Estudio comparativo de los niveles de receptor soluble de interleucina 2 y adenosín-desaminasa en líquidos pleurales tuberculosos y de otras etiologías
Comparative assessment of soluble interleukin 2 receptor and adenosin-desaminase levels in pleural fluid of patients with tubercsulosis or other diseases
Sección de Neumología. Hospital Los Arcos. Santiago de la Ribera. Murcia
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"apellidos" => "Contessotto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Sección de Neumología. Hospital Los Arcos. Santiago de la Ribera. Murcia" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Servicio de Neumología. Hospital Los Arcos. Paseo de Colón, 54. 30720 Santiago de la Ribera. Murcia." ] ] ] 1 => array:3 [ "autoresLista" => "J. Ontañón, M. Muro, P. Berlinches, J. de la Torre, F. Sánchez Gascón, M.R. Álvarez López" "autores" => array:6 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Ontañón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Muro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Berlinches" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "de la Torre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "F." "apellidos" => "Sánchez Gascón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "M.R." "apellidos" => "Álvarez López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Sección de Neumología. Hospital Santa María del Rosell. Cartagena" "etiqueta" => "*" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Sección de Inmunología. Hospital Virgen de la Arrixaca. Murcia" "etiqueta" => "**" "identificador" => "aff0015" ] 2 => array:3 [ "entidad" => "Sección de Neumología. Hospital General de Murcia. Murcia" "etiqueta" => "***" "identificador" => "aff0020" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comparative assessment of soluble interleukin 2 receptor and adenosin-desaminase levels in pleural fluid of patients with tubercsulosis or other diseases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1996-01-30" "fechaAceptado" => "1996-05-07" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec546181" "palabras" => array:5 [ 0 => "Derrame pleural tuberculoso" 1 => "Receptor soluble de interleucina 2" 2 => "Adenosín-desaminasa" 3 => "Inmunología de la tuberculosis" 4 => "Derrame pleural" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec546180" "palabras" => array:5 [ 0 => "Tuberculous pleural exudate" 1 => "Soluble receptor of interleukin 2" 2 => "Adenosin-desaminase" 3 => "Immunology in tuberculosis" 4 => "Pleural effusions" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En el marco de las investigaciones básicas dirigidas a esclarecer los mecanismos inmunológicos que configuran la respuesta del huésped frente a la infección por <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>, se han valorado los niveles de receptor soluble de interleucina 2 (sIL-2R) en exudados pleurales tuberculosos, en comparación con líquidos de etiología no micobacteriana.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Para ello, se han estudiado 40 enfermos con derrame pleural: 10 con pleuresía tuberculosa, 10 con neoplasia, 10 con neumonía bacteriana no tuberculosa y 10 con trasudado. La determinación de la concentración de sIL-2R se efectuó mediante técnica ELISA.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En pacientes con tuberculosis, el valor de sIL-2R en líquido pleural fue 14.666<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.634 U/ml, significativamente superior a los niveles encontrados en cualquier otro grupo de patología, que fueron 4.341<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.655 U/ml en los derrames neumónicos, 5.542<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.682 U/ml en los neoplásicos y 1.377<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>125 U/ml en los trasudados</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En la tuberculosis pleuropulmonar, la compartimentalización de la respuesta inmune de la cavidad pleural determina la existencia de niveles significativamente más elevados de sIL-2R con respecto a los detectados en los líquidos pleurales de otraetiología. Esta observación, así como la demostración de una estrecha correlación entre sIL-2R y ADA, permite plantear la posible utilización de esta molécula como un parámetro accesorio en el diagnóstico diferencial de los derrames pleurales, aunque en este estudio no parece alcanzar el grado de fiabilidad de la ADA.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In order to better understand the immunological mechanisms involved in host protection against <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> infection, we studied soluble interleukin 2 receptor (sIL-2R) concentration in tuberculous pleural exudates as well as in pleural fluids of non-mycobacterial etiology.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We collected pleural fluid from 40 patients: 10 with tuberculous pleurisy, 10 with neoplasia, 10 with non-tuberculous bacterial pneumonía and 10 with trasudate. Soluble IL-2R was measured in the stored specimens using a standard ELISA technique.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In patients with tuberculosis, sIL-2R in pleural fluid was 14,666<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5,634 U/ml, significantly higher than was detected in any other group, being 4,341<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2,655 U/ml in pneumonic exudates, 5,542<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3,682 U/ml in neoplasic exudates and 1,377<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>125 in trasudates (p < 0.001). Also, an excellent correlation was demonstrated between adenosin-desaminase (ADA) and sIL-2R in tuberculous pleural fluids, with p < 0.001 and r= 0,805.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In pleuropulmonary tuberculosis, compartmentalization of the immune response in the pleural space is responsable for the significantly higher levels of sIL-2R that were found in tuberculous pleural liquids compared with the ones detected in other diseases. This observation, as well as the demonstration of a good correlation between sIL-2R and ADA, suggest the possible usefulness of this molecule as an additional marker in the differential diagnosis of pleural effusions, though in the present study it appears to be less reliable than ADA.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The soluble interleukin-2 receptor: biology, function and clinical application" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.A. Rubin" 1 => "D.L. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 43 | 16 | 59 |
| 2024 September | 59 | 24 | 83 |
| 2024 August | 59 | 35 | 94 |
| 2024 July | 40 | 24 | 64 |
| 2024 June | 67 | 22 | 89 |
| 2024 May | 46 | 25 | 71 |
| 2024 April | 28 | 30 | 58 |
| 2024 March | 45 | 23 | 68 |
| 2024 February | 45 | 28 | 73 |
| 2024 January | 0 | 4 | 4 |
| 2023 December | 0 | 1 | 1 |
| 2023 November | 0 | 9 | 9 |
| 2023 October | 3 | 14 | 17 |
| 2023 September | 4 | 12 | 16 |
| 2023 August | 7 | 18 | 25 |
| 2023 July | 2 | 12 | 14 |
| 2023 June | 0 | 2 | 2 |
| 2023 May | 0 | 13 | 13 |
| 2023 April | 0 | 1 | 1 |
| 2023 March | 5 | 1 | 6 |
| 2023 February | 49 | 27 | 76 |
| 2023 January | 32 | 29 | 61 |
| 2022 December | 53 | 36 | 89 |
| 2022 November | 63 | 29 | 92 |
| 2022 October | 42 | 26 | 68 |
| 2022 September | 35 | 22 | 57 |
| 2022 August | 42 | 54 | 96 |
| 2022 July | 27 | 37 | 64 |
| 2022 June | 31 | 33 | 64 |
| 2022 May | 33 | 27 | 60 |
| 2022 April | 43 | 26 | 69 |
| 2022 March | 44 | 35 | 79 |
| 2022 February | 40 | 28 | 68 |
| 2022 January | 68 | 34 | 102 |
| 2021 December | 24 | 35 | 59 |
| 2021 November | 25 | 42 | 67 |
| 2021 October | 32 | 55 | 87 |
| 2021 September | 19 | 37 | 56 |
| 2021 August | 23 | 29 | 52 |
| 2021 July | 24 | 34 | 58 |
| 2021 June | 30 | 22 | 52 |
| 2021 May | 28 | 32 | 60 |
| 2021 April | 27 | 76 | 103 |
| 2021 March | 42 | 23 | 65 |
| 2021 February | 36 | 18 | 54 |
| 2021 January | 36 | 19 | 55 |
| 2020 December | 25 | 14 | 39 |
| 2020 November | 23 | 21 | 44 |
| 2020 October | 19 | 13 | 32 |
| 2020 September | 18 | 10 | 28 |
| 2020 August | 20 | 28 | 48 |
| 2020 July | 23 | 14 | 37 |
| 2020 June | 14 | 16 | 30 |
| 2020 May | 19 | 14 | 33 |
| 2020 April | 25 | 16 | 41 |
| 2020 March | 18 | 29 | 47 |
| 2020 February | 38 | 27 | 65 |
| 2020 January | 28 | 25 | 53 |
| 2019 December | 21 | 31 | 52 |
| 2019 November | 11 | 25 | 36 |
| 2019 October | 15 | 28 | 43 |
| 2019 September | 10 | 34 | 44 |
| 2019 August | 16 | 11 | 27 |
| 2019 July | 16 | 34 | 50 |
| 2019 June | 14 | 34 | 48 |
| 2019 May | 31 | 60 | 91 |
| 2019 April | 13 | 53 | 66 |
| 2019 March | 9 | 34 | 43 |
| 2019 February | 11 | 12 | 23 |
| 2019 January | 13 | 12 | 25 |
| 2018 December | 7 | 16 | 23 |
| 2018 November | 34 | 22 | 56 |
| 2018 October | 31 | 12 | 43 |
| 2018 September | 11 | 12 | 23 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 5 | 6 | 11 |
| 2018 March | 7 | 7 | 14 |
| 2018 February | 8 | 7 | 15 |
| 2018 January | 5 | 6 | 11 |
| 2017 December | 9 | 9 | 18 |
| 2017 November | 6 | 11 | 17 |
| 2017 October | 8 | 9 | 17 |
| 2017 September | 6 | 5 | 11 |
| 2017 August | 8 | 12 | 20 |
| 2017 July | 2 | 17 | 19 |
| 2017 June | 14 | 10 | 24 |
| 2017 May | 8 | 10 | 18 |
| 2017 April | 5 | 6 | 11 |
| 2017 March | 6 | 16 | 22 |
| 2017 February | 4 | 7 | 11 |
| 2017 January | 4 | 8 | 12 |
| 2016 December | 14 | 11 | 25 |
| 2016 November | 24 | 16 | 40 |
| 2016 October | 17 | 15 | 32 |
| 2016 September | 20 | 14 | 34 |
| 2016 August | 19 | 5 | 24 |
| 2016 July | 16 | 6 | 22 |
| 2016 June | 25 | 8 | 33 |
| 2016 May | 16 | 6 | 22 |
| 2016 April | 12 | 0 | 12 |
| 2016 March | 11 | 0 | 11 |
| 2016 February | 9 | 0 | 9 |
| 2016 January | 21 | 17 | 38 |
| 2015 December | 22 | 12 | 34 |
| 2015 November | 25 | 8 | 33 |
| 2015 October | 8 | 2 | 10 |
| 2015 September | 1 | 0 | 1 |
| 2015 June | 1 | 0 | 1 |
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