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Pulmonary Metastasis of Cribriform-Morular Variant of Thyroid Carcinoma
Metástasis pulmonar de la variante cribiforme-morular de carcinoma tiroideo
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(B) Tumor cells showing strong, diffuse staining for β-catenin. β-Catenin 400×. (C) Diffuse staining of tumor cell nuclei with thyroid transcription factor (TTF-1). TTF-1, 200×. (D) Tumor cells showing diffuse, strong staining with progesterone receptors. Progesterone receptor, 200×.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cribriform-morular variant of thyroid carcinoma (CMV-TC) is an uncommon variant of papillary thyroid carcinoma.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> The immunohistochemical phenotype is thyroid transcription factor (TTF-1+) with focal staining for thyroglobulin, cytokeratin 7 (CK7) and CK19. The hallmark feature, however, is strong staining for β-catenin. CMV-TC metastasizes to the regional lymph nodes in 10% of patients and to distant sites in 6%.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> We report a case of sporadic CMV-TC in a 45-year-old woman with regional lymph node metastases and, 7 years after diagnosis, lung metastases. Thoracic CT showed multiple bilateral nodules measuring up to 2<span class="elsevierStyleHsp" style=""></span>cm in diameter. In 2018, a chest CT scan revealed a significant increase in nodule size and multiple lesions in the left lower lobe (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). The lesions were positive by PET and a lung core biopsy was performed. The immunohistochemical study showed strong, diffuse positivity for β-catenin, TTF-1, ER and PR (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B–D), all characteristic findings in CMV-TC.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 744 "Ancho" => 950 "Tamanyo" => 196038 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Thorax computed tomography scan showing bilateral multiple nodules. (B) Tumor cells showing strong, diffuse staining for β-catenin. β-Catenin 400×. (C) Diffuse staining of tumor cell nuclei with thyroid transcription factor (TTF-1). TTF-1, 200×. (D) Tumor cells showing diffuse, strong staining with progesterone receptors. Progesterone receptor, 200×.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Papillary thyroid carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Rosai" 1 => "J. Albores Saavedra" 2 => "S. Asioli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "R.V.Lloyd, R.Y.Osamura, G.Klöppel" "titulo" => "World Health Organization Classification of Tumors. Pathology and genetics of tumours of endocrine organs" "paginaInicial" => "81" "paginaFinal" => "91" "edicion" => "4th ed." "serieFecha" => "2017" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Cameselle-Teijeiro" 1 => "D. Peteiro-González" 2 => "J. Caneiro-Gómez" 3 => "M. Sánchez-Ares" 4 => "I. Abdulkader" 5 => "C. Eloy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41379-018-0070-2" "Revista" => array:6 [ "tituloSerie" => "Mod Pathol" "fecha" => "2018" "volumen" => "31" "paginaInicial" => "1168" "paginaFinal" => "1179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29785019" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005600000002/v4_202007190708/S0300289619301176/v4_202007190708/en/main.assets" "Apartado" => array:4 [ "identificador" => "45361" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imagen clínica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005600000002/v4_202007190708/S0300289619301176/v4_202007190708/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619301176?idApp=UINPBA00003Z" ]
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