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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizamos los niveles s&#233;ricos de prote&#237;na cati&#243;nica del eosin&#243;f&#237;lo &#40;ECP&#41; y su evoluci&#243;n tras tratamiento con corticoides v&#237;a t&#243;pica nasal&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 53 personas sanas &#40;grupo control&#41; y 21 pacientes&#44; diagnosticados de rinitis al&#233;rgica &#40;RA&#41; con o sin asma bronquial&#44; que presentaban al ser incluidos sintomatolog&#237;a exclusivamente rin&#237;tica&#46; Se realizaron tests cut&#225;neos por el m&#233;todo de Prick&#44; espirometr&#237;a forzada&#44; prueba de provocaci&#243;n con metacolina&#44; cuantif&#237;caci&#243;n de inmunoglobulina E&#44; hemograma con recuento de eosin&#243;filos y determinamos los niveles s&#233;ricos de ECP por la t&#233;cnica del fluoroinmunoan&#225;lisis&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes recibieron budesonida t&#243;pica nasal a dosis de 200<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Se efectuaron determinaciones de ECP y cuantif&#237;caci&#243;n de eosin&#243;f&#237;los&#44; antes del inicio del tratamiento &#40;basal&#41; y durante su realizaci&#243;n &#40;a los 21 y 60 d&#237;as&#41;&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Encontramos diferencias significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; entre los niveles s&#233;ricos de ECP del grupo control &#40;9&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;76&#41; y de pacientes &#40;determinaci&#243;n basal<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;28&#41;&#46; Estos valores descendieron significativamente a los 21-60 d&#237;as de tratamiento&#44; respecto a los basales&#44; aunque no entre los 21 y 60 d&#237;as&#46; No se apreci&#243; un descenso significativo en el n&#250;mero de eosin&#243;f&#237;los&#46; Hallamos una correlaci&#243;n entre el n&#250;mero de eosin&#243;f&#237;los y los niveles de ECP basales &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;53&#41;&#44; y no tras el tratamiento &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;25&#41;&#46; Ning&#250;n paciente present&#243; sintoma- tolog&#237;a bronquial durante el estudio&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Concluimos que encontramos diferencias significativas en los niveles s&#233;ricos de ECP entre el grupo control y de pacientes rin&#237;ticos&#46; Observamos descensos significativos de estos niveles&#44; posiblemente debido al tratamiento con corticoides por v&#237;a nasal&#44; mientras que no se hall&#243; una disminuci&#243;n del n&#250;mero de eosin&#243;f&#237;los&#46; Por todo ello&#44; los niveles de ECP podr&#237;an utilizarse para monitorizar la actividad inflamatoria en pacientes con rinitis al&#233;rgica&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We analyze changes in eosinophilic cationic protein &#40;ECP&#41; serum levels after treatment with intranasal corticoids&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifty-three healthy individuals &#40;control group&#41; and 21 patients diagnosed of allergic rhinitis&#44; with or without bronchial asthma&#44; were enrolled at a time when they had only nasal symptoms&#46; Data were collected from skin Prick tests&#44; forced spirometry&#44; methacholine challenge&#44; and complete blood workups&#44; incluiding IgE measurement&#44; eosinophil counts and ECP serum levels determined by immunofluorescence&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The patients received intranasal budesonide at a dose of 200<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; ECP levels and eosinophil counts were determined before &#40;baseline levels&#41; and during treatment &#40;on days 21 and 60&#41;&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We found significant differences &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; in baseline ECP levels of the Controls &#40;9&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;76&#41; and patients &#40;16&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;28&#41;&#46; These values were significantly lower than baseline 21 and 60 days after treatment&#44; although the changes be- tween days 21 and 60 were not significant&#46; Eosinophil counts did not fall significantly&#46; We also found that eosinophil counts and ECP levels were correlated &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;53&#41; at baseline but not after treatment &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;25&#41;&#46; No patient experienced bronchial symptoms during the study&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We conclude that ECP serum levels in patients with symptoms of rhinitis are significantly higher than levels in non symptomatic individuals&#46; These levels fall significantly&#44; possibly due to intranasal corticoid treatment&#44; although eosinophil counts remain constant&#46; ECP levels can therefore be used to monitor inflammatory activity in patients with allergic rhinitis&#46;</p></span>"
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Niveles séricos de proteína catiónica del eosinófílo en pacientes con rinitis alérgica. Evolución tras tratamiento con corticoides*
Eosinophilic cationic protein serum levels in patients with allergic rhinitis. Evolution after treatment of corticoids
F.J. Álvarez Gutiérrez1, F. Valenzuela Mateos, J.A. Rodríguez Portal, R. Sánchez Gil, E. Tabernero Huguet, J. Castillo Gómez
Servicio de Neumología. Hospital Universitario Virgen del Rocío. Sevilla
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizamos los niveles s&#233;ricos de prote&#237;na cati&#243;nica del eosin&#243;f&#237;lo &#40;ECP&#41; y su evoluci&#243;n tras tratamiento con corticoides v&#237;a t&#243;pica nasal&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 53 personas sanas &#40;grupo control&#41; y 21 pacientes&#44; diagnosticados de rinitis al&#233;rgica &#40;RA&#41; con o sin asma bronquial&#44; que presentaban al ser incluidos sintomatolog&#237;a exclusivamente rin&#237;tica&#46; Se realizaron tests cut&#225;neos por el m&#233;todo de Prick&#44; espirometr&#237;a forzada&#44; prueba de provocaci&#243;n con metacolina&#44; cuantif&#237;caci&#243;n de inmunoglobulina E&#44; hemograma con recuento de eosin&#243;filos y determinamos los niveles s&#233;ricos de ECP por la t&#233;cnica del fluoroinmunoan&#225;lisis&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes recibieron budesonida t&#243;pica nasal a dosis de 200<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Se efectuaron determinaciones de ECP y cuantif&#237;caci&#243;n de eosin&#243;f&#237;los&#44; antes del inicio del tratamiento &#40;basal&#41; y durante su realizaci&#243;n &#40;a los 21 y 60 d&#237;as&#41;&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Encontramos diferencias significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; entre los niveles s&#233;ricos de ECP del grupo control &#40;9&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;76&#41; y de pacientes &#40;determinaci&#243;n basal<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;28&#41;&#46; Estos valores descendieron significativamente a los 21-60 d&#237;as de tratamiento&#44; respecto a los basales&#44; aunque no entre los 21 y 60 d&#237;as&#46; No se apreci&#243; un descenso significativo en el n&#250;mero de eosin&#243;f&#237;los&#46; Hallamos una correlaci&#243;n entre el n&#250;mero de eosin&#243;f&#237;los y los niveles de ECP basales &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;53&#41;&#44; y no tras el tratamiento &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;25&#41;&#46; Ning&#250;n paciente present&#243; sintoma- tolog&#237;a bronquial durante el estudio&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Concluimos que encontramos diferencias significativas en los niveles s&#233;ricos de ECP entre el grupo control y de pacientes rin&#237;ticos&#46; Observamos descensos significativos de estos niveles&#44; posiblemente debido al tratamiento con corticoides por v&#237;a nasal&#44; mientras que no se hall&#243; una disminuci&#243;n del n&#250;mero de eosin&#243;f&#237;los&#46; Por todo ello&#44; los niveles de ECP podr&#237;an utilizarse para monitorizar la actividad inflamatoria en pacientes con rinitis al&#233;rgica&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We analyze changes in eosinophilic cationic protein &#40;ECP&#41; serum levels after treatment with intranasal corticoids&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifty-three healthy individuals &#40;control group&#41; and 21 patients diagnosed of allergic rhinitis&#44; with or without bronchial asthma&#44; were enrolled at a time when they had only nasal symptoms&#46; Data were collected from skin Prick tests&#44; forced spirometry&#44; methacholine challenge&#44; and complete blood workups&#44; incluiding IgE measurement&#44; eosinophil counts and ECP serum levels determined by immunofluorescence&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The patients received intranasal budesonide at a dose of 200<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; ECP levels and eosinophil counts were determined before &#40;baseline levels&#41; and during treatment &#40;on days 21 and 60&#41;&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We found significant differences &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; in baseline ECP levels of the Controls &#40;9&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;76&#41; and patients &#40;16&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;28&#41;&#46; These values were significantly lower than baseline 21 and 60 days after treatment&#44; although the changes be- tween days 21 and 60 were not significant&#46; Eosinophil counts did not fall significantly&#46; We also found that eosinophil counts and ECP levels were correlated &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;53&#41; at baseline but not after treatment &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;25&#41;&#46; No patient experienced bronchial symptoms during the study&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We conclude that ECP serum levels in patients with symptoms of rhinitis are significantly higher than levels in non symptomatic individuals&#46; These levels fall significantly&#44; possibly due to intranasal corticoid treatment&#44; although eosinophil counts remain constant&#46; ECP levels can therefore be used to monitor inflammatory activity in patients with allergic rhinitis&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="np0050">Trabajo parcialmente subvencionado por la Beca SEPAR 1994</p>"
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                          "etal" => false
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                            0 => "K&#46; Aas"
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                  "contribucion" => array:1 [
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                  "contribucion" => array:1 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "A&#46;M&#46; Vermeulen"
                            3 => "F&#46;J&#46; Zijlstra"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical eosinophil responses after allergen challenge in patients with nasal allergy"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Narita"
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                            2 => "K&#46; Asakura"
                            3 => "H&#46; Shirasaki"
                            4 => "A&#46; Kataura"
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                  "host" => array:1 [
                    0 => array:1 [
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Article information
ISSN: 03002896
Original language: Spanish
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