Comparacion entre procaterol y salbutamol mediante dosis-respuesta acumulada en pacientes con limitacion cronica al flujo aereo
Comparison between procaterol and salbutamol by means of cumulative dose-response in patients with chronic limitation to airflow
M. Mayos, M. González, P. Casán, J. García-Barbal, J. Sanchís
Unitat de Funcíó Pulmonar. Hospital de la Santa Creu i Sant Pau. Barcelona
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Agustí, F. Burgos, R. Rodríguez Roisín, A. Agustí Vidal" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A.G.N." "apellidos" => "Agustí" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Burgos" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Rodríguez Roisín" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Agustí Vidal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317622?idApp=UINPBA00003Z" "url" => "/03002896/0000002500000002/v1_201509151020/S0300289615317622/v1_201509151020/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Comparacion entre procaterol y salbutamol mediante dosis-respuesta acumulada en pacientes con limitacion cronica al flujo aereo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "65" "paginaFinal" => "68" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Mayos, M. González, P. Casán, J. García-Barbal, J. Sanchís" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Mayos" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "González" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Casán" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "García-Barbal" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Sanchís" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unitat de Funcíó Pulmonar. Hospital de la Santa Creu i Sant Pau. Barcelona" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comparison between procaterol and salbutamol by means of cumulative dose-response in patients with chronic limitation to airflow" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1988-10-26" "fechaAceptado" => "1988-11-14" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El efecto broncodilatador de un nuevo adrenérgico beta-2 inhalado, el procaterol, se comparó con el salbutamol, mediante una técnica de dosis respuesta acumulada.</p><p id="sp2500" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 14 pacientes con limitación crónica al flujo aéreo y respuesta broncodilatadora significativa. El estudio se realizó en dos días consecutivos según diseño ciego simple. Cada día se administró al paciente 10 inhalaciones de uno u otro fármaco, repartidas en dos inhalaciones cada 10 min. La dosis de salbutamol (S) utilizada fue de 0,1<span class="elsevierStyleHsp" style=""></span>mg/inh. con dosis máxima de 1<span class="elsevierStyleHsp" style=""></span>mg y la de procaterol (P) de 0,01<span class="elsevierStyleHsp" style=""></span>mg/ihn. con dosis máxima de 0,1<span class="elsevierStyleHsp" style=""></span>mg. Tres pacientes fueron excluidos por excesiva variación de su espirometría basal durante el estudio y uno por problemas en la administración del aerosol.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El incremento del FEV1 en los primeros 10 min, expresado en porcentaje ponderado sobre el valor basal, fue de 28 SD15% con S y 24 SD17% con P (NS). El incremento máximo fue de 44 SD18% con S y de 41 SD19% con P (NS). Este efecto máximo se alcanzó entre la cuarta y quinta dosis. El incremento alcanzado a los 10 min en relación al máximo fue de 59 SD20% con S y de 46 SD27% con P (NS). En el resto de parámetros espirométricos tampoco hubo diferencias significativas.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En resumen, el procaterol logró un efecto broncodilatador similar al salbutamol. En ambos casos, los resultados obtenidos con la administración acumulativa de fármaco apoyan la posibilidad de aumentar las dosis habitualmente recomendadas para uso clínico de beta-2 en aerosol.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The effect of a new inhaled beta-2-adrenergic drug, procaterol, was compared with that of salbutamol by means of a cumulative dose-response technique.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Fourteen patients with chronic limitation to the airflow and significant bronchodilator response were evaluated. The study was caried out in two consecutive days with a single blind design. Each day, the patient received ten inhalations of either one or the other drug, distributed in two inhalations every 10 minutes. The salbutamol (S) dose was 0,1<span class="elsevierStyleHsp" style=""></span>mg/inhalation, with a maximal dose of 1<span class="elsevierStyleHsp" style=""></span>mg, and that of procaterol (P) was 0,01<span class="elsevierStyleHsp" style=""></span>mg/inhalation, with a maximal dose of 0,1<span class="elsevierStyleHsp" style=""></span>mg. Three patients were excluded because an excessive variation of their baseline spirometric values, and because of problems in the administration of the aerosol.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The increase of FEV1 in the initial 10 minutes, expressed as a weighted percent value of the baseline value, was 28% (SD 15) with S, and 41% (SD 19) with P (NS). The maximal increase was 44% (SD 18) with S and 41% (SD 19) with P (NS). This maximal effect was achieved between the fourth and fifth doses. The maximal increase achieved after 10 minutes as related with the maximal value was 59% (SD 20) with S and 46% (SD 27) with P (NS). In the remaining spirometric parameters there were not significant differences either.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To summarize, procaterol achieved a bronchodilator effect similar to that of salbutamol. In both cases, the results with the cumulative administration of the drug favor the possibility to increase the usually recommended doses for the clinical use of beta-2-adrenergic agents in aerosol.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 18 | 8 | 26 |
| 2024 October | 97 | 37 | 134 |
| 2024 September | 73 | 51 | 124 |
| 2024 August | 104 | 76 | 180 |
| 2024 July | 62 | 51 | 113 |
| 2024 June | 68 | 42 | 110 |
| 2024 May | 87 | 42 | 129 |
| 2024 April | 54 | 40 | 94 |
| 2024 March | 72 | 38 | 110 |
| 2024 February | 50 | 38 | 88 |
| 2024 January | 0 | 6 | 6 |
| 2023 December | 0 | 13 | 13 |
| 2023 November | 0 | 14 | 14 |
| 2023 October | 0 | 7 | 7 |
| 2023 September | 0 | 2 | 2 |
| 2023 August | 0 | 4 | 4 |
| 2023 July | 0 | 18 | 18 |
| 2023 June | 0 | 6 | 6 |
| 2023 May | 0 | 1 | 1 |
| 2023 April | 0 | 1 | 1 |
| 2023 March | 6 | 5 | 11 |
| 2023 February | 48 | 18 | 66 |
| 2023 January | 55 | 33 | 88 |
| 2022 December | 34 | 35 | 69 |
| 2022 November | 80 | 17 | 97 |
| 2022 October | 61 | 35 | 96 |
| 2022 September | 49 | 28 | 77 |
| 2022 August | 41 | 30 | 71 |
| 2022 July | 45 | 37 | 82 |
| 2022 June | 38 | 31 | 69 |
| 2022 May | 47 | 23 | 70 |
| 2022 April | 52 | 33 | 85 |
| 2022 March | 44 | 25 | 69 |
| 2022 February | 56 | 19 | 75 |
| 2022 January | 58 | 27 | 85 |
| 2021 December | 37 | 26 | 63 |
| 2021 November | 42 | 21 | 63 |
| 2021 October | 27 | 37 | 64 |
| 2021 September | 35 | 37 | 72 |
| 2021 August | 23 | 14 | 37 |
| 2021 July | 39 | 30 | 69 |
| 2021 June | 28 | 24 | 52 |
| 2021 May | 28 | 12 | 40 |
| 2021 April | 53 | 49 | 102 |
| 2021 March | 52 | 12 | 64 |
| 2021 February | 53 | 16 | 69 |
| 2021 January | 43 | 19 | 62 |
| 2020 December | 38 | 10 | 48 |
| 2020 November | 31 | 10 | 41 |
| 2020 October | 34 | 15 | 49 |
| 2020 September | 31 | 5 | 36 |
| 2020 August | 33 | 16 | 49 |
| 2020 July | 45 | 15 | 60 |
| 2020 June | 23 | 17 | 40 |
| 2020 May | 48 | 19 | 67 |
| 2020 April | 37 | 25 | 62 |
| 2020 March | 28 | 26 | 54 |
| 2020 February | 36 | 27 | 63 |
| 2020 January | 52 | 24 | 76 |
| 2019 December | 50 | 33 | 83 |
| 2019 November | 24 | 28 | 52 |
| 2019 October | 25 | 26 | 51 |
| 2019 September | 50 | 43 | 93 |
| 2019 August | 27 | 19 | 46 |
| 2019 July | 48 | 29 | 77 |
| 2019 June | 40 | 43 | 83 |
| 2019 May | 41 | 49 | 90 |
| 2019 April | 51 | 40 | 91 |
| 2019 March | 22 | 25 | 47 |
| 2019 February | 17 | 21 | 38 |
| 2019 January | 12 | 21 | 33 |
| 2018 December | 8 | 18 | 26 |
| 2018 November | 19 | 23 | 42 |
| 2018 October | 18 | 23 | 41 |
| 2018 September | 16 | 12 | 28 |
| 2018 May | 10 | 2 | 12 |
| 2018 April | 9 | 5 | 14 |
| 2018 March | 6 | 6 | 12 |
| 2018 February | 10 | 9 | 19 |
| 2018 January | 6 | 7 | 13 |
| 2017 December | 11 | 17 | 28 |
| 2017 November | 7 | 16 | 23 |
| 2017 October | 10 | 24 | 34 |
| 2017 September | 9 | 16 | 25 |
| 2017 August | 14 | 29 | 43 |
| 2017 July | 11 | 22 | 33 |
| 2017 June | 21 | 44 | 65 |
| 2017 May | 19 | 15 | 34 |
| 2017 April | 12 | 17 | 29 |
| 2017 March | 5 | 32 | 37 |
| 2017 February | 3 | 20 | 23 |
| 2017 January | 5 | 14 | 19 |
| 2016 December | 9 | 11 | 20 |
| 2016 November | 16 | 24 | 40 |
| 2016 October | 15 | 36 | 51 |
| 2016 September | 28 | 33 | 61 |
| 2016 August | 27 | 11 | 38 |
| 2016 July | 24 | 15 | 39 |
| 2016 June | 37 | 18 | 55 |
| 2016 May | 23 | 9 | 32 |
| 2016 April | 20 | 0 | 20 |
| 2016 March | 19 | 0 | 19 |
| 2016 February | 18 | 1 | 19 |
| 2016 January | 15 | 4 | 19 |
| 2015 December | 26 | 15 | 41 |
| 2015 November | 27 | 7 | 34 |
| 2015 October | 8 | 2 | 10 |
| 2015 September | 2 | 0 | 2 |
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