Estudio de las resistencias primarias a fármacos antituberculosos en Galicia
Study of primary resistance to anti-tuberculosis drugs in Galicia
Read
3804
Timeswas read the article
1719
Total PDF
2085
Total HTML
Share statistics
array:23 [ "pii" => "S0300289615310589" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31058-9" "estado" => "S300" "fechaPublicacion" => "1994-06-01" "aid" => "71128" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "1994" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1994;30:297-300" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1456 "formatos" => array:3 [ "EPUB" => 70 "HTML" => 765 "PDF" => 621 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289615310590" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31059-0" "estado" => "S300" "fechaPublicacion" => "1994-06-01" "aid" => "71129" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Arch Bronconeumol. 1994;30:301-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6943 "formatos" => array:3 [ "EPUB" => 72 "HTML" => 1149 "PDF" => 5722 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Uso de los medidores del flujo espiratorio máximo (FEM) en el asma" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "301" "paginaFinal" => "306" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. López Guillén, L. Marqués Amat" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "López Guillén" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Marqués Amat" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310590?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000006/v1_201509151236/S0300289615310590/v1_201509151236/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289615310577" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31057-7" "estado" => "S300" "fechaPublicacion" => "1994-06-01" "aid" => "71127" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1994;30:291-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2218 "formatos" => array:3 [ "EPUB" => 86 "HTML" => 1218 "PDF" => 914 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Fibrobroncoscopia en el cáncer de pulmón: relación entre radiología, endoscopia, histología y rendimiento diagnóstico en una serie de 1.801 casos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "291" "paginaFinal" => "296" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Fibrobronchoscopy in lung cancer: associations among radiology, endoscopy, histology and diagnostic value in a series of 1,801 cases" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "E. Martínez Moragón, J. Sanchis Aldás, A. de Diego Damiá, M. Martínez Francés, E. Cases Viedma, F. Sanchis Moret" "autores" => array:6 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Martínez Moragón" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Sanchis Aldás" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "de Diego Damiá" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Martínez Francés" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Cases Viedma" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Sanchis Moret" ] ] ] 1 => array:2 [ "autoresLista" => "J. Aparicio Urtasun" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Aparicio Urtasun" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310577?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000006/v1_201509151236/S0300289615310577/v1_201509151236/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Estudio de las resistencias primarias a fármacos antituberculosos en Galicia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "297" "paginaFinal" => "300" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Álvarez, J.M. Valle, M.V. Martino, P. Gordo, J. Carreira, L. Valdés" "autores" => array:6 [ 0 => array:3 [ "nombre" => "D." "apellidos" => "Álvarez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "Valle" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M.V." "apellidos" => "Martino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Gordo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Carreira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "L." "apellidos" => "Valdés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Neumología. Hospital de Conxo. Santiago de Compostela. Burela. Lugo" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología. Hospital de Conxo. Santiago de Compostela. Burela. Lugo" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Interna. Hospital da Costa. Burela. Lugo" "etiqueta" => "***" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Unidad de Neumología. Hospital de Conxo. Rúa Dr. Ramón Bailar, s/n. Santiago de Compostela. La Coruña." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Study of primary resistance to anti-tuberculosis drugs in Galicia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1993-08-25" "fechaAceptado" => "1993-11-16" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A lo largo de 15 meses se estudió, de forma prospectiva, la resistencia primaria de 100 cepas de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> aisladas en enfermos diagnosticados de tuberculosis activa mediante confirmación bacteriológica. Se encontraron cepas resistentes, a uno o más fármacos, en el 5% de los pacientes. Tres enfermos presentaron resistencias a dos fármacos (isoniacida y estreptomicina en 2 casos y rifampicina e isoniacida en el otro), uno a tres (isoniacida, estreptomicina y etambutol) y otro únicamente a la pirazinamida. Debido al escaso número de resistencias primarias halladas, no fue posible establecer si alguno de los factores analizados en cada paciente se relacionaba con una mayor tasa de resistencias, si bien 4 de las 5 cepas con resistencia primaria procedían de muestras respiratorias.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Concluimos que la tasa de resistencias primarias en nuestro medio es escasa, lo que nos permite, por una parte, prescindir del uso de un cuarto fármaco durante los dos primeros meses del tratamiento antituberculoso y, por otra, no realizar de forma sistemática pruebas de sensibilidad a pacientes que no refieran historia de tratamiento antituberculoso previo.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The primary resistance of 100 specimens of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> isolated in patients with active tuberculosis confirmed bacteriologically was studied prospectively over a period of 15 months. Strains resistant to 1 or more drugs were found in 5 patients. Three patients presented resistance to 2 drugs (isoniacide and streptomycin in 2 and rifampicin and isoniazid, streptomycin and ethambutol); and the fifth was resistant only to pyrazinamide. Owing to the few instances of primary resistance found, it was impossible to establish whether any of the factors analyzed in each patient was related to a higher index of resistance, although 4 of the 5 resistant strains came from respiratory specimens.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We conclude that the index of primary resistance in our area is low and this allows us to do without prescribing a fourth drug in the first two months of anti-tuberculosis therapy, and makes routine sensitivity tests unnecessary for patients with no history of prior treatment for tuberculosis.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio epidemiológico de la tuberculosis en el Área Sanitaria de Santiago de Compostela durante los años 89. 90 y 91 [resumen]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "M. Salgueiro" 1 => "C. Zamarrón" 2 => "M. Tumbeiro" 3 => "J.M. Valle" 4 => "J.M. Álvarez Dobaño" 5 => "M.L. Pérez del Molino" 6 => "J.R. Rodríguez Suárez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1992" "volumen" => "28" "paginaInicial" => "1.075" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid drug susceptibility testing of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "D.E. Snider" 1 => "R.C. Good" 2 => "J.O. Kilburn" 3 => "L.F. Laskowski Jr." 4 => "R.H. Lusk" 5 => "J.J. Marr" 6 => "Z. Reggiardo" 7 => "G. Middlebrook" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1981.123.4.402" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1981" "volumen" => "123" "paginaInicial" => "402" "paginaFinal" => "406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6784624" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mesure de la sensibilité du bacille tuberculeux aux drogues antibacilaires par le methode des proportions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Canetti" 1 => "N. Rist" 2 => "J. Grosset" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Tuberc Pneumol" "fecha" => "1963" "volumen" => "27" "paginaInicial" => "263" "paginaFinal" => "272" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic standards and classification of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/142.3.725" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1990" "volumen" => "142" "paginaInicial" => "725" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2389921" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistencia primaria a fármacos antituberculosos." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Caminero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1989" "volumen" => "93" "paginaInicial" => "30" "paginaFinal" => "36" "itemHostRev" => array:3 [ "pii" => "S0140673605673941" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consenso Nacional para el control de la Tuberculosis en España." "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo de Trabajo sobre Tuberculosis" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1992" "volumen" => "98" "paginaInicial" => "24" "paginaFinal" => "31" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Investigación de la resistencia adquirida del <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> en la tuberculosis pulmonar del adulto" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Ortega" 1 => "L. Velasco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Enfer Torax" "fecha" => "1973" "volumen" => "22" "paginaInicial" => "537" "paginaFinal" => "548" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistencia bacteriana primaria en la tuberculosis del adulto." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. De Velasco" 1 => "A. Ortega" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1973" "volumen" => "60" "paginaInicial" => "459" "paginaFinal" => "464" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consideraciones sobre la importancia de la bacteriología en la lucha actual contra la tuberculosis en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Casal Román" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev San Hig Pub" "fecha" => "1976" "volumen" => "50" "paginaInicial" => "987" "paginaFinal" => "1.012" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic significance of primary resistance in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. March" 1 => "J.L. López-Sanmartín" 2 => "G. Smidt" 3 => "T. Seix" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1977" "volumen" => "72" "paginaInicial" => "683" "paginaFinal" => "684" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/410596" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dirección General de Salud Pública. Tuberculosis (resistencia del Mycobacterium tuberculosis)." "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Ministerio de Sanidad, Seguridad Social" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Bol Epidemiol Sem" "fecha" => "1980" "paginaInicial" => "1.430" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dirección General de Salud Pública. Vigilancia de la tuberculosis." "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Ministerio de Sanidad, Consumo" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Bol Epidemiol Sem" "fecha" => "1982" "paginaInicial" => "1.539" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aislamiento de Mycobacterias en pacientes de Santa Cruz de Tenerife" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Álvarez" 1 => "A. Sierra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Laboratorio (Granada)" "fecha" => "1982" "volumen" => "74" "paginaInicial" => "425" "paginaFinal" => "432" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dirección General de Salud Pública. Vigilancia de Mycobacterium tuberculosis y otras Mycobacterias" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Ministerio de Sanidad, Consumo" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Bol Epidemiol Sem" "fecha" => "1983" "paginaInicial" => "1.597" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio de las resistencias bacterianas primarias en enfermos tuberculosos de un hospital general." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Ausina" 1 => "L. Matas" 2 => "B. Mirelis" 3 => "P. Coll" 4 => "J. Castella" 5 => "G. Prats" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1984" "volumen" => "82" "paginaInicial" => "741" "paginaFinal" => "744" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dirección General de Salud Pública. Vigilancia de Mycobacterium tuberculosis y otras Mycobacterias." "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Ministerio de Sanidad, Consumo" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Bol Epidemiol Sem" "fecha" => "1984" "paginaInicial" => "1.655" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio de la resistencia inicial de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> en Santa Cruz de Tenerife" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Álvarez" 1 => "A. Sierra" 2 => "J. Doreste" 3 => "R. Chiscano" 4 => "A. Dorta" 5 => "M.I. Camacho" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Enf Infec Microbiol Clin" "fecha" => "1987" "volumen" => "5" "paginaInicial" => "343" "paginaFinal" => "345" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio de las resistencias bacterianas primarias e iniciales en enfermos tuberculosos de un hospital general durante 1983-1987" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Ausina" 1 => "M. García-Barceló" 2 => "M. Luquín" 3 => "F. Belda" 4 => "J. Fernández" 5 => "G. Esteban" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Enf Infec Microbiol Clin" "fecha" => "1990" "volumen" => "8" "paginaInicial" => "274" "paginaFinal" => "277" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Información epidemiológica y tuberculosis en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.F. Martínez Navarro" 1 => "M.V. Martínez de Aragón Esquivias" 2 => "A.C. Berjón Barrientos" 3 => "H. Rebollo Rodrigo" 4 => "P. Gutiérrez Meléndez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev San Hig Pub" "fecha" => "1990" "volumen" => "64" "paginaInicial" => "347" "paginaFinal" => "357" "itemHostRev" => array:3 [ "pii" => "S0735109706010436" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología de las resistencias bacilares en la isla de Gran Canaria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Caminero" 1 => "A. González" 2 => "F. Rodríguez de Castro" 3 => "G. Juliá" 4 => "J.M. Fernández" 5 => "P. Cabrera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1991" "volumen" => "27" "paginaInicial" => "17" "paginaFinal" => "22" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of tuberculosis and other mycobacterial disease" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1983.127.6.790" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1983" "volumen" => "127" "paginaInicial" => "790" "paginaFinal" => "796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6859666" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistencias primarias y secundarias a las drogas antituberculosas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. March" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Revista Ibys" "fecha" => "1970" "volumen" => "2" "paginaInicial" => "137" "paginaFinal" => "174" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug resistance in tuberculosis control" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Shimao" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Tubercle" "fecha" => "1987" "volumen" => "68" "numero" => "Supl" "paginaInicial" => "5" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3120383" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of drug-resistant <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.L. Aitken" 1 => "R. Sparks" 2 => "K. Anderson" 3 => "R.K. Albert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1984.130.5.831" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1984" "volumen" => "130" "paginaInicial" => "831" "paginaFinal" => "833" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6437306" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003000000006/v1_201509151236/S0300289615310589/v1_201509151236/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003000000006/v1_201509151236/S0300289615310589/v1_201509151236/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310589?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 4 | 8 |
| 2024 October | 50 | 16 | 66 |
| 2024 September | 38 | 11 | 49 |
| 2024 August | 47 | 24 | 71 |
| 2024 July | 43 | 26 | 69 |
| 2024 June | 58 | 26 | 84 |
| 2024 May | 47 | 36 | 83 |
| 2024 April | 42 | 29 | 71 |
| 2024 March | 34 | 34 | 68 |
| 2024 February | 41 | 46 | 87 |
| 2024 January | 0 | 8 | 8 |
| 2023 September | 0 | 1 | 1 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 1 | 1 |
| 2023 March | 5 | 4 | 9 |
| 2023 February | 33 | 16 | 49 |
| 2023 January | 32 | 24 | 56 |
| 2022 December | 47 | 45 | 92 |
| 2022 November | 53 | 15 | 68 |
| 2022 October | 25 | 26 | 51 |
| 2022 September | 23 | 15 | 38 |
| 2022 August | 41 | 45 | 86 |
| 2022 July | 22 | 29 | 51 |
| 2022 June | 25 | 35 | 60 |
| 2022 May | 37 | 28 | 65 |
| 2022 April | 29 | 32 | 61 |
| 2022 March | 36 | 37 | 73 |
| 2022 February | 36 | 20 | 56 |
| 2022 January | 35 | 33 | 68 |
| 2021 December | 16 | 34 | 50 |
| 2021 November | 27 | 24 | 51 |
| 2021 October | 20 | 38 | 58 |
| 2021 September | 15 | 41 | 56 |
| 2021 August | 16 | 29 | 45 |
| 2021 July | 23 | 27 | 50 |
| 2021 June | 18 | 24 | 42 |
| 2021 May | 13 | 20 | 33 |
| 2021 April | 24 | 29 | 53 |
| 2021 March | 31 | 14 | 45 |
| 2021 February | 29 | 14 | 43 |
| 2021 January | 21 | 9 | 30 |
| 2020 December | 17 | 19 | 36 |
| 2020 November | 9 | 2 | 11 |
| 2020 October | 12 | 5 | 17 |
| 2020 September | 17 | 7 | 24 |
| 2020 August | 17 | 2 | 19 |
| 2020 July | 21 | 13 | 34 |
| 2020 June | 12 | 19 | 31 |
| 2020 May | 18 | 19 | 37 |
| 2020 April | 25 | 14 | 39 |
| 2020 March | 17 | 18 | 35 |
| 2020 February | 28 | 18 | 46 |
| 2020 January | 34 | 19 | 53 |
| 2019 December | 41 | 29 | 70 |
| 2019 November | 9 | 10 | 19 |
| 2019 October | 19 | 17 | 36 |
| 2019 September | 9 | 14 | 23 |
| 2019 August | 18 | 9 | 27 |
| 2019 July | 16 | 21 | 37 |
| 2019 June | 11 | 15 | 26 |
| 2019 May | 22 | 29 | 51 |
| 2019 April | 34 | 38 | 72 |
| 2019 March | 15 | 21 | 36 |
| 2019 February | 12 | 10 | 22 |
| 2019 January | 10 | 15 | 25 |
| 2018 December | 12 | 13 | 25 |
| 2018 November | 13 | 15 | 28 |
| 2018 October | 35 | 21 | 56 |
| 2018 September | 15 | 4 | 19 |
| 2018 May | 6 | 1 | 7 |
| 2018 April | 5 | 3 | 8 |
| 2018 March | 8 | 4 | 12 |
| 2018 February | 6 | 8 | 14 |
| 2018 January | 8 | 5 | 13 |
| 2017 December | 9 | 12 | 21 |
| 2017 November | 2 | 3 | 5 |
| 2017 October | 9 | 8 | 17 |
| 2017 September | 8 | 19 | 27 |
| 2017 August | 10 | 10 | 20 |
| 2017 July | 5 | 15 | 20 |
| 2017 June | 10 | 14 | 24 |
| 2017 May | 8 | 12 | 20 |
| 2017 April | 13 | 18 | 31 |
| 2017 March | 5 | 21 | 26 |
| 2017 February | 5 | 8 | 13 |
| 2017 January | 3 | 7 | 10 |
| 2016 December | 14 | 11 | 25 |
| 2016 November | 22 | 16 | 38 |
| 2016 October | 25 | 18 | 43 |
| 2016 September | 20 | 16 | 36 |
| 2016 August | 21 | 12 | 33 |
| 2016 July | 22 | 7 | 29 |
| 2016 June | 25 | 14 | 39 |
| 2016 May | 31 | 18 | 49 |
| 2016 April | 16 | 0 | 16 |
| 2016 March | 19 | 1 | 20 |
| 2016 February | 15 | 1 | 16 |
| 2016 January | 19 | 6 | 25 |
| 2015 December | 26 | 14 | 40 |
| 2015 November | 28 | 9 | 37 |
| 2015 October | 7 | 2 | 9 |
| 2015 September | 1 | 0 | 1 |
Show all
