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Clinical image
Primary Pleural Lymphoma
Linfoma pleural primario
Filipa Ramalho Fernandesa,
Corresponding author
filipasrfernandes@gmail.com

Corresponding author.
, Rui Caetano Oliveirab, Luís Vaz Rodriguesa
a Department of Pneumology, Unidade Local de Saúde da Guarda E.P.E. – Hospital Sousa Martins, Portugal
b Department of Anatomical Pathology, Centro Hospitalar e Universitário de Coimbra, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 80-year-old male&#44; smoker&#44; presented with chronic complaints of dyspnoea&#44; anorexia and asthenia&#46; Lung sounds were absent on the lower two-thirds of the right hemithorax&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Chest computed tomography &#40;CT&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; confirmed the presence of extensive right pleural effusion&#44; without mediastinal or hilar lymphadenopathies&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Thoracentesis revealed an exudative pleural effusion with absence of malignant cells&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Medical thoracoscopy allowed the visualization and biopsy of multifocal parietal pleural based pericentimetric macular lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Histopathological examination revealed small and intermediate cells &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#44; with eosinophilic cytoplasm and mild nuclear irregularity with occasional nucleoli&#44; expressing CD20 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#44; Bcl2&#44; Bcl6&#44; PAX5 and CD70a&#44; CD10&#44; MUM1 and p53&#59; there was no expression of CD5 and TTF1&#59; MIB-1 proliferative index was 50&#37;&#46; There was also mesothelial cells hyperplasia&#44; with eosinophils&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Neck&#44; abdomen and bone positron emission CT showed no abnormalities&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A final diagnosis of primary pleural lymphoma &#40;PPL&#41; was made and chemotherapy was started&#46; PPL is a rare cause of pleural effusion and its endoscopic appearance has seldom been fully characterized &#40;both as multifocal nodular lesions and diffuse unspecified pleural involvement&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a> The clinical manifestations are unspecific and large biopsy samples are the key to the diagnosis&#44; allowing for extensive immunohistochemical analysis&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Chest CT &#40;axial plan &#40;AP&#41;&#41;&#58; extensive right pleural effusion conditioning almost complete atelectasis of the middle and lower lobes&#46; No mediastinal or hilar pulmonary lymphadenopathies were found&#46; &#40;B&#41; Medical thoracoscopy&#58; pericentrimetric macular lesions with multifocal distribution and stony consistency&#46; &#40;C&#41; Small to intermedium lymphocytes with nuclear irregularity&#44; admixed with mesothelial cells&#44; H&#38;E 400&#215;&#46; &#40;D&#41; Diffuse expression of CD20 in the neoplastic cells&#44; 400&#215;&#46;</p>"
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                          "etal" => false
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Article information
ISSN: 03002896
Original language: English
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