Receptor para el factor de crecimiento epidérmico en el cáncer de pulmón no microcítico
Epidermic growth factor receptor in non-small cell carcinoma of the lung
M. Díeza,*, M.L. Maestrob, A. Torresc, F. Hernandoc, M.D. Ortegad, J.A. García-Asenjoe, A. Picardoc, J.M. Mugüerzaa, A. Sánchez-Pernautec, J.L. Balibreac
a Servicio de Cirugía General. Hospital Universitario. Alcalá de Henares. Madrid
b Servicios de Medicina Nuclear, Hospital Universitario San Carlos. Madrid
c Servicios de Cirugía General II, Hospital Universitario San Carlos. Madrid
d Servicios de Bioquímica Clínica, Hospital Universitario San Carlos. Madrid
e Servicios de Anatomía Patológica.Hospital Universitario San Carlos. Madrid
Read
4880
Timeswas read the article
2035
Total PDF
2845
Total HTML
Share statistics
array:23 [ "pii" => "S0300289615310553" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31055-3" "estado" => "S300" "fechaPublicacion" => "1994-06-01" "aid" => "71125" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "1994" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1994;30:282-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2045 "formatos" => array:3 [ "EPUB" => 86 "HTML" => 1132 "PDF" => 827 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289615310565" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31056-5" "estado" => "S300" "fechaPublicacion" => "1994-06-01" "aid" => "71126" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1994;30:287-90" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1379 "formatos" => array:3 [ "EPUB" => 57 "HTML" => 822 "PDF" => 500 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Utilidad de los dispositivos deshumidificadores en la reducción de la concentración de ácaros" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "287" "paginaFinal" => "290" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Use of dehumidifiers in the reduction of dust mites" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.F. Medina Gallardo, J. Castillo Gómez, F. Capote Gil, R. Ayerbe García, M.A. Sánchez Armengol, M.L. Muñoz Biedma" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Medina Gallardo" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Castillo Gómez" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Capote Gil" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Ayerbe García" ] 4 => array:2 [ "nombre" => "M.A." "apellidos" => "Sánchez Armengol" ] 5 => array:2 [ "nombre" => "M.L." "apellidos" => "Muñoz Biedma" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310565?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000006/v1_201509151236/S0300289615310565/v1_201509151236/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289615310541" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31054-1" "estado" => "S300" "fechaPublicacion" => "1994-06-01" "aid" => "71124" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1994;30:278-81" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1196 "formatos" => array:3 [ "EPUB" => 81 "HTML" => 653 "PDF" => 462 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Comparación de la rapidez de acción de terbutalino en inhalador de polvo seco con el aerosol presurizado" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "278" "paginaFinal" => "281" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Speed of action of dry-powder vs pressurized aerosol terbutaline" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Belda Ramírez, P. Casan Clarà, M. González Molina, J. Sanchis Aldás" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Belda Ramírez" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Casan Clarà" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "González Molina" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Sanchis Aldás" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310541?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000006/v1_201509151236/S0300289615310541/v1_201509151236/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Receptor para el factor de crecimiento epidérmico en el cáncer de pulmón no microcítico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "282" "paginaFinal" => "286" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Díez, M.L. Maestro, A. Torres, F. Hernando, M.D. Ortega, J.A. García-Asenjo, A. Picardo, J.M. Mugüerza, A. Sánchez-Pernaute, J.L. Balibrea" "autores" => array:10 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Díez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.L." "apellidos" => "Maestro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Hernando" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "M.D." "apellidos" => "Ortega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "J.A." "apellidos" => "García-Asenjo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "A." "apellidos" => "Picardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 7 => array:3 [ "nombre" => "J.M." "apellidos" => "Mugüerza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 8 => array:3 [ "nombre" => "A." "apellidos" => "Sánchez-Pernaute" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 9 => array:3 [ "nombre" => "J.L." "apellidos" => "Balibrea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía General. Hospital Universitario. Alcalá de Henares. Madrid" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios de Medicina Nuclear, Hospital Universitario San Carlos. Madrid" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicios de Cirugía General II, Hospital Universitario San Carlos. Madrid" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicios de Bioquímica Clínica, Hospital Universitario San Carlos. Madrid" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicios de Anatomía Patológica.Hospital Universitario San Carlos. Madrid" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Cirugía General. Hospital Universitario. Alcalá de Henares. Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidermic growth factor receptor in non-small cell carcinoma of the lung" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1993-07-01" "fechaAceptado" => "1993-10-29" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En este trabajo se estudia la concentración de receptor para el factor epidérmico de crecimiento (EGFr) en el cáncer de pulmón no microcítico (CPNM) y se analiza la relación con factores anatomopatológicos y clínicos de estas neoplasias. La concentración de EGFr en 62 muestras de tejido tumoral fue 9,9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>14 fmol/mg, superior a la encontrada en 14 muestras de tejido procedente de neumotórax espontáneo (3,9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3,6 fmol/ mg) (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,005). La concentración de EGFr en el tejido pulmonar no afectado por la neoplasia fue 6,5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>10 fmol/mg. En 21 (33%) casos de CPNM la concentración fue superior al nivel adoptado como umbral de normalidad (10 fmol/mg). El valor de EGFr fue superior en los carcinomas epidermoides que en los otros tipos histológicos (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,042). No se detectó relación significativa entre nivel de EGFr y estadio TNM, grado de diferenciación e índice mitótico. La probabilidad de permanecer libre de recidiva tumoral y la supervivencia global a los 24 meses entre los sujetos que presentaron una concentración de EGFr en el tumor inferior a 10 fmol/mg fueron 34 y 40%, respectivamente. Dichas tasas para los pacientes con valores superiores al dintel fueron 20% (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,32) y 25% (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,26), respectivamente. Los resultados parecen indicar que el estudio de la concentración de EGFr, de forma aislada, no implica consecuencias prácticas importantes para el manejo clínico de los pacientes con CPNM intervenidos quirúrgicamente. La expresión de EGFr en CPNM se comporta como un marcador del grado de diferenciación, con implicaciones pronósticas derivadas de su relación con otros factores asociados.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In this study we determined the concentration of epidermic growth factor receptors (EGFr) in non-small cell carcinoma of the lung (NSCCL) and analyzed its relation to the anatomical, pathological and clinical factors of these neoplasms. The concentration of EGFr in 62 tumor tissue samples was 9.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>14 fmol/mg, higher than that found in 14 tissue samples from cases of spontaneous pneumothorax (3.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.6 fmol/mg) (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.005). EGFr concentration in lung tissue with no signs of neoplasm was 6.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>10 fmol/mg. In 21 (33%) cases of NSCCL the concentration exceded the normal threshold of 10 fmol/mg. EGFr concentration was higher in cases of epidermoid carcinoma than in other tissue samples (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.042). No significant association was found between EGFr levels and status of tumor node metastasis, degree of differentiation and mitotic index. The probability of remaining free of tumor recurrence and of survival after 24 months among patients whose tumoral EGFr concentration was below 10 fmol/mg was 34 and 40%, respectively. The rates for patients with concentrations that exceeded the threshold were 20% (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.32) and 25% (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.26), respectively. The results seem to indicate that the study of EGFr concentration alone does not yield practically important information for the management of patients with NSCCL who have undergone surgery. The concentration of EGFr marks degree of differentiation in NSCCL and has prognostic implications derived from its association with other factors.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung Cancer Biology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.N. Carney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "1991" "volumen" => "27" "paginaInicial" => "369" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1827333" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemial growth factor and transforming growth factor alfa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.W. Burgess" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br Med Bull" "fecha" => "1989" "volumen" => "45" "paginaInicial" => "401" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2688814" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemial growth factor, its receptor and related proteins" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Carpenter" 1 => "J.G. Zendegui" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Exp Cell Res" "fecha" => "1986" "volumen" => "164" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3007185" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth of mammary epithelial cells in breast cancer biopsies correlated with EGF binding" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Spitzer" 1 => "R. Grosse" 2 => "D. Kunde" 3 => "H.E. Schmidt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Cancer" "fecha" => "1987" "volumen" => "39" "paginaInicial" => "279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3493223" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemial growth factor receptor status as predictor of early recurrence and of death from breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.R.C. Sainsbury" 1 => "J.R. Farndon" 2 => "G.K. Needham" 3 => "A.J. Malcom" 4 => "A.L. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S2352-3018(14)70027-X" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1987" "volumen" => "1" "paginaInicial" => "1.398" "paginaFinal" => "1.402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26366430" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of Her-2/neu oncogene protein product and epidermal growth factor receptors in surgical specimens of human breast cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.E. Moe" 1 => "K.S. Moe" 2 => "P. Porter" 3 => "A. Gown" 4 => "G. Ellis" 5 => "D. Tapper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg" "fecha" => "1991" "volumen" => "161" "paginaInicial" => "580" "paginaFinal" => "583" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1674411" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological Typing of Lung Tumors" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "WHO" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "edicion" => "2.<span class="elsevierStyleSup">a</span>" "fecha" => "1981" "editorial" => "Ginebra" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumors of the lower respiratory tract" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Carter" 1 => "J.L. Eggleston" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Atlas of tumor pathology. Serono Series. Pt 17" "fecha" => "1980" "editorial" => "AFIP" "editorialLocalizacion" => "Washington DC" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma of the Lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.J. Mooi" 1 => "B.J. Addis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The Lungs. Edimburg" "paginaInicial" => "341" "paginaFinal" => "372" "serieFecha" => "1990" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new International Staging system for lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.F. Mountain" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1986" "volumen" => "89" "numero" => "Supl" "paginaInicial" => "225" "paginaFinal" => "231" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cáncer. Use of archival tissue and correlation of RGF-R with histology, tumor size, node status and survival" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "H. Dazzi" 1 => "P.S. Hasleton" 2 => "N. Thatcher" 3 => "D.M. Barnes" 4 => "S. Wilkes" 5 => "R. Swindell" 6 => "R.A.M. Lawson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1989" "volumen" => "59" "paginaInicial" => "746" "paginaFinal" => "749" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2544220" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human squamous cell lung cancers express increased epidermal growth factor receptors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.J. Handler" 1 => "B.W. Ozanne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI111463" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1984" "volumen" => "74" "paginaInicial" => "647" "paginaFinal" => "651" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6086719" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth factor receptor in lung malignancies. Comparison between cancer and normal tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "R. Dittadi" 1 => "M. Gion" 2 => "V. Pagan" 3 => "A. Brazzale" 4 => "O. Del Maschio" 5 => "A. Bargossi" 6 => "A. Busetto" 7 => "G. Bruscagnin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1991" "volumen" => "64" "paginaInicial" => "741" "paginaFinal" => "744" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1654986" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of EGF. TGF-alpha and EGFR in squamous cell lung carcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "V. Gorgoulis" 1 => "D. Aninos" 2 => "P. Mikou" 3 => "P. Kanavaros" 4 => "A. Karameris" 5 => "J. Joardanoglou" 6 => "A. Rasidakis" 7 => "M. Veslemes" 8 => "B. Ozanne" 9 => "D.A. Spandidos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anticancer Res" "fecha" => "1992" "volumen" => "12" "paginaInicial" => "1.183" "paginaFinal" => "1.187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1363515" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth factor receptors in lung tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.S. Berger" 1 => "W.J. Gullick" 2 => "C. Greenfield" 3 => "S. Evans" 4 => "B.J. Addis" 5 => "M.D. Waterfíeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/path.1711520408" "Revista" => array:5 [ "tituloSerie" => "J Pathol" "fecha" => "1987" "volumen" => "152" "paginaInicial" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3668732" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth factor receptors in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Veale" 1 => "T. Asheroft" 2 => "C. Marsh" 3 => "G.J. Gigson" 4 => "A.L. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1987" "volumen" => "55" "paginaInicial" => "513" "paginaFinal" => "516" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3038157" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of epidermal growth factor receptors in human lung tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.L. Hwang" 1 => "Y.C. Tay" 2 => "S.S. Lin" 3 => "A. Lev-Ran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Cancer" "fecha" => "1986" "volumen" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3756819" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of epidermal growth factor receptor in primary human non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Veale" 1 => "N. Kerr" 2 => "G.J. Gigson" 3 => "A.L. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1989" "volumen" => "49" "paginaInicial" => "1.313" "paginaFinal" => "1.317" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2684406" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth factor receptor: results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroup" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Nicholson" 1 => "J. Richard" 2 => "C. Sainsbury" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1054/bjoc.2000.1192" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1991" "volumen" => "83" "paginaInicial" => "146" "paginaFinal" => "150" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10901362" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "and imaging trial of indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ 0 => "C.R. Divgi" 1 => "S. Welt" 2 => "S. Kris" 3 => "F.X. Real" 4 => "S.D. Yeh" 5 => "R. Gralla" 6 => "B. Merchant" 7 => "S. Schweighart" 8 => "M. Unger" 9 => "S.M. Larson" 10 => "I. Phase" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "1991" "volumen" => "83" "paginaInicial" => "97" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1988695" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003000000006/v1_201509151236/S0300289615310553/v1_201509151236/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003000000006/v1_201509151236/S0300289615310553/v1_201509151236/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310553?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 1 | 4 |
| 2024 October | 40 | 23 | 63 |
| 2024 September | 33 | 17 | 50 |
| 2024 August | 50 | 29 | 79 |
| 2024 July | 35 | 26 | 61 |
| 2024 June | 43 | 32 | 75 |
| 2024 May | 50 | 28 | 78 |
| 2024 April | 37 | 28 | 65 |
| 2024 March | 47 | 34 | 81 |
| 2024 February | 39 | 48 | 87 |
| 2024 January | 0 | 16 | 16 |
| 2023 December | 0 | 4 | 4 |
| 2023 November | 0 | 3 | 3 |
| 2023 October | 0 | 2 | 2 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 3 | 3 |
| 2023 May | 0 | 3 | 3 |
| 2023 March | 5 | 2 | 7 |
| 2023 February | 50 | 15 | 65 |
| 2023 January | 32 | 24 | 56 |
| 2022 December | 30 | 20 | 50 |
| 2022 November | 45 | 20 | 65 |
| 2022 October | 38 | 31 | 69 |
| 2022 September | 20 | 22 | 42 |
| 2022 August | 41 | 43 | 84 |
| 2022 July | 24 | 31 | 55 |
| 2022 June | 25 | 40 | 65 |
| 2022 May | 40 | 30 | 70 |
| 2022 April | 30 | 27 | 57 |
| 2022 March | 52 | 36 | 88 |
| 2022 February | 46 | 16 | 62 |
| 2022 January | 26 | 39 | 65 |
| 2021 December | 29 | 42 | 71 |
| 2021 November | 23 | 40 | 63 |
| 2021 October | 45 | 41 | 86 |
| 2021 September | 43 | 41 | 84 |
| 2021 August | 19 | 28 | 47 |
| 2021 July | 23 | 31 | 54 |
| 2021 June | 27 | 45 | 72 |
| 2021 May | 26 | 29 | 55 |
| 2021 April | 82 | 43 | 125 |
| 2021 March | 57 | 18 | 75 |
| 2021 February | 48 | 13 | 61 |
| 2021 January | 26 | 14 | 40 |
| 2020 December | 49 | 17 | 66 |
| 2020 November | 36 | 10 | 46 |
| 2020 October | 30 | 1 | 31 |
| 2020 September | 23 | 8 | 31 |
| 2020 August | 19 | 4 | 23 |
| 2020 July | 34 | 18 | 52 |
| 2020 June | 44 | 15 | 59 |
| 2020 May | 54 | 9 | 63 |
| 2020 April | 51 | 8 | 59 |
| 2020 March | 32 | 31 | 63 |
| 2020 February | 42 | 22 | 64 |
| 2020 January | 62 | 27 | 89 |
| 2019 December | 64 | 23 | 87 |
| 2019 November | 50 | 19 | 69 |
| 2019 October | 49 | 25 | 74 |
| 2019 September | 44 | 36 | 80 |
| 2019 August | 31 | 22 | 53 |
| 2019 July | 56 | 23 | 79 |
| 2019 June | 53 | 28 | 81 |
| 2019 May | 70 | 44 | 114 |
| 2019 April | 88 | 25 | 113 |
| 2019 March | 36 | 37 | 73 |
| 2019 February | 19 | 13 | 32 |
| 2019 January | 14 | 9 | 23 |
| 2018 December | 31 | 20 | 51 |
| 2018 November | 32 | 16 | 48 |
| 2018 October | 36 | 14 | 50 |
| 2018 September | 30 | 18 | 48 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 8 | 7 | 15 |
| 2018 March | 8 | 6 | 14 |
| 2018 February | 5 | 8 | 13 |
| 2018 January | 8 | 8 | 16 |
| 2017 December | 11 | 9 | 20 |
| 2017 November | 3 | 4 | 7 |
| 2017 October | 10 | 25 | 35 |
| 2017 September | 12 | 16 | 28 |
| 2017 August | 16 | 43 | 59 |
| 2017 July | 6 | 32 | 38 |
| 2017 June | 8 | 36 | 44 |
| 2017 May | 7 | 46 | 53 |
| 2017 April | 13 | 21 | 34 |
| 2017 March | 4 | 23 | 27 |
| 2017 February | 5 | 9 | 14 |
| 2017 January | 1 | 10 | 11 |
| 2016 December | 7 | 7 | 14 |
| 2016 November | 17 | 13 | 30 |
| 2016 October | 12 | 18 | 30 |
| 2016 September | 23 | 18 | 41 |
| 2016 August | 18 | 10 | 28 |
| 2016 July | 16 | 6 | 22 |
| 2016 June | 14 | 9 | 23 |
| 2016 May | 13 | 5 | 18 |
| 2016 April | 8 | 0 | 8 |
| 2016 March | 7 | 0 | 7 |
| 2016 February | 6 | 0 | 6 |
| 2016 January | 17 | 7 | 24 |
| 2015 December | 18 | 11 | 29 |
| 2015 November | 27 | 5 | 32 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 1 | 0 | 1 |
Show all
