Impact of Early Mobilization Added to Respiratory Physiotherapy Postextubation on Weaning Success

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Pericàs, Héctor Peroni, Enric Barbeta, Albert Gabarrús, Antoni Torres" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Catia" "apellidos" => "Cillóniz" ] 1 => array:2 [ "nombre" => "Juan M." 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Within this pandemic situation with a focus on critical patients over those on mechanical ventilation, we considered how to improve the hospital stay. Clinicians face several challenges when taking care of COVID-19 patients,<a class="elsevierStyleCrossRef" href="#bib0115">2</a> and intensive care unit (ICU) acquired weakness (AW) – (ICU-AW) –<a class="elsevierStyleCrossRef" href="#bib0120">3</a> is historically one of those specially in IMV patient.Chest physiotherapy (CPT) in the mechanically ventilated patient has been recognized as an essential component of respiratory care within the ICU. The main goal of CPT includes airway clearance that helps reduce airway resistance and improve lung compliance.<a class="elsevierStyleCrossRefs" href="#bib0125">4,5</a> The benefits of CPT are reflected in a reduced incidence of ventilator associated pneumonia (VAP), reduced duration of ICU stay and greater success of liberation from mechanical ventilation. Moreover, ICU acquired weakness (ICU-AW) is a potential risk factor for extubation failure and prolonged weaning, increasing patient mortality and morbidity by up to 25%.<a class="elsevierStyleCrossRefs" href="#bib0135">6,7</a> The integration of early mobilization (EM) protocols in ICUs has been recognized as a preventative strategy against the incidence of ICU-AW with strong recommendations (Grade 2+) supporting their use for extubation success.<a class="elsevierStyleCrossRefs" href="#bib0145">8,9</a> However, there is no evidence that promotes the combination of EM with early CPT following extubation to increase weaning success. During the COVID-19 pandemic, there has been a high incidence of ICU-AW and prolonged weaning from invasive mechanical ventilation (IMV), which may consequently prolong ICU and hospital length of stay.<a class="elsevierStyleCrossRefs" href="#bib0155">10,11</a> Therefore, the aim of our study is to determine whether early CPT following extubation reduces the risk of reintubation with in 24–72h, in addition to an EM protocol in a COVID-19 population.An observational study was completed at the ICU of Vall d’ Hebron Hospital. Adult patients admitted to ICU with severe SARS-CoV-2 pneumonia for IMV care were studied. Severe respiratory illness was defined as acute respiratory distress syndrome (ARDS) in accordance with the Berlin criteria.<a class="elsevierStyleCrossRef" href="#bib0165">12</a> Only patients who received intubation via an endotracheal tube were studied, where tracheostomized patients and prolonged weaning cases were excluded. Prolonged weaning is defined as failure of 3 spontaneous breathing trials (SBT) or ongoing need for IMV 7 days after the first SBT.<a class="elsevierStyleCrossRef" href="#bib0170">13</a> The weaning protocol included daily screening for weaning readiness according to general criteria and extubation failure, which was defined as the need for reintubation within 48h of tube removal.<a class="elsevierStyleCrossRef" href="#bib0120">3</a> Spontaneous breathing trials were performed, varying between T-piece and pressure support ventilation.<a class="elsevierStyleCrossRef" href="#bib0175">14</a>All patients received CPT during mechanical ventilation, however not all patients received CPT within two hours of IMV withdrawal. This situation occurred in cases when extubation took place outside of physiotherapy service hours and when extubation took place during weekend hours where the on-call physiotherapist was not informed. CPT sessions following extubation included treatments such as airway clearance techniques, assisted cough using mechanical in-exsufflation devices, manual hyperinflation, rib cage compressions, positive expiratory pressure devices and inspiratory muscle training. In addition, an EM protocol was followed for all patients within the first 24h of initiating IMV, with the sole exception of cases with hemodynamic instability or pulmonary thromboembolism. Deep sedation or neuromuscular blockade was not an absolute contraindication to EM. In cases where patients were proned, EM was not implemented until they were supinated. The EM interventions included active, assisted or passive limb mobilization, cycle-ergometry, transfers to sitting and standing. The duration of EM sessions was a total of 1h/day/patient (30min, twice daily). The outcome measures included extubation success, days of IMV, length of ICU stay and hospital survival. The study was approved by the local Clinical Research Ethics Committee (PR(ATR)164/2021).Twenty-eight patients were included in this study. The main characteristics of our population, such as age, gender and comorbidities, are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Proned ventilation and neuromuscular blockade was used in 57% and 82% of the population, respectively. The main complication during IMV was VAP [20 (71%)]. All patients required high-flow nasal cannula (HFNC) post-extubation [28 (100%)], where 7% required additional support from non-invasive ventilation (NIV). As there were no contraindications in our sample, EM protocol was implemented for all patients and no patient was denied EM treatment [28 (100%)]. CPT within two hours of extubation was provided to 32% of our study population. This study shows that only two patients (7%) required reintubation and eventual need for a tracheostomy.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Our study is the first to investigate how the combination of early CPT within 2h of extubation and an EM protocol may imply a decrease in extubation failure rate. In a similar approach to ours, a randomized controlled study in Taiwan observed that EM and CPT during IMV significantly reduced the reintubation rate by half (8% vs 16%).<a class="elsevierStyleCrossRef" href="#bib0180">15</a> However, unlike our research, this study considers the benefits of CPT during IMV and not immediately after extubation. On the whole, research regarding physiotherapy in weaning from IMV mainly focuses on EM protocols. The benefits of EM in the ICU were first studied in 2008 for their association with a decreased length of ICU stay when compared to standard care.<a class="elsevierStyleCrossRef" href="#bib0185">16</a> However, unlike in our study where EM began within 24h, this study began EM within 48h of initiating IMV. A more recent study considered a multimodal rehabilitation program for IMV patients however this was provided to a prolonged weaning group, with IMV for greater than 14 days.<a class="elsevierStyleCrossRef" href="#bib0190">17</a> It does not consider early CPT post extubation in simple weaning and first attempt extubation. Moreover, the general evidence suggests that there is a 10–20% of reintubation rates following planned extubation in ICUs.<a class="elsevierStyleCrossRef" href="#bib0195">18</a> However, in a more recent study, where the use of CPT and EM was not considered, the extubation failure rate was 38% as opposed to our study's 7%<a class="elsevierStyleCrossRef" href="#bib0200">19</a>; thus highlighting the importance of our findings. It is key to mention than in our study, extubation success may have also been supported by using HFNC for all of our patients. Hernandez et al described a reintubation rate of 22.8% with the use of HFNC post extubation, however this was not a study that included the use of CPT post extubation and EM protocols, alongside HFNC.<a class="elsevierStyleCrossRef" href="#bib0205">20</a>We recognize that our study has several limitations. This study is a single-center study and the typology of patients only includes those affected by SARS-CoV-2 pneumonia, creating a homogenous sample. There is limited evidence available for comparison with regards to weaning success in the COVID-19 population, particularly in the context of early post-extubation CPT and EM. Furthermore, the small sample size is another limiting factor, making it difficult to compare it with the aforementioned studies. This will be addressed by conducting this study as a multicenter study to expand the sample size and make it heterogenous, to aid generalizability of its findings. The decision to publish these preliminary results is relevant, as we have implemented early CPT following extubation and EM protocols, achieving important results in weaning success despite our limitations. Moreover, a randomized controlled trial was not considered for this research due to the ethical implications of depriving control group patients from health benefitting treatments, such as CPT and EM. These widely recognized benefits include reducing muscle atrophy, duration of IMV, length of hospital stay and increasing functional capacity.<a class="elsevierStyleCrossRef" href="#bib0210">21</a> Finally, the lack of information regarding the premorbid functional status of our population and absence of a mobility assessment scale may have hindered the interpretation of our results in the context of EM. We were unable to achieve baseline mobility measurements for each patient due to the requirement of deep sedation in the majority of our study population. We aim to include these measurements as an outcome measure in future studies. In fact, we are in the process of analyzing our results in a more powerful study format such as cases – retrospective controls. However, the early mobilization program has worked within our care organization with very good results and acceptance, and in addition, we have obtained these preliminary results that we consider very good, with a reintubation rate of only 7% in a population with severe ARDS, so we considered its publicity relevant.In conclusion, we are the first to describe a lower than usual extubation failure with physiotherapy interventions that include CPT within 2h of extubation and EM protocols before and after extubation. We want to highlight that these interventions may imply a decreased in extubation failure rate. The future completion of a multicenter study will include a multivariate analysis with a larger sample size to give us more generalizable results in the future.Statement of ethicsWe complied with the guidelines for human studies and our research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. Information revealing the subject's identity is to be avoided. The study was approved by the local Clinical Research Ethics Committee (PR(ATR)164/2021) with exemption from informed consentFundingNo funding.Author contributionsWe were all involved in providing care for the patient. We were all involved in writing and reviewing the manuscript.Availability of data and materialsThe datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.Consent for publicationThe study was approved by the local Clinical Research Ethics Committee (PR(AG)270/2020) with exemption from informed consent.Conflict of interestThe authors have no conflicts of interest to declare." 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entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59±12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gender (n, %) (male) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15/28 (53%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comorbidities</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HBP (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13/28 (46%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">COPD (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/28 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asthma (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/28 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chronic renal failure (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/28 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chronic heart failure (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/28 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetes mellitus (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4/28 (14%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI>30kg/m2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/28 (18%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SOFA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4±1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">APACHE II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14±8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Early mobilization \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28/28 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest physiotherapy (CPT) within 2h after extubation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9/28 (32%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HFNC post-extubation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28/28 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ARDS related variables</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PaO2/FIO2 (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">129±37 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PEEP (cmH2O) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14±2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prone position during ICU course (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/28 (57%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VAP (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20/28 (71%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Delirium during weaning course (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/28 (42%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sedation strategies</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neuromuscular blockade during ICU course (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23/28 (82%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Respiratory support after extubation</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HFNC (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28/28 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NIMV (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/28 (6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Renal failure</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AKI (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/28 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AKI I (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/1 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CRRT (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/28 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Results/Outcomes</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IMV duration (days) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7±4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Successful extubation (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26/28 (92%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reintubation (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/28 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Need for tracheostomy (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/28 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prolonged weaning (n,%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/28 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Length of ICU stay (days) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17±11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Outcome Hospital (survived) (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28/28 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Patient demographic data and supportive related therapies. The lowest PaO2/FIO2 and highest PEEP values were documented. We define early mobilization as the one performed within the first 24h after initiation of IMV. ARDS: acute respiratory distress syndrome; CPT: chest physiotherapy; SOFA: sequential organ failure assessment; APACHE II: Acute Physiology and Chronic Health disease Classification System II; COPD: chronic obstructive pulmonary disease; HBP: high blood pressure; ICU: intensive care unit; IMV: invasive mechanical ventilation; HFNC: high flow nasal cannula; NIMV: non-invasive mechanical ventilation; PF: PaO2/FiO2 ratio; PEEP: positive end expiratory pressure; AKI: acute kidney injury; CRRT: continuous renal replacement therapy; LMWH: low-molecular-weight heparin; VAP: ventilator associated pneumonia." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0110" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Care for critically ill patients with COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. 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Scientific Letter

Impact of Early Mobilization Added to Respiratory Physiotherapy Postextubation on Weaning Success

Luis Chiscano-Camóna,b, Gonzalo Ballesteros-Reviriegoc,d,

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gballesteros@vhebron.net

Corresponding author.

, Alba Ruiz-Rodríguezc, Bernat Planas-Pascualc,d, Marcos Pérez-Carrascoa,b, Alba Gómez-Garridoe, Sofia Contrerasa,b, Stefania Spiliopoulouc, Ricard Ferrera,b

a Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

b Shock, Organ Dysfunction and Resuscitation Research Group,, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

c Physiotherapy and Occupational Therapy Unit, Rehabilitation Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

d Early Rehabilitation Group, Sociedad Española de Enfermería Intensiva y Unidades Coronarias (SEEIUC), Spain

e Physical medicine and Rehabilitation Department, Cardiopulmonary Rehabilitation Unit, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A significant number of patients with severe acute respiratory syndrome Coronavirus-2 &#40;SARS-CoV-2&#41; disease developed acute respiratory distress syndrome &#40;ARDS&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> and invasive mechanical ventilation &#40;IMV&#41; is cornerstone in its supportive treatment&#46; Within this pandemic situation with a focus on critical patients over those on mechanical ventilation&#44; we considered how to improve the hospital stay&#46; Clinicians face several challenges when taking care of COVID-19 patients&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">2</span></a> and intensive care unit &#40;ICU&#41; acquired weakness &#40;AW&#41; &#8211; &#40;ICU-AW&#41; &#8211;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">3</span></a> is historically one of those specially in IMV patient&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Chest physiotherapy &#40;CPT&#41; in the mechanically ventilated patient has been recognized as an essential component of respiratory care within the ICU&#46; The main goal of CPT includes airway clearance that helps reduce airway resistance and improve lung compliance&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#44;5</span></a> The benefits of CPT are reflected in a reduced incidence of ventilator associated pneumonia &#40;VAP&#41;&#44; reduced duration of ICU stay and greater success of liberation from mechanical ventilation&#46; Moreover&#44; ICU acquired weakness &#40;ICU-AW&#41; is a potential risk factor for extubation failure and prolonged weaning&#44; increasing patient mortality and morbidity by up to 25&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">6&#44;7</span></a> The integration of early mobilization &#40;EM&#41; protocols in ICUs has been recognized as a preventative strategy against the incidence of ICU-AW with strong recommendations &#40;Grade 2&#43;&#41; supporting their use for extubation success&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">8&#44;9</span></a> However&#44; there is no evidence that promotes the combination of EM with early CPT following extubation to increase weaning success&#46; During the COVID-19 pandemic&#44; there has been a high incidence of ICU-AW and prolonged weaning from invasive mechanical ventilation &#40;IMV&#41;&#44; which may consequently prolong ICU and hospital length of stay&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">10&#44;11</span></a> Therefore&#44; the aim of our study is to determine whether early CPT following extubation reduces the risk of reintubation with in 24&#8211;72<span class="elsevierStyleHsp" style=""></span>h&#44; in addition to an EM protocol in a COVID-19 population&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">An observational study was completed at the ICU of Vall d&#8217; Hebron Hospital&#46; Adult patients admitted to ICU with severe SARS-CoV-2 pneumonia for IMV care were studied&#46; Severe respiratory illness was defined as acute respiratory distress syndrome &#40;ARDS&#41; in accordance with the Berlin criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">12</span></a> Only patients who received intubation via an endotracheal tube were studied&#44; where tracheostomized patients and prolonged weaning cases were excluded&#46; Prolonged weaning is defined as failure of 3 spontaneous breathing trials &#40;SBT&#41; or ongoing need for IMV 7 days after the first SBT&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">13</span></a> The weaning protocol included daily screening for weaning readiness according to general criteria and extubation failure&#44; which was defined as the need for reintubation within 48<span class="elsevierStyleHsp" style=""></span>h of tube removal&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">3</span></a> Spontaneous breathing trials were performed&#44; varying between T-piece and pressure support ventilation&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">14</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">All patients received CPT during mechanical ventilation&#44; however not all patients received CPT within two hours of IMV withdrawal&#46; This situation occurred in cases when extubation took place outside of physiotherapy service hours and when extubation took place during weekend hours where the on-call physiotherapist was not informed&#46; CPT sessions following extubation included treatments such as airway clearance techniques&#44; assisted cough using mechanical in-exsufflation devices&#44; manual hyperinflation&#44; rib cage compressions&#44; positive expiratory pressure devices and inspiratory muscle training&#46; In addition&#44; an EM protocol was followed for all patients within the first 24<span class="elsevierStyleHsp" style=""></span>h of initiating IMV&#44; with the sole exception of cases with hemodynamic instability or pulmonary thromboembolism&#46; Deep sedation or neuromuscular blockade was not an absolute contraindication to EM&#46; In cases where patients were proned&#44; EM was not implemented until they were supinated&#46; The EM interventions included active&#44; assisted or passive limb mobilization&#44; cycle-ergometry&#44; transfers to sitting and standing&#46; The duration of EM sessions was a total of 1<span class="elsevierStyleHsp" style=""></span>h&#47;day&#47;patient &#40;30<span class="elsevierStyleHsp" style=""></span>min&#44; twice daily&#41;&#46; The outcome measures included extubation success&#44; days of IMV&#44; length of ICU stay and hospital survival&#46; The study was approved by the local Clinical Research Ethics Committee &#40;PR&#40;ATR&#41;164&#47;2021&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Twenty-eight patients were included in this study&#46; The main characteristics of our population&#44; such as age&#44; gender and comorbidities&#44; are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Proned ventilation and neuromuscular blockade was used in 57&#37; and 82&#37; of the population&#44; respectively&#46; The main complication during IMV was VAP &#91;20 &#40;71&#37;&#41;&#93;&#46; All patients required high-flow nasal cannula &#40;HFNC&#41; post-extubation &#91;28 &#40;100&#37;&#41;&#93;&#44; where 7&#37; required additional support from non-invasive ventilation &#40;NIV&#41;&#46; As there were no contraindications in our sample&#44; EM protocol was implemented for all patients and no patient was denied EM treatment &#91;28 &#40;100&#37;&#41;&#93;&#46; CPT within two hours of extubation was provided to 32&#37; of our study population&#46; This study shows that only two patients &#40;7&#37;&#41; required reintubation and eventual need for a tracheostomy&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Our study is the first to investigate how the combination of early CPT within 2<span class="elsevierStyleHsp" style=""></span>h of extubation and an EM protocol may imply a decrease in extubation failure rate&#46; In a similar approach to ours&#44; a randomized controlled study in Taiwan observed that EM and CPT during IMV significantly reduced the reintubation rate by half &#40;8&#37; vs 16&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">15</span></a> However&#44; unlike our research&#44; this study considers the benefits of CPT during IMV and not immediately after extubation&#46; On the whole&#44; research regarding physiotherapy in weaning from IMV mainly focuses on EM protocols&#46; The benefits of EM in the ICU were first studied in 2008 for their association with a decreased length of ICU stay when compared to standard care&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">16</span></a> However&#44; unlike in our study where EM began within 24<span class="elsevierStyleHsp" style=""></span>h&#44; this study began EM within 48<span class="elsevierStyleHsp" style=""></span>h of initiating IMV&#46; A more recent study considered a multimodal rehabilitation program for IMV patients however this was provided to a prolonged weaning group&#44; with IMV for greater than 14 days&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">17</span></a> It does not consider early CPT post extubation in simple weaning and first attempt extubation&#46; Moreover&#44; the general evidence suggests that there is a 10&#8211;20&#37; of reintubation rates following planned extubation in ICUs&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">18</span></a> However&#44; in a more recent study&#44; where the use of CPT and EM was not considered&#44; the extubation failure rate was 38&#37; as opposed to our study&#39;s 7&#37;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">19</span></a>&#59; thus highlighting the importance of our findings&#46; It is key to mention than in our study&#44; extubation success may have also been supported by using HFNC for all of our patients&#46; Hernandez et al described a reintubation rate of 22&#46;8&#37; with the use of HFNC post extubation&#44; however this was not a study that included the use of CPT post extubation and EM protocols&#44; alongside HFNC&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">20</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We recognize that our study has several limitations&#46; This study is a single-center study and the typology of patients only includes those affected by SARS-CoV-2 pneumonia&#44; creating a homogenous sample&#46; There is limited evidence available for comparison with regards to weaning success in the COVID-19 population&#44; particularly in the context of early post-extubation CPT and EM&#46; Furthermore&#44; the small sample size is another limiting factor&#44; making it difficult to compare it with the aforementioned studies&#46; This will be addressed by conducting this study as a multicenter study to expand the sample size and make it heterogenous&#44; to aid generalizability of its findings&#46; The decision to publish these preliminary results is relevant&#44; as we have implemented early CPT following extubation and EM protocols&#44; achieving important results in weaning success despite our limitations&#46; Moreover&#44; a randomized controlled trial was not considered for this research due to the ethical implications of depriving control group patients from health benefitting treatments&#44; such as CPT and EM&#46; These widely recognized benefits include reducing muscle atrophy&#44; duration of IMV&#44; length of hospital stay and increasing functional capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">21</span></a> Finally&#44; the lack of information regarding the premorbid functional status of our population and absence of a mobility assessment scale may have hindered the interpretation of our results in the context of EM&#46; We were unable to achieve baseline mobility measurements for each patient due to the requirement of deep sedation in the majority of our study population&#46; We aim to include these measurements as an outcome measure in future studies&#46; In fact&#44; we are in the process of analyzing our results in a more powerful study format such as cases &#8211; retrospective controls&#46; However&#44; the early mobilization program has worked within our care organization with very good results and acceptance&#44; and in addition&#44; we have obtained these preliminary results that we consider very good&#44; with a reintubation rate of only 7&#37; in a population with severe ARDS&#44; so we considered its publicity relevant&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; we are the first to describe a lower than usual extubation failure with physiotherapy interventions that include CPT within 2<span class="elsevierStyleHsp" style=""></span>h of extubation and EM protocols before and after extubation&#46; We want to highlight that these interventions may imply a decreased in extubation failure rate&#46; The future completion of a multicenter study will include a multivariate analysis with a larger sample size to give us more generalizable results in the future&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Statement of ethics</span><p id="par0045" class="elsevierStylePara elsevierViewall">We complied with the guidelines for human studies and our research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki&#46; Information revealing the subject&#39;s identity is to be avoided&#46; The study was approved by the local Clinical Research Ethics Committee &#40;PR&#40;ATR&#41;164&#47;2021&#41; with exemption from informed consent</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0050" class="elsevierStylePara elsevierViewall">No funding&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Author contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">We were all involved in providing care for the patient&#46; We were all involved in writing and reviewing the manuscript&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Availability of data and materials</span><p id="par0060" class="elsevierStylePara elsevierViewall">The datasets used and&#47;or analyzed during the current study are available from the corresponding author on reasonable request&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Consent for publication</span><p id="par0065" class="elsevierStylePara elsevierViewall">The study was approved by the local Clinical Research Ethics Committee &#40;PR&#40;AG&#41;270&#47;2020&#41; with exemption from informed consent&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conflict of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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                  \t\t\t\t">15&#47;28 &#40;53&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidities</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HBP &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#47;28 &#40;46&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;28 &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asthma &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;28 &#40;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chronic renal failure &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;28 &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chronic heart failure &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;28 &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#47;28 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BMI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;28 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">SOFA</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">APACHE II</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Early mobilization</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#47;28 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Chest physiotherapy &#40;CPT&#41; within 2</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">h after extubation</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#47;28 &#40;32&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HFNC post-extubation</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#47;28 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">ARDS related variables</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PaO<span class="elsevierStyleInf">2</span>&#47;F<span class="elsevierStyleInf">I</span>O<span class="elsevierStyleInf">2</span> &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PEEP &#40;cmH<span class="elsevierStyleInf">2</span>O&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prone position during ICU course &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#47;28 &#40;57&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VAP &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;28 &#40;71&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Delirium during weaning course &#40;n&#44; &#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;28 &#40;42&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sedation strategies</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neuromuscular blockade during ICU course &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#47;28 &#40;82&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Respiratory support after extubation</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HFNC &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#47;28 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NIMV &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;28 &#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Renal failure</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AKI &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;28 &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AKI I &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;1 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRRT &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Results&#47;Outcomes</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Successful extubation &#40;<span class="elsevierStyleItalic">n</span>&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26&#47;28 &#40;92&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#47;28 &#40;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prolonged weaning &#40;<span class="elsevierStyleItalic">n</span>&#44;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">28&#47;28 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patient demographic data and supportive related therapies&#46; The lowest PaO<span class="elsevierStyleInf">2</span>&#47;F<span class="elsevierStyleInf">I</span>O<span class="elsevierStyleInf">2</span> and highest PEEP values were documented&#46; We define early mobilization as the one performed within the first 24<span class="elsevierStyleHsp" style=""></span>h after initiation of IMV&#46; ARDS&#58; acute respiratory distress syndrome&#59; CPT&#58; chest physiotherapy&#59; SOFA&#58; sequential organ failure assessment&#59; APACHE II&#58; Acute Physiology and Chronic Health disease Classification System II&#59; COPD&#58; chronic obstructive pulmonary disease&#59; HBP&#58; high blood pressure&#59; ICU&#58; intensive care unit&#59; IMV&#58; invasive mechanical ventilation&#59; HFNC&#58; high flow nasal cannula&#59; NIMV&#58; non-invasive mechanical ventilation&#59; PF&#58; PaO2&#47;FiO2 ratio&#59; PEEP&#58; positive end expiratory pressure&#59; AKI&#58; acute kidney injury&#59; CRRT&#58; continuous renal replacement therapy&#59; LMWH&#58; low-molecular-weight heparin&#59; VAP&#58; ventilator associated pneumonia&#46;</p>"
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                            0 => "S&#46; Murthy"
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                            1 => "F&#46;X&#46; Lescure"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;H&#46; Houz&#233;"
                            1 => "N&#46; Deye"
                            2 => "J&#46; Mateo"
                            3 => "B&#46; M&#233;garbane"
                            4 => "F&#46; Bizouard"
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                      ]
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                  ]
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Raurell-Torred&#224;"
                            1 => "E&#46;E&#46; Regaira-Mart&#237;nez"
                            2 => "B&#46; Planas-Pascual"
                            3 => "R&#46; Ferrer-Roca"
                            4 => "J&#46;D&#46; Mart&#237;"
                            5 => "E&#46; Blazquez-Mart&#237;nez"
                          ]
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                    ]
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Quintard"
                            1 => "E&#46; l&#8217;Her"
                            2 => "J&#46; Pottecher"
                            3 => "F&#46; Adnet"
                            4 => "J&#46;M&#46; Constantin"
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                      "titulo" => "Severe SARS-CoV-2 infections&#58; practical considerations and management strategy for intensivists"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Bouadma"
                            1 => "F&#46;X&#46; Lescure"
                            2 => "J&#46;C&#46; Lucet"
                            3 => "Y&#46; Yazdanpanah"
                            4 => "J&#46;F&#46; Timsit"
                          ]
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                      ]
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                            2 => "A&#46; Wilmer"
                            3 => "R&#46; Gosselink"
                            4 => "G&#46; Hermans"
                            5 => "P&#46; Meersseman"
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                            0 => "V&#46; Ranieri"
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                            2 => "B&#46; Thompson"
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                            4 => "E&#46; Caldwell"
                            5 => "E&#46; Fan"
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                        0 => array:2 [
                          "etal" => true
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                            1 => "F&#46; Frutos"
                            2 => "M&#46;J&#46; Tobin"
                            3 => "I&#46; Al&#237;a"
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Article information

ISSN: 03002896
Original language: English

DOI:10.1016/j.arbres.2022.03.002

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