Teofilinas de liberación sostenida de 12 y 24 horas. Estudio comparativo
A comparison of 12 and 24 hours sustained-release theophylline formulas
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Estudio comparativo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "397" "paginaFinal" => "402" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "M. Vendrell, X. Muñoz, J. de Gracia, F. Morell, A. Anguera, C. Mayordomo" "autores" => array:6 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Vendrell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Muñoz" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "de Gracia" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Morell" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Anguera" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Mayordomo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital General Universitario Vall d’Hebron. Barcelona" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Servicio de Neumología. Hospital General Universitario Vall d’Hebron. P.° Vall d’Hehron. 119-129. 08035 Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "L. Pou" "autores" => array:1 [ 0 => array:3 [ "nombre" => "L." "apellidos" => "Pou" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Bioquímica. Hospital General Universitario Vall d’Hebron. Barcelona" "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A comparison of 12 and 24 hours sustained-release theophylline formulas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1995-12-18" "fechaAceptado" => "1996-03-05" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec546086" "palabras" => array:2 [ 0 => "Teofilina retardada" 1 => "Asma bronquial" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec546085" "palabras" => array:2 [ 0 => "Delayed-release theophylline" 1 => "Bronchial asthma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este trabajo ha sido comparar en pacientes asmáticos una teofilina de acción sostenida de administración cada 24 horas con las de administración cada 12 en relación a: la estabilidad clínica y funcional respiratoria, los efectos secundarios y las dosis requeridas en función de la tolerancia clínica y las concentraciones plasmáticas.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron pacientes con asma bronquial en fase estable que seguían tratamiento con teofilinas de 12 horas. Cada sujeto recibió teofdinas de 12 y de 24 horas en un estudio prospectivo, cruzado y con datos apareados durante períodos de 15 días. Se evaluaron las dosis de teofdinas, teofilinemias, evolución clínica y funcional respiratoria, y los efectos secundarios.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 20 casos. No hubo diferencias notables en las dosis medias de teofilina por kilogramo de peso requeridas para obtener concentraciones plasmáticas terapéuticas entre los 2 tratamientos (tratamiento A: 9,36<span class="elsevierStyleInf">1</span><span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,88<span class="elsevierStyleHsp" style=""></span>mg/kg/día, tratamiento B: 9,6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,7<span class="elsevierStyleHsp" style=""></span>mg/kg/día). La teofilinemia media en el momento previo a la administración de la siguiente dosis fue menor con las teofilinas de 24 horas, pero dentro de los márgenes terapéuticos (tratamiento A: 7,31<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2,27<span class="elsevierStyleHsp" style=""></span>μg/ml; tratamiento B: 10,66<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2,86<span class="elsevierStyleHsp" style=""></span>μg/ml; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,002). No hubo diferencias en los efectos secundarios tras el período de ajuste ni en el FEV<span class="elsevierStyleInf">1</span> al finalizar cada período de tratamiento. El flujo espiratorio máximo se mantuvo estable durante todo el estudio.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En los pacientes asmáticos, las teofilinas retardadas de 24 horas en relación a las de 12 horas, consiguieron con dosis similares concentraciones plasmáticas terapéuticas durante las 24 horas del día.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To compare 24-h and 12-h delayed-release theophylline in asthmatic patients, in terms of clinical stability and respiratory function, side effects and required dose, clinical tolerance and plasma concentrations.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Patients with bronchial asthma in stable phase taking theophylline every 12 h were selected. Each patient received 12-h (treatment A) and 24-h (treatment B) theophylline formulas in a prospective, cross-over study with paired data for periods of 15 days. We evaluated theophylline doses, blood levels, clinical course, lung function and side effects.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Twenty patients were enrolled. No significant differences between the two treatments were observed in mean dose of theophylline per kg body weight required to obtain therapeutic plasma concentrations (treatment A: 9.36<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.88<span class="elsevierStyleHsp" style=""></span>mg/kg/day; treatment B: 9.6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.7 mg/kg/day). Mean blood level just before administration of a the next dose was lower with the 24-h formula, but still within therapeutic margins (treatment A: 7.31<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.27<span class="elsevierStyleHsp" style=""></span>μg/ml; treatment B: 10.66<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.86<span class="elsevierStyleHsp" style=""></span>μg/ml; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002). There were no differences in side effects after the adjustment period or in FEV<span class="elsevierStyleInf">1</span> after each treatment period. Peak expiratory flow remained stable during the study.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The 24-h delayed release theophylline formula was similar to the 12-h formula in dose required by asthmatic patients and in therapeutic plasma concentrations throughout the day.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:42 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiinflammatory effects of low-dose oral teophylline inatopic asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Sullivan" 1 => "S. Bekir" 2 => "Z. Jaffar" 3 => "C. Page" 4 => "P. Jeffery" 5 => "J. 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Reichman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/140.6.1727" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1989" "volumen" => "140" "paginaInicial" => "1.57.3" "paginaFinal" => "1.577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2690707" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003200000008/v1_201506230038/S0300289615307237/v1_201506230038/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003200000008/v1_201506230038/S0300289615307237/v1_201506230038/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615307237?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 40 | 16 | 56 |
| 2024 September | 55 | 21 | 76 |
| 2024 August | 79 | 28 | 107 |
| 2024 July | 47 | 24 | 71 |
| 2024 June | 70 | 42 | 112 |
| 2024 May | 60 | 35 | 95 |
| 2024 April | 49 | 14 | 63 |
| 2024 March | 57 | 25 | 82 |
| 2024 February | 30 | 25 | 55 |
| 2024 January | 0 | 2 | 2 |
| 2023 November | 0 | 3 | 3 |
| 2023 October | 0 | 4 | 4 |
| 2023 September | 0 | 1 | 1 |
| 2023 August | 1 | 1 | 2 |
| 2023 July | 0 | 2 | 2 |
| 2023 June | 0 | 1 | 1 |
| 2023 May | 0 | 2 | 2 |
| 2023 March | 4 | 4 | 8 |
| 2023 February | 40 | 20 | 60 |
| 2023 January | 35 | 30 | 65 |
| 2022 December | 34 | 29 | 63 |
| 2022 November | 52 | 14 | 66 |
| 2022 October | 29 | 33 | 62 |
| 2022 September | 26 | 25 | 51 |
| 2022 August | 45 | 43 | 88 |
| 2022 July | 26 | 35 | 61 |
| 2022 June | 23 | 30 | 53 |
| 2022 May | 50 | 26 | 76 |
| 2022 April | 31 | 35 | 66 |
| 2022 March | 39 | 54 | 93 |
| 2022 February | 28 | 34 | 62 |
| 2022 January | 28 | 30 | 58 |
| 2021 December | 28 | 40 | 68 |
| 2021 November | 29 | 37 | 66 |
| 2021 October | 38 | 38 | 76 |
| 2021 September | 31 | 39 | 70 |
| 2021 August | 33 | 24 | 57 |
| 2021 July | 19 | 30 | 49 |
| 2021 June | 36 | 34 | 70 |
| 2021 May | 37 | 24 | 61 |
| 2021 April | 80 | 49 | 129 |
| 2021 March | 42 | 16 | 58 |
| 2021 February | 46 | 11 | 57 |
| 2021 January | 30 | 20 | 50 |
| 2020 December | 25 | 20 | 45 |
| 2020 November | 35 | 16 | 51 |
| 2020 October | 48 | 3 | 51 |
| 2020 September | 114 | 10 | 124 |
| 2020 August | 53 | 15 | 68 |
| 2020 July | 48 | 14 | 62 |
| 2020 June | 52 | 11 | 63 |
| 2020 May | 37 | 11 | 48 |
| 2020 April | 29 | 5 | 34 |
| 2020 March | 26 | 21 | 47 |
| 2020 February | 40 | 11 | 51 |
| 2020 January | 59 | 16 | 75 |
| 2019 December | 48 | 30 | 78 |
| 2019 November | 36 | 13 | 49 |
| 2019 October | 19 | 18 | 37 |
| 2019 September | 43 | 34 | 77 |
| 2019 August | 27 | 7 | 34 |
| 2019 July | 39 | 30 | 69 |
| 2019 June | 27 | 11 | 38 |
| 2019 May | 42 | 21 | 63 |
| 2019 April | 67 | 14 | 81 |
| 2019 March | 18 | 18 | 36 |
| 2019 February | 11 | 6 | 17 |
| 2019 January | 15 | 14 | 29 |
| 2018 December | 10 | 9 | 19 |
| 2018 November | 25 | 14 | 39 |
| 2018 October | 49 | 13 | 62 |
| 2018 September | 18 | 4 | 22 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 10 | 6 | 16 |
| 2018 March | 7 | 6 | 13 |
| 2018 February | 9 | 13 | 22 |
| 2018 January | 5 | 9 | 14 |
| 2017 December | 8 | 14 | 22 |
| 2017 November | 8 | 11 | 19 |
| 2017 October | 7 | 6 | 13 |
| 2017 September | 7 | 8 | 15 |
| 2017 August | 17 | 11 | 28 |
| 2017 July | 5 | 9 | 14 |
| 2017 June | 12 | 13 | 25 |
| 2017 May | 10 | 10 | 20 |
| 2017 April | 7 | 6 | 13 |
| 2017 March | 8 | 3 | 11 |
| 2017 February | 15 | 9 | 24 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 8 | 5 | 13 |
| 2016 November | 17 | 16 | 33 |
| 2016 October | 16 | 14 | 30 |
| 2016 September | 15 | 10 | 25 |
| 2016 August | 16 | 7 | 23 |
| 2016 July | 21 | 5 | 26 |
| 2016 June | 19 | 9 | 28 |
| 2016 May | 12 | 3 | 15 |
| 2016 April | 12 | 0 | 12 |
| 2016 March | 9 | 1 | 10 |
| 2016 February | 13 | 2 | 15 |
| 2016 January | 30 | 15 | 45 |
| 2015 December | 19 | 14 | 33 |
| 2015 November | 24 | 8 | 32 |
| 2015 October | 11 | 2 | 13 |
| 2015 September | 1 | 0 | 1 |
| 2015 June | 1 | 0 | 1 |
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