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est&#225; consiguiendo excelentes resultados en el diagn&#243;stico de tumores pulmonares que requieren un abordaje transtor&#225;cico<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46; Esta t&#233;cnica tambi&#233;n se realiza guiada con TC o ecograf&#237;a y la principal diferencia est&#225; en el mayor tama&#241;o de su aguja&#44; y por tanto&#44; de la muestra obtenida&#46; Las indicaciones son similares que para la PAAFT&#44; llev&#225;ndola a cabo en caso de lesiones perif&#233;ricas no alcanzables por otro procedimiento y cuando hay discordancia entre la probabilidad cl&#237;nica de c&#225;ncer y los resultados de las pruebas de imagen&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La muestra obtenida mediante BAG&#44; parece ser tambi&#233;n suficiente para la clasificaci&#243;n y el an&#225;lisis molecular del CP<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#46; Aun as&#237;&#44; 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donde la sensibilidad y la especificidad de la BAG fueron respectivamente del 89 y 100&#37;&#44; y de la PAAFT del 95 y 81&#37;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&#46; Adem&#225;s&#44; a pesar de que ambas t&#233;cnicas son eficaces en el an&#225;lisis de biomarcadores&#47;mutaciones&#44; los recientes estudios de Ocak S et al&#46; y Schneider F et al&#46; mostraron que la BAG podr&#237;a identificar mejor las lesiones y ser m&#225;s rentable en estos an&#225;lisis<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;5</span></a>&#46; Esta mayor rentabilidad de la BAG pudiera estar ligada al tama&#241;o mayor de la muestra obtenida&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Por otro lado&#44; ninguno de estos estudios mostr&#243; diferencias significativas en el porcentaje de complicaciones con las 2 t&#233;cnicas&#44; a pesar de que en algunos casos pudieran ser mayores con la BAG<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2-4</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Con todo ello podemos elaborar una nueva recomendaci&#243;n&#44; 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Carta al Director
Biopsia con aguja gruesa versus punción aspiración con aguja fina en el diagnóstico del cáncer de pulmón
Core Needle Biopsy Versus Fine Needle Aspiration Biopsy in Diagnosing Lung Cancer
Felipe Villar Álvareza,
Corresponding author
fvillarleon@yahoo.es

Autor para correspondencia.
, Ignacio Muguruza Truebab, Javier Flandes Aldeyturriagac
a Servicio de Neumología, IIS Fundación Jiménez Díaz, UAM, CIBERES, Madrid, España
b Departamento de Cirugía Torácica, Hospitales IDCSalud, Madrid, España
c Unidad de Broncoscopias y Neumología Intervencionista, Servicio de Neumología, IIS Fundación Jiménez Díaz, UAM, CIBERES, Madrid, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">En el apartado de &#171;Estudios de confirmaci&#243;n citohistol&#243;gica y estadificaci&#243;n&#187; del manuscrito &#171;Recomendaciones SEPAR de diagn&#243;stico y tratamiento del c&#225;ncer de pulm&#243;n de c&#233;lulas no peque&#241;as&#187;&#44; publicado en 2016<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> se hace referencia a la punci&#243;n aspiraci&#243;n con aguja fina transtor&#225;cica &#40;PAAFT&#41; como t&#233;cnica de diagn&#243;stico histol&#243;gico transtor&#225;cico del c&#225;ncer de pulm&#243;n &#40;CP&#41;&#46; Esta se realiza guiada habitualmente con tomograf&#237;a computarizada &#40;TC&#41;&#44; o con control ecogr&#225;fico&#46; Los resultados apuntan a una sensibilidad global para diagn&#243;stico de malignidad mayor o igual al 90&#37;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Desde hace algunos a&#241;os la biopsia con aguja gruesa &#40;BAG&#41; est&#225; consiguiendo excelentes resultados en el diagn&#243;stico de tumores pulmonares que requieren un abordaje transtor&#225;cico<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46; Esta t&#233;cnica tambi&#233;n se realiza guiada con TC o ecograf&#237;a y la principal diferencia est&#225; en el mayor tama&#241;o de su aguja&#44; y por tanto&#44; de la muestra obtenida&#46; Las indicaciones son similares que para la PAAFT&#44; llev&#225;ndola a cabo en caso de lesiones perif&#233;ricas no alcanzables por otro procedimiento y cuando hay discordancia entre la probabilidad cl&#237;nica de c&#225;ncer y los resultados de las pruebas de imagen&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La muestra obtenida mediante BAG&#44; parece ser tambi&#233;n suficiente para la clasificaci&#243;n y el an&#225;lisis molecular del CP<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#46; Aun as&#237;&#44; existe cierta controversia en la literatura acerca de cu&#225;l t&#233;cnica es m&#225;s id&#243;nea para la clasificaci&#243;n de estos tumores o para la identificaci&#243;n de mutaciones&#44; como el <span class="elsevierStyleItalic">epidermal growth factor receptor</span> &#40;EGFR&#41; o el <span class="elsevierStyleItalic">anaplastic lymphoma kinase</span> &#40;ALK&#41;&#44; entre otros&#44; y con un menor &#237;ndice de complicaciones&#46; En este sentido encontramos varios estudios que han comparado distintas t&#233;cnicas&#46; En un primer metaan&#225;lisis de Yao X et al&#46; se concluy&#243; que no exist&#237;an diferencias entre las 2 t&#233;cnicas para diagnosticar el CP&#44; pero la BAG pudiera ser m&#225;s util para identificar lesiones benignas<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46; Estudios m&#225;s recientes han mostrado resultados similares para el diagn&#243;stico del CP&#44; como el de Sangha B et al&#46;&#44; donde la sensibilidad y la especificidad de la BAG fueron respectivamente del 89 y 100&#37;&#44; y de la PAAFT del 95 y 81&#37;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&#46; Adem&#225;s&#44; a pesar de que ambas t&#233;cnicas son eficaces en el an&#225;lisis de biomarcadores&#47;mutaciones&#44; los recientes estudios de Ocak S et al&#46; y Schneider F et al&#46; mostraron que la BAG podr&#237;a identificar mejor las lesiones y ser m&#225;s rentable en estos an&#225;lisis<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;5</span></a>&#46; Esta mayor rentabilidad de la BAG pudiera estar ligada al tama&#241;o mayor de la muestra obtenida&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Por otro lado&#44; ninguno de estos estudios mostr&#243; diferencias significativas en el porcentaje de complicaciones con las 2 t&#233;cnicas&#44; a pesar de que en algunos casos pudieran ser mayores con la BAG<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2-4</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Con todo ello podemos elaborar una nueva recomendaci&#243;n&#44; 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Article information
ISSN: 03002896
Original language: Spanish
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2019 November 66 25 91
2019 October 73 25 98
2019 September 77 14 91
2019 August 58 15 73
2019 July 57 18 75
2019 June 46 17 63
2019 May 82 16 98
2019 April 92 46 138
2019 March 53 30 83
2019 February 48 19 67
2019 January 50 17 67
2018 December 50 25 75
2018 November 110 32 142
2018 October 150 26 176
2018 September 76 17 93
2018 July 4 0 4
2018 June 1 0 1
2018 May 26 2 28
2018 April 62 16 78
2018 March 46 21 67
2018 February 46 34 80
2018 January 8 1 9
2017 December 4 0 4
2017 November 43 13 56
2017 October 2 8 10
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