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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The quality of life &#40;QoL&#41; in patients with chronic obstructive pulmonary disease &#40;COPD&#41;&#44; a condition largely caused by smoking&#44; is usually adversely affected&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Associated comorbidities contribute to disease severity and lead to poorer QoL&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Over the last 15 years&#44; awareness of nasal inflammation in COPD has increased&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> and the estimated prevalence of upper airway symptoms vary from 40&#37; to 88&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#8211;6</span></a> The presence of upper airway symptoms negatively affects the already poor QoL&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#8211;9</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of this study is to determine the incidence of upper airway symptoms in patients with COPD and its impact on QoL&#46; Newly referred symptomatic smokers over 35 years of age with COPD according to the Global Initiative for Chronic Obstructive Lung Disease guidelines<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> were included&#46; The incidence of upper airway symptoms was assessed on the basis of the Allergic Rhinitis and its Impact on Asthma<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> workshop report&#46; The study variables were&#58; respiratory symptoms&#44; upper airway symptoms&#44; spirometry with reversibility&#44; peripheral blood eosinophil count&#44; and computed tomography of paranasal sinuses &#40;CT-PNS&#41;&#46; CT-PNS was scored in accordance with the Lund-Mackay staging system&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> QoL in patients with upper airway symptoms was assessed using the St&#46; George&#39;s Respiratory Questionnaire &#40;SGRQ&#41;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> and Sino Nasal Outcome Test-22 &#40;SNOT-22&#41; questionnaire&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> Patients were divided into 2 groups&#58; Group 1&#44; COPD with upper airway symptoms&#59; and Group 2&#44; COPD without upper airway symptoms &#40;controls&#41;&#46; Radiological sinusitis was defined in accordance with the European Position Paper on Rhinosinusitis and Nasal Polyps 2012 criteria<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> along with CT-PNS findings&#46; All patients gave their informed&#44; written consent&#46; The study was approved by the institutional research ethics committee&#46; Data were analyzed using SPSS &#40;version 11&#46;5&#44; SPSS&#44; Inc&#46;&#44; Chicago&#44; IL&#41;&#46; Chi-Square&#44; Student&#39;s <span class="elsevierStyleItalic">t</span>-test and Pearson&#39;s correlation test were used for data analysis&#46; A significance level of <span class="elsevierStyleItalic">P</span>&#60;&#46;05 was accepted for all analysis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nearly two-thirds &#40;27&#47;41&#59; 65&#46;9&#37;&#41; of patients with COPD had upper airway symptoms &#40;Group 1&#41;&#46; These patients presented with higher peripheral blood eosinophilia&#44; more severe lower airway obstruction&#44; and an increased incidence of sinusitis on CT-PNS&#46; They also reported a significantly poorer QoL on the SGRQ and SNOT-22 questionnaires &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In Group 1&#44; patients with radiological sinusitis&#44; moderate positive correlation was observed between CT-PNS &#40;Lund-Mackay&#41; and SNOT-22 QoL scores &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;58&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;009&#41;&#46; Furthermore&#44; a positive correlation was observed between nasal symptoms based on SNOT-22 and more general SGRQ scores in these patients &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;41&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;03&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The incidence of upper airway symptoms in different studies ranges from 40&#37; to 88&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#8211;6</span></a> Three-quarters of the 61 patients with moderate-to-severe COPD from the East London COPD &#40;ELCOPD&#41; study cohort presented at least 1 nasal symptom&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> An inverse relationship was established between nasal patency in COPD and severity of airflow obstruction&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In our series&#44; patients with upper airway symptoms also presented with more severe lower airway obstruction&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Radiological sinusitis was documented in 19&#47;27 &#40;70&#46;4&#37;&#41; Group 1 patients&#46; QoL scores were consistent with findings from other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#44;6&#8211;8</span></a> The ELCOPD study<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> reported a mean SNOT-20 score of 1&#46;24&#44; showing that nasal symptoms impaired QoL&#46; The higher symptom&#44; total SGRQ and SNOT-22 scores showed significantly poorer QoL in Group 1 patients&#44; highlighting the adverse impact of upper airway symptoms in patients with COPD&#46; A positive correlation was observed between SNOT-22 and total SGRQ scores in Group 1 patients&#44; indicating a negative impact on overall QoL&#46; In the 19 patients with sinusitis on CT-PNS in Group 1&#44; CT-PNS scores showed a moderately strong positive correlation with SNOT-22 scores&#44; which is consistent with a previous study&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> The small sample size in our study was a limitation&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">This study highlights the incidence and significant impact of upper airway symptoms on QoL in patients with COPD&#46; It is therefore imperative to determine upper airway involvement in patients with COPD&#44; as this may lead to suboptimal control of the disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">This study was funded by the <span class="elsevierStyleGrantSponsor" id="gs1">Vallabhbhai Patel Chest Institute&#44; University of Delhi&#44; Delhi</span>&#46;</p></span></span>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;3&#177;6&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Current smokers&#58; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of smoking &#40;years&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#46;2&#177;11&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;4&#177;11&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pack years of smoking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;48&#177;25&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#46;07&#177;32&#46;77 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;257&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Absolute eosinophil count &#40;cells&#47;mm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">335&#46;03&#177;301&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">149&#46;92&#177;66&#46;17 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre-bronchodilator FEV<span class="elsevierStyleInf">1</span> &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;44&#177;0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;96&#177;0&#46;76 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;04&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Post-bronchodilator FEV<span class="elsevierStyleInf">1</span> &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;53&#177;0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;07&#177;0&#46;77 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;03&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre-bronchodilator FVC &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;81&#177;0&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;88 &#177;0&#46;68 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Post-bronchodilator FVC &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;91&#177;0&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;01&#177;0&#46;67 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Post-bronchodilator FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;8&#177;13&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;7&#177;8&#46;7 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;64&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#47;14 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;003&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CT-PNS &#40;L-M&#41; scores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;19&#177;2&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;29&#177;0&#46;61 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SNOT 22 score&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;87&#177;0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;38&#177;0&#46;38 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;0001&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;46&#177;15&#46;37 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;0005&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ activity&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#46;9&#177;18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;54&#177;20&#46;54 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ impact&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#46;8&#177;13&#46;23 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ total&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;28&#177;14&#46;5 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;01&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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      "titulo" => "References"
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            0 => array:3 [
              "identificador" => "bib0080"
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                0 => array:1 [
                  "referenciaCompleta" => "Global Strategy for the Diagnosis&#44; Management and Prevention of COPD&#44; Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41;&#59; 2016&#46; Available at&#58; <a href="http://www.goldcopd.org/">http&#58;&#47;&#47;www&#46;goldcopd&#46;org</a>&#46;"
                ]
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              "identificador" => "bib0085"
              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nosing around in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Shah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Chest Dis Allied Sci"
                        "fecha" => "2011"
                        "volumen" => "53"
                        "paginaInicial" => "5"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21446217"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of nasal symptoms and their relation to self-reported asthma and chronic bronchitis&#47;emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Montn&#233;mery"
                            1 => "C&#46; Svensson"
                            2 => "E&#46; Adelroth"
                            3 => "C&#46;G&#46; L&#246;fdahl"
                            4 => "M&#46; Andersson"
                            5 => "L&#46; Greiff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2001"
                        "volumen" => "17"
                        "paginaInicial" => "596"
                        "paginaFinal" => "603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401051"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between chronic nasal and respiratory symptoms in patients with COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Roberts"
                            1 => "S&#46;J&#46; Lloyd-Owen"
                            2 => "F&#46; Rapado"
                            3 => "I&#46;S&#46; Patel"
                            4 => "T&#46;M&#46; Wilkinson"
                            5 => "G&#46;C&#46; Donaldson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2003"
                        "volumen" => "97"
                        "paginaInicial" => "909"
                        "paginaFinal" => "914"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12924517"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Upper airway symptoms and quality of life in chronic obstructive pulmonary disease &#40;COPD&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;R&#46; Hurst"
                            1 => "T&#46;M&#46; Wilkinson"
                            2 => "G&#46;C&#46; Donaldson"
                            3 => "J&#46;A&#46; Wedzicha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2004"
                        "volumen" => "98"
                        "paginaInicial" => "767"
                        "paginaFinal" => "770"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15303642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of chronic nasal symptoms with dyspnoea and quality-of-life impairment in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Initiatives BPCO Scientific Committee and Investigators"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Caillaud"
                            1 => "P&#46; Chanez"
                            2 => "R&#46; Escamilla"
                            3 => "P&#46;R&#46; Burgel"
                            4 => "I&#46; Court-Fortune"
                            5 => "P&#46; Nesme-Meyer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/resp.12224"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "346"
                        "paginaFinal" => "352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24330257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sinonasal pathology in nonallergic asthma and COPD&#58; &#8216;united airway disease&#8217; beyond the scope of allergy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Hens"
                            1 => "B&#46;M&#46; Vanaudenaerde"
                            2 => "D&#46;M&#46; Bullens"
                            3 => "M&#46; Piessens"
                            4 => "M&#46; Decramer"
                            5 => "L&#46;J&#46; Dupont"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2007.01545.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2008"
                        "volumen" => "63"
                        "paginaInicial" => "261"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18053011"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The frequency of chronic rhinosinusitis&#47;nasal polyp in COPD and its effect on the severity of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Kelemence"
                            1 => "O&#46; Abadoglu"
                            2 => "C&#46; Gumus"
                            3 => "S&#46; Berk"
                            4 => "K&#46; Epozturk"
                            5 => "I&#46; Akkurt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/15412555.2010.540272"
                      "Revista" => array:6 [
                        "tituloSerie" => "COPD"
                        "fecha" => "2011"
                        "volumen" => "8"
                        "paginaInicial" => "8"
                        "paginaFinal" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21299473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0120"
              "etiqueta" => "9"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Nasal symptomatology&#44; obstruction&#44; and paranasal sinus opacity in patients with chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "P&#46; Celakovsky"
                            1 => "K&#46; Smatanova"
                            2 => "D&#46; Kalfert"
                            3 => "S&#46; Pracharova"
                            4 => "V&#46; Koblizek"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.3109/00016489.2014.999876"
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                        "tituloSerie" => "Acta Otolaryngol"
                        "fecha" => "2015"
                        "volumen" => "135"
                        "paginaInicial" => "598"
                        "paginaFinal" => "601"
                        "link" => array:1 [
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                      ]
                    ]
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                        "paginaInicial" => "41"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
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Scientific letter
Incidence and Impact of Upper Airway Symptoms in Patients With Chronic Obstructive Pulmonary Disease
Frecuencia e impacto de los síntomas de las vías respiratorias superiores en pacientes con enfermedad pulmonar obstructiva crónica
Avi Kumar, Shekhar Kunal, Ashok Shah
Corresponding author
ashokshah99@yahoo.com

Corresponding author.
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The quality of life &#40;QoL&#41; in patients with chronic obstructive pulmonary disease &#40;COPD&#41;&#44; a condition largely caused by smoking&#44; is usually adversely affected&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Associated comorbidities contribute to disease severity and lead to poorer QoL&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Over the last 15 years&#44; awareness of nasal inflammation in COPD has increased&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> and the estimated prevalence of upper airway symptoms vary from 40&#37; to 88&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#8211;6</span></a> The presence of upper airway symptoms negatively affects the already poor QoL&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#8211;9</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of this study is to determine the incidence of upper airway symptoms in patients with COPD and its impact on QoL&#46; Newly referred symptomatic smokers over 35 years of age with COPD according to the Global Initiative for Chronic Obstructive Lung Disease guidelines<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> were included&#46; The incidence of upper airway symptoms was assessed on the basis of the Allergic Rhinitis and its Impact on Asthma<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> workshop report&#46; The study variables were&#58; respiratory symptoms&#44; upper airway symptoms&#44; spirometry with reversibility&#44; peripheral blood eosinophil count&#44; and computed tomography of paranasal sinuses &#40;CT-PNS&#41;&#46; CT-PNS was scored in accordance with the Lund-Mackay staging system&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> QoL in patients with upper airway symptoms was assessed using the St&#46; George&#39;s Respiratory Questionnaire &#40;SGRQ&#41;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> and Sino Nasal Outcome Test-22 &#40;SNOT-22&#41; questionnaire&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> Patients were divided into 2 groups&#58; Group 1&#44; COPD with upper airway symptoms&#59; and Group 2&#44; COPD without upper airway symptoms &#40;controls&#41;&#46; Radiological sinusitis was defined in accordance with the European Position Paper on Rhinosinusitis and Nasal Polyps 2012 criteria<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> along with CT-PNS findings&#46; All patients gave their informed&#44; written consent&#46; The study was approved by the institutional research ethics committee&#46; Data were analyzed using SPSS &#40;version 11&#46;5&#44; SPSS&#44; Inc&#46;&#44; Chicago&#44; IL&#41;&#46; Chi-Square&#44; Student&#39;s <span class="elsevierStyleItalic">t</span>-test and Pearson&#39;s correlation test were used for data analysis&#46; A significance level of <span class="elsevierStyleItalic">P</span>&#60;&#46;05 was accepted for all analysis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nearly two-thirds &#40;27&#47;41&#59; 65&#46;9&#37;&#41; of patients with COPD had upper airway symptoms &#40;Group 1&#41;&#46; These patients presented with higher peripheral blood eosinophilia&#44; more severe lower airway obstruction&#44; and an increased incidence of sinusitis on CT-PNS&#46; They also reported a significantly poorer QoL on the SGRQ and SNOT-22 questionnaires &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In Group 1&#44; patients with radiological sinusitis&#44; moderate positive correlation was observed between CT-PNS &#40;Lund-Mackay&#41; and SNOT-22 QoL scores &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;58&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;009&#41;&#46; Furthermore&#44; a positive correlation was observed between nasal symptoms based on SNOT-22 and more general SGRQ scores in these patients &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;41&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;03&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The incidence of upper airway symptoms in different studies ranges from 40&#37; to 88&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#8211;6</span></a> Three-quarters of the 61 patients with moderate-to-severe COPD from the East London COPD &#40;ELCOPD&#41; study cohort presented at least 1 nasal symptom&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> An inverse relationship was established between nasal patency in COPD and severity of airflow obstruction&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In our series&#44; patients with upper airway symptoms also presented with more severe lower airway obstruction&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Radiological sinusitis was documented in 19&#47;27 &#40;70&#46;4&#37;&#41; Group 1 patients&#46; QoL scores were consistent with findings from other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#44;6&#8211;8</span></a> The ELCOPD study<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> reported a mean SNOT-20 score of 1&#46;24&#44; showing that nasal symptoms impaired QoL&#46; The higher symptom&#44; total SGRQ and SNOT-22 scores showed significantly poorer QoL in Group 1 patients&#44; highlighting the adverse impact of upper airway symptoms in patients with COPD&#46; A positive correlation was observed between SNOT-22 and total SGRQ scores in Group 1 patients&#44; indicating a negative impact on overall QoL&#46; In the 19 patients with sinusitis on CT-PNS in Group 1&#44; CT-PNS scores showed a moderately strong positive correlation with SNOT-22 scores&#44; which is consistent with a previous study&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> The small sample size in our study was a limitation&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">This study highlights the incidence and significant impact of upper airway symptoms on QoL in patients with COPD&#46; It is therefore imperative to determine upper airway involvement in patients with COPD&#44; as this may lead to suboptimal control of the disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">This study was funded by the <span class="elsevierStyleGrantSponsor" id="gs1">Vallabhbhai Patel Chest Institute&#44; University of Delhi&#44; Delhi</span>&#46;</p></span></span>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">COPD&#58; chronic obstructive pulmonary disease&#59; FEV1&#58; forced expiratory volume in one second&#59; FVC&#58; forced vital capacity&#59; L&#58; liters&#59; L-M&#58; Lund-Mackay&#59; SD&#58; standard deviation&#59; SGRQ&#58; St&#46; George&#39;s Respiratory Questionnaire&#59; SNOT-22&#58; Sino Nasal Outcome Test-22&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Descriptor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">COPD patients with upper airway symptoms &#40;Group 1&#41;<br>&#40;n&#61;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">COPD patients without upper airway symptoms &#40;Group 2&#41;<br>&#40;n&#61;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;7&#177;10&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&#46;9&#177;11&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gender male&#58; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;96&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;92&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of symptoms&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;8&#177;7&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;3&#177;6&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Current smokers&#58; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of smoking &#40;years&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#46;2&#177;11&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;4&#177;11&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pack years of smoking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;48&#177;25&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#46;07&#177;32&#46;77 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;257&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Absolute eosinophil count &#40;cells&#47;mm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">335&#46;03&#177;301&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">149&#46;92&#177;66&#46;17 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre-bronchodilator FEV<span class="elsevierStyleInf">1</span> &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;44&#177;0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;96&#177;0&#46;76 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;04&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Post-bronchodilator FEV<span class="elsevierStyleInf">1</span> &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;53&#177;0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;07&#177;0&#46;77 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;03&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre-bronchodilator FVC &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;81&#177;0&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;88 &#177;0&#46;68 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Post-bronchodilator FVC &#40;L&#41;&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;91&#177;0&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;01&#177;0&#46;67 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Post-bronchodilator FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;8&#177;13&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;7&#177;8&#46;7 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Radiological sinusitis&#47;mucosal thickening on CT-PNS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#47;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#47;14 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;003&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CT-PNS &#40;L-M&#41; scores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;19&#177;2&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;29&#177;0&#46;61 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SNOT 22 score&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;87&#177;0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;38&#177;0&#46;38 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;0001&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ symptoms&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&#46;7&#177;16&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;46&#177;15&#46;37 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;0005&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ activity&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#46;9&#177;18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;54&#177;20&#46;54 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ impact&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;8&#177;22&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#46;8&#177;13&#46;23 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SGRQ total&#58; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#46;5&#177;16&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;28&#177;14&#46;5 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;01&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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      "titulo" => "References"
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                  "referenciaCompleta" => "Global Strategy for the Diagnosis&#44; Management and Prevention of COPD&#44; Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41;&#59; 2016&#46; Available at&#58; <a href="http://www.goldcopd.org/">http&#58;&#47;&#47;www&#46;goldcopd&#46;org</a>&#46;"
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                      "titulo" => "Nosing around in chronic obstructive pulmonary disease"
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                            0 => "A&#46; Shah"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Chest Dis Allied Sci"
                        "fecha" => "2011"
                        "volumen" => "53"
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                    0 => array:2 [
                      "titulo" => "Prevalence of nasal symptoms and their relation to self-reported asthma and chronic bronchitis&#47;emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Montn&#233;mery"
                            1 => "C&#46; Svensson"
                            2 => "E&#46; Adelroth"
                            3 => "C&#46;G&#46; L&#246;fdahl"
                            4 => "M&#46; Andersson"
                            5 => "L&#46; Greiff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2001"
                        "volumen" => "17"
                        "paginaInicial" => "596"
                        "paginaFinal" => "603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401051"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between chronic nasal and respiratory symptoms in patients with COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Roberts"
                            1 => "S&#46;J&#46; Lloyd-Owen"
                            2 => "F&#46; Rapado"
                            3 => "I&#46;S&#46; Patel"
                            4 => "T&#46;M&#46; Wilkinson"
                            5 => "G&#46;C&#46; Donaldson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2003"
                        "volumen" => "97"
                        "paginaInicial" => "909"
                        "paginaFinal" => "914"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12924517"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Upper airway symptoms and quality of life in chronic obstructive pulmonary disease &#40;COPD&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;R&#46; Hurst"
                            1 => "T&#46;M&#46; Wilkinson"
                            2 => "G&#46;C&#46; Donaldson"
                            3 => "J&#46;A&#46; Wedzicha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "2004"
                        "volumen" => "98"
                        "paginaInicial" => "767"
                        "paginaFinal" => "770"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15303642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of chronic nasal symptoms with dyspnoea and quality-of-life impairment in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Initiatives BPCO Scientific Committee and Investigators"
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                          "autores" => array:6 [
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                            2 => "R&#46; Escamilla"
                            3 => "P&#46;R&#46; Burgel"
                            4 => "I&#46; Court-Fortune"
                            5 => "P&#46; Nesme-Meyer"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1111/resp.12224"
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                        "tituloSerie" => "Respirology"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "346"
                        "paginaFinal" => "352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24330257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sinonasal pathology in nonallergic asthma and COPD&#58; &#8216;united airway disease&#8217; beyond the scope of allergy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Hens"
                            1 => "B&#46;M&#46; Vanaudenaerde"
                            2 => "D&#46;M&#46; Bullens"
                            3 => "M&#46; Piessens"
                            4 => "M&#46; Decramer"
                            5 => "L&#46;J&#46; Dupont"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2007.01545.x"
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                        "tituloSerie" => "Allergy"
                        "fecha" => "2008"
                        "volumen" => "63"
                        "paginaInicial" => "261"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18053011"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The frequency of chronic rhinosinusitis&#47;nasal polyp in COPD and its effect on the severity of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            1 => "O&#46; Abadoglu"
                            2 => "C&#46; Gumus"
                            3 => "S&#46; Berk"
                            4 => "K&#46; Epozturk"
                            5 => "I&#46; Akkurt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/15412555.2010.540272"
                      "Revista" => array:6 [
                        "tituloSerie" => "COPD"
                        "fecha" => "2011"
                        "volumen" => "8"
                        "paginaInicial" => "8"
                        "paginaFinal" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21299473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "9"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Nasal symptomatology&#44; obstruction&#44; and paranasal sinus opacity in patients with chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "D&#46; Kalfert"
                            3 => "S&#46; Pracharova"
                            4 => "V&#46; Koblizek"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "Acta Otolaryngol"
                        "fecha" => "2015"
                        "volumen" => "135"
                        "paginaInicial" => "598"
                        "paginaFinal" => "601"
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              "etiqueta" => "10"
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                    0 => array:2 [
                      "titulo" => "Allergic Rhinitis and its Impact on Asthma &#40;2010&#41; guidelines&#58; 2010 revision"
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                          "colaboracion" => "Global Allergy and Asthma European Network&#59; Grading of Recommendations Assessment&#44; Development and Evaluation Working Group"
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                            2 => "C&#46;E&#46; Baena-Cagnani"
                            3 => "S&#46; Bonini"
                            4 => "G&#46;W&#46; Canonica"
                            5 => "T&#46;B&#46; Casale"
                          ]
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                      ]
                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2010"
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                        "paginaInicial" => "466"
                        "paginaFinal" => "476"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Staging in rhinosinusitus"
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                        "paginaInicial" => "183"
                        "paginaFinal" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8140385"
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The St&#46; George&#39;s Respiratory Questionnaire"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;W&#46; Jones"
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                        "tituloSerie" => "Thorax"
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                        "paginaInicial" => "676"
                        "paginaFinal" => "682"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1835178"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Psychometric and clinimetric validity of the 20-item Sino-Nasal Outcome Test &#40;SNOT-20&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "M&#46;L&#46; Richards"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mhn.2002.121022"
                      "Revista" => array:6 [
                        "tituloSerie" => "Otolaryngol Head Neck Surg"
                        "fecha" => "2002"
                        "volumen" => "126"
                        "paginaInicial" => "41"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11821764"
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                    ]
                  ]
                ]
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              "etiqueta" => "14"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "EPOS 2012&#58; European position paper on rhinosinusitis and nasal polyps 2012&#46; A summary for otorhinolaryngologists"
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                        0 => array:2 [
                          "etal" => true
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                            3 => "C&#46; Bachert"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.4193/Rhino50E2"
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                        "tituloSerie" => "Rhinology"
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                        "volumen" => "50"
                        "paginaInicial" => "1"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22469599"
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                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nasal symptoms&#44; airway obstruction and disease severity in chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Hurst"
                            1 => "R&#46; Kuchai"
                            2 => "P&#46; Michael"
                            3 => "W&#46;R&#46; Perera"
                            4 => "T&#46;M&#46; Wilkinson"
                            5 => "J&#46;A&#46; Wedzicha"
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                        ]
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1475-097X.2006.00683.x"
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                        "tituloSerie" => "Clin Physiol Funct Imaging"
                        "fecha" => "2006"
                        "volumen" => "26"
                        "paginaInicial" => "251"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16836700"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
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ISSN: 03002896
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