Hipoventilacion alveolar cronica primaria
J.A. Garrido, E. Llorca, N. González Mangado, J.M. Castrillo
Fundación Jiménez Díaz. Madrid
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Lobo Beristain, S. Luzarraga, L. Ponce de León, M. Pérez-Martí" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Lobo Beristain" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Luzarraga" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Ponce de León" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Pérez-Martí" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615318172?idApp=UINPBA00003Z" "url" => "/03002896/0000002400000005/v1_201509151026/S0300289615318172/v1_201509151026/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Hipoventilacion alveolar cronica primaria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "221" "paginaFinal" => "224" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J.A. Garrido, E. Llorca, N. González Mangado, J.M. Castrillo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Garrido" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Llorca" ] 2 => array:2 [ "nombre" => "N." "apellidos" => "González Mangado" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Castrillo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Fundación Jiménez Díaz. Madrid" "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1987-12-21" "fechaAceptado" => "1988-04-21" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una mujer de 36 años con un síndrome de hipoventilación alveolar primaria. Comenzó sus síntomas en la infancia con cianosis durante el sueño, siendo diagnosticada de cardiopatía congénita cianógena, añadiéndose después cianosis diurna, astenia, púrpura y edema en miembros inferiores. No tenía antecedentes de enfermedad neurológica. Destacaba poliglobulia con estudio de hemoglobinas normal. Un estudio hemodinámico descartó cortocircuitos y lesiones valvulares, existiendo hipertensión pulmonar moderada. Sus pruebas funcionales respiratorias no mostraron alteraciones y presentaba acidosis respiratoria con hipoxemia, que se corregían con la hiperventiladón y con el ejercicio. El estudio del sueño no apoyaba el diagnóstico de «Sleep-apnea». Demostramos la ausencia de respuesta ventilatoria adecuada frente a la hipoxia. La presencia de hipercapnia en ausenda de enfermedad pulmonar, neuromuscular o de la caja torácica, reflejaba disminución de la sensibilidad central al CO2. Los hallazgos permiten sugerir una afectación mixta de quimiorreceptores centrales y periféricos con indemnidad de los mecanismos reflejos al esfuerzo.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the case of a 36-year-old woman with a primary alveolar hypoventilation syndrome. She began presenting symptoms at infancy, with cyanosis during the sleep, being diagnosed of cyanotic congenital malformation of the heart; she subsequently developed diurnal cyanosis, fatigue, purpura, and lower limbs edema. She gave no history of neurological disease. As laboratory data, there was polyglobulia and the hemoglobins study was normal. A hemodynamic exploration ruled out circulatory shunts and valvular lesions, confirming a moderate pulmonary hypertension. The tests of respiratory function did not reveal any alteration; the patient presented respiratory acidosis with hypoxemia, which normalized with hyperventilation and physical exercise. The sleep study did not support the diagnosis of sleep apnea. We confirmed the lack of an adequate ventilatory response to hypoxia. The presence of hypercapnia in the absence of pulmonary, neuromuscular and thoracic cage diseases reflected the decrease in the central sensitivity to CO2. The findings may suggest an alteration in the central and peripheral chemorreceptors with sparing of the reflex machanisms to physical effort.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| 2020 July | 200 | 60 | 260 |
| 2020 June | 244 | 28 | 272 |
| 2020 May | 288 | 74 | 362 |
| 2020 April | 304 | 53 | 357 |
| 2020 March | 279 | 66 | 345 |
| 2020 February | 264 | 59 | 323 |
| 2020 January | 258 | 66 | 324 |
| 2019 December | 242 | 86 | 328 |
| 2019 November | 279 | 128 | 407 |
| 2019 October | 280 | 150 | 430 |
| 2019 September | 347 | 276 | 623 |
| 2019 August | 210 | 91 | 301 |
| 2019 July | 286 | 91 | 377 |
| 2019 June | 287 | 119 | 406 |
| 2019 May | 314 | 165 | 479 |
| 2019 April | 257 | 130 | 387 |
| 2019 March | 229 | 131 | 360 |
| 2019 February | 177 | 136 | 313 |
| 2019 January | 154 | 110 | 264 |
| 2018 December | 135 | 137 | 272 |
| 2018 November | 163 | 233 | 396 |
| 2018 October | 154 | 144 | 298 |
| 2018 September | 177 | 216 | 393 |
| 2018 May | 82 | 2 | 84 |
| 2018 April | 179 | 12 | 191 |
| 2018 March | 79 | 4 | 83 |
| 2018 February | 9 | 8 | 17 |
| 2018 January | 11 | 11 | 22 |
| 2017 December | 12 | 85 | 97 |
| 2017 November | 11 | 141 | 152 |
| 2017 October | 200 | 67 | 267 |
| 2017 September | 260 | 39 | 299 |
| 2017 August | 200 | 27 | 227 |
| 2017 July | 198 | 34 | 232 |
| 2017 June | 223 | 48 | 271 |
| 2017 May | 249 | 36 | 285 |
| 2017 April | 199 | 27 | 226 |
| 2017 March | 297 | 36 | 333 |
| 2017 February | 226 | 45 | 271 |
| 2017 January | 79 | 50 | 129 |
| 2016 December | 104 | 15 | 119 |
| 2016 November | 200 | 44 | 244 |
| 2016 October | 28 | 226 | 254 |
| 2016 September | 117 | 296 | 413 |
| 2016 August | 140 | 170 | 310 |
| 2016 July | 66 | 57 | 123 |
| 2016 June | 43 | 42 | 85 |
| 2016 May | 27 | 18 | 45 |
| 2016 April | 18 | 0 | 18 |
| 2016 March | 10 | 0 | 10 |
| 2016 February | 7 | 1 | 8 |
| 2016 January | 33 | 30 | 63 |
| 2015 December | 35 | 18 | 53 |
| 2015 November | 35 | 11 | 46 |
| 2015 October | 4 | 1 | 5 |
| 2015 September | 2 | 0 | 2 |
Show all
