Proteinosis alveolar: a proposito de tres observaciones
Pulmonary alveolar proteinosis: three cases report
J. Fernandez-Bujarrabal Villoslada, A. Garcia De Cabo, J.A. Hermida Gutierrez, A. Nevado Caballero, L. Sanchez Agudo, F.J. Guerra Sanz
Servicio de Neumología. Hospital Victoria Eugenia. Madrid
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Morell Brotad" "autores" => array:1 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Morell Brotad" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615321918?idApp=UINPBA00003Z" "url" => "/03002896/0000002100000002/v1_201509151142/S0300289615321918/v1_201509151142/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Proteinosis alveolar: a proposito de tres observaciones" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "51" "paginaFinal" => "54" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Fernandez-Bujarrabal Villoslada, A. Garcia De Cabo, J.A. Hermida Gutierrez, A. Nevado Caballero, L. Sanchez Agudo, F.J. Guerra Sanz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Fernandez-Bujarrabal Villoslada" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Garcia De Cabo" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "Hermida Gutierrez" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Nevado Caballero" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Sanchez Agudo" ] 5 => array:2 [ "nombre" => "F.J." "apellidos" => "Guerra Sanz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital Victoria Eugenia. Madrid" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary alveolar proteinosis: three cases report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1984-04-12" "fechaAceptado" => "1984-11-24" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presentan tres casos de proteinosis alveolar (PA), enfermedad pulmonar infrecuente cuya etiopatogenia permanece aún sin aclarar y que se caracteriza por el depósito en los espacios aéreos pulmonares de una sustancia lipidoproteica semejante al surfactante pulmonar.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se señala que si bien la clínica y la radiología no son características, deben hacernos sospechar que se trate de esta entidad. La fibrobroncoscopia es una técnica auxiliar importante mediante la cual podemos realizar lavados brocoalveolares y biopsia transbronquial, permitiéndonos en algunos casos obviar la necesidad de llegar a la biopsia pulmonar abierta para establecer el diagnóstico de certeza.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El lavado broncopulmonar es en la actualidad el tratamiento de mayor validez para la PA; sin embargo, es una técnica compleja no exenta de riesgos, lo que unido a que más de la mitad de los casos de esta enfermedad no cursan con gravedad, hace que haya que valorar adecuadamente la indicación del mismo para cada caso en particular.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pulmonary alveolar proteinosis is an infrequently seen disease characterized by filling of the distal air spaces with a lipoproteinaceous material similar to pulmonary surfactant.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Three cases with the disease are described below.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Although neither the clinical symptoms or radiographic findings are characteristic they may suggest the presence of the entity.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fiberoptic bronchoscopy is a useful diagnostic aid which will permit bronchoalveolar lavage and transbronchial biopsy and may in certain cases avoid the need for open pulmonary biopsy to establish a firm diagnosis.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Bronchopulmonary lavage is at present the most effective treatment although it carnes certain risks to the patient and is a complicated technique; it should therefore only be used in carefully selected cases especially as more than half of all patients do not present serious symptoms.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.H. Rosen" 1 => "B. Castelman" 2 => "A.A. Lebow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM195806052582301" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1958" "volumen" => "258" "paginaInicial" => "1123" "paginaFinal" => "1142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13552931" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis: eleven-year follow up in one case" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Jehan" 1 => "B. Borel" 2 => "J. Brun" 3 => "A. Boulier" 4 => "J. Lemenager" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Poumon et Coeur" "fecha" => "1982" "volumen" => "38" "paginaInicial" => "35" "paginaFinal" => "41" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and magnament of alveolar proteinosis: The role of electron microscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.F. Costello" 1 => "D.C. Mariarty" 2 => "M.A. Branthwaite" 3 => "M. Turner-Warwick" 4 => "B. Corrin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1975" "volumen" => "30" "paginaInicial" => "121" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1179307" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.I. Mc Clenahan" 1 => "R. Mussenden" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1974" "volumen" => "133" "paginaInicial" => "284" "paginaFinal" => "287" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4405909" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis of experimental pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Corrin" 1 => "E. King" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1970" "volumen" => "25" "paginaInicial" => "230" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5441994" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alveolar proteinosis. It's experimental production in rodents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Gross" 1 => "R. De Treville" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Pathol" "fecha" => "1968" "volumen" => "86" "paginaInicial" => "255" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4300130" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis: nature and origin of alveolar lipids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Ramírez-R" 1 => "W. Harlan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1968" "volumen" => "45" "paginaInicial" => "502" "paginaFinal" => "512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5678094" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis. Report of a case with application of a special sputum examination as an aid to diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.J. Kroeker" 1 => "S. Korfmacher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1963.87.3P1.416" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1963" "volumen" => "87" "paginaInicial" => "416" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14035899" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis Treatment in a case complicated by tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Ramírez-R.F J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1967.95.3.491" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1967" "volumen" => "95" "paginaInicial" => "491" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6066626" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis: The diagnosis by segmental lavage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Martin" 1 => "J. Coalson" 2 => "R. Rogers" 3 => "F. Horton" 4 => "L.E. Manous" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1980.121.5.819" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1980" "volumen" => "121" "paginaInicial" => "819" "paginaFinal" => "825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7406316" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis. A case report with unusual clinical features and laboratory manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.B. Landis" 1 => "H.D. Rose" 2 => "R.O. Steinlib" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1959" "volumen" => "80" "paginaInicial" => "248" "paginaFinal" => "254" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.B. Lovette" 1 => "G.J. Magovern" 2 => "E.M. Kent" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1961" "volumen" => "108" "paginaInicial" => "611" "paginaFinal" => "613" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14466903" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The course of the first case in Japan of pulmonary proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Oka" 1 => "K. Shiraishi" 2 => "K. Ogata" 3 => "Y. Goto" 4 => "T. Yasuda" 5 => "H. Yanagihara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1966.93.4.608" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1966" "volumen" => "93" "paginaInicial" => "608" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5910681" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiopulmonary Phisiology in a case of pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.H. Snider" 1 => "F.M. Wilner" 2 => "B.M. Lewis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1960" "volumen" => "52" "paginaInicial" => "1318" "paginaFinal" => "1328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13832294" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis. A roentgenologic analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Ramírez-R.F J." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Roentgenol" "fecha" => "1964" "volumen" => "92" "paginaInicial" => "571" "paginaFinal" => "577" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Preger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/92.6.1291" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "1969" "volumen" => "92" "paginaInicial" => "1291" "paginaFinal" => "1295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5790638" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute silicoproteinosis: a new pathologic variant of acute silicosis in sandblasters, characterized by histologic features resembling alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.A. Buechner" 1 => "A. Ansari" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dis Chest" "fecha" => "1969" "volumen" => "55" "paginaInicial" => "274" "paginaFinal" => "284" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5775743" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnosis of pulmonary alveolar proteinosis by sputum examination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.A. Vidone" 1 => "L. Hoffman" 2 => "P.B. Hukill" 3 => "K.A. Nesbitt" 4 => "F.J. Me Mahon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dis Chest" "fecha" => "1966" "volumen" => "49" "paginaInicial" => "326" "paginaFinal" => "332" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transbronchial lung biopsy via fiberoptic bronchoscope" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.C. Lewin" 1 => "A.B. Wicks" 2 => "J.H. Ellis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1974" "volumen" => "110" "paginaInicial" => "4" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4613231" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Davidson" 1 => "W. Mc Leod" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dis Chest" "fecha" => "1969" "volumen" => "63" "paginaInicial" => "13" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4886263" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis: report of six cases, review of the literature and formulation of a new theory" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.K. Larson" 1 => "R. Gordinier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1965" "volumen" => "62" "paginaInicial" => "292" "paginaFinal" => "312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14259213" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alveolar proteinosis: experience with trypsin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.L. Arcra" 1 => "R.M. Roger" 2 => "R.L. Mayock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Med" "fecha" => "1968" "volumen" => "48" "paginaInicial" => "889" "paginaFinal" => "899" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis: a new tecnique and rationale for treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Ramírez-R.F J." 1 => "R.B. Schult" 2 => "R.E. Dutton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1963" "volumen" => "112" "paginaInicial" => "419" "paginaFinal" => "431" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14045290" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchopulmonary lavage in man" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Ramírez-R.F J." 1 => "R.F. Kieffer Jr." 2 => "W.C. Ball Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1965" "volumen" => "63" "paginaInicial" => "819" "paginaFinal" => "828" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5848630" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung lavage (alveolar washing) in alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Wasserman" 1 => "N. Blanck" 2 => "G. Fletcher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1968" "volumen" => "44" "paginaInicial" => "611" "paginaFinal" => "617" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5642718" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in the treatment of pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Kao" 1 => "K. Wasserman" 2 => "D. Costley" 3 => "J.R. Benfield" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/141.2.361" "Revista" => array:5 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1975" "paginaInicial" => "361" "paginaFinal" => "363" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2301854" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extracorporeal membrana oxigenation during broncopulmonary lavage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.D. Altose" 1 => "R.E. Hicks" 2 => "M.W. Edwards" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Surg" "fecha" => "1976" "volumen" => "111" "paginaInicial" => "1148" "paginaFinal" => "1153" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000002100000002/v1_201509151142/S030028961532192X/v1_201509151142/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000002100000002/v1_201509151142/S030028961532192X/v1_201509151142/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961532192X?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 29 | 14 | 43 |
| 2024 September | 27 | 17 | 44 |
| 2024 August | 45 | 30 | 75 |
| 2024 July | 27 | 26 | 53 |
| 2024 June | 38 | 17 | 55 |
| 2024 May | 36 | 32 | 68 |
| 2024 April | 51 | 13 | 64 |
| 2024 March | 32 | 25 | 57 |
| 2024 February | 34 | 34 | 68 |
| 2024 January | 0 | 4 | 4 |
| 2023 November | 0 | 2 | 2 |
| 2023 October | 0 | 3 | 3 |
| 2023 September | 0 | 7 | 7 |
| 2023 August | 0 | 7 | 7 |
| 2023 July | 0 | 1 | 1 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 4 | 2 | 6 |
| 2023 February | 18 | 22 | 40 |
| 2023 January | 16 | 22 | 38 |
| 2022 December | 22 | 24 | 46 |
| 2022 November | 26 | 17 | 43 |
| 2022 October | 20 | 30 | 50 |
| 2022 September | 16 | 29 | 45 |
| 2022 August | 27 | 35 | 62 |
| 2022 July | 21 | 40 | 61 |
| 2022 June | 20 | 30 | 50 |
| 2022 May | 17 | 23 | 40 |
| 2022 April | 18 | 31 | 49 |
| 2022 March | 26 | 31 | 57 |
| 2022 February | 29 | 22 | 51 |
| 2022 January | 20 | 26 | 46 |
| 2021 December | 10 | 24 | 34 |
| 2021 November | 18 | 35 | 53 |
| 2021 October | 13 | 33 | 46 |
| 2021 September | 12 | 25 | 37 |
| 2021 August | 4 | 13 | 17 |
| 2021 July | 5 | 25 | 30 |
| 2021 June | 17 | 24 | 41 |
| 2021 May | 9 | 14 | 23 |
| 2021 April | 26 | 35 | 61 |
| 2021 March | 36 | 8 | 44 |
| 2021 February | 16 | 13 | 29 |
| 2021 January | 21 | 13 | 34 |
| 2020 December | 8 | 14 | 22 |
| 2020 November | 16 | 14 | 30 |
| 2020 October | 7 | 8 | 15 |
| 2020 September | 15 | 5 | 20 |
| 2020 August | 16 | 10 | 26 |
| 2020 July | 10 | 15 | 25 |
| 2020 June | 10 | 8 | 18 |
| 2020 May | 15 | 5 | 20 |
| 2020 April | 24 | 13 | 37 |
| 2020 March | 16 | 17 | 33 |
| 2020 February | 28 | 15 | 43 |
| 2020 January | 25 | 16 | 41 |
| 2019 December | 13 | 22 | 35 |
| 2019 November | 5 | 10 | 15 |
| 2019 October | 8 | 4 | 12 |
| 2019 September | 10 | 14 | 24 |
| 2019 August | 11 | 11 | 22 |
| 2019 July | 10 | 25 | 35 |
| 2019 June | 4 | 35 | 39 |
| 2019 May | 23 | 28 | 51 |
| 2019 April | 15 | 22 | 37 |
| 2019 March | 11 | 25 | 36 |
| 2019 February | 5 | 5 | 10 |
| 2019 January | 8 | 8 | 16 |
| 2018 December | 5 | 18 | 23 |
| 2018 November | 7 | 13 | 20 |
| 2018 October | 20 | 12 | 32 |
| 2018 September | 12 | 8 | 20 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 7 | 4 | 11 |
| 2018 March | 4 | 4 | 8 |
| 2018 February | 6 | 13 | 19 |
| 2018 January | 4 | 7 | 11 |
| 2017 December | 11 | 12 | 23 |
| 2017 November | 6 | 14 | 20 |
| 2017 October | 7 | 8 | 15 |
| 2017 September | 4 | 11 | 15 |
| 2017 August | 7 | 8 | 15 |
| 2017 July | 7 | 4 | 11 |
| 2017 June | 16 | 13 | 29 |
| 2017 May | 16 | 11 | 27 |
| 2017 April | 10 | 5 | 15 |
| 2017 March | 8 | 6 | 14 |
| 2017 February | 16 | 10 | 26 |
| 2017 January | 7 | 7 | 14 |
| 2016 December | 14 | 5 | 19 |
| 2016 November | 20 | 15 | 35 |
| 2016 October | 21 | 18 | 39 |
| 2016 September | 17 | 3 | 20 |
| 2016 August | 21 | 4 | 25 |
| 2016 July | 22 | 5 | 27 |
| 2016 June | 15 | 4 | 19 |
| 2016 May | 19 | 2 | 21 |
| 2016 April | 10 | 0 | 10 |
| 2016 March | 14 | 0 | 14 |
| 2016 February | 5 | 2 | 7 |
| 2016 January | 16 | 6 | 22 |
| 2015 December | 21 | 17 | 38 |
| 2015 November | 26 | 9 | 35 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 1 | 0 | 1 |
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