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Letter to the Director
Reply to “Absence of Relevant Clinical Effects of SARS-CoV-2 on the Affinity of Hemoglobin for O2 in Patients With COVID-19”
Respuesta a «Ausencia de efectos clínicos destacables del SARS-CoV-2 sobre la afinidad de la hemoglobina por el O2 en pacientes con COVID-19»
Sergi Pascual-Guàrdiaa, Antoni Ferrera, Oscar Diazb, Antonio O. Caguanaa, Elvira Tejedorb, Diego A. Rodríguez-Chiaradiaa, Joaquim Geaa,
Corresponding author
Quim.gea@upf.edu

Corresponding author.
a Servicio de Neumología, Hospital del Mar – IMIM, Departamento MELIS, Universitat Pompeu Fabra, CIBERES, ISCiii, BRN, Barcelona, Spain
b Laboratorio de Referencia de Cataluña, El Prat de Llobregat, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the scientific letter from Prof&#46; B&#246;ning et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> commenting on our article on the affinity of hemoglobin for oxygen in patients with COVID-19&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The aim of our study was to reply from a clinical point of view to the hypothesis generated by two basic research papers that suggested that the virus decreases this affinity by way of different mechanisms&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> We&#44; like previous authors such as Gille et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and Laredo et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> found that the virus appears to have little effect on the interaction of hemoglobin with oxygen&#46; However&#44; these results contrast with those published by other authors&#44; such as Vogel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> It is important for the management of patients that these discrepancies are clarified&#44; since the clinical impact of this affinity affects the real value of PaO<span class="elsevierStyleInf">2</span> as an indicator of blood oxygenation&#46; The dispersion of our data&#44; which included hospitalized patients with COVID-19 of heterogeneous severity&#44; prompted Prof&#46; B&#246;ning&#39;s group of physiologists to suggest that a reduced affinity between hemoglobin and oxygen may be a particular problem in more serious patients&#46; They also suggest that this may be caused by shifts in the oxygen&#8211;hemoglobin dissociation curve&#44; due&#44; for example&#44; to changes in the concentration of 2&#8211;3 diphosphoglycerate &#40;2&#46;3-BPG&#41;&#46; Unfortunately&#44; we did not determine blood levels of this 1&#46;3-diphosphoglycerate isomer&#44; which&#44; together with several other variables that were analyzed in our study &#40;PaCO<span class="elsevierStyleInf">2</span>&#44; pH&#44; temperature&#41;&#44; affects the shape of the above-mentioned curve&#46; We reanalyzed our data&#44; including only the group of patients admitted to the intensive care unit for lung involvement that led to respiratory failure &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>75&#44; with a total of 343 arterial and 220 venous samples&#41;&#44; but this procedure did not reveal any relevant discrepancies between measured and calculated saturation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; so we conclude that there does not appear to be a loss of normal affinity of hemoglobin for oxygen&#46; The possible decrease in hemoglobin itself&#44; another parameter that varies considerably among clinical studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> could be due to different causes&#44; such as the viral disease itself&#44; nutritional deficiencies&#44; or the proinflammatory state of critical patients&#46; Another cause could be the frequent repetition of laboratory tests in intensive care units&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> a practice that was particularly common for both healthcare and for research reasons in severe COVID-19 patients&#46; However&#44; the rate of anemia in our severe patients was 27&#46;8&#37; &#40;mean hemoglobin 12&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&#44; even lower than in critical patients with other diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> It should be noted here that our hospital was very restrictive with regard to blood draws for research&#58; a single sample was drawn from each patient and competitively allocated among the various studies&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0010" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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