Valoracion del efecto broncodilatador en la curva de flujo-volumen segun diferentes metodos de medida
Evaluation of the bronchodilator effect in the flow-volume curve by different measuring methods
P. Morales Marin, R. Navarro Ivañez, B. Togores Solivellas, J. Gil Carbonell, V. Macian Gisbert, E. Benlloch Garcia, V. Marco Martinez
Servicio de Neumología. Ciudad Sanitaria La Fe. Valencia
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"apellidos" => "Ignacio Garcia" ] 4 => array:2 [ "nombre" => "M.R." "apellidos" => "Melchor Iñiguez" ] 5 => array:2 [ "nombre" => "P." 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Sebastian Quetglas, A. Fernandez Lopez, L. Muñoz Cabrera, J. Lopez Pujol, F. Lopez Rubio" "autores" => array:5 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Sebastian Quetglas" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Fernandez Lopez" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Muñoz Cabrera" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Lopez Pujol" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Lopez Rubio" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961532247X?idApp=UINPBA00003Z" "url" => "/03002896/0000002000000003/v1_201509151156/S030028961532247X/v1_201509151156/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Valoracion del efecto broncodilatador en la curva de flujo-volumen segun diferentes metodos de medida" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "112" "paginaFinal" => "117" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "P. Morales Marin, R. Navarro Ivañez, B. Togores Solivellas, J. Gil Carbonell, V. Macian Gisbert, E. Benlloch Garcia, V. Marco Martinez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Morales Marin" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Navarro Ivañez" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Togores Solivellas" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Gil Carbonell" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Macian Gisbert" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Benlloch Garcia" ] 6 => array:2 [ "nombre" => "V." "apellidos" => "Marco Martinez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Ciudad Sanitaria La Fe. Valencia" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Evaluation of the bronchodilator effect in the flow-volume curve by different measuring methods" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1983-06-06" "fechaAceptado" => "1983-09-24" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En el asmático, la modificación que se produce en los volúmenes pulmonares, tras inhalación de un broncodilatador, puede resultar en un cambio del segmento de volumen al cual se midan los flujos espiratorios forzados. Nosotros hemos analizado en 15 asmáticos, el comportamiento de los volúmenes pulmonares tras la administración de 200 mcg de salbutamol y su repercusión en el flujo espiratorio al 50% de la capacidad vital forzada (V·50) en la curva de flujo-volumen, utilizando tres métodos: curvas basal y postbroncodilatador independientes; curvas superpuestas al punto de máxima inflación, midiendo el V·50 postbroncodilatador en el punto de la capacidad vital forzada correspondiente al V·50 de la curva basal; curvas situadas a partir del volumen residual correspondiente, midiendo el V·50 como en el método anterior. La capacidad vital forzada (FVC) aumentó un 6,6% y el volumen residual (RV) disminuyó un 15,9%. La capacidad pulmonar total (TLC) globalmente permaneció inmodificada aunque en tres casos disminuyó. En los pacientes en los que la TLC no se modificó, el incremento del V·50 fue significativamente mayor (p < 0,01) por los métodos II (Δ V·50; 69,9%) y III (Δ V·50; 72,3 <%), que por el método I (Δ V·50; 56,6%), mientras que no hubo diferencias entre estos dos métodos excepto por pequeñas discrepancias debidas a la variabilidad en la determinación del RV. Por tanto, como en la mayoría de los casos la TLC no se modifica pero sí aumenta la FVC, el método I sistemáticamente infraestima la respuesta broncodilatadora. Por el contrario en los que la TLC disminuye puede sobrestimarla el método II. Aunque el método III seria el ideal, no es práctico y se obtiene la misma información observando el comportamiento de la FVC además de los flujos espiratorios. Estos métodos podrían ser útiles, sin embargo, para estudios comparativos entre diferentes fármacos.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The changes in lung volumes that occur in the asthmatic patient after inhalation of a bronchodilator may result in a change of the volume segment used for estimating forced expiratory flows. We have analyzed in 15 patients the changes in lung volumes after the administration of 200 mcg of salbutamol and their influence on the expiratory flow at 50% of forced vital capacity (V·50) in the flow-volume curve by using three methods: baseline curves and independent post-bronchodilator curves; curves superposed to the maximal inflation point measuring post-bronchodiiator V·50 on the forced vital capacity corresponding to the baseline curve V·50; curves situated from the corresponding residual volume by measuring V·50 as in the previous method. Forced vital capacity (FVC) increased 6.6% and residual volume (RV) decreased 15.9%. The overall total lung capacity was not modified although it diminished in three cases. In those patients with non-modified TLC, the increase of V·50 was significantly higher (p < 0.01) by methods II (Δ V·50: 69.9%) and III (Δ V·50: 72.3%) than by method I (Δ V·50: 56.6%), while there were no differences between these two methods except for small discrepancies due to the variability of RV determination. Therefore, since most of the times TLC is not modified but FVC increases, method I systematically underestimates the bronchodilator response. On the other hand, method II may overestimate it when TLC diminishes. Although the ideal method would be method III, it is not practical and the same information is obtained by observing the changes of FVC in adition to the expiratory flows. Nevertheless, it could be useful in comparative studies of different drugs.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A method for interpreting acute response to bronchodilators from the spirogram" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.R. Olsen" 1 => "F.C. Hale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ara Rev Respir Dis" "fecha" => "1968" "volumen" => "98" "paginaInicial" => "301" "paginaFinal" => "303" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maximal expiratory flow and total respiratory resistance during induced bronchoconstriction in asthmatic subjets" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.T. Olive Jr." 1 => "R.E. Hyatt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1972.106.3.366" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1972" "volumen" => "106" "paginaInicial" => "366" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5080708" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significanceof volume-adjusting the maximal midexpiratory flow in assessing the response to a bronchodilator drug" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.B. Sherter" 1 => "J.J. Connolly" 2 => "D.P. Schilder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "1978" "volumen" => "73" "paginaInicial" => "568" "paginaFinal" => "571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/648206" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0920996413004659" "estado" => "S300" "issn" => "09209964" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Volume adjustment of maximal midexpiratory flow Importance of changes in total lung capacity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.W. Cockcroft" 1 => "B.A. Berscheid" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1980" "volumen" => "78" "paginaInicial" => "595" "paginaFinal" => "600" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7418483" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Letter to the Editor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.B. Teculescu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "1981" "volumen" => "80" "paginaInicial" => "765" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7307607" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Volume-adjusting the FEF25-75% When is change significant?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.B. Sherter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "1980" "volumen" => "78" "paginaInicial" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7418478" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology standardization project" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1978.118.1.75" "Revista" => array:7 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1978" "volumen" => "118" "numero" => "6 Part 2" "paginaInicial" => "75" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/677560" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung volumes in exacerbations of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.J. Woolcock" 1 => "J. Read" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1966" "volumen" => "41" "paginaInicial" => "259" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5912303" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary function in bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Meisner" 1 => "P. Hugh-Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brit Med J" "fecha" => "1968" "volumen" => "1" "paginaInicial" => "470" "paginaFinal" => "475" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/837168" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute. bronchial asthma Relations between clinical and physiologic manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.R. Mc Fadden Jr." 1 => "R. Kiser" 2 => "W.J. De Groot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1973" "volumen" => "288" "paginaInicial" => "221" "paginaFinal" => "226" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Significance of the relationship between lung recoil and maximum expiratory flow" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Mead" 1 => "J.M. Turner" 2 => "P.T. Macklem" 3 => "J.B. Little" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Appl Physiol" "fecha" => "1967" "volumen" => "22" "paginaInicial" => "95" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6017658" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung volume changes in asthma measured concurrently by two methods" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.J. Woolcock" 1 => "A.S. Rebuck" 2 => "J.F. Cade" 3 => "J. Read" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1971.104.5.703" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1971" "volumen" => "104" "paginaInicial" => "703" "paginaFinal" => "709" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4942104" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reassessment of lung volume measurement by helium dilution and by body plethysmography in chronic air-flow obstruction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.O. Rodenstein" 1 => "D.C. Stanescu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1982.126.6.1040" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1982" "volumen" => "126" "paginaInicial" => "1040" "paginaFinal" => "1044" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7181224" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in lung mechanics: flow-volume relations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.E. Hyatt" 1 => "J. Mead" 2 => "J.R. Rodarte" 3 => "T.A. Wilson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The lung in the transition between health and disease." "paginaInicial" => "73" "paginaFinal" => "112" "serieFecha" => "1979" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000002000000003/v1_201509151156/S0300289615322481/v1_201509151156/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000002000000003/v1_201509151156/S0300289615322481/v1_201509151156/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615322481?idApp=UINPBA00003Z" ]
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| 2020 May | 9 | 7 | 16 |
| 2020 April | 15 | 6 | 21 |
| 2020 March | 12 | 14 | 26 |
| 2020 February | 18 | 10 | 28 |
| 2020 January | 37 | 14 | 51 |
| 2019 December | 20 | 9 | 29 |
| 2019 November | 11 | 5 | 16 |
| 2019 October | 5 | 3 | 8 |
| 2019 September | 6 | 15 | 21 |
| 2019 August | 10 | 5 | 15 |
| 2019 July | 15 | 18 | 33 |
| 2019 June | 10 | 8 | 18 |
| 2019 May | 8 | 9 | 17 |
| 2019 April | 36 | 29 | 65 |
| 2019 March | 10 | 11 | 21 |
| 2019 February | 4 | 6 | 10 |
| 2019 January | 7 | 7 | 14 |
| 2018 December | 6 | 10 | 16 |
| 2018 November | 5 | 11 | 16 |
| 2018 October | 16 | 14 | 30 |
| 2018 September | 13 | 6 | 19 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 10 | 7 | 17 |
| 2018 March | 5 | 5 | 10 |
| 2018 February | 8 | 9 | 17 |
| 2018 January | 6 | 3 | 9 |
| 2017 December | 6 | 11 | 17 |
| 2017 November | 6 | 5 | 11 |
| 2017 October | 5 | 10 | 15 |
| 2017 September | 4 | 6 | 10 |
| 2017 August | 8 | 10 | 18 |
| 2017 July | 8 | 3 | 11 |
| 2017 June | 7 | 8 | 15 |
| 2017 May | 15 | 17 | 32 |
| 2017 April | 4 | 3 | 7 |
| 2017 March | 5 | 3 | 8 |
| 2017 February | 8 | 9 | 17 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 5 | 4 | 9 |
| 2016 November | 19 | 14 | 33 |
| 2016 October | 19 | 26 | 45 |
| 2016 September | 18 | 11 | 29 |
| 2016 August | 11 | 5 | 16 |
| 2016 July | 19 | 4 | 23 |
| 2016 June | 19 | 11 | 30 |
| 2016 May | 12 | 5 | 17 |
| 2016 April | 6 | 0 | 6 |
| 2016 March | 5 | 0 | 5 |
| 2016 February | 10 | 0 | 10 |
| 2016 January | 11 | 7 | 18 |
| 2015 December | 24 | 12 | 36 |
| 2015 November | 25 | 9 | 34 |
| 2015 October | 5 | 1 | 6 |
| 2015 September | 2 | 0 | 2 |
Show all
