important to bear in mind that segmentectomy is a technically more complex procedure than lobectomy and requires more prolonged surgery.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> This means that more operating rooms will be needed to allow hospitals to continue offering patients the shortest possible surgery waiting time.</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion, the results of the JCOG0802 study denote a clear change of mindset in the treatment of early-stage NSCLC (stage IA), reinforcing the idea that at least in this type of tumor, resection of a smaller amount of tissue may improve life expectancy. The details of this study still have to be thoroughly analyzed, but we hope that this new evidence will soon be incorporated into the clinical practice guidelines. Perhaps a new day has dawned.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0065" class="elsevierStylePara elsevierViewall">JIDV declares no conflicts of interest.</p><p id="par0070" class="elsevierStylePara elsevierViewall">GRR declares no conflicts of interest.</p><p id="par0075" class="elsevierStylePara elsevierViewall">BAN has received payments for scientific consultancy and/or activities in the last 3 years from AstraZeneca, Laboratories Bial, Boehringer Ingelheim, Chiesi, Gilead, GSK, Laboratories Menarini, MSD, and Novartis AG.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interests" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0085" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0015" ] ] ] ] "multimedia" => array:1 [ 0 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 141333 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0070" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The European cancer burden in 2020: incidence and mortality estimates for 40 countries and 25 major cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. 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Year/Month | Html | Total | |
---|---|---|---|
2024 October | 110 | 22 | 132 |
2024 September | 142 | 28 | 170 |
2024 August | 117 | 41 | 158 |
2024 July | 190 | 32 | 222 |
2024 June | 124 | 25 | 149 |
2024 May | 143 | 25 | 168 |
2024 April | 94 | 26 | 120 |
2024 March | 94 | 20 | 114 |
2024 February | 82 | 36 | 118 |
2024 January | 146 | 26 | 172 |
2023 December | 77 | 23 | 100 |
2023 November | 112 | 30 | 142 |
2023 October | 205 | 39 | 244 |
2023 September | 137 | 36 | 173 |
2023 August | 75 | 34 | 109 |
2023 July | 79 | 29 | 108 |
2023 June | 47 | 20 | 67 |
2023 May | 68 | 20 | 88 |
2023 April | 83 | 35 | 118 |
2023 March | 115 | 22 | 137 |
2023 February | 78 | 27 | 105 |
2023 January | 59 | 40 | 99 |
2022 December | 88 | 52 | 140 |
2022 November | 135 | 58 | 193 |
2022 October | 617 | 167 | 784 |
2022 September | 1 | 0 | 1 |