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To our knowledge&#44; this is the only published case of pleural exudate in this context&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our patient was a 33-year-old woman&#44; with no drug allergies&#44; smoker of 5 pack-years&#44; with no medical or surgical history of interest&#46; She was not receiving any regular treatment&#44; and worked at home as a mother of 2 children with a dog and a cat as pets&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">She attended the emergency room with a 3-week history of sternal pain that worsened with postural changes&#46; The symptoms had developed 5 days after administration of the second dose of the Moderna vaccine&#46; She also reported moderate dyspnea on exertion&#44; low-grade fever&#44; and arthralgias&#44; with no cough or other symptoms&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">On physical examination&#44; she was in good general condition&#44; with normal coloring&#44; normal hydration&#44; and normal breathing at rest&#46; She had no supraclavicular lymphadenopathies or nail clubbing&#46; Blood pressure was 101&#47;70<span class="elsevierStyleHsp" style=""></span>mmHg&#44; heart rate 74<span class="elsevierStyleHsp" style=""></span>bpm&#44; respiration rate 12 breaths&#47;m&#44; and SpO<span class="elsevierStyleInf">2</span> &#40;room air&#41; 98&#37;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Cardiac auscultation was normal and pulmonary auscultation showed decreased breath sounds in the lower third of both lungs&#44; with decreased transmission of vocal fremitus&#44; dullness on percussion&#44; and signs of pleural effusion&#46; The rest of the examination was normal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Antigen and polymerase chain reaction &#40;PCR&#41; for COVID-19 were negative&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Chest X-ray in the emergency room showed blunting of both costophrenic angles consistent with bilateral pleural effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The blood count showed 10&#46;1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;l leukocytes with 5&#46;9&#37; eosinophils &#40;600<span class="elsevierStyleHsp" style=""></span>eosinophils&#41; and hemoglobin 14&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#46; Biochemistry showed total proteins 6&#46;69<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; LDH 257<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; CRP 4&#46;03<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Coagulation tests showed D-dimer 2656<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Pneumococcus and <span class="elsevierStyleItalic">Legionella</span> antigens in urine and parallel respiratory serology for <span class="elsevierStyleItalic">Legionella</span>&#44; <span class="elsevierStyleItalic">Mycoplasma</span> and respiratory viruses were negative&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A chest computed tomography angiogram conducted to rule out pulmonary thromboembolism confirmed moderate bilateral pleural effusion with bibasilar and middle lobe atelectasis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; This was confirmed on chest ultrasound that also ruled out vascular involvement&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Echocardiography showed mild pericardial effusion not affecting cavity filling&#46; Abdominal ultrasound was normal&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Thoracentesis showed exudate &#40;proteins 4&#46;25<span class="elsevierStyleHsp" style=""></span>g&#47;dl and LDH 191<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41; with predominantly polymorphonuclear cells &#40;73&#46;2&#37;&#41;&#44; normal ADA &#40;6&#46;7<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41;&#44; cholesterol 75<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; CEA<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;7<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; and negative antinuclear antibodies&#46; Cytology was negative for malignancy&#44; culture showed no microorganisms&#44; and Ziehl-Neelsen and culture in L&#246;wenstein-Jensen media were negative&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h and methylprednisolone 40<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h were administered for 6 days with favorable clinical and radiological evolution&#44; and the patient was discharged with prednisone 30<span class="elsevierStyleHsp" style=""></span>mg in a tapering regimen and azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h for a further 4 days&#44; and was referred for monitoring in the outpatient clinic&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Follow-up chest CT at 15 days showed a marked decrease in pleural and pericardial effusion&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Follow-up clinical laboratory tests at 23 days after discharge showed normal antinuclear antibodies and anti-neutrophil cytoplasm antibodies &#40;P-ANCA and <span class="elsevierStyleSmallCaps">C</span>-ANCA&#41;&#46; Serology was positive for SARS-CoV-2 IgG&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The Moderna mRNA-1273 vaccine is given in 2 doses and has demonstrated 94&#46;7&#37; efficacy and very good safety&#46; Most of the adverse effects are mild&#44; and while serious events&#44; such as myalgias&#44; arthralgias and asthenia&#44; have been reported&#44; particularly after the second dose&#44; pleural and pericardial effusion are not listed in the Summary of Product Characteristics or reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Our patient&#44; who had recently received the Moderna vaccine&#44; developed bilateral and pericardial pleural effusion&#46; After ruling out other causes&#44; her clinical picture was consistent with MIS caused by the Moderna vaccine&#44; resulting in bilateral pleural and pericardial exudate&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">MIS after vaccination &#40;usually the second dose&#41; is exceptional&#44; and very few cases have been published&#44; particularly in children and adolescents&#46; It consists of a systemic clinical syndrome &#40;diarrhea&#44; dyspnea&#44; abdominal pain&#44; skin rash&#44; and hypotension&#41; involving at least 2 organs&#46; Progress is favorable after administration of corticosteroids and&#44; in some cases&#44; intravenous immunoglobulins&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This entity may have clinical similarities with active SARS-CoV-2 infection&#44; so assessment of the vaccination history is essential when taking the medical history&#46; Most cases are reported at 2&#8211;4 weeks after administration and involve gastrointestinal symptoms&#46; The only cases of pleural effusion reported have been associated with heart failure&#44; and none of these patients were studied for pleural fluid&#46; Long-term functional consequences are unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The SARS-CoV-2 vaccine &#8211; generally the Janssen vaccine &#8211; has been associated with some rare reports of MIS in the literature&#44; and in no case has pleural fluid been studied to complete the diagnosis&#46; Exudative pleural-pericardial effusion without accompanying myocarditis should be considered among the complications caused by the mRNA-1273 vaccine&#46;</p></span>"
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Letter to the Director
Pleuropericardial Effusion and Systemic Inflammatory Syndrome Secondary to the Administration of the mRNA-1273 Vaccine for SARS-CoV-2
Derrame pleuropericárdico y síndrome inflamatorio sistémico secundario a la administración de vacuna ARNm-1273 para coronavirus del síndrome respiratorio agudo grave de tipo 2 (SARS-CoV-2)
Ignacio Boira, Anastasiya Torba, Carmen Castelló, Violeta Esteban, Sandra Vañes, Eusebi Chiner
Corresponding author
chiner_eus@gva.es

Corresponding author.
Servicio de Neumología, Hospital Universitario San Juan de Alicante, Alicante, Spain
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    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Director</span>"
    "titulo" => " Pleuropericardial Effusion and Systemic Inflammatory Syndrome Secondary to the Administration of the mRNA-1273 Vaccine for SARS-CoV-2"
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        "titulo" => "Derrame pleuroperic&#225;rdico y s&#237;ndrome inflamatorio sist&#233;mico secundario a la administraci&#243;n de vacuna ARNm-1273 para coronavirus del s&#237;ndrome respiratorio agudo grave de tipo 2 &#40;SARS-CoV-2&#41;"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Anterior-posterior chest X-ray at admission showing right pleural effusion and left costophrenic angle blunting&#46; &#40;B&#41; Chest computed axial tomography showing bilateral pleural effusion and pericardial effusion &#40;upper arrow indicates pericardial effusion and the right arrow indicates pleural effusion&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">SARS-CoV-2 infection has caused more than 5 million deaths worldwide and has had a major impact on the economy and healthcare&#46; Vaccination has changed the management of these patients by preventing transmission and reducing mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Side effects associated with SARS-CoV-2 mRNA vaccines&#44; some serious&#44; have been reported&#46; One of the major adverse events associated with the Moderna vaccine &#40;mRNA-1273&#41;&#44; myocarditis&#44; seen primarily in young adults&#44; occasionally occurs concomitantly with heart disease&#44; while another rarely reported event is multisystem inflammatory syndrome &#40;MIS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report a clinical case of MIS following administration of the Moderna vaccine&#46; To our knowledge&#44; this is the only published case of pleural exudate in this context&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our patient was a 33-year-old woman&#44; with no drug allergies&#44; smoker of 5 pack-years&#44; with no medical or surgical history of interest&#46; She was not receiving any regular treatment&#44; and worked at home as a mother of 2 children with a dog and a cat as pets&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">She attended the emergency room with a 3-week history of sternal pain that worsened with postural changes&#46; The symptoms had developed 5 days after administration of the second dose of the Moderna vaccine&#46; She also reported moderate dyspnea on exertion&#44; low-grade fever&#44; and arthralgias&#44; with no cough or other symptoms&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">On physical examination&#44; she was in good general condition&#44; with normal coloring&#44; normal hydration&#44; and normal breathing at rest&#46; She had no supraclavicular lymphadenopathies or nail clubbing&#46; Blood pressure was 101&#47;70<span class="elsevierStyleHsp" style=""></span>mmHg&#44; heart rate 74<span class="elsevierStyleHsp" style=""></span>bpm&#44; respiration rate 12 breaths&#47;m&#44; and SpO<span class="elsevierStyleInf">2</span> &#40;room air&#41; 98&#37;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Cardiac auscultation was normal and pulmonary auscultation showed decreased breath sounds in the lower third of both lungs&#44; with decreased transmission of vocal fremitus&#44; dullness on percussion&#44; and signs of pleural effusion&#46; The rest of the examination was normal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Antigen and polymerase chain reaction &#40;PCR&#41; for COVID-19 were negative&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Chest X-ray in the emergency room showed blunting of both costophrenic angles consistent with bilateral pleural effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The blood count showed 10&#46;1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;l leukocytes with 5&#46;9&#37; eosinophils &#40;600<span class="elsevierStyleHsp" style=""></span>eosinophils&#41; and hemoglobin 14&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#46; Biochemistry showed total proteins 6&#46;69<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; LDH 257<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; CRP 4&#46;03<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Coagulation tests showed D-dimer 2656<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Pneumococcus and <span class="elsevierStyleItalic">Legionella</span> antigens in urine and parallel respiratory serology for <span class="elsevierStyleItalic">Legionella</span>&#44; <span class="elsevierStyleItalic">Mycoplasma</span> and respiratory viruses were negative&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A chest computed tomography angiogram conducted to rule out pulmonary thromboembolism confirmed moderate bilateral pleural effusion with bibasilar and middle lobe atelectasis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; This was confirmed on chest ultrasound that also ruled out vascular involvement&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Echocardiography showed mild pericardial effusion not affecting cavity filling&#46; Abdominal ultrasound was normal&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Thoracentesis showed exudate &#40;proteins 4&#46;25<span class="elsevierStyleHsp" style=""></span>g&#47;dl and LDH 191<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41; with predominantly polymorphonuclear cells &#40;73&#46;2&#37;&#41;&#44; normal ADA &#40;6&#46;7<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41;&#44; cholesterol 75<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; CEA<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#46;7<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; and negative antinuclear antibodies&#46; Cytology was negative for malignancy&#44; culture showed no microorganisms&#44; and Ziehl-Neelsen and culture in L&#246;wenstein-Jensen media were negative&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h and methylprednisolone 40<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h were administered for 6 days with favorable clinical and radiological evolution&#44; and the patient was discharged with prednisone 30<span class="elsevierStyleHsp" style=""></span>mg in a tapering regimen and azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h for a further 4 days&#44; and was referred for monitoring in the outpatient clinic&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Follow-up chest CT at 15 days showed a marked decrease in pleural and pericardial effusion&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Follow-up clinical laboratory tests at 23 days after discharge showed normal antinuclear antibodies and anti-neutrophil cytoplasm antibodies &#40;P-ANCA and <span class="elsevierStyleSmallCaps">C</span>-ANCA&#41;&#46; Serology was positive for SARS-CoV-2 IgG&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The Moderna mRNA-1273 vaccine is given in 2 doses and has demonstrated 94&#46;7&#37; efficacy and very good safety&#46; Most of the adverse effects are mild&#44; and while serious events&#44; such as myalgias&#44; arthralgias and asthenia&#44; have been reported&#44; particularly after the second dose&#44; pleural and pericardial effusion are not listed in the Summary of Product Characteristics or reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Our patient&#44; who had recently received the Moderna vaccine&#44; developed bilateral and pericardial pleural effusion&#46; After ruling out other causes&#44; her clinical picture was consistent with MIS caused by the Moderna vaccine&#44; resulting in bilateral pleural and pericardial exudate&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">MIS after vaccination &#40;usually the second dose&#41; is exceptional&#44; and very few cases have been published&#44; particularly in children and adolescents&#46; It consists of a systemic clinical syndrome &#40;diarrhea&#44; dyspnea&#44; abdominal pain&#44; skin rash&#44; and hypotension&#41; involving at least 2 organs&#46; Progress is favorable after administration of corticosteroids and&#44; in some cases&#44; intravenous immunoglobulins&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This entity may have clinical similarities with active SARS-CoV-2 infection&#44; so assessment of the vaccination history is essential when taking the medical history&#46; Most cases are reported at 2&#8211;4 weeks after administration and involve gastrointestinal symptoms&#46; The only cases of pleural effusion reported have been associated with heart failure&#44; and none of these patients were studied for pleural fluid&#46; Long-term functional consequences are unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The SARS-CoV-2 vaccine &#8211; generally the Janssen vaccine &#8211; has been associated with some rare reports of MIS in the literature&#44; and in no case has pleural fluid been studied to complete the diagnosis&#46; Exudative pleural-pericardial effusion without accompanying myocarditis should be considered among the complications caused by the mRNA-1273 vaccine&#46;</p></span>"
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ISSN: 03002896
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