Statistics

 array:22 [
  "pii" => "S0300289615326818"
  "issn" => "03002896"
  "doi" => "10.1016/S0300-2896(15)32681-8"
  "estado" => "S300"
  "fechaPublicacion" => "1977-07-01"
  "aid" => "72750"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
  "copyrightAnyo" => "1977"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 1977;13:168-73"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1332
    "formatos" => array:3 [
      "EPUB" => 69
      "HTML" => 663
      "PDF" => 600
    ]
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0300289615326806"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)32680-6"
    "estado" => "S300"
    "fechaPublicacion" => "1977-07-01"
    "aid" => "72749"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1977;13:166-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1223
      "formatos" => array:3 [
        "EPUB" => 58
        "HTML" => 658
        "PDF" => 507
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Quiste aereo pulmonar gigante en un sindrome de marfan"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "166"
          "paginaFinal" => "167"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Giant air cyst in marfan's syndrome"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Medicina Chamorro, J. Vera Megías, F. Martos Marín"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Medicina"
              "apellidos" => "Chamorro"
            ]
            1 => array:2 [
              "nombre" => "J."
              "apellidos" => "Vera Megías"
            ]
            2 => array:2 [
              "nombre" => "F."
              "apellidos" => "Martos Marín"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615326806?idApp=UINPBA00003Z"
    "url" => "/03002896/0000001300000003/v1_201509151327/S0300289615326806/v1_201509151327/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Estudio de las alteraciones de las propiedades tensioactivas del surfactante pulmonar del perro por la produccion de un enfisema experimental papainico"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "168"
        "paginaFinal" => "173"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "B. Vicens, J. Reventós, E. Concustell"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "B."
            "apellidos" => "Vicens"
          ]
          1 => array:2 [
            "nombre" => "J."
            "apellidos" => "Reventós"
          ]
          2 => array:2 [
            "nombre" => "E."
            "apellidos" => "Concustell"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Asmatología y Alergia Servicio de Cirugía Experimental, Servicio de Bioquímica, Hospital de la Santa Cruz y San Pablo. Barcelona"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Study of the alterations of the tensioactive properties of the pulmonary surfactant in dog, by the production of a papainic emphysema"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En el presente trabajo se han estudiado las propiedades tensioactivas y la composici&#243;n bioqu&#237;mica del surfactante pulmonar obtenido por lavado en nueve perros bastardos antes y despu&#233;s de haberles provocado un enfisema panlobulillar experimental mediante papa&#237;na&#44; para tratar de establecer un nexo de uni&#243;n entre dos teor&#237;as etiopatog&#233;nicas invocadas para el enfisema&#44; por un lado la disminuci&#243;n de la tensi&#243;n superficial del surfactante pulmonar&#44; y por otro la digesti&#243;n proteica intrapulmonar anormal secundaria a una disminuci&#243;n de la inhibici&#243;n de las proteasas liberadas en el pulm&#243;n por diferentes mecanismos&#46; Los resultados sugieren que en la g&#233;nesis del enfisema podr&#237;an jugar un papel tanto el aumento de la proteolisis intrapulmonar como la alteraci&#243;n de la actividad tensioactiva del surfactante pulmonar&#44; probablemente dependiendo el segundo hecho del primero&#44; si bien de forma diferente a la que induc&#237;an a pensar los estudios realizados hasta la fecha&#46;</p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The tensoactive properties as well as the Biochemical composition of the pulmonary surfactant obtained by washlung in nine mongrel dogs&#44; before and after papain-induced panlobulillar experimental emphysema was obtained&#44; are studied&#46; A relationship between the two advocated theories for the production of emphysema is tried to establish&#58; a&#41; The diminution of surface tension of pulmonary surfactant and b&#41; The abnormal intrapulmonary proteic digestion secundary to a diminution of the inhibition of the proteases liberated by the lung by various mechanisms&#46; The results suggest that in the genesis of emphysema the increase of the intrapulmonary proteolysis&#44; as well as the alteration of the tensoactivity of the surfactant could play an important role&#46; Possibly the latter fact is secondary to the former one&#44; but in a different way as it is considered at present&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#42;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Este trabajo ha sido realizado gracias a la ayuda de las Fundaciones Mar&#237;a Francisca Roviralta y Picasso-Revent&#243;s de Barcelona&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:43 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of cigarrette smoke on surface characteristics of lung extracts&#58; Amer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Miller"
                            1 => "S&#46; Bobdurant"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1962"
                        "volumen" => "85"
                        "paginaInicial" => "692"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The alveolar lining&#46; A method of extraction&#59; the surface tension lowering elfect of cigarrete smoke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Bondurant"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "L&#46; Clin&#46; Invest&#46;"
                        "fecha" => "1960"
                        "volumen" => "39"
                        "paginaInicial" => "973"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Films from lung washings as a mechanism model for injury by ozone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;M&#46; Menden Hall"
                            1 => "H&#46;E&#46; Stokinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Appl&#46; Physiol&#46;"
                        "fecha" => "1962"
                        "volumen" => "17"
                        "paginaInicial" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14472542"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary surface tension after sulfur dioxide exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;M&#46; Kahana"
                            1 => "M&#46; Aronovitch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1968.98.2.311"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1968"
                        "volumen" => "98"
                        "paginaInicial" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5667760"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pulmonary surfactant system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;M&#46; Scarpelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Clin&#46; Notes Resp&#46; Dis&#46;"
                        "fecha" => "1970"
                        "volumen" => "9"
                        "paginaInicial" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary surfactant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;E&#46; Morgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "New Engl&#46;J&#46; Med&#46;"
                        "fecha" => "1971"
                        "volumen" => "284"
                        "paginaInicial" => "1&#46;185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5567256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The electrophoretic globulin-pathern of serun in alpha-l-abtitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;B&#46; Laurell"
                            1 => "S&#46; Erikson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Scand&#46; J&#46; Clin&#46; Lab&#46; Invest&#46;"
                        "fecha" => "1963"
                        "volumen" => "15"
                        "paginaInicial" => "132"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchopneumopathies chroniques familiales et d&#233;ficit homozigote en &#945;l-antitrypsine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Vidal"
                            1 => "P&#46; Cazal"
                            2 => "N&#46; Robinet-Levy"
                            3 => "F&#46;B&#46; Michel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Poumon et Coeur"
                        "fecha" => "1971"
                        "volumen" => "27"
                        "paginaInicial" => "79"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "L&#8217;emphys&#233;me Bulleux diss&#233;min&#233; &#225; &#233;volution progressivement destructive"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Brun"
                            1 => "J&#46; Kofman"
                            2 => "A&#46; Guichard"
                            3 => "M&#46; Perrin-Fayole"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Poumon et Coeur"
                        "fecha" => "1967"
                        "volumen" => "23"
                        "paginaInicial" => "1&#46;049"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchite chronique et emphys&#233;me familial&#44; d&#233;ficit en &#945;l-antitrysene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Galy"
                            1 => "J&#46; Brune"
                            2 => "C&#46;L&#46; Quincy"
                            3 => "T&#46; Wiesendanger"
                            4 => "J&#46;D&#46; Berthou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Fran&#231;&#46; M&#233;d&#46; Chir&#46; Thor&#46;"
                        "fecha" => "1968"
                        "volumen" => "22"
                        "paginaInicial" => "449"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5740234"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#945;l-Antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;C&#46; Hunter"
                            1 => "J&#46;A&#46; Pierce"
                            2 => "J&#46;B&#46; Laborde"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J&#46;A&#46;M&#46;A&#46;"
                        "fecha" => "1968"
                        "volumen" => "205"
                        "paginaInicial" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hereditary &#945;l-antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;C&#46; Talamo"
                            1 => "J&#46;D&#46; Allen"
                            2 => "M&#46;G&#46; Kahan"
                            3 => "K&#46;F&#46; Austen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM196802152780701"
                      "Revista" => array:5 [
                        "tituloSerie" => "New Engl&#46; J&#46; Med&#46;"
                        "fecha" => "1968"
                        "volumen" => "278"
                        "paginaInicial" => "345"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4169707"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pattern of lung discase associated with &#945; l-antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;A&#46; Guenter"
                            1 => "M&#46;H&#46; Welch"
                            2 => "T&#46;R&#46; Russell"
                            3 => "R&#46;M&#46; Hyde"
                            4 => "J&#46;F&#46; Hammarsten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arch&#46; Inter&#46; Med&#46;"
                        "fecha" => "1968"
                        "volumen" => "122"
                        "paginaInicial" => "254"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary emphysema and &#945;l-antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;P&#46; Tarkoff"
                            1 => "F&#46; Kueppers"
                            2 => "W&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; J&#46; Med&#46;"
                        "fecha" => "1968"
                        "volumen" => "45"
                        "paginaInicial" => "220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5666650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recherche du d&#233;ficiten &#945; 1-antitrypsine dans 100 cas de broncho-pneumopathie chronique obstructive"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Ch&#46; Haas"
                            1 => "A&#46; Moutte"
                            2 => "D&#46; Rueff"
                            3 => "D&#46; Uzzan"
                            4 => "J&#46; Chebat"
                            5 => "R&#46; Israel-Asselain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev&#46; Tuber&#46; &#40;Paris&#41;"
                        "fecha" => "1969"
                        "volumen" => "33"
                        "paginaInicial" => "1&#46;063"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathologie respiratoire et d&#233;ficit h&#233;r&#233;ditaire en &#945; 1-antitrypsine Press"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;P&#46; Lemercier"
                            1 => "C&#46;I&#46; Ropartz"
                            2 => "A&#46; Langlois"
                            3 => "N&#46; Durdas"
                            4 => "J&#46; Desseauve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "M&#233;d&#46;"
                        "fecha" => "1969"
                        "volumen" => "77"
                        "paginaInicial" => "967"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prevalence of &#945; 1-antitrypsine deficiency in selected groups of patients with chronic obstructive lung disease Mayo Clin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;G&#46; Hepper"
                            1 => "L&#46;F&#46; Black"
                            2 => "G&#46;J&#46; Gleich"
                            3 => "E&#46; Kueppers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Proc&#46;"
                        "fecha" => "1969"
                        "volumen" => "44"
                        "paginaInicial" => "697"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Les syndromes emphys&#233;mateux essentiels d&#8217;origine non bronchitique&#58; facteurs familiaux et g&#233;n&#233;tiques"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Brun"
                            1 => "J&#46; Kofman"
                            2 => "N&#46; Biot"
                            3 => "M&#46; Perrin-Fayole"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Poumon et Coeur"
                        "fecha" => "1971"
                        "volumen" => "27"
                        "paginaInicial" => "53"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enzymatically produced pulmonary emphysema&#58; A preliminary report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Gross"
                            1 => "M&#46; Babyah"
                            2 => "E&#46; Tolker"
                            3 => "M&#46; Kaschak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Occup&#46; Med&#46;"
                        "fecha" => "1964"
                        "volumen" => "6"
                        "paginaInicial" => "481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14241128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanical properties of the lung in experimental pulmonary emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;S&#46; Park"
                            1 => "I&#46;P&#46; Goldring"
                            2 => "C&#46;S&#46; Shim"
                            3 => "M&#46;H&#46; Williams Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Appl&#46; Physiol&#46;"
                        "fecha" => "1969"
                        "volumen" => "26"
                        "paginaInicial" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5786403"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Papain induced experimental emphysema indogs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Marco"
                            1 => "D&#46;R&#46; Meranze"
                            2 => "I&#46;G&#46; Bentivoglio"
                            3 => "P&#46; Kimbel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Fed&#46; Proc&#46;"
                        "fecha" => "1969"
                        "volumen" => "28"
                        "paginaInicial" => "526"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental papain-induced emphysema in dogs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Pushpakom"
                            1 => "J&#46;C&#46; Hogg"
                            2 => "A&#46;J&#46; Woolcock"
                            3 => "A&#46;E&#46; Angus"
                            4 => "P&#46;T&#46; Macklem"
                            5 => "W&#46;M&#46; Thurbeck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Am&#46; Rev Dis&#46;"
                        "fecha" => "1970"
                        "volumen" => "102"
                        "paginaInicial" => "778"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mcro-determination of inorganic phosphate in biological material"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Baginski"
                            1 => "P&#46; Foa"
                            2 => "B&#46; Zak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin&#46; Chem&#46;"
                        "fecha" => "1967"
                        "volumen" => "13"
                        "paginaInicial" => "326"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6036717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elastic Properties and geometry of the lungs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Pierce"
                            1 => "J&#46;B&#46; Jocott"
                            2 => "B&#46;F&#46; Hefley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI104433"
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Clin&#46; Invest&#46;"
                        "fecha" => "1961"
                        "volumen" => "40"
                        "paginaInicial" => "1&#46;515"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14449402"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies on human pulmonary connective tissue&#46; I&#46; Amino acid composition of elastins isolated by alkaline digesti&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Fitz Patrik"
                            1 => "U&#46;D&#46; Hospelhorn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J&#46; Lab&#46; Clin&#46;"
                        "fecha" => "1962"
                        "volumen" => "60"
                        "paginaInicial" => "799"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung scleroproteins in age and emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Johnson Jr&#46;"
                            1 => "F&#46;A&#46; Andrews"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Chrst"
                        "fecha" => "1970"
                        "volumen" => "57"
                        "paginaInicial" => "239"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conectivo tissue damage in emphysema&#44; an electron microscopio study of papain-inducec emphysema in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;G&#46; Johanson Jr&#46;"
                            1 => "R&#46;C&#46; Reynolds"
                            2 => "T&#46;C&#46; Scott"
                            3 => "A&#46;K&#46; Pierce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1973.107.4.589"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1973"
                        "volumen" => "107"
                        "paginaInicial" => "589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4697668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phisical chracterization of pig lung surfactant lipoprotein"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;M&#46; Pruitt"
                            1 => "M&#46;J&#46; Cherung"
                            2 => "H&#46;L&#46; Spitzer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch&#46; Intern&#46; Med&#46;"
                        "fecha" => "1971"
                        "volumen" => "127"
                        "paginaInicial" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5544307"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The biosyntesis and turnover of surfactant lecithin and protein"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;L&#46; Spitzer"
                            1 => "J&#46;R&#46; Norman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch&#46; Intern&#46; Med&#46;"
                        "fecha" => "1971"
                        "volumen" => "127"
                        "paginaInicial" => "429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5544314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunologic characterization of a lung surfactant preparation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;A&#46; Marinckovich"
                            1 => "R&#46;G&#46; Klein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1972.105.2.229"
                      "Revista" => array:5 [
                        "tituloSerie" => "Amer&#46; Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1972"
                        "volumen" => "105"
                        "paginaInicial" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4621611"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surface phenomena in relation to pulmonary function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;A&#46; Clements"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Physiolocgist&#46;"
                        "fecha" => "1962"
                        "volumen" => "5"
                        "paginaInicial" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of cigarrette smoke on incorporation of radioisotopically labeled palmitic Ac&#46; into pulmonary surfactant and on surta ce activity of canine lung extracts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;T&#46; Giammona"
                            1 => "P&#46; Tocci"
                            2 => "W&#46;R&#46; Webb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1971.104.3.358"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1971"
                        "volumen" => "104"
                        "paginaInicial" => "358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5110043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarrette smoke and surfactant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;R&#46; Webb"
                            1 => "W&#46;A&#46; Cook"
                            2 => "J&#46;W&#46; Lanius"
                            3 => "R&#46;R&#46; Shaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1967.95.2.244"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1967"
                        "volumen" => "95"
                        "paginaInicial" => "244"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6017041"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surfactant in chronic smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;A&#46; Cook"
                            1 => "W&#46;R&#46; Webb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "An&#46; Thorac Surg"
                        "fecha" => "1966"
                        "volumen" => "2"
                        "paginaInicial" => "327"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low yeld of pulmonayr surfactant in cigarrette smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;N&#46; Finley"
                            1 => "A&#46;J&#46; Ladman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "New Engl&#46; Med&#46;"
                        "fecha" => "1972"
                        "volumen" => "286"
                        "paginaInicial" => "223"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular structure and biological activity of pulmonary surfactants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Colacicco"
                            1 => "E&#46;M&#46; Scarpelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "&#171;Horizons in surface scinece&#58; Biological applications"
                        "serieFecha" => "1973"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assayof surfactant active material from emphyscmatous lungs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;S&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med&#46; Thorac&#46;"
                        "fecha" => "1965"
                        "volumen" => "22"
                        "paginaInicial" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14309804"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surfece tension and static volume-presure hysteresis in pulmonary emphysema and other conditions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;M&#46; Kahana"
                            1 => "W&#46;M&#46; Thubeck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1972.105.2.217"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; Rev&#46; Resp&#46; Dis&#46;"
                        "fecha" => "1972"
                        "volumen" => "105"
                        "paginaInicial" => "217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5009800"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic lung biopsy&#58; A correlative determination of histopathology and pulmonary surfactant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;A&#46; Thomas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Am&#46; Rev&#46; Resp&#46; Dis"
                        "fecha" => "1967"
                        "volumen" => "96"
                        "paginaInicial" => "122"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of emphysema&#46; Capitulo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Reid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "1967"
                        "paginaInicial" => "8"
                        "editorial" => "Lloyd-Luke"
                        "editorialLocalizacion" => "Londres"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood plas&#44; a contamination of the lung alveolar surfactant obtained by various sampling tecniques"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Reifenrath"
                            1 => "I&#46; Zimmermann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev&#46; Physiol&#46;"
                        "fecha" => "1973"
                        "volumen" => "18"
                        "paginaInicial" => "238"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary surface activity in induced pulmonary edema&#46;J"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;T&#46; Said"
                            1 => "M&#46;E&#46; Avery"
                            2 => "R&#46;K&#46; Davis"
                            3 => "C&#46;M&#46; Banerjee"
                            4 => "M&#46; El-Gohary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Clin&#46; Invest&#46;"
                        "fecha" => "1965"
                        "volumen" => "44"
                        "paginaInicial" => "458"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The surfactant system of the lung Lea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;M&#46; Sacrpelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1968"
                        "editorial" => "Ferbiger"
                        "editorialLocalizacion" => "Filadelfia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03002896/0000001300000003/v1_201509151327/S0300289615326818/v1_201509151327/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "41253"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Nuevas t&#233;cnicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000001300000003/v1_201509151327/S0300289615326818/v1_201509151327/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615326818?idApp=UINPBA00003Z"
]