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respiratory phenotypes&#44; but only few studies documented this&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In this report&#44; we compared the respiratory manifestations and the chest imaging findings from a cohort of pediatric and adult patients from a tertiary level hospital&#44; a major referral for PID&#44; located in Campania region&#44; in Southern Italy&#46; In order to describe the respiratory phenotypes in different PID groups and to investigate their prevalence&#44; we conducted a retrospective study over a three-year period&#44; from mid-2018 to mid-2020 and created a database of 269 patients with PID including 182 children &#40;mean age&#44; 9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 years&#59; 67&#37; of the total&#41; and 87 adults &#40;mean age&#44; 20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;5 years&#59; 33&#37; of the total&#41;&#46; According to the underlying diagnosis&#44; patients were allocated to three groups&#58; cellular immunity defects &#91;Group 1&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#44; 17&#46;9&#37; of the total&#44; including Ataxia&#8211;Teleangiectasia &#40;A&#8211;T&#41;&#44; partial DiGeorge syndrome &#40;pDGS&#41;&#44; or Severe Combined Immune-deficiencies &#40;SCID&#41; before treatment&#93;&#59; humoral immunity defects &#91;Group 2&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>203&#44; 75&#46;5&#37; of the total&#44; including Common Variable Immune-deficiency &#40;CVID&#41;&#44; X-linked Agammaglobulinemia &#40;XLA&#41;&#44; or selective IgA Deficiency &#40;sIgAD&#41;&#93;&#59; innate immunity defects &#91;Group 3&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#44; 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<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; In more than half of the cases&#44; a diagnosis of cellular immunity defect was established&#44; in nearly 90&#37;&#44; of cases in the first decade &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; A wide variability of age at diagnosis was found in cases with humoral immunity defects&#44; while patients with defects of innate immunity were diagnosed always before adolescence&#46; The diagnostic delay was lower in patients with cellular immunity defects than in other groups &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#59; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Rhinosinusitis was more common in Group 2&#44; with a significant difference when compared to Groups 1 and 3 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#44; and otitis was more frequent in Group 1&#46; No significant difference in the prevalence of lower airway infections was found among all groups &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In order to investigate whether a different localization of airway infections in each disease group was associated with a specific immunological defect&#44; we compared the prevalence within subgroups&#46; In Group 1&#44; upper airway infections were more frequent in A-T patients&#44; while lower airway infections were more prevalent among SCID patients &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>E&#8211;F&#41;&#46; Within the pediatric patients from Group 2&#44; we compared the prevalence among XLA&#44; CVID and sIgAD&#44; and found that rhinosinusitis was more prevalent in the CVID subgroup &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>G&#41;&#46; Within Group 3&#44; patients with CGD or other innate immunity disorders showed higher prevalence of pneumonia in the CGD subgroup &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>H&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Of 269 patients&#44; 197 &#40;72&#46;3&#37;&#41; underwent chest imaging examinations at the time of database creation&#46; Four major categories of radiological changes were analyzed&#58; consolidation&#44; bronchiectasis&#44; interstitial lung disease and Granulomatous and Lymphocytic Interstitial Lung Disease &#40;GLILD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Consolidation was more common among patients with cellular and innate immunity defects than in those with humoral immunity defects &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Prevalence of bronchiectasis was significantly higher in patients with humoral immunity defects compared to cellular immunity defects &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; As the only group including both pediatric and adult patients is Group 2&#44; we compared the general characteristics&#44; clinical manifestations and chest imaging findings between the two age subgroups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; As expected&#44; adults with humoral immunity defects had a straightforward delay in the diagnosis of PID &#40;6&#46;1 <span class="elsevierStyleItalic">versus</span> 1&#46;3 years in the pediatric population&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;00001&#41;&#44; while children showed a fairly higher rate of otitis than adults &#40;55&#37; <span class="elsevierStyleItalic">versus</span> 6&#46;8&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;00001&#41;&#46; Finally&#44; no noteworthy difference was found in the prevalence of radiological findings between the two age subgroups&#44; except for GLILD that was found in 28 CVID patients of which 93&#37; were adults &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Overall&#44; our report reveals&#44; as expected&#44; that in cases with the most severe PID&#44; such as cellular or innate immunity defects&#44; respiratory symptoms start early&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> This resulted in a prompt immunological diagnosis&#46; Patients with humoral immunity defects usually present with mild upper respiratory tract infections which might be&#44; indeed&#44; overlooked&#44; thus delaying the referral to the immunology center&#46; The association with other non-immunological features may also reduce the diagnostic delay in selected cases &#40;A-T or DGS&#41;&#46; Moreover&#44; the finding that rhinosinusitis is the most prevalent respiratory manifestation in CVID &#40;Group 2&#41; or A-T patients &#40;Group 1&#41; might be explained by the long-lasting T-cell defect in both disorders&#44; rather than by the severity of T-cell impairment or the selective humoral immunity defects&#46; While we did not find any significant difference in lower respiratory tract infections distribution among all groups&#44; rhinosinusitis associated with GLILD appeared a distinctive feature of the respiratory phenotype of CVID&#46; Early recurrent sinopulmonary infections are extremely common in CVID&#44; and a high proportion of cases may develop chronic lung disease with bronchiectasis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> A host of other systemic manifestations&#44; including autoimmune disorders and lymphoproliferation may also occur which significantly worsen patients&#8217; morbidity and mortality&#46; Prognosis of CVID is largely affected by GLILD&#44; a lymphoproliferative disorder characterized by progressive lung damage including airway disease and the need for continuous chest treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the hallmarks of respiratory manifestations in the different groups of PID are already known&#44; our report&#44; through a stratified sampling method on a single-center cohort including both pediatric and adult patients&#44; highlights that rhinosinusitis and GLILD are almost exclusively found in CVID&#44; suggesting that the contextual presence of a cell-mediated defect of long duration in association with the humoral defect is necessary for its development&#46; Hopefully&#44; the precocious identification of the lung disease may help improve the final outcome of the disease and more importantly may significantly impact the quality of life of patients with PID&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare to have no conflict of interest directly or indirectly related to the manuscript contents&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Age of onset of respiratory symptoms&#46; &#40;b&#41; Age distribution at diagnosis according to different IEI&#46; &#40;c&#41; Diagnostic delay&#46; &#40;d&#41; Distribution of respiratory infections among the three groups&#46; &#40;e&#41; Upper respiratory tract infections within Group 1&#46; &#40;f&#41; Lower respiratory tract infections within Group 1&#46; &#40;g&#41; Prevalence of rhinosinusitis in Group 2&#46; &#40;h&#41; Distribution of respiratory infections within Group 3&#46; &#42;<span class="elsevierStyleItalic">P</span>-value<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;05&#44; &#42;&#42; <span class="elsevierStyleItalic">P</span>-value<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;01&#44; &#42;&#42;&#42; <span class="elsevierStyleItalic">P</span>-value<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#46;</p>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; GLILD&#44; granulomatous lymphocytic interstitial lung disease&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Whole Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Children&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Adults&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients&#44; <span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">203&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gender&#44; &#37; males&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean age at last clinical follow-up&#44; years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;00001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagnostic delay&#44; years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">9&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;00001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Clinical manifestations</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Rhinosinusitis&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otitis&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;00001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bronchitis&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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Scientific Letter
Respiratory Manifestations in Primary Immunodeficiencies: Findings From a Pediatric and Adult Cohort
Manifestaciones respiratorias en las inmunodeficiencias primarias: hallazgo de una cohorte pediátrica y adulta
Roberta Romanoa, Melissa Borrellia, Emilia Cirilloa, Giuliana Giardinoa, Giuseppe Spadarob, Ludovica Crescenzib, Ilaria Mormileb, Laura Vendittoa, Claudio Pignataa,,
Corresponding author
pignata@unina.it

Corresponding authors.
, Francesca Santamariaa,,
Corresponding author
santamar@unina.it

Corresponding authors.
a Department of Translational Medical Sciences – Section of Pediatrics, University of Naples Federico II, Naples, Italy
b Department of Translational Medical Sciences – Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Italy
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary immunodeficiencies &#40;PIDs&#41; are a heterogeneous group of more than 400 inherited immune system disorders&#44; with overall prevalence 1&#47;1000&#8211;1&#47;5000&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> At any age&#44; recurrent-to-persistent respiratory infections are often the first presenting sign of PIDs&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Poor defense from opportunistic or non-opportunistic pathogens&#44; as well as non-infectious complications may significantly impact morbidity and mortality of the conditions&#44; even when early detected&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In PIDs&#44; type&#44; outcome and severity of the underlying defect might influence type and severity of patients&#8217; respiratory phenotypes&#44; but only few studies documented this&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In this report&#44; we compared the respiratory manifestations and the chest imaging findings from a cohort of pediatric and adult patients from a tertiary level hospital&#44; a major referral for PID&#44; located in Campania region&#44; in Southern Italy&#46; In order to describe the respiratory phenotypes in different PID groups and to investigate their prevalence&#44; we conducted a retrospective study over a three-year period&#44; from mid-2018 to mid-2020 and created a database of 269 patients with PID including 182 children &#40;mean age&#44; 9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 years&#59; 67&#37; of the total&#41; and 87 adults &#40;mean age&#44; 20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;5 years&#59; 33&#37; of the total&#41;&#46; According to the underlying diagnosis&#44; patients were allocated to three groups&#58; cellular immunity defects &#91;Group 1&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#44; 17&#46;9&#37; of the total&#44; including Ataxia&#8211;Teleangiectasia &#40;A&#8211;T&#41;&#44; partial DiGeorge syndrome &#40;pDGS&#41;&#44; or Severe Combined Immune-deficiencies &#40;SCID&#41; before treatment&#93;&#59; humoral immunity defects &#91;Group 2&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>203&#44; 75&#46;5&#37; of the total&#44; including Common Variable Immune-deficiency &#40;CVID&#41;&#44; X-linked Agammaglobulinemia &#40;XLA&#41;&#44; or selective IgA Deficiency &#40;sIgAD&#41;&#93;&#59; innate immunity defects &#91;Group 3&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#44; 6&#46;6&#37; of the total&#44; including Chronic Granulomatous Disease &#40;CGD&#41;&#44; <span class="elsevierStyleItalic">STAT1</span> gain of function&#44; hyper IgE Syndrome&#44; <span class="elsevierStyleItalic">MYD88</span> Deficiency&#44; or congenital neutropenia&#93;&#46; We analyzed variables including gender&#44; type of PID&#44; age at diagnosis&#44; age at onset of respiratory symptoms&#44; diagnostic delay &#40;the time elapsed between the onset of respiratory symptoms and the diagnosis of PID&#41;&#44; history of upper &#40;i&#46;e&#46; rhinosinusitis and&#47;or otitis&#41; or lower &#40;i&#46;e&#46; bronchitis and&#47;or pneumonia&#41; airway infections&#44; chest imaging phenotypes &#40;at X-ray or Computed Tomography or Magnetic Resonance Imaging&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> In our study population&#44; Groups 1 and 3 included only children&#44; while Group 2 was composed of both pediatric and adult patients with humoral immunity defects&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Comparisons between groups were performed applying t-test for numerical variables and chi-test for categorical variables&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The age at onset of respiratory symptoms was significantly higher in Group 2 than Groups 1 and 3 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#59; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; In more than half of the cases&#44; a diagnosis of cellular immunity defect was established&#44; in nearly 90&#37;&#44; of cases in the first decade &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; A wide variability of age at diagnosis was found in cases with humoral immunity defects&#44; while patients with defects of innate immunity were diagnosed always before adolescence&#46; The diagnostic delay was lower in patients with cellular immunity defects than in other groups &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#59; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Rhinosinusitis was more common in Group 2&#44; with a significant difference when compared to Groups 1 and 3 &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#44; and otitis was more frequent in Group 1&#46; No significant difference in the prevalence of lower airway infections was found among all groups &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In order to investigate whether a different localization of airway infections in each disease group was associated with a specific immunological defect&#44; we compared the prevalence within subgroups&#46; In Group 1&#44; upper airway infections were more frequent in A-T patients&#44; while lower airway infections were more prevalent among SCID patients &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>E&#8211;F&#41;&#46; Within the pediatric patients from Group 2&#44; we compared the prevalence among XLA&#44; CVID and sIgAD&#44; and found that rhinosinusitis was more prevalent in the CVID subgroup &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>G&#41;&#46; Within Group 3&#44; patients with CGD or other innate immunity disorders showed higher prevalence of pneumonia in the CGD subgroup &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>H&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Of 269 patients&#44; 197 &#40;72&#46;3&#37;&#41; underwent chest imaging examinations at the time of database creation&#46; Four major categories of radiological changes were analyzed&#58; consolidation&#44; bronchiectasis&#44; interstitial lung disease and Granulomatous and Lymphocytic Interstitial Lung Disease &#40;GLILD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Consolidation was more common among patients with cellular and innate immunity defects than in those with humoral immunity defects &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Prevalence of bronchiectasis was significantly higher in patients with humoral immunity defects compared to cellular immunity defects &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; As the only group including both pediatric and adult patients is Group 2&#44; we compared the general characteristics&#44; clinical manifestations and chest imaging findings between the two age subgroups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; As expected&#44; adults with humoral immunity defects had a straightforward delay in the diagnosis of PID &#40;6&#46;1 <span class="elsevierStyleItalic">versus</span> 1&#46;3 years in the pediatric population&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;00001&#41;&#44; while children showed a fairly higher rate of otitis than adults &#40;55&#37; <span class="elsevierStyleItalic">versus</span> 6&#46;8&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;00001&#41;&#46; Finally&#44; no noteworthy difference was found in the prevalence of radiological findings between the two age subgroups&#44; except for GLILD that was found in 28 CVID patients of which 93&#37; were adults &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Overall&#44; our report reveals&#44; as expected&#44; that in cases with the most severe PID&#44; such as cellular or innate immunity defects&#44; respiratory symptoms start early&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> This resulted in a prompt immunological diagnosis&#46; Patients with humoral immunity defects usually present with mild upper respiratory tract infections which might be&#44; indeed&#44; overlooked&#44; thus delaying the referral to the immunology center&#46; The association with other non-immunological features may also reduce the diagnostic delay in selected cases &#40;A-T or DGS&#41;&#46; Moreover&#44; the finding that rhinosinusitis is the most prevalent respiratory manifestation in CVID &#40;Group 2&#41; or A-T patients &#40;Group 1&#41; might be explained by the long-lasting T-cell defect in both disorders&#44; rather than by the severity of T-cell impairment or the selective humoral immunity defects&#46; While we did not find any significant difference in lower respiratory tract infections distribution among all groups&#44; rhinosinusitis associated with GLILD appeared a distinctive feature of the respiratory phenotype of CVID&#46; Early recurrent sinopulmonary infections are extremely common in CVID&#44; and a high proportion of cases may develop chronic lung disease with bronchiectasis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> A host of other systemic manifestations&#44; including autoimmune disorders and lymphoproliferation may also occur which significantly worsen patients&#8217; morbidity and mortality&#46; Prognosis of CVID is largely affected by GLILD&#44; a lymphoproliferative disorder characterized by progressive lung damage including airway disease and the need for continuous chest treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the hallmarks of respiratory manifestations in the different groups of PID are already known&#44; our report&#44; through a stratified sampling method on a single-center cohort including both pediatric and adult patients&#44; highlights that rhinosinusitis and GLILD are almost exclusively found in CVID&#44; suggesting that the contextual presence of a cell-mediated defect of long duration in association with the humoral defect is necessary for its development&#46; Hopefully&#44; the precocious identification of the lung disease may help improve the final outcome of the disease and more importantly may significantly impact the quality of life of patients with PID&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare to have no conflict of interest directly or indirectly related to the manuscript contents&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Age of onset of respiratory symptoms&#46; &#40;b&#41; Age distribution at diagnosis according to different IEI&#46; &#40;c&#41; Diagnostic delay&#46; &#40;d&#41; Distribution of respiratory infections among the three groups&#46; &#40;e&#41; Upper respiratory tract infections within Group 1&#46; &#40;f&#41; Lower respiratory tract infections within Group 1&#46; &#40;g&#41; Prevalence of rhinosinusitis in Group 2&#46; &#40;h&#41; Distribution of respiratory infections within Group 3&#46; &#42;<span class="elsevierStyleItalic">P</span>-value<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;05&#44; &#42;&#42; <span class="elsevierStyleItalic">P</span>-value<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;01&#44; &#42;&#42;&#42; <span class="elsevierStyleItalic">P</span>-value<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#46;</p>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; GLILD&#44; granulomatous lymphocytic interstitial lung disease&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Whole Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patients&#44; <span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">203&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gender&#44; &#37; males&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;017&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean age at last clinical follow-up&#44; years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;00001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diagnostic delay&#44; years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#60;&#46;00001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Rhinosinusitis&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;78&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otitis&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#60;&#46;00001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pneumonia&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;059&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">General Characteristics&#44; Clinical Manifestations and Chest Imaging Findings of Group 2 Including Pediatric and Adult Patients With Humoral Immunity Defects&#59; the Comparison Between the Two Age Groups&#44; Calculated Using Either t-test or chi-test&#44; Are Shown on the Right Column&#46;</p>"
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Article information
ISSN: 03002896
Original language: English
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