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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue valorar la respuesta ventilatoria a la estimulaci&#243;n con carb&#243;nico en pacientes con s&#237;ndrome de apneas obstructivas durante el sue&#241;o &#40;SAOS&#41; sin enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41;&#44; examinando las diferencias entre enfermos hiper y normoc&#225;pnicos y comparando los resultados obtenidos con las dos t&#233;cnicas usualmente empleadas en la estimulaci&#243;n hiperc&#225;pnica &#40;<span class="elsevierStyleItalic">rebreathing</span> y estado-estable&#41;&#46; Para ello&#44; hemos estudiado a 15 pacientes obesos&#44; todos ellos con &#237;ndice de apnea-hipopnea &#40;IAH&#41; superior a 10 en el registro polisomnogr&#225;fico practicado durante una noche completa&#44; a los que realizamos las siguientes pruebas funcionales respiratorias&#58; espirometr&#237;a&#44; determinaci&#243;n de resistencias de v&#237;as a&#233;reas y vol&#250;menes est&#225;ticos pulmonares mediante pletismograf&#237;a y gasometr&#237;a arterial&#46; Posteriormente analizamos la respuesta ventilatoria mediante el m&#233;todo de estado-estable&#44; con concentraciones de CO<span class="elsevierStyleInf">2</span> progresivamente crecientes &#40;1-9&#37;&#41; y la t&#233;cnica de <span class="elsevierStyleItalic">rebreathing</span>&#46; En el grupo total de enfermos obtuvimos resultados similares mediante ambos m&#233;todos&#44; en el an&#225;lisis de&#58; &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#40;0&#44;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;35 frente a 0&#44;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;48 1&#47;min&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;59&#41;&#44; &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;28&#44;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;23 frente a 26&#44;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;94 ml&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;9&#41;&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;28&#44;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;9 frente a 29&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#44;78 ml&#47;s&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#41; y &#916;P0&#44; l&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;0&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;07 frente a 0&#44;117<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;05 cmH<span class="elsevierStyleInf">2</span>O&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;58&#41;&#46; Comparamos los resultados obtenidos por ambas t&#233;cnicas dividiendo a nuestra poblaci&#243;n en 2 grupos de 7 y 8 pacientes respectivamente&#44; seg&#250;n el nivel de PaCO<span class="elsevierStyleInf">2</span> en vigilia fuese superior o inferior a 45 mmHg&#46; Los enfermos hiperc&#225;pnicos &#40;grupo I&#41; ten&#237;an una mayor edad &#40;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 frente a 50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 a&#241;os&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41; sin presentar diferencias en el &#237;ndice de masa corporal con respecto a los pacientes normoc&#225;pnicos &#40;grupo II&#41; &#40;37&#44;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;4 frente a 34&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;75 kg&#47;m<span class="elsevierStyleSup">2</span>&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;33&#41;&#46; Los resultados de ambas t&#233;cnicas de estimulaci&#243;n hiperc&#225;pnica fueron similares en los miembros de un mismo grupo existiendo una disminuci&#243;n estad&#237;sticamente significativa &#40;p &#60; 0&#44;03&#41;&#44; en los sujetos con hipercapnia diurna en &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span> y &#916;P0&#44;1&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#46; Concluimos que no existen diferencias en los resultados obtenidos en el estudio del control de la ventilaci&#243;n con las t&#233;cnicas de <span class="elsevierStyleItalic">rebreathing</span> y estado-estable&#46; As&#237; mismo&#44; la respuesta ventilatoria a la estimulaci&#243;n con CO<span class="elsevierStyleInf">2</span> en individuos con SAOS e hipoventilaci&#243;n diurna se encuentra disminuida en comparaci&#243;n con enfermos normoc&#225;pnicos&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The objetive of this study was to assess ventilatory response to stimulation with CO<span class="elsevierStyleInf">2</span> in patients suffering obstructive sleep apnea syndrome &#40;OSAS&#41; but without chronic obstructive pulmonary disease &#40;COPD&#41;&#44; by examining differences between hyper and normocapnic patients and comparing the results obtained with the usual techniques used to stimulate hypercapnia &#40;rebreathing and stable-state&#41;&#46; To this end&#44; we studied 15 obese patients&#44; all with an apnea-hypopnea index greater than 10 from a polysomnograph lasting a full night&#46; The following lung function tests were performed&#58; spirometry&#44; air way resistance measures and static lung volumes by plethysmograph and arterial gasometry&#46; We later analized ventilatory response by the stable-state method&#44; with increasing CO<span class="elsevierStyleInf">2</span> concentrations &#40;from 1 to 9&#37;&#41; and by the rebreathing method&#46; Results from the two methods were similar for all patients&#58; &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;0&#44;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;35 vs 0&#44;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;48 1&#47;min&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;59&#41;&#44; &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#40;28&#44;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;23 vs 26&#44;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;94 ml&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;9&#41;&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#40;28&#44;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;9 vs 29&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#44;78 ml&#47;s&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#41; y &#916;P0&#44; l&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;0&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;07 vs 0&#44;117<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;05 cmH<span class="elsevierStyleInf">2</span>O&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>038&#41;&#46; We compared the results obtained by the two techniques by dividing the sample into two groups of 7 and 8 patients&#44; respectively&#44; depending on whether PaCO<span class="elsevierStyleInf">2</span> level before stimulation was higher or lower than 45mmHg&#46; The hypercapnic patients &#40;group <span class="elsevierStyleSmallCaps">I</span>&#41; were older &#40;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 vs 50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41; but were not different with respect to body mass freom the normocapnic patients &#40;group <span class="elsevierStyleSmallCaps">II</span>&#41; &#40;37&#44;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;4 vs 34&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;75 kg&#47;m<span class="elsevierStyleSup">2</span>&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;33&#41;&#46; The results from the two techniques for stimulating hypercapnia were similar within each group&#44; with a statistically significant decrease &#40;p &#60; 0&#44;03&#41; in patients with daytime hypercapnia in &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span> and &#916;P0&#44;1&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#46; We conclude that there are no differences in the results obtained with the rebreathing and stable state techniques&#46; Likewise&#44; ventilatory response to stimulation with CO<span class="elsevierStyleInf">2</span> in individuals with OSAS and daytime hypoventilation is less than of normocapnic patients&#46;</p></span>"
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Estimulación hipercápnica y respuesta ventilatoria en el síndrome de apnea obstructiva del sueño. Comparación de reinhalación y estado-estable
Hypercapnic stimulation and ventilatory response in obstructive sleep apnea syndrome. Comparison of rebreathing and stable techniques
J.G. Soto Campos*, S. Cano Gómez, J. Fernández Guerra, M.A. Sánchez Armengol, F. Capote Gil, J. Castillo Gómez
Servicio de Neumología. Hospital Universitario Virgen del Rocío. Sevilla
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            "entidad" => "Servicio de Neumolog&#237;a&#46; Hospital Universitario Virgen del Roc&#237;o&#46; Sevilla"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
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          ]
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    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Hypercapnic stimulation and ventilatory response in obstructive sleep apnea syndrome&#46; Comparison of rebreathing and stable techniques"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1995-11-28"
    "fechaAceptado" => "1996-02-27"
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          "palabras" => array:4 [
            0 => "Respuesta ventilatoria hiperc&#225;pnica"
            1 => "S&#237;ndrome de apneas durante el sue&#241;o"
            2 => "Control de respiraci&#243;n"
            3 => "M&#233;todo de reinspiraciones repetidas"
          ]
        ]
      ]
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Ventilatory responses to CO<span class="elsevierStyleInf">2</span>"
            1 => "Sleep apnea syndrome"
            2 => "Control of breathing"
            3 => "Rebreathing"
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      "es" => array:1 [
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue valorar la respuesta ventilatoria a la estimulaci&#243;n con carb&#243;nico en pacientes con s&#237;ndrome de apneas obstructivas durante el sue&#241;o &#40;SAOS&#41; sin enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41;&#44; examinando las diferencias entre enfermos hiper y normoc&#225;pnicos y comparando los resultados obtenidos con las dos t&#233;cnicas usualmente empleadas en la estimulaci&#243;n hiperc&#225;pnica &#40;<span class="elsevierStyleItalic">rebreathing</span> y estado-estable&#41;&#46; Para ello&#44; hemos estudiado a 15 pacientes obesos&#44; todos ellos con &#237;ndice de apnea-hipopnea &#40;IAH&#41; superior a 10 en el registro polisomnogr&#225;fico practicado durante una noche completa&#44; a los que realizamos las siguientes pruebas funcionales respiratorias&#58; espirometr&#237;a&#44; determinaci&#243;n de resistencias de v&#237;as a&#233;reas y vol&#250;menes est&#225;ticos pulmonares mediante pletismograf&#237;a y gasometr&#237;a arterial&#46; Posteriormente analizamos la respuesta ventilatoria mediante el m&#233;todo de estado-estable&#44; con concentraciones de CO<span class="elsevierStyleInf">2</span> progresivamente crecientes &#40;1-9&#37;&#41; y la t&#233;cnica de <span class="elsevierStyleItalic">rebreathing</span>&#46; En el grupo total de enfermos obtuvimos resultados similares mediante ambos m&#233;todos&#44; en el an&#225;lisis de&#58; &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#40;0&#44;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;35 frente a 0&#44;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;48 1&#47;min&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;59&#41;&#44; &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;28&#44;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;23 frente a 26&#44;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;94 ml&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;9&#41;&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;28&#44;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;9 frente a 29&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#44;78 ml&#47;s&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#41; y &#916;P0&#44; l&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;0&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;07 frente a 0&#44;117<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;05 cmH<span class="elsevierStyleInf">2</span>O&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;58&#41;&#46; Comparamos los resultados obtenidos por ambas t&#233;cnicas dividiendo a nuestra poblaci&#243;n en 2 grupos de 7 y 8 pacientes respectivamente&#44; seg&#250;n el nivel de PaCO<span class="elsevierStyleInf">2</span> en vigilia fuese superior o inferior a 45 mmHg&#46; Los enfermos hiperc&#225;pnicos &#40;grupo I&#41; ten&#237;an una mayor edad &#40;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 frente a 50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 a&#241;os&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41; sin presentar diferencias en el &#237;ndice de masa corporal con respecto a los pacientes normoc&#225;pnicos &#40;grupo II&#41; &#40;37&#44;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;4 frente a 34&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;75 kg&#47;m<span class="elsevierStyleSup">2</span>&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;33&#41;&#46; Los resultados de ambas t&#233;cnicas de estimulaci&#243;n hiperc&#225;pnica fueron similares en los miembros de un mismo grupo existiendo una disminuci&#243;n estad&#237;sticamente significativa &#40;p &#60; 0&#44;03&#41;&#44; en los sujetos con hipercapnia diurna en &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span> y &#916;P0&#44;1&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#46; Concluimos que no existen diferencias en los resultados obtenidos en el estudio del control de la ventilaci&#243;n con las t&#233;cnicas de <span class="elsevierStyleItalic">rebreathing</span> y estado-estable&#46; As&#237; mismo&#44; la respuesta ventilatoria a la estimulaci&#243;n con CO<span class="elsevierStyleInf">2</span> en individuos con SAOS e hipoventilaci&#243;n diurna se encuentra disminuida en comparaci&#243;n con enfermos normoc&#225;pnicos&#46;</p></span>"
      ]
      "en" => array:1 [
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The objetive of this study was to assess ventilatory response to stimulation with CO<span class="elsevierStyleInf">2</span> in patients suffering obstructive sleep apnea syndrome &#40;OSAS&#41; but without chronic obstructive pulmonary disease &#40;COPD&#41;&#44; by examining differences between hyper and normocapnic patients and comparing the results obtained with the usual techniques used to stimulate hypercapnia &#40;rebreathing and stable-state&#41;&#46; To this end&#44; we studied 15 obese patients&#44; all with an apnea-hypopnea index greater than 10 from a polysomnograph lasting a full night&#46; The following lung function tests were performed&#58; spirometry&#44; air way resistance measures and static lung volumes by plethysmograph and arterial gasometry&#46; We later analized ventilatory response by the stable-state method&#44; with increasing CO<span class="elsevierStyleInf">2</span> concentrations &#40;from 1 to 9&#37;&#41; and by the rebreathing method&#46; Results from the two methods were similar for all patients&#58; &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;0&#44;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;35 vs 0&#44;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;48 1&#47;min&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;59&#41;&#44; &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#40;28&#44;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;23 vs 26&#44;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;94 ml&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;9&#41;&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#40;28&#44;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;9 vs 29&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#44;78 ml&#47;s&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#41; y &#916;P0&#44; l&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#40;0&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;07 vs 0&#44;117<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;05 cmH<span class="elsevierStyleInf">2</span>O&#47;mmHg&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>038&#41;&#46; We compared the results obtained by the two techniques by dividing the sample into two groups of 7 and 8 patients&#44; respectively&#44; depending on whether PaCO<span class="elsevierStyleInf">2</span> level before stimulation was higher or lower than 45mmHg&#46; The hypercapnic patients &#40;group <span class="elsevierStyleSmallCaps">I</span>&#41; were older &#40;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 vs 50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41; but were not different with respect to body mass freom the normocapnic patients &#40;group <span class="elsevierStyleSmallCaps">II</span>&#41; &#40;37&#44;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;4 vs 34&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;75 kg&#47;m<span class="elsevierStyleSup">2</span>&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;33&#41;&#46; The results from the two techniques for stimulating hypercapnia were similar within each group&#44; with a statistically significant decrease &#40;p &#60; 0&#44;03&#41; in patients with daytime hypercapnia in &#916;VE&#47;&#916;PCO<span class="elsevierStyleInf">2</span> &#916;Vt&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#44; &#916;Vt&#47;Ti&#47;&#916;PCO<span class="elsevierStyleInf">2</span> and &#916;P0&#44;1&#47;&#916;PCO<span class="elsevierStyleInf">2</span>&#46; We conclude that there are no differences in the results obtained with the rebreathing and stable state techniques&#46; Likewise&#44; ventilatory response to stimulation with CO<span class="elsevierStyleInf">2</span> in individuals with OSAS and daytime hypoventilation is less than of normocapnic patients&#46;</p></span>"
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              "etiqueta" => "2&#46;"
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                      "titulo" => "Hypercapnia in the obstructive sleep apnea syndrome&#58; a reevaluation of the &#8220;Pickwickian Syndrome&#8221;"
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                          "etal" => false
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                            0 => "D&#46;M&#46; Rapoport"
                            1 => "S&#46;M&#46; Garay"
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            2 => array:3 [
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                      "titulo" => "Extreme obesity associated with alveolar hypoventilation&#46; A pickwickian syndrome"
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                          "etal" => false
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                            0 => "C&#46;S&#46; Burwell"
                            1 => "E&#46;D&#46; Robin"
                            2 => "R&#46;D&#46; Whaley"
                            3 => "A&#46;G&#46; Bickelmann"
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                    0 => array:2 [
                      "titulo" => "Compliance of respiratory system and its components in health and obesity"
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                          "autores" => array:2 [
                            0 => "A&#46; Naimark"
                            1 => "R&#46;M&#46; Cherniack"
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                      "titulo" => "The respiratory defects in extreme obesity"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;C&#46; Cullen"
                            1 => "P&#46;F&#46; Formel"
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                      "titulo" => "Regional distribution of pulmonar ventilation and perfusion in obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46;S&#46; Holley"
                            1 => "J&#46; Milic Emili"
                            2 => "M&#46;R&#46; Becklade"
                            3 => "D&#46;V&#46; Bates"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI78789"
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                        "fecha" => "1967"
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                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of diffuse airway obstruction in the hypercapnia of obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;D&#46; Bradley"
                            1 => "R&#46; Rutherford"
                            2 => "F&#46; Lue"
                            3 => "H&#46; Moldofsky"
                            4 => "R&#46;F&#46; Grossman"
                            5 => "N&#46; Zamel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1986.134.5.920"
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                        "fecha" => "1986"
                        "volumen" => "134"
                        "paginaInicial" => "920"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3777688"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determinants of hypercapnia in occlusive sleep apnea syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;A&#46; Leech"
                            1 => "E&#46; &#214;nal"
                            2 => "P&#46; Baer"
                            3 => "M&#46; Lopata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1987"
                        "volumen" => "92"
                        "paginaInicial" => "807"
                        "paginaFinal" => "813"
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              "identificador" => "bib0045"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive sleep apnea with severe chronic airflow limitation&#46; Comparison of hypercapnic and eucapnic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;S&#46; Chan"
                            1 => "R&#46;R&#46; Grunstein"
                            2 => "P&#46;T&#46;P&#46; Bye"
                            3 => "A&#46;J&#46; Woolcock"
                            4 => "C&#46;E&#46; Sullivan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/140.6.1727"
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Article information
ISSN: 03002896
Original language: Spanish
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