Análisis de la expresión del antígeno nuclear de proliferación celular (PCNA) en 24 carcinomas primarios de pulmón de células no pequeñas y correlación con la supervivencia
Analysis of proliferating cell nuclear antigen expression in 24 cases of primary non-small cell lung cancer and correlation with survival
Departamento de Anatomía Patológica. Hospital Universitario 12 de Octubre. Madrid
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Ruiz, A. Teixidó, M. Gallego, J. Ribas, J. Morera" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Ruiz" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Teixidó" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Gallego" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Ribas" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Morera" ] ] ] 1 => array:2 [ "autoresLista" => "X. Aguilar, J. Fernández-Muixí, C. Richart" "autores" => array:3 [ 0 => array:2 [ "nombre" => "X." "apellidos" => "Aguilar" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Fernández-Muixí" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Richart" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615307973?idApp=UINPBA00003Z" "url" => "/03002896/0000003200000003/v1_201506230045/S0300289615307973/v1_201506230045/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Análisis de la expresión del antígeno nuclear de proliferación celular (PCNA) en 24 carcinomas primarios de pulmón de células no pequeñas y correlación con la supervivencia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "131" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "V.M. Castellano, T. Sotelo, C. Ballestín" "autores" => array:3 [ 0 => array:3 [ "nombre" => "V.M." "apellidos" => "Castellano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Sotelo" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Ballestín" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Anatomía Patológica. Hospital Universitario 12 de Octubre. Madrid" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Departamento de Anatomía Patológica. Hospital 12 de Octubre. Ctra. de Andalucía, km 5.400. 28041 Madrid." ] ] ] 1 => array:3 [ "autoresLista" => "A. López-Encuentra, G. Varela" "autores" => array:2 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "López-Encuentra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Varela" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Universitario 12 de Octubre. Madrid" "etiqueta" => "*" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Torácica. Hospital Universitario 12 de Octubre. Madrid" "etiqueta" => "**" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Analysis of proliferating cell nuclear antigen expression in 24 cases of primary non-small cell lung cancer and correlation with survival" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1995-06-15" "fechaAceptado" => "1995-10-24" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec546118" "palabras" => array:6 [ 0 => "Cáncer de pulmón" 1 => "Antígeno nuclear de proliferación celular (PCNA)" 2 => "Ciclina" 3 => "Supervivencia" 4 => "Factor pronóstico" 5 => "Immunohistoquímica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec546119" "palabras" => array:7 [ 0 => "Lung cancer" 1 => "Proliferating cell nuclear antigen" 2 => "PCNA" 3 => "Cyclin" 4 => "Survival" 5 => "Prognostic factor" 6 => "Immunohistochemistry" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El antígeno nuclear de proliferación celular (PCNA) o ciclina es una proteína nuclear de 36 kD que está involucrada en la replicación del ADN celular y es considerada como un índice de proliferación en algunas neoplasias. Este trabajo analiza la expresión de PCNA en 24 carcinomas primarios de pulmón de células no pequeñas empleando el anticuerpo monoclonal PC-10 en material procesado en parafina. Encontramos importantes variaciones inter e intratumorales en la expresión de PCNA. No observamos relación estadísticamente significativa entre la cantidad de PCNA expresada y el tamaño y localización tumoral, índice mitósico, tipo histológico del tumor y edad del paciente. Estudiamos la supervivencia en los pacientes en 19 casos con el propósito de correlacionarla con la expresión de PCNA, obteniendo una relación estadísticamente significativa (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,47; p < 0,05) entre la cantidad de PCNA expresada y la supervivencia en los casos incluidos en nuestro estudio, pero al establecer un sistema de graduación de la expresión de PCNA en tres grados -leve (0-25%), moderado (25-50%) e intenso (> 50%)- no encontramos diferencias estadísticamente significativas entre las supervivencias ni un valor pronóstico en la graduación de PCNA.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Proliferating cell nuclear antigen (PCNA) is a 36kD nuclear protein involved in DNA replication that is believed to provide an indication of proliferation in some neoplasms. This study analyzes PCNA expression in 24 cases of primary non-small cell lung cancer using monoclonal PC-10 antibodies in paraffin embedded material. We found significant inter and intra-tumoral variations in PCNA expression, and no statistically significant relation between the amount of PCNA expression and the size and location of tumors, index of mitosis, histological tumor type or patient age. We found a statistically significant relation (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.47; p < 0.05) between survival and amount of PCNA expression in a sample of 19 cases, but no statistically significant differences in survival related to whether PCNA expression was slight (0-25), moderate (25%-50%) or high (> 50%), and no prognostic value for degree of PCNA expression.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An auloantibody to a nuclear antigen in proliferating cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Miyachi" 1 => "M.J. Frilzlcr" 2 => "E.M. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 13 | 3 | 16 |
| 2024 October | 106 | 40 | 146 |
| 2024 September | 134 | 24 | 158 |
| 2024 August | 153 | 42 | 195 |
| 2024 July | 116 | 78 | 194 |
| 2024 June | 134 | 109 | 243 |
| 2024 May | 111 | 82 | 193 |
| 2024 April | 79 | 44 | 123 |
| 2024 March | 101 | 61 | 162 |
| 2024 February | 133 | 59 | 192 |
| 2024 January | 0 | 18 | 18 |
| 2023 December | 1 | 13 | 14 |
| 2023 November | 0 | 28 | 28 |
| 2023 October | 1 | 28 | 29 |
| 2023 September | 0 | 6 | 6 |
| 2023 August | 1 | 8 | 9 |
| 2023 July | 0 | 10 | 10 |
| 2023 June | 0 | 7 | 7 |
| 2023 May | 0 | 21 | 21 |
| 2023 April | 0 | 18 | 18 |
| 2023 March | 34 | 42 | 76 |
| 2023 February | 136 | 31 | 167 |
| 2023 January | 97 | 37 | 134 |
| 2022 December | 117 | 32 | 149 |
| 2022 November | 148 | 30 | 178 |
| 2022 October | 137 | 30 | 167 |
| 2022 September | 158 | 36 | 194 |
| 2022 August | 122 | 52 | 174 |
| 2022 July | 114 | 34 | 148 |
| 2022 June | 124 | 44 | 168 |
| 2022 May | 151 | 41 | 192 |
| 2022 April | 161 | 30 | 191 |
| 2022 March | 148 | 34 | 182 |
| 2022 February | 163 | 47 | 210 |
| 2022 January | 122 | 36 | 158 |
| 2021 December | 80 | 47 | 127 |
| 2021 November | 88 | 50 | 138 |
| 2021 October | 106 | 57 | 163 |
| 2021 September | 78 | 49 | 127 |
| 2021 August | 90 | 58 | 148 |
| 2021 July | 91 | 30 | 121 |
| 2021 June | 77 | 48 | 125 |
| 2021 May | 72 | 39 | 111 |
| 2021 April | 181 | 59 | 240 |
| 2021 March | 135 | 43 | 178 |
| 2021 February | 70 | 29 | 99 |
| 2021 January | 51 | 26 | 77 |
| 2020 December | 52 | 25 | 77 |
| 2020 November | 70 | 24 | 94 |
| 2020 October | 63 | 31 | 94 |
| 2020 September | 66 | 12 | 78 |
| 2020 August | 142 | 31 | 173 |
| 2020 July | 133 | 17 | 150 |
| 2020 June | 126 | 22 | 148 |
| 2020 May | 161 | 22 | 183 |
| 2020 April | 95 | 14 | 109 |
| 2020 March | 97 | 31 | 128 |
| 2020 February | 108 | 28 | 136 |
| 2020 January | 85 | 50 | 135 |
| 2019 December | 94 | 46 | 140 |
| 2019 November | 91 | 62 | 153 |
| 2019 October | 102 | 123 | 225 |
| 2019 September | 91 | 133 | 224 |
| 2019 August | 50 | 86 | 136 |
| 2019 July | 57 | 60 | 117 |
| 2019 June | 47 | 75 | 122 |
| 2019 May | 47 | 131 | 178 |
| 2019 April | 27 | 78 | 105 |
| 2019 March | 14 | 51 | 65 |
| 2019 February | 7 | 23 | 30 |
| 2019 January | 9 | 28 | 37 |
| 2018 December | 10 | 20 | 30 |
| 2018 November | 21 | 36 | 57 |
| 2018 October | 24 | 25 | 49 |
| 2018 September | 13 | 53 | 66 |
| 2018 May | 8 | 2 | 10 |
| 2018 April | 9 | 7 | 16 |
| 2018 March | 4 | 8 | 12 |
| 2018 February | 8 | 13 | 21 |
| 2018 January | 6 | 8 | 14 |
| 2017 December | 6 | 23 | 29 |
| 2017 November | 10 | 40 | 50 |
| 2017 October | 6 | 33 | 39 |
| 2017 September | 10 | 46 | 56 |
| 2017 August | 7 | 48 | 55 |
| 2017 July | 3 | 33 | 36 |
| 2017 June | 15 | 48 | 63 |
| 2017 May | 10 | 67 | 77 |
| 2017 April | 7 | 28 | 35 |
| 2017 March | 4 | 31 | 35 |
| 2017 February | 4 | 63 | 67 |
| 2017 January | 4 | 9 | 13 |
| 2016 December | 7 | 29 | 36 |
| 2016 November | 22 | 34 | 56 |
| 2016 October | 17 | 40 | 57 |
| 2016 September | 31 | 46 | 77 |
| 2016 August | 37 | 27 | 64 |
| 2016 July | 37 | 24 | 61 |
| 2016 June | 41 | 31 | 72 |
| 2016 May | 38 | 24 | 62 |
| 2016 April | 11 | 0 | 11 |
| 2016 March | 11 | 1 | 12 |
| 2016 February | 11 | 2 | 13 |
| 2016 January | 12 | 7 | 19 |
| 2015 December | 22 | 12 | 34 |
| 2015 November | 28 | 9 | 37 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 2 | 0 | 2 |
| 2015 June | 1 | 0 | 1 |
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