Carcinoma pulmonar de celula pequeña. Revision de 88 casos y resultados terapeuticos en 48
Small cell pulmonary carcinoma. A review of 88 cases with a report on results of therapy in 48
J. Sauret Valet, C. Martinez Garcia, P. Franci Piera, J. Rifa Ferrer, C. Puzo Ardanuy, R. Cornudella
Hospital de la Santa Cruz y San Pablo. Servicios de Aparato Respiratorio y Oncología. Barcelona
Read
3976
Timeswas read the article
2070
Total PDF
1906
Total HTML
Share statistics
array:23 [ "pii" => "S0300289615323723" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)32372-3" "estado" => "S300" "fechaPublicacion" => "1982-03-01" "aid" => "72442" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "1982" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1982;18:69-72" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1377 "formatos" => array:3 [ "EPUB" => 63 "HTML" => 599 "PDF" => 715 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289615323735" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)32373-5" "estado" => "S300" "fechaPublicacion" => "1982-03-01" "aid" => "72443" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1982;18:73-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1296 "formatos" => array:3 [ "EPUB" => 58 "HTML" => 702 "PDF" => 536 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Espirograma espiratorio forzado: analisis y valor diagnostico en la obstruccion leve de la via aerea" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "73" "paginaFinal" => "79" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Evaluation and diagnostic value of forced expiratory spirograms in mild airways obstruction" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Romero Candeira, E. Delgado Perez, J. Picher Nuñez, D. Ferrer Marin-Blazquez, J. Jaurena Chury, S. Garcia Rull" "autores" => array:6 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Romero Candeira" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Delgado Perez" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Picher Nuñez" ] 3 => array:2 [ "nombre" => "D." "apellidos" => "Ferrer Marin-Blazquez" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Jaurena Chury" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Garcia Rull" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615323735?idApp=UINPBA00003Z" "url" => "/03002896/0000001800000002/v1_201509151137/S0300289615323735/v1_201509151137/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289615323711" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)32371-1" "estado" => "S300" "fechaPublicacion" => "1982-03-01" "aid" => "72441" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1982;18:61-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1301 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 597 "PDF" => 662 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Rendimiento diagnostico de la biopsia pulmonar por toracotomia en la enfermedad pulmonar difusa. Resultados sobre 94 casos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "68" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The diagnostic uselfuness of pulmonary biopsy by thoracotomy in diffuse pulmonary disease. results in 94 cases" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Morera Prat, J. Ruiz Manzano, E. Fite, J. Oriol, L. Bernado, A. Aranda, F. Morell, R. Vidal, C. Plans" "autores" => array:9 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Morera Prat" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Ruiz Manzano" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Fite" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Oriol" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Bernado" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Aranda" ] 6 => array:2 [ "nombre" => "F." "apellidos" => "Morell" ] 7 => array:2 [ "nombre" => "R." "apellidos" => "Vidal" ] 8 => array:2 [ "nombre" => "C." "apellidos" => "Plans" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615323711?idApp=UINPBA00003Z" "url" => "/03002896/0000001800000002/v1_201509151137/S0300289615323711/v1_201509151137/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Carcinoma pulmonar de celula pequeña. Revision de 88 casos y resultados terapeuticos en 48" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "69" "paginaFinal" => "72" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Sauret Valet, C. Martinez Garcia, P. Franci Piera, J. Rifa Ferrer, C. Puzo Ardanuy, R. Cornudella" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Sauret Valet" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Martinez Garcia" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Franci Piera" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Rifa Ferrer" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Puzo Ardanuy" ] 5 => array:2 [ "nombre" => "R." "apellidos" => "Cornudella" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hospital de la Santa Cruz y San Pablo. Servicios de Aparato Respiratorio y Oncología. Barcelona" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Small cell pulmonary carcinoma. A review of 88 cases with a report on results of therapy in 48" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1980-09-19" "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="absec0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio de 88 casos de carcinoma broncogénico indiferenciado de célula pequeña, diagnosticados en los servicios de Aparato Respiratorio y Oncología del Hospital de la Santa Cruz y San Pablo, durante los años 1977 y 1978.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La incidencia en el sexo masculino fue muy elevada (86 varones). El 97,7 % eran fumadores y de ellos el 90,6 % de más de 20 cigarrillos al día. Radiográficamente el signo más frecuentemente observado, fue la patología hiliar (56,9 %). La broncofibroscopia tuvo una alta rentabilidad en cuanto al diagnóstico (83,7 %). Además, la broncofibroscopia es imprescindible para apreciar las remisiones del tumor tras el tratamiento. En 48 pacientes se realizó tratamiento con poliquimioterapia (ciclofosfamida 500 mg/m<span class="elsevierStyleInf">2</span> i.v. cada 3 semanas, CCNU 50 mg/m<span class="elsevierStyleInf">2</span> oral cada 6 semanas y methotrexate 10 mg/m<span class="elsevierStyleInf">2</span> i.m. 2 veces por semana) combinada con radioterapia en régimen de <span class="elsevierStyleItalic">split-dose</span>, con los siguientes resultados:</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Respuesta positiva al tratamiento en el 54,1 % de casos, en forma de remisión completa en el 19 % y en forma de remisión parcial en el 35 %, respuesta nula en el 46 %. La supervivencia al año de tratamiento en el grupo de remisión completa fue del 63 %, en los de respuesta parcial del 33 %, y en los de respuesta nula del 5 % de los casos.</p></span>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span id="absec0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A review of the 88 cases of small cell undifferentiated carcinoma of the lung which were diagnosed during 1977 and 1978 at the Respiratory and Oncology Services of the Santa Cruz and San Pablo hospital, is presented.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Incidence was highest among males (86); 97.7 % were smokers of which 90.6 % smoked more than 20 cigarettes daily. The hilar form was the most frequently seen on x-ray (56.9 %). Bronchoscopy was often diagnostic (83.7 %) and is also highly useful to check remission of the tumor after therapy. Combined chemotherapy (cyclophosphamides 500 mg/m<span class="elsevierStyleInf">2</span> i.v. every 3 weeks, C.C.N.U. 50 mg/m<span class="elsevierStyleInf">2</span> taken orally every 6 weeks and methotrexate 10 mg/m<span class="elsevierStyleInf">2</span> i.m. twice weekly) together with radiotherapy in a split-dose regime were given to 48 patients with the following results:</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Positive response was seen in 54.1 %, which in 19 % was complete remission and in 35 % partial remission. No response was induced in 46 %. The survival rate one year later was 63 % for the complete remission group; 33 % for the partial remission group and 5 % in those who had no response to therapy.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer Medicine. Lea and Febiger" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.F. Holland" 1 => "E. Frei" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Filadelfia" "fecha" => "1973" "paginaInicial" => "1473" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma de pulmón I. Correlaciones clínico-patológicas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Sauret" 1 => "C. Puzo" 2 => "D. Nauffal" 3 => "J. Tarres" 4 => "J.M. Rodríguez-Arias" 5 => "J. Castella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Med Clínica" "fecha" => "1978" "volumen" => "70" "paginaInicial" => "432" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell carcinoma of lung: Reppraisal of current management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.H. Choi" 1 => "R.W. Carey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer" "fecha" => "1976" "volumen" => "37" "paginaInicial" => "2651" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/949683" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma pulmonar II. Correlaciones radiológicopatológicas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Tarres" 1 => "J.M. Rodríguez-Arias" 2 => "D. Nauffal" 3 => "C. Puzo" 4 => "J. Sauret" 5 => "J. Castella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Med Clínica" "fecha" => "1978" "volumen" => "71" "paginaInicial" => "6" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Oat cell</span> carcinoma as a malignant apudoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.H. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "1975" "volumen" => "70" "paginaInicial" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/168443" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variable content of histaminase L-dopa decarboxylase and calcitonin in small carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.B. Baylin" 1 => "W.R. Weisburger" 2 => "J.C. Eggleston" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "N Engl J Med" "fecha" => "1978" "volumen" => "299" "paginaInicial" => "106" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cambios en las características morfológicas y bioquímicas de carcinoma de células pequeñas de pulmón Estudio clínico-patológico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.D. Abeloff" 1 => "J.C. Eggleston" 2 => "M.B. Mendelsohn" 3 => "D.S. Ettinger" 4 => "S.B. Baylin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Med (Edic. Española)" "fecha" => "1979" "volumen" => "9" "paginaInicial" => "357" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell carcinoma of the lung Prognosis in relation to histologic sub-type" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.G.W. Burdon" 1 => "R.A. Sinclair" 2 => "M.M. Henderson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "1979" "volumen" => "76" "paginaInicial" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/223817" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical therapy in lung cancer: biological, physiological and technical determinants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.F. Mountain" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semin Oncol" "fecha" => "1974" "volumen" => "1" "paginaInicial" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4377937" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small-cell lung cancer: A curable disease?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Arnold" 1 => "C.J. Williams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Dis Chest" "fecha" => "1979" "volumen" => "73" "paginaInicial" => "327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/233419" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of radiation response in lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Salazar" 1 => "P. Rubin" 2 => "J.C. Brown" 3 => "M.L. Fedstein" 4 => "M.S. Keller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer" "fecha" => "1976" "volumen" => "37" "paginaInicial" => "2636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/820420" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small-cell carcinoma of the lung: combined chemotherapy and radiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "R.B. Livingston" 1 => "I.N. Moore" 2 => "L. Heilbrun" 3 => "R. Bottomley" 4 => "D. Lehane" 5 => "E. Rivkin" 6 => "T. Thigpen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Ann Inter Med" "fecha" => "1978" "volumen" => "88" "paginaInicial" => "194" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylactic cranial irradiation in small cell carcinoma of the lung: a randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.R. White" 1 => "C.L. Spurr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JAMA" "fecha" => "1977" "volumen" => "237" "paginaInicial" => "2730" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/577226" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small-cell carcinoma of the lung: Therapeutic management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.B. Weiss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1978" "volumen" => "88" "paginaInicial" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/205153" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La quimioterapia en el tratamiento del carcinoma no resecable del pulmón. A propósito de 78 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Simó Camps" 1 => "F. Manresa" 2 => "E. Batlló" 3 => "G. Vidal-López" 4 => "J.M. Puigdollers" 5 => "G. Manresa Formosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Med Clínica" "fecha" => "1976" "volumen" => "66" "paginaInicial" => "214" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of bronchogenic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.E. Broder" 1 => "M.H. Cohen" 2 => "O.S. Selawry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Treat. Rev" "fecha" => "1977" "volumen" => "4" "paginaInicial" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/203396" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma pulmonar de células pequeñas: remisiones clínicas, radiográficas y broncoscópicas completas, y mejoría de la supervivencia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.A. Greco" 1 => "R.L. Richardson" 2 => "J.D. Snell" 3 => "S.L. Stroup" 4 => "R.K. Oldham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Med (Edic. Espa.)" "fecha" => "1976" "volumen" => "91" "paginaInicial" => "295" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000001800000002/v1_201509151137/S0300289615323723/v1_201509151137/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000001800000002/v1_201509151137/S0300289615323723/v1_201509151137/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615323723?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 27 | 52 | 79 |
| 2024 September | 47 | 38 | 85 |
| 2024 August | 36 | 47 | 83 |
| 2024 July | 25 | 48 | 73 |
| 2024 June | 43 | 36 | 79 |
| 2024 May | 41 | 36 | 77 |
| 2024 April | 25 | 25 | 50 |
| 2024 March | 30 | 31 | 61 |
| 2024 February | 37 | 34 | 71 |
| 2024 January | 0 | 1 | 1 |
| 2023 March | 5 | 5 | 10 |
| 2023 February | 22 | 35 | 57 |
| 2023 January | 54 | 31 | 85 |
| 2022 December | 46 | 38 | 84 |
| 2022 November | 41 | 39 | 80 |
| 2022 October | 43 | 42 | 85 |
| 2022 September | 39 | 31 | 70 |
| 2022 August | 30 | 48 | 78 |
| 2022 July | 27 | 55 | 82 |
| 2022 June | 28 | 45 | 73 |
| 2022 May | 45 | 34 | 79 |
| 2022 April | 32 | 46 | 78 |
| 2022 March | 31 | 33 | 64 |
| 2022 February | 43 | 21 | 64 |
| 2022 January | 25 | 19 | 44 |
| 2021 December | 23 | 26 | 49 |
| 2021 November | 21 | 36 | 57 |
| 2021 October | 20 | 37 | 57 |
| 2021 September | 14 | 35 | 49 |
| 2021 August | 14 | 28 | 42 |
| 2021 July | 17 | 27 | 44 |
| 2021 June | 24 | 28 | 52 |
| 2021 May | 22 | 25 | 47 |
| 2021 April | 26 | 37 | 63 |
| 2021 March | 56 | 22 | 78 |
| 2021 February | 32 | 7 | 39 |
| 2021 January | 35 | 17 | 52 |
| 2020 December | 17 | 13 | 30 |
| 2020 November | 10 | 17 | 27 |
| 2020 October | 23 | 13 | 36 |
| 2020 September | 8 | 3 | 11 |
| 2020 August | 20 | 11 | 31 |
| 2020 July | 21 | 18 | 39 |
| 2020 June | 17 | 14 | 31 |
| 2020 May | 24 | 21 | 45 |
| 2020 April | 17 | 12 | 29 |
| 2020 March | 15 | 26 | 41 |
| 2020 February | 24 | 22 | 46 |
| 2020 January | 33 | 21 | 54 |
| 2019 December | 20 | 29 | 49 |
| 2019 November | 20 | 8 | 28 |
| 2019 October | 16 | 17 | 33 |
| 2019 September | 23 | 35 | 58 |
| 2019 August | 8 | 15 | 23 |
| 2019 July | 9 | 31 | 40 |
| 2019 June | 15 | 39 | 54 |
| 2019 May | 24 | 41 | 65 |
| 2019 April | 42 | 65 | 107 |
| 2019 March | 13 | 28 | 41 |
| 2019 February | 4 | 19 | 23 |
| 2019 January | 8 | 16 | 24 |
| 2018 December | 7 | 23 | 30 |
| 2018 November | 8 | 27 | 35 |
| 2018 October | 28 | 24 | 52 |
| 2018 September | 9 | 11 | 20 |
| 2018 May | 5 | 2 | 7 |
| 2018 April | 3 | 4 | 7 |
| 2018 March | 3 | 10 | 13 |
| 2018 February | 6 | 14 | 20 |
| 2018 January | 8 | 6 | 14 |
| 2017 December | 8 | 11 | 19 |
| 2017 November | 6 | 8 | 14 |
| 2017 October | 6 | 8 | 14 |
| 2017 September | 5 | 5 | 10 |
| 2017 August | 13 | 9 | 22 |
| 2017 July | 2 | 3 | 5 |
| 2017 June | 6 | 12 | 18 |
| 2017 May | 11 | 8 | 19 |
| 2017 April | 5 | 1 | 6 |
| 2017 March | 6 | 40 | 46 |
| 2017 February | 5 | 5 | 10 |
| 2017 January | 4 | 5 | 9 |
| 2016 December | 5 | 9 | 14 |
| 2016 November | 9 | 12 | 21 |
| 2016 October | 8 | 16 | 24 |
| 2016 September | 17 | 17 | 34 |
| 2016 August | 10 | 5 | 15 |
| 2016 July | 17 | 5 | 22 |
| 2016 June | 22 | 12 | 34 |
| 2016 May | 17 | 5 | 22 |
| 2016 April | 4 | 0 | 4 |
| 2016 March | 8 | 0 | 8 |
| 2016 February | 10 | 1 | 11 |
| 2016 January | 14 | 4 | 18 |
| 2015 December | 16 | 10 | 26 |
| 2015 November | 30 | 7 | 37 |
| 2015 October | 4 | 1 | 5 |
| 2015 September | 2 | 0 | 2 |
Show all
