Bases farmacologicas de la utilizacion clinica de las teofilinas de liberacion retardada
Pharmacological bases for the clinical use of slow release theophylline
E. Gil Luna, R. Azagra Ledesma, J.A. Salva Miquel
Servicio de Farmacología Clínica. Hospital Clínico de Barcelona
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"apellidos" => "Koch" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615320640?idApp=UINPBA00003Z" "url" => "/03002896/0000002200000001/v1_201509151052/S0300289615320640/v1_201509151052/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Bases farmacologicas de la utilizacion clinica de las teofilinas de liberacion retardada" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "12" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "E. Gil Luna, R. Azagra Ledesma, J.A. Salva Miquel" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Gil Luna" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Azagra Ledesma" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "Salva Miquel" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Farmacología Clínica. Hospital Clínico de Barcelona" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pharmacological bases for the clinical use of slow release theophylline" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1985-02-19" "fechaAceptado" => "1985-10-18" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Un preparado teofilínico de liberación retardada pretende disminuir la velocidad de absorción del fármaco para obtener concentraciones plasmáticas sin fluctuaciones y aumentar así el intervalo de dosificación. Esto se consigue habitualmente mediante el sistema galénico de microencapsulación.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lo que distingue a estos preparados de los clásicos de absorción rápida son sus características farmacocinéticas: inician sus efectos más tardíamente, mejoran el cumplimiento de la prescripción, evitan fluctuaciones y estabilizan los niveles plasmáticos. Clínicamente están indicados en asmáticos con síntomas nocturnos y en aquellos metabolizadores rápidos de teofilina.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La dosis a utilizar (para adultos), es de 13 mg/kg/día, a la que se llega de forma escalonada. La dosis de mantenimiento vendrá determinada por los resultados de la monitorización plasmática del fármaco.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Numerosos factores alteran el aclaramiento de teofilina, y hay que tenerlos en cuenta para poder modificar adecuadamente las pautas de dosificación.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En caso de intoxicación masiva, debe iniciarse tan pronto como sea posible una hemoperfusión extracorpórea con carbón activado.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A slow release thephylline preparation is designed to decrease the absorption rate and so attain nonfluctuating plasma concentrations and thus increase the dosis interval. This usually is achieved with the galenic method of micro-encapsulation.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">These preparations differ from the classical rapidly absorbed ones in their pharmacokinetic characteristics in that their activity starts later, improve prescription compliance, avoid fluctuations and stabilize plasma levels. They are indicated for clinical use in asthmatic patients with nocturnal attacks and those who rapidly metabolize theophylline.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The adult dosage is 13 mg/kg/day reached through staggered administration; the maintenance dosis is established on the basis of the results of plasma monitoring.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There are numerous factors influencing theophylline clearance and these must be taken into account for adequate modification of the dosage schedule. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 4 | 11 |
| 2024 October | 35 | 55 | 90 |
| 2024 September | 31 | 46 | 77 |
| 2024 August | 49 | 50 | 99 |
| 2024 July | 42 | 34 | 76 |
| 2024 June | 51 | 41 | 92 |
| 2024 May | 35 | 66 | 101 |
| 2024 April | 21 | 55 | 76 |
| 2024 March | 45 | 49 | 94 |
| 2024 February | 50 | 57 | 107 |
| 2024 January | 0 | 26 | 26 |
| 2023 December | 0 | 32 | 32 |
| 2023 November | 0 | 27 | 27 |
| 2023 October | 0 | 26 | 26 |
| 2023 September | 0 | 15 | 15 |
| 2023 August | 0 | 9 | 9 |
| 2023 July | 0 | 15 | 15 |
| 2023 June | 0 | 1 | 1 |
| 2023 May | 0 | 1 | 1 |
| 2023 April | 0 | 3 | 3 |
| 2023 March | 8 | 14 | 22 |
| 2023 February | 14 | 36 | 50 |
| 2023 January | 31 | 49 | 80 |
| 2022 December | 33 | 42 | 75 |
| 2022 November | 31 | 43 | 74 |
| 2022 October | 32 | 61 | 93 |
| 2022 September | 27 | 21 | 48 |
| 2022 August | 38 | 49 | 87 |
| 2022 July | 26 | 39 | 65 |
| 2022 June | 38 | 37 | 75 |
| 2022 May | 31 | 43 | 74 |
| 2022 April | 40 | 47 | 87 |
| 2022 March | 33 | 40 | 73 |
| 2022 February | 38 | 46 | 84 |
| 2022 January | 29 | 67 | 96 |
| 2021 December | 15 | 60 | 75 |
| 2021 November | 22 | 50 | 72 |
| 2021 October | 26 | 56 | 82 |
| 2021 September | 19 | 71 | 90 |
| 2021 August | 28 | 43 | 71 |
| 2021 July | 26 | 49 | 75 |
| 2021 June | 29 | 50 | 79 |
| 2021 May | 28 | 37 | 65 |
| 2021 April | 92 | 66 | 158 |
| 2021 March | 104 | 25 | 129 |
| 2021 February | 62 | 17 | 79 |
| 2021 January | 28 | 20 | 48 |
| 2020 December | 33 | 24 | 57 |
| 2020 November | 35 | 22 | 57 |
| 2020 October | 29 | 29 | 58 |
| 2020 September | 35 | 14 | 49 |
| 2020 August | 52 | 16 | 68 |
| 2020 July | 34 | 16 | 50 |
| 2020 June | 43 | 17 | 60 |
| 2020 May | 32 | 19 | 51 |
| 2020 April | 27 | 15 | 42 |
| 2020 March | 31 | 23 | 54 |
| 2020 February | 56 | 21 | 77 |
| 2020 January | 34 | 24 | 58 |
| 2019 December | 29 | 33 | 62 |
| 2019 November | 23 | 7 | 30 |
| 2019 October | 42 | 10 | 52 |
| 2019 September | 27 | 15 | 42 |
| 2019 August | 19 | 7 | 26 |
| 2019 July | 17 | 23 | 40 |
| 2019 June | 20 | 18 | 38 |
| 2019 May | 26 | 14 | 40 |
| 2019 April | 65 | 35 | 100 |
| 2019 March | 15 | 22 | 37 |
| 2019 February | 4 | 8 | 12 |
| 2019 January | 6 | 8 | 14 |
| 2018 December | 6 | 10 | 16 |
| 2018 November | 12 | 11 | 23 |
| 2018 October | 24 | 12 | 36 |
| 2018 September | 10 | 8 | 18 |
| 2018 May | 7 | 1 | 8 |
| 2018 April | 18 | 7 | 25 |
| 2018 March | 4 | 4 | 8 |
| 2018 February | 9 | 10 | 19 |
| 2018 January | 6 | 5 | 11 |
| 2017 December | 7 | 12 | 19 |
| 2017 November | 5 | 7 | 12 |
| 2017 October | 10 | 8 | 18 |
| 2017 September | 6 | 11 | 17 |
| 2017 August | 6 | 7 | 13 |
| 2017 July | 4 | 8 | 12 |
| 2017 June | 9 | 14 | 23 |
| 2017 May | 7 | 8 | 15 |
| 2017 April | 6 | 8 | 14 |
| 2017 March | 5 | 31 | 36 |
| 2017 February | 4 | 6 | 10 |
| 2017 January | 2 | 7 | 9 |
| 2016 December | 11 | 13 | 24 |
| 2016 November | 15 | 14 | 29 |
| 2016 October | 16 | 16 | 32 |
| 2016 September | 16 | 14 | 30 |
| 2016 August | 17 | 5 | 22 |
| 2016 July | 18 | 8 | 26 |
| 2016 June | 24 | 12 | 36 |
| 2016 May | 16 | 6 | 22 |
| 2016 April | 9 | 0 | 9 |
| 2016 March | 6 | 0 | 6 |
| 2016 February | 8 | 0 | 8 |
| 2016 January | 19 | 7 | 26 |
| 2015 December | 24 | 16 | 40 |
| 2015 November | 23 | 8 | 31 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 2 | 0 | 2 |
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