Clinical Image
Chronic Pulmonary Aspergillosis and the Effect of Corticosteroids
Aspergilosis pulmonar crónica y el efecto de los corticosteroides
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array:23 [ "pii" => "S030028962100017X" "issn" => "03002896" "doi" => "10.1016/j.arbres.2020.12.033" "estado" => "S300" "fechaPublicacion" => "2021-09-01" "aid" => "2720" "copyright" => "SEPAR" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:591" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0300289621000193" "issn" => "03002896" "doi" => "10.1016/j.arbres.2021.01.002" "estado" => "S300" "fechaPublicacion" => "2021-09-01" "aid" => "2722" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:592" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Jelly-like Pleural Effusions: An Uncommon Manifestation of Pseudomyxoma Peritonei" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "592" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Derrames pleurales gelatinosos: una manifestación infrecuente del pseudomixoma peritoneal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1570 "Ancho" => 1500 "Tamanyo" => 488514 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest CT scan showed massive pleural effusions on the right side with local atelectasis of the right lung (A). Abdominal CT scan revealed multiple low-density shadows of unequal size in the liver, and the edge of the lesions were slightly enhanced (B). An open thoracotomy revealed 1500<span class="elsevierStyleHsp" style=""></span>ml free mucus in the right pleural space (C), and multiple masses along the pleura, diaphragm and liver (D). Postoperative pathological showed low-grade mucinous neoplasm (E).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yimin Ma, Zhenguo Qiao, Haidong Chen" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Yimin" "apellidos" => "Ma" ] 1 => array:2 [ "nombre" => "Zhenguo" "apellidos" => "Qiao" ] 2 => array:2 [ "nombre" => "Haidong" "apellidos" => "Chen" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289621000193?idApp=UINPBA00003Z" "url" => "/03002896/0000005700000009/v1_202109020750/S0300289621000193/v1_202109020750/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289620300491" "issn" => "03002896" "doi" => "10.1016/j.arbres.2020.01.017" "estado" => "S300" "fechaPublicacion" => "2021-09-01" "aid" => "2410" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:590" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Paracoccidioidomycosis: Endobronchial Involvement in a Rare Disease in Europe" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "590" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Paracoccidioidomicosis: aspectos endobronquiales de una enfermedad rara en Europa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 719 "Ancho" => 950 "Tamanyo" => 189044 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Computed tomographic image of the patient thorax (a) and endobronchial aspects of disease at the distal third of patient's trachea (b); Histochemical detection of fungal forms in PAS coloration (c) and Grocott coloration (d).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cláudia Sousa, José Alves, Michelle Cordeiro" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Cláudia" "apellidos" => "Sousa" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Alves" ] 2 => array:2 [ "nombre" => "Michelle" "apellidos" => "Cordeiro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300491?idApp=UINPBA00003Z" "url" => "/03002896/0000005700000009/v1_202109020750/S0300289620300491/v1_202109020750/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Chronic Pulmonary Aspergillosis and the Effect of Corticosteroids" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "591" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cláudia S. Sousa, Pedro Mendes, António Brazão" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Cláudia S." "apellidos" => "Sousa" "email" => array:1 [ 0 => "claudiasabinafsousa@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Pedro" "apellidos" => "Mendes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "António" "apellidos" => "Brazão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia do Hospital Central do Funchal, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Serviço de Cirurgia Cardiotorácica do Hospital Central do Funchal, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aspergilosis pulmonar crónica y el efecto de los corticosteroides" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2097 "Ancho" => 1583 "Tamanyo" => 415502 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a, b) X-ray evolution of the patient. The X-ray on the left (a) was performed before corticosteroids therapy and the one on the right (b) about seven months after the beginning of that therapy; (c, d) coronal and axial views of thoracic computed tomography performed after six months of Itraconazole, showing giant aspergilloma in left lung; (e, f) necrotic material of fungus ball observed during surgery.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic pulmonary aspergillosis (CPA) is a rare disease, frequently affecting patients with current or prior lung disease, leading to the development of air cavities in the middle of lung parenchyma. Chronic cavitary pulmonary aspergillosis (CCPA) is the most common form of CPA, presenting as a single or as multiple pulmonary cavities with thickened walls, with or without an aspergilloma inside. When not treated appropriately, it can progress to chronic fibrosing pulmonary aspergillosis (CFPA), which is characterized by severe fibrotic destruction of at least two lobes of lung, ultimately leading to a major loss of lung function .<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">These two forms of CPA, similarly to what happens to single aspergilloma and <span class="elsevierStyleItalic">Aspergillus</span> nodules, usually occur in patients who are not immunosuppressed, differently from what happens in invasive pulmonary aspergillosis. On another hand, subacute invasive aspergillosis (SAIA), previously named chronic necrotizing aspergillosis, contrasts from invasive pulmonary aspergillosis due to its slower progression (usually 1–3 months), befaling in mildly immunocompromised patients and having similar clinical and radiological features to CCPA but a more rapid progression.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report the case of a 44-year-old woman with bronchiectasis due to whooping cough in childhood. She was referred to an autoimmune diseases consultation due to a lower limb vasculitis, whose study was negative except for anti-neutrophil cytoplasmic antibodies (ANCAs – atypical pattern) of 1/160. She started steroid therapy in considerable doses in order to control her disease. Chest X-rays demonstrated evolution of previous lung lesions to aspergilloma and a six-month course of itraconazole was prescribed. Despite that, clear worsening of the lesions with complete destruction of the left lung was perceived and the patient was proposed for left pneumectomy. At the surgery, filling of the left pleural cavity with brown necrotic material was observed. Histological exam of the surgical fragments revealed one re-epithelized cavitated lesion associated with fungal structures of the <span class="elsevierStyleItalic">Aspergillus</span> type. The microbiology of the surgical specimen identified <span class="elsevierStyleItalic">Aspergillus fumigatus</span>. Patient status after surgery has improved (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">This case highlights the multiple forms of CPA. The progression of this patient lesions do not fit the definition of SAIA, but we consider that the new imunossupressive status contributed to a more rapidly progression from CCPA to CFPA.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2097 "Ancho" => 1583 "Tamanyo" => 415502 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a, b) X-ray evolution of the patient. The X-ray on the left (a) was performed before corticosteroids therapy and the one on the right (b) about seven months after the beginning of that therapy; (c, d) coronal and axial views of thoracic computed tomography performed after six months of Itraconazole, showing giant aspergilloma in left lung; (e, f) necrotic material of fungus ball observed during surgery.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0010" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European society for clinical microbiology and infectious diseases and European Respiratory Society Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.W. Denning" 1 => "J. Cadranel" 2 => "C. Beigelman-Aubry" 3 => "F. Ader" 4 => "A. Chakrabarti" 5 => "S. Blot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/13993003.00583-2015" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2016" "volumen" => "47" "paginaInicial" => "45" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26699723" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005700000009/v1_202109020750/S030028962100017X/v1_202109020750/en/main.assets" "Apartado" => array:4 [ "identificador" => "21422" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Clinical Images / Imágenes clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005700000009/v1_202109020750/S030028962100017X/v1_202109020750/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028962100017X?idApp=UINPBA00003Z" ]
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