Efecto preventivo de la nifedipina sobre la broncoconstriccion inducida por metacolina
Preventive effect of nifedipine on metacholine induced bronchoconstriction
J.L. Heredia, R. Cornudella, R. Tomas
Servei d’Aparell Respiratori. Hospital de la Sta. Creu i St. Pau. Barcelona
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De Vega Gomez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "De Vega Gomez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615320512?idApp=UINPBA00003Z" "url" => "/03002896/0000002200000003/v1_201509151111/S0300289615320512/v1_201509151111/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Efecto preventivo de la nifedipina sobre la broncoconstriccion inducida por metacolina" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "115" "paginaFinal" => "118" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J.L. Heredia, R. Cornudella, R. Tomas" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Heredia" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Cornudella" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Tomas" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servei d’Aparell Respiratori. Hospital de la Sta. Creu i St. Pau. Barcelona" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Preventive effect of nifedipine on metacholine induced bronchoconstriction" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1985-06-19" "fechaAceptado" => "1985-12-11" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se estudia en ocho pacientes asmáticos el efecto preventivo de la nifedipina (NF) sobre la broncoconstricción inducida por metacolina. A todos los pacientes se les había efectuado previamente un test de provocación con metacolina con el que FEV<span class="elsevierStyleInf">1</span> había caído 20% con respecto al basal. El estudio se realizó en dos días distintos administrándose 20 mg de NF sublingual o placebo de forma aleatoria y a doble ciego. Con NF hubo un descenso significativamente menor (p < 0,01) de la FVC y FEV<span class="elsevierStyleInf">1</span> que con el placebo o cuando no se le administró al paciente medicación alguna. No obstante, se apreció una importante variación interindividual en el efecto profiláctico con NF.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The preventive efect of nifedipine on metacholine induced bronchoconstriction was studied in eight asthmatic patients. Before the start of the study all patients underwent a metacholine challenge test which resulted in a 20% drop from the baseline value for FEV<span class="elsevierStyleInf">1</span>. The study was done over two days, with random, double blind administration of 20 mg sublingual nifedipine or placebo. Patients receiving nifedipine showed a significantly smaller reduction (p < 0.01) in the FVC and FEV<span class="elsevierStyleInf">1</span>, values than did those with placebo or variation in the prophylactic effect of nifedipine between patients.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A calcium antagonist, nifedipine, modifics exercise-induced asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.J. Barnes" 1 => "N.M. Wilson" 2 => "M.J. 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