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Sclerosing Pneumocytoma Presenting as Endobronchial Tumor With Negative Autofluorescence
Tumor endobronquial con autofluorescencia negativa: Neumocitoma esclerosante
a Pulmonology Department, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, Barcelona, Spain
b High School of Health Sciences, Tecnocampus Mataró-Maresme, Pompeu Fabra University, Barcelona, Spain
c Family Medicine Department, CAP Cirera Molins, Mataró, Consorci Sanitari del Maresme, Mataró, Barcelona, Spain
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(B) Coronal thoracoabdominal-CT image shows new right subphrenic collection contiguous with diaphragm, consistent with an abscess; multiples focal hepatic lesions, one extending to right lung base, with a fistulous track (arrow). (C) Bronchofibroscopy revealed yellowish secretions in all bronchial tree. (D) Bronchofibroscopy revealed mucosa inflammation of medial basal segment of right lower lobe bronchus, from where yellowish secretions flowed, confirming fistulization site (circle). (E) Coronal CT image performed after embolization of the fistulous track shows the presence of high-attenuation embolization material (metallic coils and cyanoacrylate glue) in the right subphrenic space extending into the thorax (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sónia Silva Guerra, Carla António" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Sónia Silva" "apellidos" => "Guerra" ] 1 => array:2 [ "nombre" => "Carla" "apellidos" => "António" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620302179?idApp=UINPBA00003Z" "url" => "/03002896/0000005700000004/v1_202104020827/S0300289620302179/v1_202104020827/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Sclerosing Pneumocytoma Presenting as Endobronchial Tumor With Negative Autofluorescence" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "300" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jordi Juanola-Pla, Mireia Carmona Tomàs, M. Pilar Ortega Castillo" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Jordi" "apellidos" => "Juanola-Pla" "email" => array:1 [ 0 => "jjuanola@csdm.cat" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Mireia Carmona" "apellidos" => "Tomàs" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "M. Pilar Ortega" "apellidos" => "Castillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Pulmonology Department, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "High School of Health Sciences, Tecnocampus Mataró-Maresme, Pompeu Fabra University, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Family Medicine Department, CAP Cirera Molins, Mataró, Consorci Sanitari del Maresme, Mataró, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor endobronquial con autofluorescencia negativa: Neumocitoma esclerosante" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1027 "Ancho" => 1625 "Tamanyo" => 193809 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT scan image with hyperdense lesion on main right bronchi.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">51 years-old female patient with stage pT3N1M1b colon adenocarcinoma, with an isolated liver injury, diagnosed in 2019, initial treatment with laparoscopic sigmoidectomy, and subsequent chemotherapy using capecitabine and oxiplatin. In the extension initial study, an hyperdense nodular lesion is observed at the entrance of the main right bronchus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> black arrow) without uptake on PET/CT. The bronchoscopy shows an hypervascular pedunculated polyp lesion at the entrance of right upper lobe bronchus (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A) with negative autofluorescence (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Biopsy shows proliferation of small cells wrapped by hyalinizing stroma with a proliferation index of KI 67 less of 2%. Immunohistochemistry with Cytokeratin AE1/AE3 and positive TTF1, was suitable with sclerosing pneumocytoma. The multidisciplinary committee agreed to treat firstly liver metastasy and reassess treatment of benign endobronchial lesion after a completely recovery.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The sclerosing pneumocytoma (SP) is a rare benign lung tumor predominant in women. The endobronchial location is not frequent (1% of the SP), commonly with an asymptomatic presentation. Bronchoscopy shows an endobronchial polypoid lesion with edematous mucosa, with an intraluminal protrusion. At the patho-histological test, a positivity is shown toward TTF1, cytokeratin AE1/AE3, napsin-A and EMA (epithelial membrane antigen).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> Surgical resection is used as the first therapeutic option, although it may be considered a conservative management.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interests" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1027 "Ancho" => 1625 "Tamanyo" => 193809 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT scan image with hyperdense lesion on main right bronchi.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 903 "Ancho" => 1583 "Tamanyo" => 130255 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Endobronchial view of pendunculated lesion on right upper lobe bronchus with white light. (B) Negative autofluorescence bronchoscopy of endobronchial lesion.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sclerosingpneumocytoma: case report of a rare endobronchial presentation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Khanna" 1 => "K. Alshabani" 2 => "S. Mukhopadhyay" 3 => "L. Lam" 4 => "S. Ghosh" 5 => "A. Khanna" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "2019" "volumen" => "98" "paginaInicial" => "e15038" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary sclerosing of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "B. Yalcin" 1 => "T.T. Bekci" 2 => "S. Kozacioglu" 3 => "O.B. Bolukbas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmcr.2019.02.002" "Revista" => array:6 [ "tituloSerie" => "Respir Med Case Rep" "fecha" => "2019" "volumen" => "26" "paginaInicial" => "285" "paginaFinal" => "287" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30847275" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005700000004/v1_202104020827/S0300289620302271/v1_202104020827/en/main.assets" "Apartado" => array:4 [ "identificador" => "21422" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Clinical Images / Imágenes clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005700000004/v1_202104020827/S0300289620302271/v1_202104020827/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620302271?idApp=UINPBA00003Z" ]
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