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    "titulo" => "Alfa 1 antitripsina y alfa 2 macroglobulina en esputo infectado y no infectado de pacientes con enfermedad pulmonar obstructiva cronica. Significacion fisiopatologica de ambas proteinas en el pulmon"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alfa 1 antitripsina &#40;&#945;<span class="elsevierStyleInf">1</span> AT&#41; y alfa 2 macroglobulina &#40;&#945;<span class="elsevierStyleInf">2</span> MG&#41; son inhibidores enzim&#225;ticos con importantes funciones en la protecci&#243;n del tejido conectivo pulmonar&#46;En el presente trabajo se determinaron ambas prote&#237;nas a nivel s&#233;rico y en fase sol de esputo en dos grupos de pacientes portadores de enfermedad pulmonar obstructiva cr&#243;nica con y sin infecci&#243;n respiratoria del tracto inferior&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Durante los per&#237;odos de infecci&#243;n pulmonar&#44; los niveles s&#233;ricos de &#945;<span class="elsevierStyleInf">1</span> AT aumentaron significativamente probablemente por incremento del metabolismo proteico&#44; mientras que la concentraci&#243;n de &#945;<span class="elsevierStyleInf">2</span> MG durante este mismo per&#237;odo decreci&#243; de forma significativa&#44; sugiriendo bien un aumento del catabolismo proteico&#44; una reducci&#243;n de la capacidad de s&#237;ntesis o la formaci&#243;n de complejos estables &#945;<span class="elsevierStyleInf">2</span> MG-endopeptidasas bacterianas&#46; Por otra parte&#44; las tasas de &#945;<span class="elsevierStyleInf">1</span> AT y &#945;<span class="elsevierStyleInf">2</span> MG en esputo y su relaci&#243;n &#40;esputo&#47;suero&#41; aumentaron significativamente en el transcurso de las infecciones pulmonares&#44; evidenciando un importante aumento de la difusi&#243;n pasiva proteica desde el plasma a la secreci&#243;n bronquial&#46; Cuando la relaci&#243;n esputo&#47;suero de ambas macromol&#233;culas fue corregida para la alb&#250;mina&#44; no existieron diferencias significativas al comparar las distribuciones de ambaspoblaciones analizadas&#44; sugiriendo un mecanismo de g&#233;nesis com&#250;n en los grupos con y sin infecci&#243;n pulmonar&#46; La buena correlaci&#243;n existente entre &#945;<span class="elsevierStyleInf">1</span>&#44; AT y alb&#250;mina en presencia de infecci&#243;n respiratoria del tracto inferior confirma que la trasudaci&#243;n proteica es un mecanismo fisiopatol&#243;gico preferencial&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las bajas concentraciones detectadas de &#945;<span class="elsevierStyleInf">1</span> AT y &#945;<span class="elsevierStyleInf">2</span> MG en la secreci&#243;n bronquial en el grupo de sujetos sin infecci&#243;n pulmonar&#44; son indicativas de su limitada contribuci&#243;n antiproteasa en este medio biol&#243;gico&#46; Durante la infecci&#243;n pulmonar la prote&#237;na &#945;<span class="elsevierStyleInf">2</span> MG aument&#243; significativamente en esputo por efecto de la difusi&#243;n pasiva desde el plasma y quiz&#225; por estimulaci&#243;n inespec&#237;fica de la producci&#243;n local&#44; pudiendo en esta circunstancia desarrollar una importante funci&#243;n inhibidora de la actividad enzim&#225;tica libre&#46; Sin embargo&#44; a pesar de la contribuci&#243;n de &#945;<span class="elsevierStyleInf">2</span> MG a la correcci&#243;n del disbalance entre proteasas neutras e inhibidores&#44; los sujetos portadores de EPOC con infecci&#243;n pulmonar intercurrente mantienen un estado de desequilibrio enzim&#225;tico con elevado riesgo para la integridad del tejido conectivo pulmonar&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Both proteins were determined in this study in the serum and in a colloidal solution of sputum in two groups of patients with chronic obstructive lung disease &#40;COLD&#41; with infection and without lower respiratory infection&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The serum levels of &#945;<span class="elsevierStyleInf">1</span> AT augmented significantly during pulmonary infection probably due to protein metabolism&#44; while &#945;<span class="elsevierStyleInf">2</span> MG concentration decreased significantly during the same period suggesting either an increase in the protein catabolism&#44; a reduction of the synthetic capacity&#44; or the formation of stable complexes of &#945;<span class="elsevierStyleInf">2</span> MG-bacterial endopeptidases&#46; On the other hand&#44; the levels of &#945;<span class="elsevierStyleInf">1</span> AT and &#945;<span class="elsevierStyleInf">2</span> MG in sputum and their ratio &#40;sputum&#47;serum&#41; augmented markedly during pulmonary infection&#44; demonstrating a significant increase in the protein passive diffusion from the plasma to the bronchial secretions&#46; There were no significant differences in the</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">ratio sputum&#47;serum of both macromolecules when comparing the 2 groups analyze after correcting for the albumin&#46; This suggests a common original mechanism in the groups with and without pulmonary infection&#46; The strong correlation between &#945;<span class="elsevierStyleInf">1</span> AT and albumin with lower respiratory infection confirms that protein transudate is a preferential physiopathological mechanism&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The low concentrations of &#945;<span class="elsevierStyleInf">1</span> AT and &#945;<span class="elsevierStyleInf">2</span> detected in bronchial secretions of patients without pulmonary infection indicate their limited contribution to antiprotease activity in this biological medium&#46; &#945;<span class="elsevierStyleInf">2</span> MG protein increased in the sputum significantly during pulmonary infection due to the passive diffusion from the plasma and perhaps too to the nonspecific stimulation of local production&#46; An important inhibitory function of the free enzyme activity could be developed in this case&#46; Nevertheless&#44; patients with COLD and recurrent pulmonary infections mantain a State of enzymatic disequilibrium in spite of the contribution of &#945;<span class="elsevierStyleInf">2</span> MG in the correction of the disequilibrium between neutral proteases and inhibitors&#46; This constitutes an important risk for the integrity of the pulmonary connective tissue&#46;</p></span>"
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                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The interactions of 2-macroglobulin with proteinases&#46; Characteristics and specifity of the reaction and a hypotesis concerning its molecular mechanism"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem J"
                        "fecha" => "1973"
                        "volumen" => "133"
                        "paginaInicial" => "709"
                        "paginaFinal" => "724"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4201304"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of human leukocyte elastase by human 2-macroglobulin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;Y&#46; Twumasi"
                            1 => "I&#46;E&#46; Liener"
                            2 => "M&#46; Galdston"
                            3 => "V&#46; Levytska"
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                    0 => array:1 [
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                        "tituloSerie" => "Nature"
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                        "paginaInicial" => "61"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/67568"
                            "web" => "Medline"
                          ]
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                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Granulocyte collagenase and elastase and their interactions with alpha 1 antitrypsin and alpha 2 macroglobulin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Ohlsson"
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                      "LibroEditado" => array:4 [
                        "titulo" => "En&#58; Proteases biological control"
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                        "paginaFinal" => "602"
                        "serieFecha" => "1975"
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                  ]
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            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies in alpha 1 antitrypsin deficiency"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Eriksson"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Med Scand"
                        "fecha" => "1965"
                        "volumen" => "177"
                        "numero" => "suppl"
                        "paginaInicial" => "1"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14251847"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            11 => array:3 [
              "identificador" => "bib0060"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of pulmonary emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Editorial"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(13)70145-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1980"
                        "volumen" => "1"
                        "paginaInicial" => "743"
                        "paginaFinal" => "745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24429277"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            12 => array:3 [
              "identificador" => "bib0065"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the protease-anti-protease theory of human destructive lung disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;E&#46; Gadek"
                            1 => "G&#46;W&#46; Hunninghake"
                            2 => "G&#46;A&#46; Fells"
                            3 => "R&#46;L&#46; Zimmerman"
                            4 => "B&#46;A&#46; Keogh"
                            5 => "R&#46;G&#46; Crystal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1980"
                        "volumen" => "16"
                        "numero" => "suppl"
                        "paginaInicial" => "27"
                        "paginaFinal" => "40"
                      ]
                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary emphysema and alpha 1 antitrypsin deficiency"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Eriksson"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Scand"
                        "fecha" => "1964"
                        "volumen" => "177"
                        "paginaInicial" => "175"
                        "paginaFinal" => "179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14279499"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inherited differences in alpha 1 antitrypsin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Kueppers"
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                      "LibroEditado" => array:4 [
                        "titulo" => "En&#58; Genetic determinants of pulmonary disease"
                        "paginaInicial" => "23"
                        "paginaFinal" => "74"
                        "serieFecha" => "1978"
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                    ]
                  ]
                ]
              ]
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            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental emphysema induced with purified human neutrophil elastase&#46; Tissue localization of the instilled protease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "A&#46; Janoff"
                            1 => "B&#46; Sloan"
                            2 => "G&#46; Weinbaum"
                            3 => "V&#46; Damiano"
                            4 => "R&#46;A&#46; Sandhaus"
                            5 => "J&#46; Elias"
                            6 => "P&#46; Kimbel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1977.115.3.461"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1977"
                        "volumen" => "115"
                        "paginaInicial" => "461"
                        "paginaFinal" => "478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/842956"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The induction of pulmonary emphysema with human leukocyte elastase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;M&#46; Senior"
                            1 => "H&#46; Tegner"
                            2 => "C&#46; Kuhn"
                            3 => "K&#46; Ohlsson"
                            4 => "B&#46;C&#46; Starcher"
                            5 => "J&#46;A&#46; Pierce"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1164/arrd.1977.116.3.469"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1977"
                        "volumen" => "116"
                        "paginaInicial" => "469"
                        "paginaFinal" => "475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/900634"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elastase&#44; collagenase&#44; emphysema and alpha 1 antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Lieberman"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1976"
                        "volumen" => "70"
                        "paginaInicial" => "62"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/179761"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            18 => array:3 [
              "identificador" => "bib0095"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in pulmonary connective tissue after a single intatracheal instillation of papain in the rat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Kobrle"
                            1 => "J&#46; Hurych"
                            2 => "R&#46; Holuva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1982.125.2.239"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1982"
                        "volumen" => "125"
                        "paginaInicial" => "239"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7065529"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The induction of emphysema with elastase&#46; II Changes in conective tissue"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Kuhn"
                            1 => "S&#46;-Y&#46; Yu"
                            2 => "M&#46; Chraplyvy"
                            3 => "H&#46;E&#46; Linder"
                            4 => "R&#46;M&#46; Senior"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lab Invest"
                        "fecha" => "1976"
                        "volumen" => "34"
                        "paginaInicial" => "372"
                        "paginaFinal" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/177809"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "State of the art&#46; Animal models of emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;B&#46; Karlinsky"
                            1 => "G&#46;L&#46; Sinder"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1978.117.6.1109"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1978"
                        "volumen" => "117"
                        "paginaInicial" => "1109"
                        "paginaFinal" => "1133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/352207"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental emphysema&#58; its production with papain in normal and silicotic rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "E&#46;Z&#46; Pfitzer"
                            2 => "E&#46; Tolker"
                            3 => "N&#46;A&#46; Babyak"
                            4 => "M&#46; Kaschak"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Environ Hlth"
                        "fecha" => "1965"
                        "volumen" => "11"
                        "paginaInicial" => "50"
                        "paginaFinal" => "58"
                      ]
                    ]
                  ]
                ]
              ]
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            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The induction of emphysema with elastase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;D&#46; Kaplan"
                            1 => "C&#46; Kuhn"
                            2 => "J&#46;A&#46; Pierce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lab Clin Med"
                        "fecha" => "1973"
                        "volumen" => "82"
                        "paginaInicial" => "349"
                        "paginaFinal" => "365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4728287"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0120"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Introduction of experimental emphysema in dogs using leukocyte homogenates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "B&#46; Mass"
                            2 => "D&#46;R&#46; Meranze"
                            3 => "G&#46; Weinbaum"
                            4 => "P&#46; Kimbel"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1971.104.4.595"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1971"
                        "volumen" => "104"
                        "paginaInicial" => "595"
                        "paginaFinal" => "598"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5094060"
                            "web" => "Medline"
                          ]
                        ]
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                    ]
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                ]
              ]
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            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagenase in the lower respiratory tract of patients with idiophatic pulmonary fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
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                            1 => "J&#46;A&#46; Kelman"
                            2 => "S&#46;E&#46; Weinberger"
                            3 => "A&#46;L&#46; Horwitz"
                            4 => "H&#46;Y&#46; Reynolds"
                            5 => "J&#46;D&#46; Fulmer"
                            6 => "R&#46;G&#46; Crystal"
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                      ]
                    ]
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                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "New Engl J Med"
                        "fecha" => "1979"
                        "volumen" => "301"
                        "paginaInicial" => "737"
                        "paginaFinal" => "742"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/225666"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            25 => array:3 [
              "identificador" => "bib0130"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Granulocite collagenase&#58; selective digestion of type 1 over type 111 collagen"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
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                            1 => "A&#46;J&#46; Hance"
                            2 => "R&#46;G&#46; Crystal"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc Nat Acad Sci Wash"
                        "fecha" => "1977"
                        "volumen" => "74"
                        "paginaInicial" => "897"
                        "paginaFinal" => "901"
                      ]
                    ]
                  ]
                ]
              ]
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            26 => array:3 [
              "identificador" => "bib0135"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Degradaron if a cartilage proteoglican by human leukocyte granule neutral proteases a model of joint injury"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
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                            1 => "G&#46; Feinstein"
                            2 => "C&#46;J&#46; Malemud"
                            3 => "J&#46;M&#46; Elias"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI108317"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1976"
                        "volumen" => "57"
                        "paginaInicial" => "615"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/129482"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung elastin content in normal and emphysematous lungs"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;M&#46; Turino"
                            1 => "S&#46; Keller"
                            2 => "P&#46; Chrzanowski"
                            3 => "M&#46; Osman"
                            4 => "J&#46; Cerreta"
                            5 => "I&#46; Mandl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1980"
                        "volumen" => "16"
                        "numero" => "suppl"
                        "paginaInicial" => "43"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
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            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The conective tissue of the lung"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46; Hance"
                            1 => "R&#46;G&#46; Crystal"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1975.112.5.657"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1975"
                        "volumen" => "112"
                        "paginaInicial" => "657"
                        "paginaFinal" => "711"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1103668"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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            29 => array:3 [
              "identificador" => "bib0150"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aetiology of emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;S&#46; Dunnill"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1979"
                        "volumen" => "15"
                        "paginaInicial" => "1015"
                        "paginaFinal" => "1029"
                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0155"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary emphysema and 1-antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;C&#46;S&#46; Hutchinson"
                            1 => "P&#46;J&#46;L&#46; Cook"
                            2 => "C&#46;E&#46; Barter"
                            3 => "H&#46; Harris"
                            4 => "P&#46; Hugh-Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brit Med J"
                        "fecha" => "1971"
                        "volumen" => "1"
                        "paginaInicial" => "689"
                        "paginaFinal" => "694"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/435740"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A comparative study of the severity of emphysema in necropsy populations in three different countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;M&#46; Thurlbeck"
                            1 => "R&#46;C&#46; Ryder"
                            2 => "N&#46; Sternby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1974.109.2.239"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1974"
                        "volumen" => "109"
                        "paginaInicial" => "239"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4811778"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible mechanisms of emphysema in smokers&#46; Cigarrette smoke condensate suppresses protease inhibition in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Janoff"
                            1 => "H&#46; Carp"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1977.116.1.65"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1977"
                        "volumen" => "116"
                        "paginaInicial" => "65"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/301725"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible mechanisms of emphysema smokers&#46; In vitro suppression of serum elastase inhibitory capacity by antioxidants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Carp"
                            1 => "A&#46; Janoff"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1978.118.3.617"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1978"
                        "volumen" => "118"
                        "paginaInicial" => "617"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/101105"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synthesis and secretion of alpha 2 macroglobulin by cultured adherent lung cells"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;F&#46; Mosher"
                            1 => "O&#46; Saksela"
                            2 => "A&#46; Valeri"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI108854"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1978"
                        "volumen" => "60"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1045"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/71307"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
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            35 => array:3 [
              "identificador" => "bib0180"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Secretion of alpha 2 macroglobulin by human alveolar macrophages"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;R&#46; White"
                            1 => "A&#46; Janoff"
                            2 => "H&#46;P&#46; Godfrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1980"
                        "volumen" => "121"
                        "numero" => "suppl"
                        "paginaInicial" => "418 &#40;A&#41;"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syntesis and secretion of alpha 2 macroglobulin by cultured human fibroblast"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;F&#46; Mosher"
                            1 => "D&#46;A&#46; Wing"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1976"
                        "volumen" => "143"
                        "paginaInicial" => "462"
                        "paginaFinal" => "467"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/55456"
                            "web" => "Medline"
                          ]
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            37 => array:3 [
              "identificador" => "bib0190"
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                    0 => array:2 [
                      "titulo" => "Proteinase &#40;elastase&#41; inhibitor from the ciliated membranes of the human respiratory tract"
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                          "etal" => false
                          "autores" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Methods Enzymol"
                        "fecha" => "1976"
                        "volumen" => "45"
                        "paginaInicial" => "869"
                        "paginaFinal" => "872"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1012039"
                            "web" => "Medline"
                          ]
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                ]
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            38 => array:3 [
              "identificador" => "bib0195"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Biochemical analyses of bronchoalveolar lavage fluids of healthy human volunteer smokers and non smokers"
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                          "etal" => false
                          "autores" => array:3 [
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                            2 => "M&#46;S&#46; Giancola"
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                    0 => array:2 [
                      "doi" => "10.1164/arrd.1978.118.5.863"
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                        "tituloSerie" => "Am Rev Respir Dis"
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                        "paginaInicial" => "863"
                        "paginaFinal" => "875"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/736357"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies on the structure of elastin and the mechanims of action of elastolytic enzymes"
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                          "autores" => array:2 [
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                        "serieFecha" => "1970"
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                ]
              ]
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            40 => array:3 [
              "identificador" => "bib0205"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Inhibition of elastase from granulocytes by the low molecular weight bronchial protease inhibitor"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Ohlsson"
                            1 => "H&#46; Tegner"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Clin Lab Invest"
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                        "volumen" => "36"
                        "paginaInicial" => "437"
                        "paginaFinal" => "445"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/185683"
                            "web" => "Medline"
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            41 => array:3 [
              "identificador" => "bib0210"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Interactions between granulocyte elastase and collagenase and the plasma proteinase inhibitors in vitro and in vivo"
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                          "etal" => false
                          "autores" => array:2 [
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            42 => array:3 [
              "identificador" => "bib0215"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteases and antiproteases in bronchoalveolar lavage"
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                          "etal" => false
                          "autores" => array:5 [
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                            4 => "B&#46; Sablonni&#233;re"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1980"
                        "volumen" => "16"
                        "numero" => "suppl"
                        "paginaInicial" => "247"
                        "paginaFinal" => "258"
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                ]
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            43 => array:3 [
              "identificador" => "bib0220"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Definition and classification of chronic bronchitis"
                      "autores" => array:1 [
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                          "colaboracion" => "Medical Research Council"
                          "etal" => false
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1965"
                        "volumen" => "1"
                        "paginaInicial" => "775"
                        "paginaFinal" => "799"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2895308"
                            "web" => "Medline"
                          ]
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            44 => array:3 [
              "identificador" => "bib0225"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunochemical quantitation of antigens by single radial immunodiffusion"
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                          "etal" => false
                          "autores" => array:3 [
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                            1 => "A&#46;D&#46; Carbonara"
                            2 => "J&#46;F&#46; Heremans"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "volumen" => "2"
                        "paginaInicial" => "235"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4956917"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            45 => array:3 [
              "identificador" => "bib0230"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alpha 1 antitrypsin and alpha 2 macroglobulin&#44; interactions with human neutrophil collagenase and elastase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann NY Acad Sci"
                        "fecha" => "1975"
                        "volumen" => "256"
                        "paginaInicial" => "409"
                        "paginaFinal" => "419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/51604"
                            "web" => "Medline"
                          ]
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            46 => array:3 [
              "identificador" => "bib0235"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A study of plasma proteins in the sol phase of sputum from patients with chronic bronchitis"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Stokley"
                            1 => "M&#46; Mistry"
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                            3 => "D&#46; Burnett"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1979"
                        "volumen" => "34"
                        "paginaInicial" => "777"
                        "paginaFinal" => "782"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/542918"
                            "web" => "Medline"
                          ]
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              ]
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            47 => array:3 [
              "identificador" => "bib0240"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interrelationships between the human alveolar macrophage and alpha 1 antitrypsin"
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                          "etal" => false
                          "autores" => array:1 [
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI107475"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
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Alfa 1 antitripsina y alfa 2 macroglobulina en esputo infectado y no infectado de pacientes con enfermedad pulmonar obstructiva cronica. Significacion fisiopatologica de ambas proteinas en el pulmon
Alpha 1-antitrypsin and alpha 2-macroglobulin in infected and non-infected sputum from patients with chronic obstructive pulmonary disease. Physiopathological significance of the two proteins in the lung
L. Oteo Ochoa, M. Maties Prats, J.L. De La Cruz Rios, A. Izquierdo Del Amo, J.L. Cruz Ramos, C. Martin Serrano, J. Picher Nuñez, A. Sueiro Bendito
Servicio de Neumología. C.E. Ramón y Cajal de la S.S. Madrid
M. Diaz Enriquez*
* Servicio de Bioquímica. C.E. Ramón y Cajal de la S.S. Madrid
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alfa 1 antitripsina &#40;&#945;<span class="elsevierStyleInf">1</span> AT&#41; y alfa 2 macroglobulina &#40;&#945;<span class="elsevierStyleInf">2</span> MG&#41; son inhibidores enzim&#225;ticos con importantes funciones en la protecci&#243;n del tejido conectivo pulmonar&#46;En el presente trabajo se determinaron ambas prote&#237;nas a nivel s&#233;rico y en fase sol de esputo en dos grupos de pacientes portadores de enfermedad pulmonar obstructiva cr&#243;nica con y sin infecci&#243;n respiratoria del tracto inferior&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Durante los per&#237;odos de infecci&#243;n pulmonar&#44; los niveles s&#233;ricos de &#945;<span class="elsevierStyleInf">1</span> AT aumentaron significativamente probablemente por incremento del metabolismo proteico&#44; mientras que la concentraci&#243;n de &#945;<span class="elsevierStyleInf">2</span> MG durante este mismo per&#237;odo decreci&#243; de forma significativa&#44; sugiriendo bien un aumento del catabolismo proteico&#44; una reducci&#243;n de la capacidad de s&#237;ntesis o la formaci&#243;n de complejos estables &#945;<span class="elsevierStyleInf">2</span> MG-endopeptidasas bacterianas&#46; Por otra parte&#44; las tasas de &#945;<span class="elsevierStyleInf">1</span> AT y &#945;<span class="elsevierStyleInf">2</span> MG en esputo y su relaci&#243;n &#40;esputo&#47;suero&#41; aumentaron significativamente en el transcurso de las infecciones pulmonares&#44; evidenciando un importante aumento de la difusi&#243;n pasiva proteica desde el plasma a la secreci&#243;n bronquial&#46; Cuando la relaci&#243;n esputo&#47;suero de ambas macromol&#233;culas fue corregida para la alb&#250;mina&#44; no existieron diferencias significativas al comparar las distribuciones de ambaspoblaciones analizadas&#44; sugiriendo un mecanismo de g&#233;nesis com&#250;n en los grupos con y sin infecci&#243;n pulmonar&#46; La buena correlaci&#243;n existente entre &#945;<span class="elsevierStyleInf">1</span>&#44; AT y alb&#250;mina en presencia de infecci&#243;n respiratoria del tracto inferior confirma que la trasudaci&#243;n proteica es un mecanismo fisiopatol&#243;gico preferencial&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las bajas concentraciones detectadas de &#945;<span class="elsevierStyleInf">1</span> AT y &#945;<span class="elsevierStyleInf">2</span> MG en la secreci&#243;n bronquial en el grupo de sujetos sin infecci&#243;n pulmonar&#44; son indicativas de su limitada contribuci&#243;n antiproteasa en este medio biol&#243;gico&#46; Durante la infecci&#243;n pulmonar la prote&#237;na &#945;<span class="elsevierStyleInf">2</span> MG aument&#243; significativamente en esputo por efecto de la difusi&#243;n pasiva desde el plasma y quiz&#225; por estimulaci&#243;n inespec&#237;fica de la producci&#243;n local&#44; pudiendo en esta circunstancia desarrollar una importante funci&#243;n inhibidora de la actividad enzim&#225;tica libre&#46; Sin embargo&#44; a pesar de la contribuci&#243;n de &#945;<span class="elsevierStyleInf">2</span> MG a la correcci&#243;n del disbalance entre proteasas neutras e inhibidores&#44; los sujetos portadores de EPOC con infecci&#243;n pulmonar intercurrente mantienen un estado de desequilibrio enzim&#225;tico con elevado riesgo para la integridad del tejido conectivo pulmonar&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Both proteins were determined in this study in the serum and in a colloidal solution of sputum in two groups of patients with chronic obstructive lung disease &#40;COLD&#41; with infection and without lower respiratory infection&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The serum levels of &#945;<span class="elsevierStyleInf">1</span> AT augmented significantly during pulmonary infection probably due to protein metabolism&#44; while &#945;<span class="elsevierStyleInf">2</span> MG concentration decreased significantly during the same period suggesting either an increase in the protein catabolism&#44; a reduction of the synthetic capacity&#44; or the formation of stable complexes of &#945;<span class="elsevierStyleInf">2</span> MG-bacterial endopeptidases&#46; On the other hand&#44; the levels of &#945;<span class="elsevierStyleInf">1</span> AT and &#945;<span class="elsevierStyleInf">2</span> MG in sputum and their ratio &#40;sputum&#47;serum&#41; augmented markedly during pulmonary infection&#44; demonstrating a significant increase in the protein passive diffusion from the plasma to the bronchial secretions&#46; There were no significant differences in the</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">ratio sputum&#47;serum of both macromolecules when comparing the 2 groups analyze after correcting for the albumin&#46; This suggests a common original mechanism in the groups with and without pulmonary infection&#46; The strong correlation between &#945;<span class="elsevierStyleInf">1</span> AT and albumin with lower respiratory infection confirms that protein transudate is a preferential physiopathological mechanism&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The low concentrations of &#945;<span class="elsevierStyleInf">1</span> AT and &#945;<span class="elsevierStyleInf">2</span> detected in bronchial secretions of patients without pulmonary infection indicate their limited contribution to antiprotease activity in this biological medium&#46; &#945;<span class="elsevierStyleInf">2</span> MG protein increased in the sputum significantly during pulmonary infection due to the passive diffusion from the plasma and perhaps too to the nonspecific stimulation of local production&#46; An important inhibitory function of the free enzyme activity could be developed in this case&#46; Nevertheless&#44; patients with COLD and recurrent pulmonary infections mantain a State of enzymatic disequilibrium in spite of the contribution of &#945;<span class="elsevierStyleInf">2</span> MG in the correction of the disequilibrium between neutral proteases and inhibitors&#46; This constitutes an important risk for the integrity of the pulmonary connective tissue&#46;</p></span>"
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                            0 => "O&#46; Auerbach"
                            1 => "E&#46;C&#46; Hammond"
                            2 => "L&#46; Garfinkel"
                            3 => "C&#46; Benante"
                          ]
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                    0 => array:2 [
                      "doi" => "10.1056/NEJM197204202861601"
                      "Revista" => array:6 [
                        "tituloSerie" => "New Engl J Med"
                        "fecha" => "1972"
                        "volumen" => "286"
                        "paginaInicial" => "853"
                        "paginaFinal" => "857"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5061068"
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                      "titulo" => "Granulocyte collagenase&#44; elastase and plasma protease inhibitors in purulent sputum"
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                          "etal" => false
                          "autores" => array:2 [
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Europ J Clin Invest"
                        "fecha" => "1975"
                        "volumen" => "5"
                        "paginaInicial" => "221"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/50236"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polymorphonuclear leukocyte collagenasa"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Ohlsson"
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                        "titulo" => "En&#58; Collagenase in normal pathological connective tissues"
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                        "paginaFinal" => "222"
                        "serieFecha" => "1980"
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                    ]
                  ]
                ]
              ]
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            5 => array:3 [
              "identificador" => "bib0030"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human leukocyte granule elastase&#58; rapid isolation and characterization"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;M&#46;J&#46; Baugh"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochemistry"
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                        "volumen" => "15"
                        "paginaInicial" => "836"
                        "paginaFinal" => "841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1082346"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Elastase release from human alveolar macrophages&#59; comparison between smokers and non-smokers"
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                          "etal" => false
                          "autores" => array:4 [
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                            2 => "R&#46;M&#46; Senior"
                            3 => "E&#46;A&#46; Levine"
                          ]
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                    0 => array:1 [
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                        "tituloSerie" => "Science"
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                        "paginaInicial" => "313"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/910131"
                            "web" => "Medline"
                          ]
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                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The interactions of 2-macroglobulin with proteinases&#46; Characteristics and specifity of the reaction and a hypotesis concerning its molecular mechanism"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                            1 => "P&#46;M&#46; Starkey"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem J"
                        "fecha" => "1973"
                        "volumen" => "133"
                        "paginaInicial" => "709"
                        "paginaFinal" => "724"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4201304"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            8 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of human leukocyte elastase by human 2-macroglobulin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;Y&#46; Twumasi"
                            1 => "I&#46;E&#46; Liener"
                            2 => "M&#46; Galdston"
                            3 => "V&#46; Levytska"
                          ]
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                    ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
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                        "paginaInicial" => "61"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/67568"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0050"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Granulocyte collagenase and elastase and their interactions with alpha 1 antitrypsin and alpha 2 macroglobulin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                      "LibroEditado" => array:4 [
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                        "paginaFinal" => "602"
                        "serieFecha" => "1975"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies in alpha 1 antitrypsin deficiency"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Eriksson"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Med Scand"
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                        "numero" => "suppl"
                        "paginaInicial" => "1"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14251847"
                            "web" => "Medline"
                          ]
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                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of pulmonary emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Editorial"
                          "etal" => false
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(13)70145-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1980"
                        "volumen" => "1"
                        "paginaInicial" => "743"
                        "paginaFinal" => "745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24429277"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            12 => array:3 [
              "identificador" => "bib0065"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the protease-anti-protease theory of human destructive lung disease"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;E&#46; Gadek"
                            1 => "G&#46;W&#46; Hunninghake"
                            2 => "G&#46;A&#46; Fells"
                            3 => "R&#46;L&#46; Zimmerman"
                            4 => "B&#46;A&#46; Keogh"
                            5 => "R&#46;G&#46; Crystal"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1980"
                        "volumen" => "16"
                        "numero" => "suppl"
                        "paginaInicial" => "27"
                        "paginaFinal" => "40"
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                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0070"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary emphysema and alpha 1 antitrypsin deficiency"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Eriksson"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Scand"
                        "fecha" => "1964"
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                        "paginaInicial" => "175"
                        "paginaFinal" => "179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14279499"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            14 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inherited differences in alpha 1 antitrypsin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Kueppers"
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                        "paginaFinal" => "74"
                        "serieFecha" => "1978"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Experimental emphysema induced with purified human neutrophil elastase&#46; Tissue localization of the instilled protease"
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                          "etal" => false
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                            4 => "R&#46;A&#46; Sandhaus"
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                    0 => array:2 [
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                        "tituloSerie" => "Am Rev Respir Dis"
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                        "paginaInicial" => "461"
                        "paginaFinal" => "478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/842956"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The induction of pulmonary emphysema with human leukocyte elastase"
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                            4 => "B&#46;C&#46; Starcher"
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                    0 => array:2 [
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                        "tituloSerie" => "Am Rev Respir Dis"
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                        "paginaInicial" => "469"
                        "paginaFinal" => "475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/900634"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Elastase&#44; collagenase&#44; emphysema and alpha 1 antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/179761"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Changes in pulmonary connective tissue after a single intatracheal instillation of papain in the rat"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "R&#46; Holuva"
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
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                        "volumen" => "125"
                        "paginaInicial" => "239"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7065529"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0100"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The induction of emphysema with elastase&#46; II Changes in conective tissue"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "S&#46;-Y&#46; Yu"
                            2 => "M&#46; Chraplyvy"
                            3 => "H&#46;E&#46; Linder"
                            4 => "R&#46;M&#46; Senior"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lab Invest"
                        "fecha" => "1976"
                        "volumen" => "34"
                        "paginaInicial" => "372"
                        "paginaFinal" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/177809"
                            "web" => "Medline"
                          ]
                        ]
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                    ]
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                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "State of the art&#46; Animal models of emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;B&#46; Karlinsky"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1978"
                        "volumen" => "117"
                        "paginaInicial" => "1109"
                        "paginaFinal" => "1133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/352207"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental emphysema&#58; its production with papain in normal and silicotic rats"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "E&#46;Z&#46; Pfitzer"
                            2 => "E&#46; Tolker"
                            3 => "N&#46;A&#46; Babyak"
                            4 => "M&#46; Kaschak"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Environ Hlth"
                        "fecha" => "1965"
                        "volumen" => "11"
                        "paginaInicial" => "50"
                        "paginaFinal" => "58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The induction of emphysema with elastase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;D&#46; Kaplan"
                            1 => "C&#46; Kuhn"
                            2 => "J&#46;A&#46; Pierce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lab Clin Med"
                        "fecha" => "1973"
                        "volumen" => "82"
                        "paginaInicial" => "349"
                        "paginaFinal" => "365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4728287"
                            "web" => "Medline"
                          ]
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            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Introduction of experimental emphysema in dogs using leukocyte homogenates"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46; Marco"
                            1 => "B&#46; Mass"
                            2 => "D&#46;R&#46; Meranze"
                            3 => "G&#46; Weinbaum"
                            4 => "P&#46; Kimbel"
                          ]
                        ]
                      ]
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                    0 => array:2 [
                      "doi" => "10.1164/arrd.1971.104.4.595"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1971"
                        "volumen" => "104"
                        "paginaInicial" => "595"
                        "paginaFinal" => "598"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5094060"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagenase in the lower respiratory tract of patients with idiophatic pulmonary fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "J&#46;E&#46; Gadek"
                            1 => "J&#46;A&#46; Kelman"
                            2 => "S&#46;E&#46; Weinberger"
                            3 => "A&#46;L&#46; Horwitz"
                            4 => "H&#46;Y&#46; Reynolds"
                            5 => "J&#46;D&#46; Fulmer"
                            6 => "R&#46;G&#46; Crystal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197910043011401"
                      "Revista" => array:6 [
                        "tituloSerie" => "New Engl J Med"
                        "fecha" => "1979"
                        "volumen" => "301"
                        "paginaInicial" => "737"
                        "paginaFinal" => "742"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/225666"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Granulocite collagenase&#58; selective digestion of type 1 over type 111 collagen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;L&#46; Horwitz"
                            1 => "A&#46;J&#46; Hance"
                            2 => "R&#46;G&#46; Crystal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc Nat Acad Sci Wash"
                        "fecha" => "1977"
                        "volumen" => "74"
                        "paginaInicial" => "897"
                        "paginaFinal" => "901"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Degradaron if a cartilage proteoglican by human leukocyte granule neutral proteases a model of joint injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Janoff"
                            1 => "G&#46; Feinstein"
                            2 => "C&#46;J&#46; Malemud"
                            3 => "J&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI108317"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1976"
                        "volumen" => "57"
                        "paginaInicial" => "615"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/129482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung elastin content in normal and emphysematous lungs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;M&#46; Turino"
                            1 => "S&#46; Keller"
                            2 => "P&#46; Chrzanowski"
                            3 => "M&#46; Osman"
                            4 => "J&#46; Cerreta"
                            5 => "I&#46; Mandl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1980"
                        "volumen" => "16"
                        "numero" => "suppl"
                        "paginaInicial" => "43"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The conective tissue of the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46; Hance"
                            1 => "R&#46;G&#46; Crystal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1975.112.5.657"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1975"
                        "volumen" => "112"
                        "paginaInicial" => "657"
                        "paginaFinal" => "711"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1103668"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aetiology of emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;S&#46; Dunnill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
                        "fecha" => "1979"
                        "volumen" => "15"
                        "paginaInicial" => "1015"
                        "paginaFinal" => "1029"
                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0155"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary emphysema and 1-antitrypsin deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;C&#46;S&#46; Hutchinson"
                            1 => "P&#46;J&#46;L&#46; Cook"
                            2 => "C&#46;E&#46; Barter"
                            3 => "H&#46; Harris"
                            4 => "P&#46; Hugh-Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brit Med J"
                        "fecha" => "1971"
                        "volumen" => "1"
                        "paginaInicial" => "689"
                        "paginaFinal" => "694"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/435740"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            31 => array:3 [
              "identificador" => "bib0160"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A comparative study of the severity of emphysema in necropsy populations in three different countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;M&#46; Thurlbeck"
                            1 => "R&#46;C&#46; Ryder"
                            2 => "N&#46; Sternby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1974.109.2.239"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1974"
                        "volumen" => "109"
                        "paginaInicial" => "239"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4811778"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            32 => array:3 [
              "identificador" => "bib0165"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible mechanisms of emphysema in smokers&#46; Cigarrette smoke condensate suppresses protease inhibition in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Janoff"
                            1 => "H&#46; Carp"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1977.116.1.65"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1977"
                        "volumen" => "116"
                        "paginaInicial" => "65"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/301725"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible mechanisms of emphysema smokers&#46; In vitro suppression of serum elastase inhibitory capacity by antioxidants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Carp"
                            1 => "A&#46; Janoff"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1978.118.3.617"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1978"
                        "volumen" => "118"
                        "paginaInicial" => "617"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/101105"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            34 => array:3 [
              "identificador" => "bib0175"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synthesis and secretion of alpha 2 macroglobulin by cultured adherent lung cells"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;F&#46; Mosher"
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                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
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                        "volumen" => "60"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1045"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/71307"
                            "web" => "Medline"
                          ]
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            35 => array:3 [
              "identificador" => "bib0180"
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                    0 => array:2 [
                      "titulo" => "Secretion of alpha 2 macroglobulin by human alveolar macrophages"
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                          "etal" => false
                          "autores" => array:3 [
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                            2 => "H&#46;P&#46; Godfrey"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev Respir Dis"
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                        "numero" => "suppl"
                        "paginaInicial" => "418 &#40;A&#41;"
                      ]
                    ]
                  ]
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              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Syntesis and secretion of alpha 2 macroglobulin by cultured human fibroblast"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;F&#46; Mosher"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
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                        "volumen" => "143"
                        "paginaInicial" => "462"
                        "paginaFinal" => "467"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/55456"
                            "web" => "Medline"
                          ]
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                      "titulo" => "Proteinase &#40;elastase&#41; inhibitor from the ciliated membranes of the human respiratory tract"
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                          "etal" => false
                          "autores" => array:1 [
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                      "Revista" => array:6 [
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                        "paginaInicial" => "869"
                        "paginaFinal" => "872"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1012039"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0195"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Biochemical analyses of bronchoalveolar lavage fluids of healthy human volunteer smokers and non smokers"
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                          "autores" => array:3 [
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                        "tituloSerie" => "Am Rev Respir Dis"
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                        "paginaFinal" => "875"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Studies on the structure of elastin and the mechanims of action of elastolytic enzymes"
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            40 => array:3 [
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                      "titulo" => "Inhibition of elastase from granulocytes by the low molecular weight bronchial protease inhibitor"
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                          "autores" => array:2 [
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                            1 => "H&#46; Tegner"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
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                        "paginaInicial" => "437"
                        "paginaFinal" => "445"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/185683"
                            "web" => "Medline"
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            41 => array:3 [
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            42 => array:3 [
              "identificador" => "bib0215"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteases and antiproteases in bronchoalveolar lavage"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Europ Physiopath Resp"
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                        "numero" => "suppl"
                        "paginaInicial" => "247"
                        "paginaFinal" => "258"
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            43 => array:3 [
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                0 => array:2 [
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                      "titulo" => "Definition and classification of chronic bronchitis"
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                        "link" => array:1 [
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                      "titulo" => "Immunochemical quantitation of antigens by single radial immunodiffusion"
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                      ]
                    ]
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                        "paginaInicial" => "235"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4956917"
                            "web" => "Medline"
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                ]
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            45 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Alpha 1 antitrypsin and alpha 2 macroglobulin&#44; interactions with human neutrophil collagenase and elastase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Olhsson"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann NY Acad Sci"
                        "fecha" => "1975"
                        "volumen" => "256"
                        "paginaInicial" => "409"
                        "paginaFinal" => "419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/51604"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "A study of plasma proteins in the sol phase of sputum from patients with chronic bronchitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Stokley"
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                            3 => "D&#46; Burnett"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1979"
                        "volumen" => "34"
                        "paginaInicial" => "777"
                        "paginaFinal" => "782"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/542918"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
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                    0 => array:2 [
                      "titulo" => "Interrelationships between the human alveolar macrophage and alpha 1 antitrypsin"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;B&#46; Cohen"
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                    0 => array:2 [
                      "doi" => "10.1172/JCI107475"
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                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1973"
                        "volumen" => "52"
                        "paginaInicial" => "2793"
                        "paginaFinal" => "2799"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4201266"
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                    0 => array:2 [
                      "titulo" => "Serum and sputum alpha 2 macroglobulin in patients with chronic obstrucive airways disease"
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                          "etal" => false
                          "autores" => array:2 [
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                  "host" => array:1 [
                    0 => array:1 [
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                        "paginaInicial" => "512"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6171904"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Protease inhibitors in chronic obstructive pulmonary disease"
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                          "autores" => array:3 [
                            0 => "T&#46;B&#46; Barnett"
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                        "tituloSerie" => "Am Rev Respir Dis"
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                        "paginaInicial" => "587"
                        "paginaFinal" => "593"
                        "link" => array:1 [
                          0 => array:2 [
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Article information
ISSN: 03002896
Original language: Spanish
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