Variaciones en la concentracion serica de oligoelementos en el curso de neumonias bacterianas
Variations in the serum concentration of oligoelements during bacterial pneumonias
J. Camacho, F. Arnalich, A.F. Zamorano, A. Aumente, E. Herrero, A. Sicilia, C. Solis, F.J. Barbado, J.J. Vazquez, R. Gasalla
C. S. SS La Paz y Facultad de Medicina. Universidad Autónoma. Madrid
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Juanmiquel Isern, J. De Gracia Roldan, J. Morera Prat" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Juanmiquel Isern" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "De Gracia Roldan" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Morera Prat" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615322316?idApp=UINPBA00003Z" "url" => "/03002896/0000002000000005/v1_201509151127/S0300289615322316/v1_201509151127/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Variaciones en la concentracion serica de oligoelementos en el curso de neumonias bacterianas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "200" "paginaFinal" => "206" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J. Camacho, F. Arnalich, A.F. Zamorano, A. Aumente, E. Herrero, A. Sicilia, C. Solis, F.J. Barbado, J.J. Vazquez, R. Gasalla" "autores" => array:10 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Camacho" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Arnalich" ] 2 => array:2 [ "nombre" => "A.F." "apellidos" => "Zamorano" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Aumente" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Herrero" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Sicilia" ] 6 => array:2 [ "nombre" => "C." "apellidos" => "Solis" ] 7 => array:2 [ "nombre" => "F.J." "apellidos" => "Barbado" ] 8 => array:2 [ "nombre" => "J.J." "apellidos" => "Vazquez" ] 9 => array:2 [ "nombre" => "R." "apellidos" => "Gasalla" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "C. S. SS La Paz y Facultad de Medicina. Universidad Autónoma. Madrid" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "autoresLista" => "J. Ortiz Vázquez, J.M. Gómez Mantilla" "autores" => array:2 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Ortiz Vázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "Gómez Mantilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna. C. S. SS La Paz y Facultad de Medicina. Universidad Autónoma. Madrid" "etiqueta" => "*" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Departamento de Laboratorio. C. S. SS La Paz y Facultad de Medicina. Universidad Autónoma. Madrid" "etiqueta" => "**" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Variations in the serum concentration of oligoelements during bacterial pneumonias" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1984-01-09" "fechaAceptado" => "1984-03-24" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En 20 pacientes con neumonía bacteriana, determinamos secuencialmente, los días 2.°, 5.° y 8.° de enfermedad y un mes tras la curación del proceso, la concentración sérica de 3 oligoelementos, hierro (Fe), zinc (Zn) y cobre (Cu), asi como de zinc intraeritrocitario (Zn-H) y de las proteínas transportadoras de dos de ellos, la trans-ferrina (TF) y la cerulaplasmina (Ce).</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En nuestros pacientes, objetivamos una muy significativa hiposideremia coincidiendo con las fases de máxima leucocitosis, que además se correlacionó directamente con un descenso paralelo de la TF.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El Zn sérico, sufrió un precoz y significativo descenso al inicio de la neumonía, que se correlacionó inversamente con la cifra de polimorfonucleares, como expresión de una probable relación fisiopatológica entre ambos. Por el contrario, el Zn-H, no se modificó a lo largo del proceso, lo cual apoya el que la hipozincemia obedezca a un mecanismo de redistribución y no a una auténtica deplección corporal.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El Cu sérico, a diferencia del Zn y del Fe, experimentó un moderado ascenso que se correlacionó estrechamente con el de la Ce, y que persistió hasta la curación de la enfermedad. Esto, hace pensar que la hipercupremia en las neumonías, obedezca al aumento de su proteína transportadora.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In 20 patients with bacterial pneumonia, we have se-quentially measured (in the 2nd, 5th and 8th days of the illness and one month after clinical cure) the serum concentratíon of 3 oligoelements; Iron (Fe), zinc (Zn) and copper (Cu). Intra-erythrocyte zinc (Zn-H) and two transport proteins, transferrin (TF) and ceruloplasmin (Ce), were measured as well.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In our patients a highly significant hyposideremia concomitant with the maximum leukocytosis and directly correlated with a parallel decrease in TF was observed.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Serum Zn showed an early and significant decrease at the onset of pneumonia, inversely correlated with the number of polymorphonuclear leukocytes, suggesting the likelihood of a pathogenetic interrelationship. On the contrary, Zn-H was unmodified during the whole course of the disease. This is consistent with low zinc level in serum being caused by a redistribution mechanism and not by true body depletion.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Serum Cu, in contrast with Zn and Fe, showed a moderate increase closely related with the increase of Ce and persisting until clinical cure. This suggests that the increase in serum copper seen in pneumonia may be caused by the increase in its transport protein.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mul tiple biological activities of a partially purified leukocytic endogenous mediator" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.F. Kampschmidth" 1 => "H.F. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 3 | 8 |
| 2024 October | 27 | 14 | 41 |
| 2024 September | 29 | 9 | 38 |
| 2024 August | 41 | 31 | 72 |
| 2024 July | 32 | 21 | 53 |
| 2024 June | 32 | 22 | 54 |
| 2024 May | 39 | 24 | 63 |
| 2024 April | 24 | 21 | 45 |
| 2024 March | 41 | 23 | 64 |
| 2024 February | 30 | 36 | 66 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 14 | 13 | 27 |
| 2023 January | 28 | 21 | 49 |
| 2022 December | 23 | 24 | 47 |
| 2022 November | 26 | 11 | 37 |
| 2022 October | 18 | 25 | 43 |
| 2022 September | 27 | 23 | 50 |
| 2022 August | 26 | 73 | 99 |
| 2022 July | 23 | 69 | 92 |
| 2022 June | 66 | 26 | 92 |
| 2022 May | 35 | 24 | 59 |
| 2022 April | 39 | 23 | 62 |
| 2022 March | 27 | 26 | 53 |
| 2022 February | 22 | 18 | 40 |
| 2022 January | 23 | 19 | 42 |
| 2021 December | 13 | 23 | 36 |
| 2021 November | 14 | 26 | 40 |
| 2021 October | 15 | 24 | 39 |
| 2021 September | 9 | 21 | 30 |
| 2021 August | 13 | 19 | 32 |
| 2021 July | 9 | 23 | 32 |
| 2021 June | 17 | 31 | 48 |
| 2021 May | 12 | 17 | 29 |
| 2021 April | 9 | 59 | 68 |
| 2021 March | 13 | 9 | 22 |
| 2021 February | 23 | 12 | 35 |
| 2021 January | 16 | 15 | 31 |
| 2020 December | 11 | 15 | 26 |
| 2020 November | 4 | 7 | 11 |
| 2020 October | 13 | 11 | 24 |
| 2020 September | 5 | 5 | 10 |
| 2020 August | 15 | 9 | 24 |
| 2020 July | 30 | 19 | 49 |
| 2020 June | 14 | 14 | 28 |
| 2020 May | 19 | 8 | 27 |
| 2020 April | 32 | 8 | 40 |
| 2020 March | 32 | 15 | 47 |
| 2020 February | 27 | 8 | 35 |
| 2020 January | 38 | 9 | 47 |
| 2019 December | 22 | 18 | 40 |
| 2019 November | 37 | 8 | 45 |
| 2019 October | 31 | 4 | 35 |
| 2019 September | 28 | 10 | 38 |
| 2019 August | 7 | 6 | 13 |
| 2019 July | 13 | 10 | 23 |
| 2019 June | 16 | 10 | 26 |
| 2019 May | 9 | 15 | 24 |
| 2019 April | 9 | 39 | 48 |
| 2019 March | 6 | 11 | 17 |
| 2019 February | 2 | 7 | 9 |
| 2019 January | 3 | 1 | 4 |
| 2018 December | 7 | 18 | 25 |
| 2018 November | 6 | 14 | 20 |
| 2018 October | 14 | 13 | 27 |
| 2018 September | 10 | 8 | 18 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 4 | 3 | 7 |
| 2018 March | 6 | 5 | 11 |
| 2018 February | 6 | 14 | 20 |
| 2018 January | 4 | 5 | 9 |
| 2017 December | 6 | 9 | 15 |
| 2017 November | 6 | 6 | 12 |
| 2017 October | 6 | 12 | 18 |
| 2017 September | 4 | 3 | 7 |
| 2017 August | 9 | 20 | 29 |
| 2017 July | 3 | 7 | 10 |
| 2017 June | 6 | 6 | 12 |
| 2017 May | 13 | 14 | 27 |
| 2017 April | 4 | 5 | 9 |
| 2017 March | 4 | 17 | 21 |
| 2017 February | 5 | 6 | 11 |
| 2017 January | 2 | 7 | 9 |
| 2016 December | 4 | 6 | 10 |
| 2016 November | 15 | 12 | 27 |
| 2016 October | 19 | 17 | 36 |
| 2016 September | 15 | 13 | 28 |
| 2016 August | 22 | 8 | 30 |
| 2016 July | 20 | 7 | 27 |
| 2016 June | 28 | 9 | 37 |
| 2016 May | 22 | 9 | 31 |
| 2016 April | 11 | 0 | 11 |
| 2016 March | 4 | 1 | 5 |
| 2016 February | 8 | 0 | 8 |
| 2016 January | 7 | 3 | 10 |
| 2015 December | 30 | 17 | 47 |
| 2015 November | 31 | 7 | 38 |
| 2015 October | 8 | 1 | 9 |
| 2015 September | 2 | 0 | 2 |
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