Enfermedad pulmonar por micobacterias ambientales oportunistas en pacientes sin infección por el virus de la inmunodefíciencia humana. Factores de riesgo, clínica, diagnóstico y evolución
Pulmonary disease due to opportunistic ambient mycobacteria in non HIV-positive patients. Risk factors, symptoms, diagnosis and evolution
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Alemany Monraval, M. Martorell Cebollada, I. Salvador Villalba, E. Martínez Leandro" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Alemany Monraval" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Martorell Cebollada" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Salvador Villalba" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Martínez Leandro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961530781X?idApp=UINPBA00003Z" "url" => "/03002896/0000003200000004/v1_201506230047/S030028961530781X/v1_201506230047/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Enfermedad pulmonar por micobacterias ambientales oportunistas en pacientes sin infección por el virus de la inmunodefíciencia humana. Factores de riesgo, clínica, diagnóstico y evolución" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "170" "paginaFinal" => "175" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "E. Martínez Moragón, R. Menéndez, V. Marco" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Martínez Moragón" ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Menéndez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Marco" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicios de Neumología, Hospital Universitario La Fe. Valencia" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Servicio de Neumología. Hospital Universitario La Fe. Avda. Campanar, 21.46009 Valencia." ] ] ] 1 => array:3 [ "autoresLista" => "M. Santos, R. Lorente" "autores" => array:2 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Lorente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicios de Microbiología. Hospital Universitario La Fe. Valencia" "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary disease due to opportunistic ambient mycobacteria in non HIV-positive patients. Risk factors, symptoms, diagnosis and evolution" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1995-07-21" "fechaAceptado" => "1995-11-16" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec546132" "palabras" => array:8 [ 0 => "Infección pulmonar" 1 => "Infección por micobacterias" 2 => "Micobacterias no tuberculosas" 3 => "Pacientes inmunocompetentes" 4 => "Factores de riesgo" 5 => "Sintomatología" 6 => "Diagnóstico" 7 => "Tratamiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec546133" "palabras" => array:8 [ 0 => "Pulmonar infection" 1 => "Infection due to mycobacterias" 2 => "Non-tuberculous mycobacterias" 3 => "Immunocompetent patients" 4 => "Risk factors" 5 => "Simptomatology" 6 => "Diagnosis" 7 => "Treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La enfermedad por micobacterias ambientales oportunistas (MAO) constituye una infección frecuente en los pacientes VIH-positivos, aunque también puede acontecer en individuos inmunocompetentes. El objetivo del presente estudio ha sido describir los factores de riesgo, las características clínicas, la evolución y el espectro microbiológico de las MAO que originan, en nuestro medio, enfermedad pulmonar en individuos sin infección por el VIH. Se han revisado 29 casos consecutivos que fueron diagnosticados de enfermedad pulmonar por MAO durante el período 1989-1994 (26 varones y 3 mujeres, edad media 58 ± 14 años). Correspondieron a infección por <span class="elsevierStyleItalic">Mycobacterium kansasii</span> 19 casos (66%), siete por <span class="elsevierStyleItalic">M. avium complex</span> (24%), dos por <span class="elsevierStyleItalic">M. chelonae</span> (7%) y uno por <span class="elsevierStyleItalic">M.flavescens</span> (3%). Los factores de riesgo más frecuentemente asociados fueron el tabaquismo y la existencia de patología pulmonar previa (enfermedad pulmonar obstructiva crónica o tuberculosis residual). Las manifestaciones clínicas fueron inespecíficas, predominando un síndrome tóxico junto a tos no productiva. La radiografía de tórax fue indistinguible de la de una enfermedad por <span class="elsevierStyleItalic">M. tuberculosis</span>, siendo el patrón más común la consolidación alveolar cavitada. El estudio de sensibilidad a fármacos in vitro demostró resistencia a isoniazida en todas las cepas, junto a resistencia a rifampicina, estreptomicina y, en menor grado, a etambutol para las cepas de <span class="elsevierStyleItalic">M. avium complex</span> y <span class="elsevierStyleItalic">M. chelonae.</span> Con tratamiento médico prolongado entre 12-14 meses, realizado con fármacos de primera línea, los 17 casos en los que se dispone de seguimiento completo presentaron una evolución favorable y sólo en 2 pacientes no se logró la erradicación bacteriológica.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diseases caused by opportunistic ambient mycobacteria (OAM) are common in HlV-positive patients, although they also occur in immunocompetent individuals. The objective of the present study was to describe the risk factors, clinical signs, course and microbiological spectrum of OAM that cause pulmonary diseases in non HlV-infected individuals in our community. We reviewed 29 consecutive patients with OAM-caused pulmonary disease between 1989-1994 (26 men and 3 women, mean age 58 ± 14 years). Infections were by <span class="elsevierStyleItalic">Mycobacterium kansasii</span>, 19 (66%) cases; <span class="elsevierStyleItalic">M. avium complex</span>, 7 (24%) cases; <span class="elsevierStyleItalic">M. chelonae</span>, 2 (7%) cases, and <span class="elsevierStyleItalic">M. flavescens</span>, one (3%) case. Risk factors most often associated to infection were smoking and a history of pulmonary disease (chronic obstructive pulmonary disease or residual tuberculosis). Clinical signs were non specific, although toxic syndrome and unproductive cough predominated. Chest films were indistinguishable from those for infection by <span class="elsevierStyleItalic">M. tuberculosis</span>, with cavitated alveolar fibrosis being the main pattern. In vitro drug sensitivity tests showed that all strains were resistant to isoniazid, and that <span class="elsevierStyleItalic">M. avium complex</span> and <span class="elsevierStyleItalic">M. chelonae</span> strains were resistant to rifampicin, streptomycin and, to a lesser degree, to ethambutol. With prolonged medical treatment lasting from 12 to 24 months with first-line drugs, outcome was good for the 17 patients for whom full follow-up information was available. Therapy failed to eradicate the bacteria in only 2 patients.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Mycobacterium avium complex</span> pulmonary disease presenting as an isolated lingular or middle lobe pattern" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Reich" 1 => "R.E. Johnson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1992" "volumen" => "101" "paginaInicial" => "1.605" "paginaFinal" => "1.609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1600786" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous mycobacteria. An under-appreciated cause of geriatric lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.P. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 33 | 20 | 53 |
| 2024 September | 40 | 16 | 56 |
| 2024 August | 44 | 29 | 73 |
| 2024 July | 30 | 29 | 59 |
| 2024 June | 45 | 27 | 72 |
| 2024 May | 51 | 38 | 89 |
| 2024 April | 33 | 26 | 59 |
| 2024 March | 49 | 31 | 80 |
| 2024 February | 35 | 21 | 56 |
| 2024 January | 0 | 5 | 5 |
| 2023 December | 0 | 9 | 9 |
| 2023 November | 0 | 4 | 4 |
| 2023 October | 0 | 5 | 5 |
| 2023 September | 0 | 1 | 1 |
| 2023 July | 0 | 17 | 17 |
| 2023 June | 0 | 6 | 6 |
| 2023 March | 7 | 4 | 11 |
| 2023 February | 33 | 21 | 54 |
| 2023 January | 33 | 24 | 57 |
| 2022 December | 44 | 20 | 64 |
| 2022 November | 70 | 30 | 100 |
| 2022 October | 37 | 30 | 67 |
| 2022 September | 36 | 20 | 56 |
| 2022 August | 58 | 39 | 97 |
| 2022 July | 61 | 39 | 100 |
| 2022 June | 58 | 29 | 87 |
| 2022 May | 87 | 30 | 117 |
| 2022 April | 59 | 42 | 101 |
| 2022 March | 54 | 31 | 85 |
| 2022 February | 46 | 19 | 65 |
| 2022 January | 71 | 37 | 108 |
| 2021 December | 39 | 37 | 76 |
| 2021 November | 44 | 39 | 83 |
| 2021 October | 80 | 48 | 128 |
| 2021 September | 45 | 31 | 76 |
| 2021 August | 35 | 29 | 64 |
| 2021 July | 34 | 25 | 59 |
| 2021 June | 64 | 41 | 105 |
| 2021 May | 46 | 32 | 78 |
| 2021 April | 76 | 45 | 121 |
| 2021 March | 79 | 40 | 119 |
| 2021 February | 46 | 20 | 66 |
| 2021 January | 53 | 21 | 74 |
| 2020 December | 33 | 19 | 52 |
| 2020 November | 38 | 11 | 49 |
| 2020 October | 40 | 12 | 52 |
| 2020 September | 16 | 7 | 23 |
| 2020 August | 35 | 11 | 46 |
| 2020 July | 46 | 17 | 63 |
| 2020 June | 21 | 8 | 29 |
| 2020 May | 25 | 16 | 41 |
| 2020 April | 38 | 13 | 51 |
| 2020 March | 36 | 18 | 54 |
| 2020 February | 27 | 18 | 45 |
| 2020 January | 45 | 17 | 62 |
| 2019 December | 37 | 26 | 63 |
| 2019 November | 28 | 17 | 45 |
| 2019 October | 38 | 9 | 47 |
| 2019 September | 68 | 20 | 88 |
| 2019 August | 23 | 4 | 27 |
| 2019 July | 31 | 25 | 56 |
| 2019 June | 9 | 16 | 25 |
| 2019 May | 34 | 21 | 55 |
| 2019 April | 34 | 35 | 69 |
| 2019 March | 14 | 16 | 30 |
| 2019 February | 16 | 5 | 21 |
| 2019 January | 12 | 5 | 17 |
| 2018 December | 20 | 14 | 34 |
| 2018 November | 24 | 14 | 38 |
| 2018 October | 32 | 9 | 41 |
| 2018 September | 27 | 3 | 30 |
| 2018 May | 3 | 2 | 5 |
| 2018 April | 7 | 3 | 10 |
| 2018 March | 11 | 8 | 19 |
| 2018 February | 10 | 6 | 16 |
| 2018 January | 8 | 10 | 18 |
| 2017 December | 7 | 10 | 17 |
| 2017 November | 12 | 12 | 24 |
| 2017 October | 10 | 13 | 23 |
| 2017 September | 6 | 16 | 22 |
| 2017 August | 14 | 13 | 27 |
| 2017 July | 15 | 10 | 25 |
| 2017 June | 12 | 27 | 39 |
| 2017 May | 18 | 19 | 37 |
| 2017 April | 8 | 9 | 17 |
| 2017 March | 8 | 18 | 26 |
| 2017 February | 10 | 16 | 26 |
| 2017 January | 7 | 6 | 13 |
| 2016 December | 31 | 18 | 49 |
| 2016 November | 51 | 22 | 73 |
| 2016 October | 63 | 39 | 102 |
| 2016 September | 46 | 26 | 72 |
| 2016 August | 34 | 11 | 45 |
| 2016 July | 41 | 10 | 51 |
| 2016 June | 44 | 16 | 60 |
| 2016 May | 45 | 18 | 63 |
| 2016 April | 31 | 0 | 31 |
| 2016 March | 31 | 2 | 33 |
| 2016 February | 25 | 6 | 31 |
| 2016 January | 37 | 15 | 52 |
| 2015 December | 40 | 20 | 60 |
| 2015 November | 73 | 40 | 113 |
| 2015 October | 10 | 2 | 12 |
Show all
