Comparación de la rapidez de acción de terbutalino en inhalador de polvo seco con el aerosol presurizado
Speed of action of dry-powder vs pressurized aerosol terbutaline
Departamento de Neumología. Hospital de la Santa Creu i Sant Pau. Barcelona
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Torres, M. El-Ebiary" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Torres" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "El-Ebiary" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961531053X?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000006/v1_201509151236/S030028961531053X/v1_201509151236/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Comparación de la rapidez de acción de terbutalino en inhalador de polvo seco con el aerosol presurizado" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "278" "paginaFinal" => "281" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Belda Ramírez, P. Casan Clarà, M. González Molina, J. Sanchis Aldás" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Belda Ramírez" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Casan Clarà" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "González Molina" ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Sanchis Aldás" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Neumología. Hospital de la Santa Creu i Sant Pau. Barcelona" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Departamento de Neumología. Hospital de la Santa Creu i Sant Pau. Avda. Sant Antoni M.<span class="elsevierStyleSup">a</span> Claret, 167. 08005 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Speed of action of dry-powder vs pressurized aerosol terbutaline" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1993-06-22" "fechaAceptado" => "1993-10-29" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En 9 pacientes con obstrucción reversible al flujo aéreo se comparó la rapidez de acción broncodilatadora de terbutalino en polvo, administrado con el sistema Turbuhaler<span class="elsevierStyleSup">®</span> y la del mismo fármaco, administrado en aerosol líquido por cartucho presurizado. En 2 días consecutivos se administraron 0,5 mg de terbutalino en cartucho presurizado o en Turbuhaler<span class="elsevierStyleSup">®</span>, realizándose una espirometría basal previa, a los 15, 45 y 90 s y a los 3, 5, 10, 15, 30, 60 y 120 min de la administración del fármaco. Ambas formas de presentación produjeron aproximadamente el 50% de su efecto máximo en los primeros 45 s, alcanzando la media de los incrementos máximos del FEV<span class="elsevierStyleInf">1</span>, el 80% a los 10 min para el aerosol en polvo y el 83% a los 10 min para el cartucho presurizado; el incremento máximo se alcanzó a los 52 (54) min para el Turbuhaler<span class="elsevierStyleSup">®</span> y a los 69 (50) min para el cartucho presurizado. El estudio estadístico no reveló diferencias significativas en la rapidez broncodilatadora de ambas formas de presentación. El sistema de administración en polvo del terbutalino (Turbuhaler<span class="elsevierStyleSup">®</span>) fue tan rápido y eficaz en su respuesta broncodilatadora como el cartucho presurizado de aerosol.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The speed of bronchodilatation with terbutaline administered through the Turbuhaler<span class="elsevierStyleSup">®</span> system and the same drug administered through a pressurized liquid aerosol device was compared in 9 patients with reversible air flow obstruction. On 2 consecutive days, terbutaline 0.5 mg in aerosol or dry-powder form (Turbuhaler<span class="elsevierStyleSup">®</span>) was administered after baseline spirometric measurements were taken. Spirometry was repeated at 15, 45 and 90 s and at 3, 5, 10, 15, 30, 60 and 120 min after administration of the drug. Both forms of presentation produced approximately 50% of their maximum effect within the first 45 s; 80% of the patients in the dry-powder group reached the mean of maximum FEV<span class="elsevierStyleInf">1</span> increase at 10 min, while 83% in the pressurized-aerosol-device group did so. The maximum increase was reached at 52 (54) min with the Turbuhaler<span class="elsevierStyleSup">®</span> and at 69 (50) min for the aerosol. The difference in speed of effect for the two pharmaceutical forms were not statistically signiflcant. The administration of terbutaline in powder form (Turbuhaler<span class="elsevierStyleSup">®</span>) was as fast and effective in achieving bronchodilatation as was the aerosol form.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 2 | 5 |
| 2024 October | 37 | 11 | 48 |
| 2024 September | 39 | 16 | 55 |
| 2024 August | 50 | 38 | 88 |
| 2024 July | 36 | 21 | 57 |
| 2024 June | 50 | 22 | 72 |
| 2024 May | 46 | 29 | 75 |
| 2024 April | 35 | 23 | 58 |
| 2024 March | 38 | 37 | 75 |
| 2024 February | 54 | 40 | 94 |
| 2024 January | 0 | 8 | 8 |
| 2023 December | 0 | 10 | 10 |
| 2023 October | 0 | 2 | 2 |
| 2023 July | 0 | 4 | 4 |
| 2023 March | 5 | 2 | 7 |
| 2023 February | 24 | 18 | 42 |
| 2023 January | 28 | 25 | 53 |
| 2022 December | 33 | 19 | 52 |
| 2022 November | 38 | 15 | 53 |
| 2022 October | 26 | 36 | 62 |
| 2022 September | 28 | 15 | 43 |
| 2022 August | 33 | 40 | 73 |
| 2022 July | 24 | 35 | 59 |
| 2022 June | 22 | 23 | 45 |
| 2022 May | 31 | 25 | 56 |
| 2022 April | 28 | 30 | 58 |
| 2022 March | 37 | 32 | 69 |
| 2022 February | 33 | 19 | 52 |
| 2022 January | 25 | 28 | 53 |
| 2021 December | 21 | 32 | 53 |
| 2021 November | 18 | 24 | 42 |
| 2021 October | 35 | 28 | 63 |
| 2021 September | 35 | 39 | 74 |
| 2021 August | 37 | 24 | 61 |
| 2021 July | 25 | 25 | 50 |
| 2021 June | 45 | 31 | 76 |
| 2021 May | 31 | 15 | 46 |
| 2021 April | 17 | 23 | 40 |
| 2021 March | 32 | 8 | 40 |
| 2021 February | 23 | 14 | 37 |
| 2021 January | 23 | 6 | 29 |
| 2020 December | 35 | 18 | 53 |
| 2020 November | 10 | 8 | 18 |
| 2020 October | 17 | 8 | 25 |
| 2020 September | 19 | 4 | 23 |
| 2020 August | 25 | 11 | 36 |
| 2020 July | 23 | 12 | 35 |
| 2020 June | 23 | 8 | 31 |
| 2020 May | 22 | 9 | 31 |
| 2020 April | 20 | 6 | 26 |
| 2020 March | 22 | 19 | 41 |
| 2020 February | 24 | 13 | 37 |
| 2020 January | 32 | 15 | 47 |
| 2019 December | 29 | 23 | 52 |
| 2019 November | 15 | 6 | 21 |
| 2019 October | 11 | 7 | 18 |
| 2019 September | 21 | 18 | 39 |
| 2019 August | 5 | 7 | 12 |
| 2019 July | 21 | 19 | 40 |
| 2019 June | 22 | 5 | 27 |
| 2019 May | 18 | 33 | 51 |
| 2019 April | 51 | 46 | 97 |
| 2019 March | 15 | 12 | 27 |
| 2019 February | 6 | 9 | 15 |
| 2019 January | 5 | 7 | 12 |
| 2018 December | 13 | 13 | 26 |
| 2018 November | 12 | 10 | 22 |
| 2018 October | 15 | 3 | 18 |
| 2018 September | 18 | 8 | 26 |
| 2018 May | 4 | 2 | 6 |
| 2018 April | 11 | 4 | 15 |
| 2018 March | 3 | 7 | 10 |
| 2018 February | 7 | 10 | 17 |
| 2018 January | 8 | 10 | 18 |
| 2017 December | 7 | 12 | 19 |
| 2017 November | 6 | 4 | 10 |
| 2017 October | 8 | 7 | 15 |
| 2017 September | 6 | 3 | 9 |
| 2017 August | 9 | 16 | 25 |
| 2017 July | 8 | 8 | 16 |
| 2017 June | 9 | 7 | 16 |
| 2017 May | 4 | 4 | 8 |
| 2017 April | 13 | 8 | 21 |
| 2017 March | 4 | 4 | 8 |
| 2017 February | 5 | 7 | 12 |
| 2017 January | 3 | 4 | 7 |
| 2016 December | 11 | 4 | 15 |
| 2016 November | 23 | 13 | 36 |
| 2016 October | 21 | 14 | 35 |
| 2016 September | 12 | 17 | 29 |
| 2016 August | 14 | 6 | 20 |
| 2016 July | 23 | 7 | 30 |
| 2016 June | 20 | 10 | 30 |
| 2016 May | 8 | 4 | 12 |
| 2016 April | 6 | 0 | 6 |
| 2016 March | 5 | 1 | 6 |
| 2016 February | 5 | 1 | 6 |
| 2016 January | 13 | 5 | 18 |
| 2015 December | 23 | 11 | 34 |
| 2015 November | 20 | 4 | 24 |
| 2015 October | 7 | 1 | 8 |
| 2015 September | 2 | 0 | 2 |
Show all
