Enfermedad pulmonar experimental por diisocianato de tolueno
Experimental pulmonary disease induced by toluene diisocyanate
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Martinez-Berganza Asensio, F. Escolar Castellon" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Martinez-Berganza Asensio" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Escolar Castellon" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Departamento de Medicina. Facultad de Medicina. Universidad de Zaragoza" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "autoresLista" => "J.D. Escolar Castellon, P. Roche Roche" "autores" => array:2 [ 0 => array:3 [ "nombre" => "J.D." "apellidos" => "Escolar Castellon" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "P." "apellidos" => "Roche Roche" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía. Facultad de Medicina. Universidad de Zaragoza." "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Experimental pulmonary disease induced by toluene diisocyanate" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1987-01-26" "fechaAceptado" => "1987-04-27" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A pesar de que la enfermedad profesional por diisocianato de tulueno (DIT) es conocida desde hace años, todavía se discuten los mecanismos patógenos que intervienen en su desencadenamiento. Para aportar datos al conocimiento de la etiopatogenia, se ha establecido un modelo experimental en ratas.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se sometió a 8 ratas a una atmósfera de vapores de DIT, de forma ininterrumpida durante 30 días, posteriormente las ratas fueron sacrificadas, se les realizó lavado broncoalveolar (LBA) y estudio histológico que incluía inmunohistioquimia para la detección de IgG.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El LBA mostró un incremento de los linfodtos (38%), lo que coincidía con la infiltración de linfodtos peribronquial y, en menor grado, de los tabiques alveolares. Asimismo, se detectaron depósitos de IgG en las paredes de los capilares alveolares. Todos estos hechos sugieren: la participación de mecanismos de hipersensibilidad retardada tipo III, mediada por IgG; así como, la implicación tanto de las vías aéreas como del parénquima pulmonar. Quedando por aclarar las posibilidades evolutivas de los depósitos de IgG, encontrados en las paredes alveolares.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Even though the occupational disease induced by toluene diisocyanate (DIT) has been known for years, the pathogenetic mechanisms that trigger this condition remain unclear. An experimental model has been developed in the rat in order to provide some insight on the etiopathogenesis of the disease.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Eight rats were mantained on an DIT atmosphere continuosly for 30 days and then killed. Bronchoalveolar lavage (LBA) and histological exam including immunohistochemical assessment for IgG detection were performed in all the animals.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">An increased proportion of lymphocytes (39%) was found in the bronchoalveolar lavage, together with a peribronchial lymphocytic infiltration of the alveolar septa. IgG deposits on the alveolar capillary walls were also found. These findings suggest that IgG-mediated type III delayed hypersensitivity mechanisms are involved, and that both airway and pulmonary parenchyma are affected. The final outcome of the IgG deposits found on the alveolar walls is still confuse.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| 2018 January | 8 | 9 | 17 |
| 2017 December | 10 | 12 | 22 |
| 2017 November | 8 | 8 | 16 |
| 2017 October | 8 | 13 | 21 |
| 2017 September | 6 | 13 | 19 |
| 2017 August | 13 | 21 | 34 |
| 2017 July | 6 | 7 | 13 |
| 2017 June | 10 | 16 | 26 |
| 2017 May | 11 | 12 | 23 |
| 2017 April | 7 | 5 | 12 |
| 2017 March | 6 | 3 | 9 |
| 2017 February | 5 | 8 | 13 |
| 2017 January | 4 | 4 | 8 |
| 2016 December | 7 | 2 | 9 |
| 2016 November | 16 | 11 | 27 |
| 2016 October | 14 | 16 | 30 |
| 2016 September | 15 | 13 | 28 |
| 2016 August | 15 | 4 | 19 |
| 2016 July | 21 | 4 | 25 |
| 2016 June | 22 | 11 | 33 |
| 2016 May | 15 | 5 | 20 |
| 2016 April | 9 | 0 | 9 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 17 | 0 | 17 |
| 2016 January | 27 | 15 | 42 |
| 2015 December | 31 | 16 | 47 |
| 2015 November | 34 | 8 | 42 |
| 2015 October | 5 | 1 | 6 |
| 2015 September | 2 | 0 | 2 |
Show all
