Tomografía computarizada y reacción en cadena de la polimerasa en la infección tuberculosa de la infancia
Computerized tomography and polymerase chain reaction in pediatric tuberculosis infection
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Jiménez Ruiz" "autores" => array:1 [ 0 => array:2 [ "nombre" => "C.A." "apellidos" => "Jiménez Ruiz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615306839?idApp=UINPBA00003Z" "url" => "/03002896/0000003200000010/v1_201506230103/S0300289615306839/v1_201506230103/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Tomografía computarizada y reacción en cadena de la polimerasa en la infección tuberculosa de la infancia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "500" "paginaFinal" => "504" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Gómez-Pastrana Durán, P. Caro Mateo, R. Torronteras Santiago, M.L. Anguita Quesada, A.M. López Barrio, A. Andrés Martín, J. Navarro González" "autores" => array:7 [ 0 => array:3 [ "nombre" => "D." "apellidos" => "Gómez-Pastrana Durán" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "P." "apellidos" => "Caro Mateo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "R." "apellidos" => "Torronteras Santiago" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "M.L." "apellidos" => "Anguita Quesada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "A.M." "apellidos" => "López Barrio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Andrés Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "J." "apellidos" => "Navarro González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Sección de Neumología Pediátrica. Hospital Infantil Universitario Virgen del Rocío. Sevilla" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Radiología. Hospital Infantil Universitario Virgen del Rocío. Sevilla" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Sección de Microbiología. Hospital Infantil Universitario Virgen del Rocío. Sevilla" "etiqueta" => "***" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Ramón Carande 28, 1.° D. 41013 Sevilla." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Computerized tomography and polymerase chain reaction in pediatric tuberculosis infection" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1995-12-27" "fechaAceptado" => "1996-02-26" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec546173" "palabras" => array:3 [ 0 => "Infección tuberculosa" 1 => "Tomografía computarizada" 2 => "Reacción en cadena de la polimerasa" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec546172" "palabras" => array:3 [ 0 => "Tuberculous infection" 1 => "Computed tomography" 2 => "Polymerase chain reaction" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La diferencia entre infección y enfermedad tuberculosa puede ser difícil de establecer en la edad pediátrica. En ocasiones, puede estar presente una mínima enfermedad activa, y no ser reconocida por la radiografía de tórax ni los métodos microbiológicos habituales. Hemos realizado una tomografía computarizada a 22 niños con infección tuberculosa, radiografía de tórax normal y bacteriología negativa. En 16 de ellos, además, se realizó amplificación de ADN mediante la reacción en cadena de la polimerasa en muestras de aspirado gástrico.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Encontramos un aumento de los ganglios linfáticos mediante la tomografía computarizada en 14 de los 22 niños estudiados (63%). Las adenopatías fueron más frecuentes en los menores de 8 años y en las cadenas paratraqueales derechas. La reacción en cadena de la polimerasa fue positiva en 4 de 8 niños con tomografía patológica y fue negativa en los 8 niños con tomografía normal.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El hallazgo de enfermedad activa no reconocida por los métodos diagnósticos tradicionales plantea la cuestión del tratamiento correcto de los niños con infección tuberculosa. La asociación de un segundo fármaco a la isoniacida sería lo más adecuado en niños menores de 8 años.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The recognition of children with tuberculous infection without disease is often difficult. Minimal active disease may be present in many cases but unrecognised on chest radiography or by microbiologic methods. We have performed computed tomography in 22 children with tuberculous infection, a normal chest radiograph and negative micobacterial culture. In 16 children we also performed DNA amplification by polymerase chain reaction in gastric aspirates.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It was found that 14 of 22 (63%) infected children had enlarged lymph nodes. Adenopathies were more frequent in children less than 8 years-old and in the right paratracheal positions. Polymerase chain reaction was positive in 4 of 8 studied children with abnormal computed tomography and in none of the children with normal computed tomography.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The demonstration of unrecognised active disease raises the question of the adequate treatment for the children with tuberculous infection. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 4 | 6 |
| 2024 October | 48 | 33 | 81 |
| 2024 September | 41 | 25 | 66 |
| 2024 August | 62 | 40 | 102 |
| 2024 July | 57 | 27 | 84 |
| 2024 June | 66 | 37 | 103 |
| 2024 May | 53 | 45 | 98 |
| 2024 April | 42 | 34 | 76 |
| 2024 March | 60 | 47 | 107 |
| 2024 February | 53 | 48 | 101 |
| 2024 January | 0 | 25 | 25 |
| 2023 December | 0 | 22 | 22 |
| 2023 November | 0 | 16 | 16 |
| 2023 October | 0 | 36 | 36 |
| 2023 September | 0 | 9 | 9 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 5 | 5 |
| 2023 June | 0 | 10 | 10 |
| 2023 May | 0 | 1 | 1 |
| 2023 April | 1 | 0 | 1 |
| 2023 March | 7 | 6 | 13 |
| 2023 February | 39 | 21 | 60 |
| 2023 January | 38 | 35 | 73 |
| 2022 December | 45 | 32 | 77 |
| 2022 November | 45 | 30 | 75 |
| 2022 October | 43 | 32 | 75 |
| 2022 September | 34 | 29 | 63 |
| 2022 August | 41 | 35 | 76 |
| 2022 July | 27 | 34 | 61 |
| 2022 June | 27 | 30 | 57 |
| 2022 May | 36 | 28 | 64 |
| 2022 April | 51 | 33 | 84 |
| 2022 March | 64 | 33 | 97 |
| 2022 February | 59 | 30 | 89 |
| 2022 January | 43 | 33 | 76 |
| 2021 December | 27 | 36 | 63 |
| 2021 November | 29 | 26 | 55 |
| 2021 October | 30 | 32 | 62 |
| 2021 September | 29 | 32 | 61 |
| 2021 August | 21 | 18 | 39 |
| 2021 July | 14 | 30 | 44 |
| 2021 June | 30 | 30 | 60 |
| 2021 May | 19 | 25 | 44 |
| 2021 April | 68 | 97 | 165 |
| 2021 March | 40 | 17 | 57 |
| 2021 February | 39 | 14 | 53 |
| 2021 January | 26 | 22 | 48 |
| 2020 December | 40 | 17 | 57 |
| 2020 November | 10 | 10 | 20 |
| 2020 October | 16 | 9 | 25 |
| 2020 September | 19 | 4 | 23 |
| 2020 August | 24 | 16 | 40 |
| 2020 July | 15 | 13 | 28 |
| 2020 June | 20 | 6 | 26 |
| 2020 May | 13 | 11 | 24 |
| 2020 April | 22 | 6 | 28 |
| 2020 March | 18 | 17 | 35 |
| 2020 February | 13 | 20 | 33 |
| 2020 January | 40 | 18 | 58 |
| 2019 December | 27 | 25 | 52 |
| 2019 November | 15 | 6 | 21 |
| 2019 October | 18 | 9 | 27 |
| 2019 September | 12 | 24 | 36 |
| 2019 August | 20 | 5 | 25 |
| 2019 July | 18 | 30 | 48 |
| 2019 June | 25 | 9 | 34 |
| 2019 May | 18 | 35 | 53 |
| 2019 April | 29 | 32 | 61 |
| 2019 March | 9 | 26 | 35 |
| 2019 February | 9 | 13 | 22 |
| 2019 January | 8 | 6 | 14 |
| 2018 December | 10 | 14 | 24 |
| 2018 November | 19 | 23 | 42 |
| 2018 October | 20 | 9 | 29 |
| 2018 September | 17 | 5 | 22 |
| 2018 May | 1 | 1 | 2 |
| 2018 April | 9 | 6 | 15 |
| 2018 March | 7 | 8 | 15 |
| 2018 February | 4 | 5 | 9 |
| 2018 January | 7 | 6 | 13 |
| 2017 December | 13 | 14 | 27 |
| 2017 November | 1 | 2 | 3 |
| 2017 October | 11 | 10 | 21 |
| 2017 September | 4 | 3 | 7 |
| 2017 August | 9 | 13 | 22 |
| 2017 July | 2 | 17 | 19 |
| 2017 June | 15 | 10 | 25 |
| 2017 May | 10 | 12 | 22 |
| 2017 April | 6 | 5 | 11 |
| 2017 March | 5 | 12 | 17 |
| 2017 February | 4 | 8 | 12 |
| 2017 January | 6 | 8 | 14 |
| 2016 December | 9 | 6 | 15 |
| 2016 November | 22 | 9 | 31 |
| 2016 October | 22 | 21 | 43 |
| 2016 September | 18 | 12 | 30 |
| 2016 August | 20 | 6 | 26 |
| 2016 July | 11 | 6 | 17 |
| 2016 June | 27 | 14 | 41 |
| 2016 May | 16 | 9 | 25 |
| 2016 April | 6 | 0 | 6 |
| 2016 March | 4 | 0 | 4 |
| 2016 February | 10 | 3 | 13 |
| 2016 January | 26 | 16 | 42 |
| 2015 December | 29 | 21 | 50 |
| 2015 November | 40 | 20 | 60 |
| 2015 October | 9 | 2 | 11 |
| 2015 September | 3 | 0 | 3 |
| 2015 August | 4 | 0 | 4 |
| 2015 June | 1 | 0 | 1 |
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