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Durán Cantolla" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Durán Cantolla" ] ] ] 1 => array:2 [ "autoresLista" => "J.J. González Macías, R. Agüero Balbín, M. Carbajo Carbajo, F.J. Ortega Morales, M. Hernández Alonso, R. Ondiviela Gracia" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.J." "apellidos" => "González Macías" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Agüero Balbín" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Carbajo Carbajo" ] 3 => array:2 [ "nombre" => "F.J." "apellidos" => "Ortega Morales" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Hernández Alonso" ] 5 => array:2 [ "nombre" => "R." "apellidos" => "Ondiviela Gracia" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310899?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000004/v1_201509151156/S0300289615310899/v1_201509151156/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Reclutamiento alveolar por insuflación transpulmonar a alta presión. Estudio morfométrico experimental" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "202" "paginaFinal" => "206" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "J.D. Escolar Castellón, C. Tejero Juste, M.A. Escolar Castellón" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J.D." "apellidos" => "Escolar Castellón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Tejero Juste" ] 2 => array:2 [ "nombre" => "M.A." "apellidos" => "Escolar Castellón" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Ciencias Morfológicas. Universidad de Zaragoza" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Departamento de Ciencias Morfológicas. Facultad de Medicina. Domingo Miral, s/n. 50008 Zaragoza." ] ] ] 1 => array:3 [ "autoresLista" => "B. Gallego Carrión" "autores" => array:1 [ 0 => array:3 [ "nombre" => "B." "apellidos" => "Gallego Carrión" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Miguel Servet. Zaragoza" "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Alveolar recruitment during inflation at high transpulmonary pressure: An experimental morphometric study" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1993-04-26" "fechaAceptado" => "1993-08-31" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta un estudio experimental en el que se cuestionan, utilizando técnicas morfométricas, los conceptos tradicionales sobre el comportamiento del alveolo ante los cambios de presión.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El incremento de la presión de insuflación pulmonar produce reclutamiento alveolar (aumento en el número de los espacios aéreos distales) por desplegamiento de sus paredes.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Para demostrar la hipótesis se han perfundido pulmones de rata a 25 y 35 cm de presión de agua. Los perfundidos a mayor presión deberán presentar: disminución del tamaño de los alveolos, con adelgazamiento de sus paredes, aumento del perímetro alveolar interno, sin que varíe la cantidad de tejido. El estudio ha sido morfométrico, realizado en un sistema informático. Los resultados se han contrastado con tests estadísticos.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se han utilizado 10 ratas Wistar. Sus pulmones se procesaron para microscopia de luz. Se cuantificaron las siguientes variables: índice de intersección lineal media (Lm), cuerda alveolar, grosor de pared, perímetro alveolar interno y porcentaje de tejido.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La disminución del Lm en los pulmones perfundidos a 35 cm de presión de agua, nos hace considerar que el número de alveolos aumentó; la disminución del Lm y de la cuerda alveolar indican reducción del tamaño de los alveolos; la pared alveolar disminuyó de grosor; el perímetro alveolar interno aumentó. Todas estas diferencias fueron estadísticamente significativas (p < 0,001), siendo el porcentaje de tejido la única variable que no sufrió variación significativa.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Todos estos resultados nos hacen considerar que el aumento de la presión de insuflación pulmonar produce reclutamiento alveolar por desplegamiento de sus paredes.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We describe an experimental study in which morphometric techniques are used to question traditional conceptions about the behavior of the alveolus under changes in pressure.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">An increase in inflation pressure in the lung results in alveolar recruitment (an increase in distal air spaces) due to stretching of its walls.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">To test this hypothesis, the lungs of rats were filled to 25 to 35 cm water pressure. Lungs filled to a higher pressure were expected to present a decrease in alveolar size along with thinning of its walls, and an increase of internal perimeter of the alveolus with no change in amount of tissue. Morphometric data were processed by Computer and results were analyzed by statistical tests.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The lungs of 10 Wistar rats were examined under light microscope. The following variables were recorded: mean linear intersection (Lm), alveolar cord, wall thickness, internal alveolar perimeter and tissue percentage.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Lower Lm in lungs filled to 35 cm water pressure allows us to consider that the number of alveoli increased; lower Lm and alveolar cord indícate that alveolar size is smaller; alveolar wall thickness decreased; internal alveolar perimeter increased. All these differences were statistically significant (p < 0.001), tissue percentage being the only variable that did not change significantly.</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">All results lead us to consider that an increase in lung inflation pressure leads to alveolar recruitment and stretching of its walls.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphological evidence for alveolar recruitment during inflation at high transpulmonary pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Lum" 1 => "I. Huang" 2 => "W. 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