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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta un estudio experimental en el que se cuestionan&#44; utilizando t&#233;cnicas morfom&#233;tricas&#44; los conceptos tradicionales sobre el comportamiento del alveolo ante los cambios de presi&#243;n&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El incremento de la presi&#243;n de insuflaci&#243;n pulmonar produce reclutamiento alveolar &#40;aumento en el n&#250;mero de los espacios a&#233;reos distales&#41; por desplegamiento de sus paredes&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Para demostrar la hip&#243;tesis se han perfundido pulmones de rata a 25 y 35 cm de presi&#243;n de agua&#46; Los perfundidos a mayor presi&#243;n deber&#225;n presentar&#58; disminuci&#243;n del tama&#241;o de los alveolos&#44; con adelgazamiento de sus paredes&#44; aumento del per&#237;metro alveolar interno&#44; sin que var&#237;e la cantidad de tejido&#46; El estudio ha sido morfom&#233;trico&#44; realizado en un sistema inform&#225;tico&#46; Los resultados se han contrastado con tests estad&#237;sticos&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se han utilizado 10 ratas Wistar&#46; Sus pulmones se procesaron para microscopia de luz&#46; Se cuantificaron las siguientes variables&#58; &#237;ndice de intersecci&#243;n lineal media &#40;Lm&#41;&#44; cuerda alveolar&#44; grosor de pared&#44; per&#237;metro alveolar interno y porcentaje de tejido&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La disminuci&#243;n del Lm en los pulmones perfundidos a 35 cm de presi&#243;n de agua&#44; nos hace considerar que el n&#250;mero de alveolos aument&#243;&#59; la disminuci&#243;n del Lm y de la cuerda alveolar indican reducci&#243;n del tama&#241;o de los alveolos&#59; la pared alveolar disminuy&#243; de grosor&#59; el per&#237;metro alveolar interno aument&#243;&#46; Todas estas diferencias fueron estad&#237;sticamente significativas &#40;p &#60; 0&#44;001&#41;&#44; siendo el porcentaje de tejido la &#250;nica variable que no sufri&#243; variaci&#243;n significativa&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Todos estos resultados nos hacen considerar que el aumento de la presi&#243;n de insuflaci&#243;n pulmonar produce reclutamiento alveolar por desplegamiento de sus paredes&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We describe an experimental study in which morphometric techniques are used to question traditional conceptions about the behavior of the alveolus under changes in pressure&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">An increase in inflation pressure in the lung results in alveolar recruitment &#40;an increase in distal air spaces&#41; due to stretching of its walls&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">To test this hypothesis&#44; the lungs of rats were filled to 25 to 35 cm water pressure&#46; Lungs filled to a higher pressure were expected to present a decrease in alveolar size along with thinning of its walls&#44; and an increase of internal perimeter of the alveolus with no change in amount of tissue&#46; Morphometric data were processed by Computer and results were analyzed by statistical tests&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The lungs of 10 Wistar rats were examined under light microscope&#46; The following variables were recorded&#58; mean linear intersection &#40;Lm&#41;&#44; alveolar cord&#44; wall thickness&#44; internal alveolar perimeter and tissue percentage&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Lower Lm in lungs filled to 35 cm water pressure allows us to consider that the number of alveoli increased&#59; lower Lm and alveolar cord ind&#237;cate that alveolar size is smaller&#59; alveolar wall thickness decreased&#59; internal alveolar perimeter increased&#46; All these differences were statistically significant &#40;p &#60; 0&#46;001&#41;&#44; tissue percentage being the only variable that did not change significantly&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">All results lead us to consider that an increase in lung inflation pressure leads to alveolar recruitment and stretching of its walls&#46;</p></span>"
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Reclutamiento alveolar por insuflación transpulmonar a alta presión. Estudio morfométrico experimental
Alveolar recruitment during inflation at high transpulmonary pressure: An experimental morphometric study
J.D. Escolar Castellón*, C. Tejero Juste, M.A. Escolar Castellón
Departamento de Ciencias Morfológicas. Universidad de Zaragoza
B. Gallego Carrión*
* Servicio de Neumología. Hospital Miguel Servet. Zaragoza
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta un estudio experimental en el que se cuestionan&#44; utilizando t&#233;cnicas morfom&#233;tricas&#44; los conceptos tradicionales sobre el comportamiento del alveolo ante los cambios de presi&#243;n&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El incremento de la presi&#243;n de insuflaci&#243;n pulmonar produce reclutamiento alveolar &#40;aumento en el n&#250;mero de los espacios a&#233;reos distales&#41; por desplegamiento de sus paredes&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Para demostrar la hip&#243;tesis se han perfundido pulmones de rata a 25 y 35 cm de presi&#243;n de agua&#46; Los perfundidos a mayor presi&#243;n deber&#225;n presentar&#58; disminuci&#243;n del tama&#241;o de los alveolos&#44; con adelgazamiento de sus paredes&#44; aumento del per&#237;metro alveolar interno&#44; sin que var&#237;e la cantidad de tejido&#46; El estudio ha sido morfom&#233;trico&#44; realizado en un sistema inform&#225;tico&#46; Los resultados se han contrastado con tests estad&#237;sticos&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se han utilizado 10 ratas Wistar&#46; Sus pulmones se procesaron para microscopia de luz&#46; Se cuantificaron las siguientes variables&#58; &#237;ndice de intersecci&#243;n lineal media &#40;Lm&#41;&#44; cuerda alveolar&#44; grosor de pared&#44; per&#237;metro alveolar interno y porcentaje de tejido&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La disminuci&#243;n del Lm en los pulmones perfundidos a 35 cm de presi&#243;n de agua&#44; nos hace considerar que el n&#250;mero de alveolos aument&#243;&#59; la disminuci&#243;n del Lm y de la cuerda alveolar indican reducci&#243;n del tama&#241;o de los alveolos&#59; la pared alveolar disminuy&#243; de grosor&#59; el per&#237;metro alveolar interno aument&#243;&#46; Todas estas diferencias fueron estad&#237;sticamente significativas &#40;p &#60; 0&#44;001&#41;&#44; siendo el porcentaje de tejido la &#250;nica variable que no sufri&#243; variaci&#243;n significativa&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Todos estos resultados nos hacen considerar que el aumento de la presi&#243;n de insuflaci&#243;n pulmonar produce reclutamiento alveolar por desplegamiento de sus paredes&#46;</p></span>"
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                            3 => "K&#46; Macrae"
                            4 => "T&#46; Tetley"
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "J Pathol"
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                        "volumen" => "156"
                        "paginaInicial" => "77"
                        "paginaFinal" => "81"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3193304"
                            "web" => "Medline"
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              "identificador" => "bib0035"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Resp Physiol"
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                        "volumen" => "11"
                        "paginaInicial" => "54"
                        "paginaFinal" => "75"
                      ]
                    ]
                  ]
                ]
              ]
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            7 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A proposed alveolar model for adult human lungs&#58; The Regular Dodecahedron"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Linhartova"
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                            2 => "A&#46;E&#46; Anderson"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Anat Record"
                        "fecha" => "1986"
                        "volumen" => "214"
                        "paginaInicial" => "266"
                        "paginaFinal" => "272"
                      ]
                    ]
                  ]
                ]
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            8 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Three-dimensional reconstruction of the rat acinus"
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                          "autores" => array:2 [
                            0 => "R&#46;R&#46; Mercer"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1987"
                        "volumen" => "63"
                        "paginaInicial" => "785"
                        "paginaFinal" => "794"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3654440"
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                    0 => array:2 [
                      "titulo" => "Alveolar septal folding and lung inflation history"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
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                        "paginaInicial" => "2&#46;369"
                        "paginaFinal" => "2&#46;379"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Branching pattern of airways and air spaces of a single human terminal bronchiole"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;E&#46; Hansen"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "J Appl Physiol"
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                        "volumen" => "38"
                        "paginaInicial" => "983"
                        "paginaFinal" => "989"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1141138"
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Article information
ISSN: 03002896
Original language: Spanish
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