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          "bibliografiaReferencia" => array:18 [
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              "identificador" => "bib0005"
              "etiqueta" => "1."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anti-spasmogenic and spasmolytic effects of BRL 34915: A comparison with nifedipine and nicorandil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J.C. Clapham"
                            1 => "C. Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Auton Pharmac"
                        "fecha" => "1987"
                        "volumen" => "7"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence that mechanism of the inhibitory action of pinacidil in rat and guinea-pig smooth muscle differs from that of glyceryl trinitrate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "K.M. Bray"
                            1 => "D.T. Newgreen"
                            2 => "R.C. Small"
                            3 => "J.S. Southertoh"
                            4 => "S.G. Taylor"
                            5 => "S.W. Weir"
                            6 => "A.H. Weston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1987"
                        "volumen" => "91"
                        "paginaInicial" => "421"
                        "paginaFinal" => "429"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of 2-nicotinamido ethyl nitrate (nicorandil) and its derivates on smooth muscle cells of the canine mesenteric artery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T. Inoue"
                            1 => "Y. Kanmura"
                            2 => "K. Fujisawa"
                            3 => "T. Itoh"
                            4 => "H. Kuriyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pharmac Exp Ther"
                        "fecha" => "1984"
                        "volumen" => "229"
                        "paginaInicial" => "793"
                        "paginaFinal" => "802"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stimulation of coronary guanylate cyclase by nicorandil as a mechanism of its vasodilating action"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K. Schmidt"
                            1 => "R. Reich"
                            2 => "W.R. Kukovetz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cyc Nuc Res"
                        "fecha" => "1985"
                        "volumen" => "10"
                        "paginaInicial" => "43"
                        "paginaFinal" => "53"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relaxant action of nicorandil in guinea-pig isolated trachealis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S.L. Alien"
                            1 => "R.W. Foster"
                            2 => "G.P. Morgan"
                            3 => "R.C. Small"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1986"
                        "volumen" => "87"
                        "paginaInicial" => "117"
                        "paginaFinal" => "127"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Electrical and mechanical effects of BRL 34915 in guinea-pig isolated trachealis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S.L. Alien"
                            1 => "J.P. Boyle"
                            2 => "J. Cortijo"
                            3 => "R.W. Foster"
                            4 => "G.P. Morgan"
                            5 => "R.C. Small"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1986"
                        "volumen" => "89"
                        "paginaInicial" => "395"
                        "paginaFinal" => "405"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An investigation into the mechanism of action of pinacidil in rat blood vessels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J.S. Southerton"
                            1 => "S.G. Taylor"
                            2 => "S.W. Weir"
                            3 => "A.H. Weston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1987"
                        "volumen" => "90"
                        "paginaInicial" => "126P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of cAMP and cGMP-dependent protein kinase and calmodulin on Ca 2+ uptake by highly purified sarcolemal vesiclers of vascular smooth muscle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E. Suematsu"
                            1 => "M. Hirata"
                            2 => "A.H. Kuriya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Acta"
                        "fecha" => "1984"
                        "volumen" => "773"
                        "paginaInicial" => "83"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6329280"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelium dependent effects of acetylcholine on membrane potential, potassium flux and cyclic GMP concentrations in rat aorta: a comparison with sodium nitroprusside and the potassium channel opener, BRL 34915"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S.G. Taylor"
                            1 => "J.S. Southerton"
                            2 => "A.H. Weston"
                            3 => "J.R.J. Baher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1988"
                        "volumen" => "94"
                        "paginaInicial" => "853"
                        "paginaFinal" => "863"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differentiation of calcium antagonists with respect to their effects in normal and skinned taenia caeci preparations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J. Cortijo"
                            1 => "R.W. Foster"
                            2 => "R.C. Small"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pharm Pharmacol"
                        "fecha" => "1987"
                        "volumen" => "39"
                        "paginaInicial" => "283"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2884292"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of some variables in the Triton X-100 method of skinning the plasmalemmal membrane from guinea pig trachealis muscle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J. Cortijo"
                            1 => "J.S. Dixon"
                            2 => "R.W. Foster"
                            3 => "R.C. Small"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pharmacol Methods"
                        "fecha" => "1987"
                        "volumen" => "18"
                        "paginaInicial" => "253"
                        "paginaFinal" => "266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3682844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanical and electrical aspects of the relaxant action of aminophylline in guinea pig isolated trachealis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S.L. Alien"
                            1 => "J. Cortijo"
                            2 => "R.W. Foster"
                            3 => "G.P. Morgan"
                            4 => "R.C. Small"
                            5 => "A.H. Weston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1986"
                        "volumen" => "88"
                        "paginaInicial" => "473"
                        "paginaFinal" => "483"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potassium channel activators lower blood pressure&#59; an initial study of BRL 34915 in hypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M.J. Vandenburg"
                            1 => "S. Arr Woodward"
                            2 => "M. Hassein"
                            3 => "P. Stewart-Long"
                            4 => "T.C.G. Tasker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Hypert"
                        "fecha" => "1986"
                        "volumen" => "4"
                        "paginaInicial" => "S166"
                        "paginaFinal" => "S167"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of nicorandil on rest and effort angina unresponsive to combination therapy with a calcium antagonist and oral nitrate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H. Araki"
                            1 => "N. Hayata"
                            2 => "J.C. Matsuguchi"
                            3 => "M. Nakamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Therap"
                        "fecha" => "1987"
                        "volumen" => "9"
                        "paginaInicial" => "174"
                        "paginaFinal" => "182"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect on the novel antihypertensive agent BRL 34915 on the nutritional blood flow of rat chronically ischaemic muscle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D. Angersbach"
                            1 => "C.D. Nicholson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Naunyn Schiedeberg's Arch Pharmac"
                        "fecha" => "1985"
                        "volumen" => "329"
                        "paginaInicial" => "R61"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversal of agonist-induced bronchoconstriction in the guinea-pig by the potassium channel activator BRL 34915"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D.R. Buckle"
                            1 => "J. Bumstead"
                            2 => "G.D. Clarke"
                            3 => "J.F. Taylor"
                            4 => "S.C. Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Br J Pharmac"
                        "fecha" => "1987"
                        "volumen" => "92"
                        "paginaInicial" => "744P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of histamine induced bronchoconstriction in normal healthy volunteers by a potassium channel activator BRL 34915"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A. Baird"
                            1 => "T.C. Hamilton"
                            2 => "D.H. Richards"
                            3 => "T. Tasker"
                            4 => "A.J. Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Br J Clin Pharmac"
                        "fecha" => "1988"
                        "volumen" => "25"
                        "paginaInicial" => "114P"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18."
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pharmacokinetics of cromakalim (BRL 34915), a new antihypertensive agent in healthy male subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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