Aportación del test broncodilatador al estudio de la reversibilidad bronquial
Contribution of the bronchodilator test in the assessment of bronchoreversibility
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Blanquer Olivas, M.A. Cabezudo Hernández, A. Capelastegui Sáiz, V. Gil Suay, M.A. De Gregorio Ariza, J.L. Lobo Beristain, D. Nauffal Mansur, M. Oribe Ibáñez, J. Ruiz Manzano, F. Ruiz Montait, R. Vidal Pía" "autores" => array:12 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Blanquer Olivas" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Cabezudo Hernández" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Capelastegui Sáiz" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Gil Suay" ] 4 => array:2 [ "nombre" => "M.A." "apellidos" => "De Gregorio Ariza" ] 5 => array:2 [ "nombre" => "J.L." "apellidos" => "Lobo Beristain" ] 6 => array:2 [ "nombre" => "D." "apellidos" => "Nauffal Mansur" ] 7 => array:2 [ "nombre" => "M." "apellidos" => "Oribe Ibáñez" ] 8 => array:2 [ "nombre" => "J." "apellidos" => "Ruiz Manzano" ] 9 => array:2 [ "nombre" => "F." "apellidos" => "Ruiz Montait" ] 10 => array:2 [ "nombre" => "R." 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Canalis Arrayás, J. Albort Ventura, J. Belda Sanchís, M. Catalán Biel, J.M. Gimferrer Garolera" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M.A." "apellidos" => "Callejas Pérez" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Canalis Arrayás" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Albort Ventura" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Belda Sanchís" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Catalán Biel" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Gimferrer Garolera" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615309996?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000010/v1_201509151217/S0300289615309996/v1_201509151217/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Aportación del test broncodilatador al estudio de la reversibilidad bronquial" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "492" "paginaFinal" => "497" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "C. Pellicer Ciscar" "autores" => array:1 [ 0 => array:3 [ "nombre" => "C." "apellidos" => "Pellicer Ciscar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital Francesc de Borja. Gandía" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Servicio de Neumología. Hospital Francesc de Borja. Passeig de les Germanies, 71. 46700 Gandía. Valencia." ] ] ] 1 => array:3 [ "autoresLista" => "M. Perpiña Tordera, A. de Diego Damia, V. Macián Gisbert" "autores" => array:3 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Perpiña Tordera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "de Diego Damia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Macián Gisbert" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Neumología. Hospital la Fe. Valencia" "etiqueta" => "*" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Contribution of the bronchodilator test in the assessment of bronchoreversibility" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1993-11-02" "fechaAceptado" => "1994-06-28" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec569891" "palabras" => array:3 [ 0 => "Reversibilidad bronquial" 1 => "Asma" 2 => "Bronquitis crónica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec569890" "palabras" => array:3 [ 0 => "Bronchoreversibility" 1 => "Asthma" 2 => "Chronic bronchitis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En el presente trabajo se investiga cuál es la dosis de salbutamol y el modo de calcular la respuesta broncodilatadora que resulta más útil en la valoración de la reversibilidad bronquial. Para ello, en 150 sujetos adultos (64 sanos, 18 riníticos, 53 asmáticos, 15 bronquíticos), se estudian los cambios provocados en el FEV<span class="elsevierStyleInf">1</span>, tras la inhalación de 3 dosis de 200 μg de salbutamol, y se calcula la respuesta broncodilatadora de 4 modos diferentes: en valor absoluto o bien en cambio porcentual respecto al FEV<span class="elsevierStyleInf">1</span>, basal, teórico o ponderado. Se observaron diferencias significativas en la respuesta provoca da, según los distintos modos de calcular ésta. Los pacientes asmáticos y bronquíticos fueron los que presentaron una mayor respuesta al salbutamol y, en ellos, se investigó la eficacia de estos índices de reversibilidad, para diferenciarlos entre sí. La mejor capacidad discriminativa se obtuvo cuando la respuesta broncodilatadora se calculó en porcentaje respecto al valor teórico de referencia si bien se obtuvo una sensibilidad baja y una especificidad variable (0,73 a 1), según los distintos puntos de corte. Este índice de reversibilidad junto con el expresado en valor absoluto fueron los que mostraron menor dependencia respecto al valor basal de FEV<span class="elsevierStyleInf">1</span>.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se concluye que para valorar la respuesta broncodilatadora, el índice que resulta más útil es el que se obtiene al calcular las modificaciones en el FEV<span class="elsevierStyleInf">1</span> en relación al valor teórico de referencia. No obstante, con esta prueba broncomotora no es posible clasificar correctamente los asmáticos y los bronquíticos.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This study sought to determine the optimum dose of salbutamol and the most useful method for calculating bronchodilator response. Changes in FEV<span class="elsevierStyleInf">1</span>, after inhalation of 3 doses of salbutamol 200 μg were measured in 150 adults (64 healthy individuals, 18 with rhinitis, 53 with asthma and 15 with bronchitis). Bronchodilator response was calculated by 4 different methods: absolute value, percent change form baseline FEV<span class="elsevierStyleInf">1</span>, from theoretical value and from weighted value. Significant differences in response were observed among the various methods of assessment. Patients with asthma and bronchitis showed the greatest response to salbutamol and their results were used to analyze the usefulness of the reversibility indices. The index that discriminated best was percent of theoretical reference value, although the sensitivity of this index was low and specificity varied from 0.73 to 1 depending on the cut-off point used. This index of reversibility along with absolute valué proved to be the least dependent on baseline FEV<span class="elsevierStyleInf">1</span>.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We conclude that bronchodilator response is best assessed by calculating changes in FEV<span class="elsevierStyleInf">1</span> in relation to a theoretical reference value. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 2 | 5 |
| 2024 October | 33 | 16 | 49 |
| 2024 September | 46 | 16 | 62 |
| 2024 August | 58 | 42 | 100 |
| 2024 July | 37 | 22 | 59 |
| 2024 June | 70 | 24 | 94 |
| 2024 May | 51 | 28 | 79 |
| 2024 April | 34 | 22 | 56 |
| 2024 March | 45 | 26 | 71 |
| 2024 February | 31 | 37 | 68 |
| 2024 January | 0 | 2 | 2 |
| 2023 December | 0 | 3 | 3 |
| 2023 November | 0 | 1 | 1 |
| 2023 October | 0 | 4 | 4 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 15 | 15 |
| 2023 June | 0 | 6 | 6 |
| 2023 March | 6 | 4 | 10 |
| 2023 February | 30 | 23 | 53 |
| 2023 January | 36 | 33 | 69 |
| 2022 December | 43 | 30 | 73 |
| 2022 November | 44 | 31 | 75 |
| 2022 October | 38 | 33 | 71 |
| 2022 September | 36 | 19 | 55 |
| 2022 August | 29 | 41 | 70 |
| 2022 July | 30 | 33 | 63 |
| 2022 June | 28 | 27 | 55 |
| 2022 May | 27 | 32 | 59 |
| 2022 April | 50 | 34 | 84 |
| 2022 March | 44 | 36 | 80 |
| 2022 February | 40 | 38 | 78 |
| 2022 January | 27 | 34 | 61 |
| 2021 December | 15 | 39 | 54 |
| 2021 November | 23 | 45 | 68 |
| 2021 October | 25 | 43 | 68 |
| 2021 September | 16 | 40 | 56 |
| 2021 August | 10 | 29 | 39 |
| 2021 July | 14 | 34 | 48 |
| 2021 June | 20 | 34 | 54 |
| 2021 May | 14 | 32 | 46 |
| 2021 April | 23 | 57 | 80 |
| 2021 March | 30 | 21 | 51 |
| 2021 February | 23 | 18 | 41 |
| 2021 January | 27 | 22 | 49 |
| 2020 December | 19 | 22 | 41 |
| 2020 November | 11 | 21 | 32 |
| 2020 October | 16 | 18 | 34 |
| 2020 September | 10 | 10 | 20 |
| 2020 August | 21 | 14 | 35 |
| 2020 July | 25 | 15 | 40 |
| 2020 June | 11 | 10 | 21 |
| 2020 May | 29 | 11 | 40 |
| 2020 April | 27 | 11 | 38 |
| 2020 March | 17 | 18 | 35 |
| 2020 February | 26 | 19 | 45 |
| 2020 January | 28 | 17 | 45 |
| 2019 December | 30 | 27 | 57 |
| 2019 November | 11 | 18 | 29 |
| 2019 October | 26 | 32 | 58 |
| 2019 September | 10 | 33 | 43 |
| 2019 August | 20 | 14 | 34 |
| 2019 July | 19 | 31 | 50 |
| 2019 June | 16 | 37 | 53 |
| 2019 May | 18 | 41 | 59 |
| 2019 April | 23 | 73 | 96 |
| 2019 March | 12 | 30 | 42 |
| 2019 February | 9 | 13 | 22 |
| 2019 January | 8 | 15 | 23 |
| 2018 December | 13 | 23 | 36 |
| 2018 November | 17 | 52 | 69 |
| 2018 October | 22 | 30 | 52 |
| 2018 September | 21 | 14 | 35 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 7 | 10 | 17 |
| 2018 March | 5 | 14 | 19 |
| 2018 February | 5 | 14 | 19 |
| 2018 January | 8 | 12 | 20 |
| 2017 December | 15 | 20 | 35 |
| 2017 November | 4 | 12 | 16 |
| 2017 October | 9 | 15 | 24 |
| 2017 September | 7 | 17 | 24 |
| 2017 August | 14 | 28 | 42 |
| 2017 July | 5 | 27 | 32 |
| 2017 June | 8 | 20 | 28 |
| 2017 May | 12 | 13 | 25 |
| 2017 April | 8 | 45 | 53 |
| 2017 March | 9 | 35 | 44 |
| 2017 February | 2 | 11 | 13 |
| 2017 January | 2 | 10 | 12 |
| 2016 December | 15 | 18 | 33 |
| 2016 November | 14 | 25 | 39 |
| 2016 October | 13 | 56 | 69 |
| 2016 September | 35 | 25 | 60 |
| 2016 August | 19 | 7 | 26 |
| 2016 July | 27 | 7 | 34 |
| 2016 June | 37 | 18 | 55 |
| 2016 May | 27 | 14 | 41 |
| 2016 April | 8 | 0 | 8 |
| 2016 March | 11 | 0 | 11 |
| 2016 February | 11 | 0 | 11 |
| 2016 January | 24 | 10 | 34 |
| 2015 December | 17 | 9 | 26 |
| 2015 November | 29 | 7 | 36 |
| 2015 October | 5 | 1 | 6 |
| 2015 September | 2 | 0 | 2 |
Show all
