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array:23 [ "pii" => "S0300289615306700" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)30670-0" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "70740" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "1997" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1997;33:6-11" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2718 "formatos" => array:3 [ "EPUB" => 58 "HTML" => 1528 "PDF" => 1132 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289615306712" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)30671-2" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "70741" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 1997;33:12-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4154 "formatos" => array:3 [ "EPUB" => 84 "HTML" => 2966 "PDF" => 1104 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Valor de la tomografía computarizada en el diagnóstico de neumoconiosis complicada de mineros del carbón" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "12" "paginaFinal" => "15" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Value of computed tomography for the diagnosis of complicated pneumoconiosis in coal miners" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "C. Martínez González, G. Fernández Rego" "autores" => array:2 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Martínez González" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Fernández Rego" ] ] ] 1 => array:2 [ "autoresLista" => "J.R. Jiménez Fernández-Blanco" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.R." "apellidos" => "Jiménez Fernández-Blanco" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615306712?idApp=UINPBA00003Z" "url" => "/03002896/0000003300000001/v1_201506200422/S0300289615306712/v1_201506200422/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289615306694" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)30669-4" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "70739" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Arch Bronconeumol. 1997;33:4-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1606 "formatos" => array:3 [ "EPUB" => 48 "HTML" => 674 "PDF" => 884 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Accidentes de tráfico y apnea del sueño" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "5" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "A. Jiménez Gómez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Jiménez Gómez" ] ] ] 1 => array:2 [ "autoresLista" => "J. Terán Santos" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Terán Santos" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615306694?idApp=UINPBA00003Z" "url" => "/03002896/0000003300000001/v1_201506200422/S0300289615306694/v1_201506200422/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Niveles séricos de proteína catiónica del eosinófílo en pacientes con rinitis alérgica. Evolución tras tratamiento con corticoides<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">*</span></a>" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "11" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F.J. Álvarez Gutiérrez, F. Valenzuela Mateos, J.A. Rodríguez Portal, R. Sánchez Gil, E. Tabernero Huguet, J. Castillo Gómez" "autores" => array:6 [ 0 => array:3 [ "nombre" => "F.J." "apellidos" => "Álvarez Gutiérrez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Valenzuela Mateos" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "Rodríguez Portal" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Sánchez Gil" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Tabernero Huguet" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Castillo Gómez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital Universitario Virgen del Rocío. Sevilla" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia; Muñoz León, 9, Portal 2, 1.° A. 41009 Sevilla." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Eosinophilic cationic protein serum levels in patients with allergic rhinitis. Evolution after treatment of corticoids" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1996-02-20" "fechaAceptado" => "1996-05-07" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec545596" "palabras" => array:3 [ 0 => "Rinitis alérgica" 1 => "Eosinófílo" 2 => "Proteína catiónica del eosinófílo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec545597" "palabras" => array:3 [ 0 => "Allergic rhinitis" 1 => "Eosinophil" 2 => "Eosinophilic cationic protein" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizamos los niveles séricos de proteína catiónica del eosinófílo (ECP) y su evolución tras tratamiento con corticoides vía tópica nasal.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 53 personas sanas (grupo control) y 21 pacientes, diagnosticados de rinitis alérgica (RA) con o sin asma bronquial, que presentaban al ser incluidos sintomatología exclusivamente rinítica. Se realizaron tests cutáneos por el método de Prick, espirometría forzada, prueba de provocación con metacolina, cuantifícación de inmunoglobulina E, hemograma con recuento de eosinófilos y determinamos los niveles séricos de ECP por la técnica del fluoroinmunoanálisis.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes recibieron budesonida tópica nasal a dosis de 200<span class="elsevierStyleHsp" style=""></span>μg/24<span class="elsevierStyleHsp" style=""></span>h. Se efectuaron determinaciones de ECP y cuantifícación de eosinófílos, antes del inicio del tratamiento (basal) y durante su realización (a los 21 y 60 días).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Encontramos diferencias significativas (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,01) entre los niveles séricos de ECP del grupo control (9,34<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5,76) y de pacientes (determinación basal<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16,47<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>15,28). Estos valores descendieron significativamente a los 21-60 días de tratamiento, respecto a los basales, aunque no entre los 21 y 60 días. No se apreció un descenso significativo en el número de eosinófílos. Hallamos una correlación entre el número de eosinófílos y los niveles de ECP basales (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,53), y no tras el tratamiento (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,25). Ningún paciente presentó sintoma- tología bronquial durante el estudio.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Concluimos que encontramos diferencias significativas en los niveles séricos de ECP entre el grupo control y de pacientes riníticos. Observamos descensos significativos de estos niveles, posiblemente debido al tratamiento con corticoides por vía nasal, mientras que no se halló una disminución del número de eosinófílos. Por todo ello, los niveles de ECP podrían utilizarse para monitorizar la actividad inflamatoria en pacientes con rinitis alérgica.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We analyze changes in eosinophilic cationic protein (ECP) serum levels after treatment with intranasal corticoids.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifty-three healthy individuals (control group) and 21 patients diagnosed of allergic rhinitis, with or without bronchial asthma, were enrolled at a time when they had only nasal symptoms. Data were collected from skin Prick tests, forced spirometry, methacholine challenge, and complete blood workups, incluiding IgE measurement, eosinophil counts and ECP serum levels determined by immunofluorescence.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The patients received intranasal budesonide at a dose of 200<span class="elsevierStyleHsp" style=""></span>μg/24<span class="elsevierStyleHsp" style=""></span>h. ECP levels and eosinophil counts were determined before (baseline levels) and during treatment (on days 21 and 60).</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We found significant differences (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01) in baseline ECP levels of the Controls (9.34<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.76) and patients (16.47<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>15.28). These values were significantly lower than baseline 21 and 60 days after treatment, although the changes be- tween days 21 and 60 were not significant. Eosinophil counts did not fall significantly. We also found that eosinophil counts and ECP levels were correlated (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.53) at baseline but not after treatment (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.25). No patient experienced bronchial symptoms during the study.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We conclude that ECP serum levels in patients with symptoms of rhinitis are significantly higher than levels in non symptomatic individuals. These levels fall significantly, possibly due to intranasal corticoid treatment, although eosinophil counts remain constant. ECP levels can therefore be used to monitor inflammatory activity in patients with allergic rhinitis.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="np0050">Trabajo parcialmente subvencionado por la Beca SEPAR 1994</p>" "identificador" => "fn0005" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophils, bronchial hyperreactivity and late-phase asthmatics reactions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.R. Durham" 1 => "A.B. Kay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Allergy" "fecha" => "1985" "volumen" => "15" "paginaInicial" => "411" "paginaFinal" => "418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4053332" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The eosinophilic leukocyte, structure and function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.J. Gleich" 1 => "C.R. Adolphson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Adv Immunol" "fecha" => "1986" "volumen" => "39" "paginaInicial" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3538819" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Albumin, bradykinins, and eosinophilic cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Svensson" 1 => "M. Anderson" 2 => "C.G.A. Persson" 3 => "P. Venge" 4 => "U. Alkner" 5 => "V. Pipkorn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1990" "volumen" => "85" "paginaInicial" => "228" "paginaFinal" => "233" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study of eosinophil cationic protein (ECP) and arylsulfatase B in nasal secretions an sera from patients with nasal allergy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Satoh" 1 => "I. Takagi" 2 => "H. Itoh" 3 => "S. Baba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nippon Jibiinkoka Gakkai Kaiho" "fecha" => "1991" "volumen" => "94" "paginaInicial" => "786" "paginaFinal" => "793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1886031" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophil cationic protein and mieloperoxidase in nasal secretion as markers of inflammation in allergic rhinitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Linder" 1 => "P. Venge" 2 => "H. Deuschl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1987" "volumen" => "42" "paginaInicial" => "583" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2447809" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophils, secretory responsiveness and gluco- corticoid-induced effects on the nasal mucosa during a weak pollen season" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Klementsson" 1 => "C. Svensson" 2 => "M. Andersson" 3 => "P. Venge" 4 => "U. Pipkorn" 5 => "C.G.A. Persson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "1991" "volumen" => "21" "paginaInicial" => "705" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1777832" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mediadores de la inflamación (proteína catiónica del eosinófilo ECP) en población normal y pacientes con asma bronquial o rinitis alérgica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F.J. Álvarez Gutiérrez" 1 => "J.A. Rodríguez Portal" 2 => "F. Valenzuela Mateos" 3 => "F. Capote Gil" 4 => "R. Sánchez Gil" 5 => "J. Castillo Gómez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1995" "volumen" => "31" "paginaInicial" => "280" "paginaFinal" => "286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7627423" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical Section of the American Lung Association" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Standards for the diagnosis, care of patients with chronic obstructive pulmonary disease (COPD), asthma" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/142.1.91" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1990" "volumen" => "142" "paginaInicial" => "91" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2195937" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heterogeneity of bronchial asthma: sub-populations or different stages of the disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Aas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1981" "volumen" => "36" "paginaInicial" => "3" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7013557" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin test used in type I allergy testing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Dreborg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1989" "volumen" => "44" "numero" => "Supl 10" "paginaInicial" => "22" "paginaFinal" => "31" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativa para la práctica de la espirometría forzada" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Sanchís" 1 => "P. Casan" 2 => "J. Castillo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1985" "volumen" => "25" "paginaInicial" => "131" "paginaFinal" => "142" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metodología aceptada en la prueba de provocación con metacolina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Rosenthal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Allergy Proceeding" "fecha" => "1990" "volumen" => "4" "paginaInicial" => "12" "paginaFinal" => "32" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Los neumólogos y la nariz [editorial]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Picado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1995" "volumen" => "31" "paginaInicial" => "314" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8777524" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase albumin, eosinophil cationic protein, histamine, leukotrienes and mast cell tryptase in nasal lavage fluid after challenge whit inhalant allergen extract" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.W. Van Toorenbergen" 1 => "R.G. Van Wij" 2 => "A.M. Vermeulen" 3 => "F.J. Zijlstra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Agents Actions" "fecha" => "1992" "volumen" => "36" "numero" => "Supl C" "paginaInicial" => "421" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical eosinophil responses after allergen challenge in patients with nasal allergy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Narita" 1 => "H. Saito" 2 => "K. Asakura" 3 => "H. Shirasaki" 4 => "A. Kataura" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nippon Jibiinkoka Gakkai Kahio" "fecha" => "1994" "volumen" => "97" "paginaInicial" => "1 062" "paginaFinal" => "1.069" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophils and eosinophil cationic protein in nasal lavage in allergen-induced hyperresposiveness: effects of topical glucocorticosteroid treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Andersson" 1 => "P. Andersson" 2 => "P. Venge" 3 => "U. Pipkorn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1989" "volumen" => "44" "paginaInicial" => "342" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2669553" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergen-induced increase of eosinophil cationic protein in nasal lavage fluid: effect of the glucocorticoid budesonide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Bisgaard" 1 => "H. Gronborg" 2 => "N. Mygind" 3 => "R. Dahl" 4 => "N. Lindqvist" 5 => "P. Venge" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1990" "volumen" => "85" "paginaInicial" => "891" "paginaFinal" => "895" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2185293" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantification of eosinophil cationic protein and eosinophils in nasal secretions of allergen-induced nasal inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.Y. Wang" 1 => "P. Clement" 2 => "J. Smitz" 3 => "M. De Waele" 4 => "P. Derde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Allergol Immunopathol" "fecha" => "1994" "volumen" => "22" "paginaInicial" => "179" "paginaFinal" => "183" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in non-specific nasal reactivity and eosinophil influx and activation after allergen challenge" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Klementsson" 1 => "M. Andersson" 2 => "C.R. Baumgarten" 3 => "P. Venge" 4 => "U. Pipkorn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "1993" "volumen" => "20" "paginaInicial" => "539" "paginaFinal" => "547" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2253085" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Wang" 1 => "P. Clement" 2 => "J. Smitz" 3 => "M. De Waale" 4 => "M.P. Derde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Arch Allergy Immunol" "fecha" => "1995" "volumen" => "106" "paginaInicial" => "278" "paginaFinal" => "285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7888790" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-5 and eosinophil cationic protein in nasal lavages of rhinitis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.M. Garrelds" 1 => "T. De Graaf-in’t Veld" 2 => "M.A. Nahori" 3 => "B.B. Vargaftig" 4 => "R. Gerth van Wijk" 5 => "F.J. Zijlstra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Pharmacol" "fecha" => "1995" "volumen" => "275" "paginaInicial" => "295" "paginaFinal" => "300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7768298" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Major basic protein, eosinophil cationic protein, and arylsulfatase in nasal secretions of patients with Japanese cedar pollinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Nishioka" 1 => "T. Ogawa" 2 => "C. Saito" 3 => "S. Nishioka" 4 => "F. Nakagawa" 5 => "T. Ohomichi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Med Okayama" "fecha" => "1995" "volumen" => "49" "paginaInicial" => "29" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7762407" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of allergic rhinitis by determining of tryptase and eosinophil cationic protein in nasal secretions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rasp" 1 => "J. Bujía" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Otorrinolaringol Esp" "fecha" => "1994" "volumen" => "45" "paginaInicial" => "437" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7873234" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of systemic steroids on eosinophils and major basic protein during nasal antigen challenge [resumen]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Bascom" 1 => "U. Pipkorn" 2 => "G. Gleich" 3 => "L.M. Lichtenstein" 4 => "R.M. Nacleiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1986" "volumen" => "77" "paginaInicial" => "246" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The influx of inflammatory cells into nasal washings during the late response to antigen challenge" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Bascom" 1 => "U. Pipkorn" 2 => "L.M. Lichtenstein" 3 => "R.M. Naclerio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/138.2.406" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1988" "volumen" => "138" "paginaInicial" => "406" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3195836" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rinitis alérgica y no alérgica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.O. Meltzer" 1 => "M. Schatz" 2 => "R.S. Zeiger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Alergia. Principios y práctica. Tomo II" "paginaInicial" => "1.164" "paginaFinal" => "1.199" "serieFecha" => "1992" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophil and eosinophil cationic protein in allergic rhinitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Beppu" 1 => "N. Ohta" 2 => "S. Gon" 3 => "K. Sakata" 4 => "K. Inamura" 5 => "S. Fukase" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Otolaryngol Sppl (Stock)" "fecha" => "1994" "volumen" => "511" "paginaInicial" => "221" "paginaFinal" => "223" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship of IgE, skin-test, eosinophilia, eosinophil cationic protein and tumor necrosis factor production in allergic rhinitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.C. Jong" 1 => "S.H. Hsaio" 2 => "M.T. Liu" 3 => "J.S. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chung Hua Min Kuo Sheng Wu Chi Mien I Hsueh Tsa Chih" "fecha" => "1991" "volumen" => "24" "paginaInicial" => "345" "paginaFinal" => "354" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of serum eosinophil cationic protein as a marker of disease activity in chronic asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.C. Fergusson" 1 => "R. Vaughan" 2 => "H. Brow" 3 => "C. Curtis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1995" "volumen" => "95" "paginaInicial" => "23" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7822660" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Total blood eosinophils, serum eosinophil cationic protein and eosinophil protein X in childhood asthma: relation to disease status and therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Zimmerman" 1 => "A. Lanner" 2 => "I. Enander" 3 => "R.S. Zimmerman" 4 => "C.G.B. Peterson" 5 => "S. Ahlstedt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clinical Experimental Allergy" "fecha" => "1993" "volumen" => "23" "paginaInicial" => "564" "paginaFinal" => "570" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8221257" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0920996414003600" "estado" => "S300" "issn" => "09209964" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Henriksen" 1 => "A. Wenzel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1984.130.6.1111" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1984" "volumen" => "130" "paginaInicial" => "1.014" "paginaFinal" => "1.018" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6568806" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of topical nasal treatment on asthma symptoms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.E. Reed" 1 => "J.P. Marcoux" 2 => "P.W. Welsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1988" "volumen" => "81" "paginaInicial" => "1.042" "paginaFinal" => "1.047" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3379231" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of allergic rhinitis with intranasal corticosteroids in patients whit mild asthma: Effect on lower airway responsiveness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.A. Wade Watson" 1 => "B. Alian Becker" 2 => "F. Estelle" 3 => "R. Simons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1993" "volumen" => "91" "paginaInicial" => "97" "paginaFinal" => "101" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8423275" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Different effects of nasal and bronchial glucocorticosteroid administration on bronchial hyperresponsiveness in patients with allergic asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Aubier" 1 => "J. Levy" 2 => "C. Clerici" 3 => "F. Neukirch" 4 => "G. Herman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/146.1.122" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1992" "volumen" => "146" "paginaInicial" => "122" "paginaFinal" => "126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1626795" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seasonal increase of bronchial reactivity in allergic rhinitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Madoni" 1 => "G. Britiaco-Vangosa" 2 => "A. Papadoca" 3 => "G. Maccagni" 4 => "A. Cardani" 5 => "F. Saporiti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1987" "volumen" => "79" "paginaInicial" => "358" "paginaFinal" => "363" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3819219" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673609600726" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003300000001/v1_201506200422/S0300289615306700/v1_201506200422/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003300000001/v1_201506200422/S0300289615306700/v1_201506200422/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615306700?idApp=UINPBA00003Z" ]
Year/Month | Html | Total | |
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2024 November | 20 | 5 | 25 |
2024 October | 111 | 15 | 126 |
2024 September | 91 | 15 | 106 |
2024 August | 82 | 31 | 113 |
2024 July | 106 | 29 | 135 |
2024 June | 111 | 30 | 141 |
2024 May | 131 | 27 | 158 |
2024 April | 89 | 30 | 119 |
2024 March | 102 | 37 | 139 |
2024 February | 102 | 35 | 137 |
2024 January | 0 | 14 | 14 |
2023 December | 0 | 13 | 13 |
2023 November | 0 | 14 | 14 |
2023 October | 0 | 10 | 10 |
2023 September | 0 | 6 | 6 |
2023 August | 0 | 4 | 4 |
2023 July | 0 | 10 | 10 |
2023 June | 0 | 1 | 1 |
2023 May | 0 | 1 | 1 |
2023 April | 0 | 4 | 4 |
2023 March | 3 | 9 | 12 |
2023 February | 36 | 28 | 64 |
2023 January | 33 | 26 | 59 |
2022 December | 35 | 26 | 61 |
2022 November | 41 | 24 | 65 |
2022 October | 28 | 25 | 53 |
2022 September | 25 | 37 | 62 |
2022 August | 45 | 46 | 91 |
2022 July | 25 | 30 | 55 |
2022 June | 37 | 31 | 68 |
2022 May | 55 | 30 | 85 |
2022 April | 36 | 26 | 62 |
2022 March | 50 | 32 | 82 |
2022 February | 42 | 27 | 69 |
2022 January | 34 | 25 | 59 |
2021 December | 24 | 35 | 59 |
2021 November | 47 | 43 | 90 |
2021 October | 33 | 36 | 69 |
2021 September | 23 | 34 | 57 |
2021 August | 40 | 31 | 71 |
2021 July | 34 | 20 | 54 |
2021 June | 75 | 41 | 116 |
2021 May | 32 | 42 | 74 |
2021 April | 34 | 51 | 85 |
2021 March | 57 | 24 | 81 |
2021 February | 61 | 17 | 78 |
2021 January | 35 | 20 | 55 |
2020 December | 29 | 19 | 48 |
2020 November | 20 | 12 | 32 |
2020 October | 48 | 13 | 61 |
2020 September | 15 | 6 | 21 |
2020 August | 42 | 17 | 59 |
2020 July | 32 | 15 | 47 |
2020 June | 28 | 5 | 33 |
2020 May | 42 | 13 | 55 |
2020 April | 37 | 12 | 49 |
2020 March | 54 | 18 | 72 |
2020 February | 53 | 12 | 65 |
2020 January | 55 | 22 | 77 |
2019 December | 55 | 29 | 84 |
2019 November | 25 | 20 | 45 |
2019 October | 27 | 32 | 59 |
2019 September | 46 | 39 | 85 |
2019 August | 28 | 12 | 40 |
2019 July | 60 | 40 | 100 |
2019 June | 45 | 28 | 73 |
2019 May | 56 | 42 | 98 |
2019 April | 101 | 63 | 164 |
2019 March | 27 | 28 | 55 |
2019 February | 22 | 12 | 34 |
2019 January | 30 | 16 | 46 |
2018 December | 15 | 31 | 46 |
2018 November | 30 | 53 | 83 |
2018 October | 50 | 27 | 77 |
2018 September | 28 | 13 | 41 |
2018 May | 21 | 2 | 23 |
2018 April | 20 | 47 | 67 |
2018 March | 18 | 37 | 55 |
2018 February | 10 | 45 | 55 |
2018 January | 5 | 38 | 43 |
2017 December | 16 | 29 | 45 |
2017 November | 7 | 30 | 37 |
2017 October | 17 | 48 | 65 |
2017 September | 8 | 23 | 31 |
2017 August | 15 | 22 | 37 |
2017 July | 13 | 19 | 32 |
2017 June | 18 | 28 | 46 |
2017 May | 13 | 17 | 30 |
2017 April | 17 | 19 | 36 |
2017 March | 9 | 17 | 26 |
2017 February | 8 | 11 | 19 |
2017 January | 15 | 13 | 28 |
2016 December | 22 | 18 | 40 |
2016 November | 49 | 27 | 76 |
2016 October | 55 | 27 | 82 |
2016 September | 29 | 16 | 45 |
2016 August | 39 | 6 | 45 |
2016 July | 42 | 10 | 52 |
2016 June | 45 | 14 | 59 |
2016 May | 43 | 10 | 53 |
2016 April | 32 | 0 | 32 |
2016 March | 28 | 0 | 28 |
2016 February | 36 | 3 | 39 |
2016 January | 34 | 10 | 44 |
2015 December | 47 | 22 | 69 |
2015 November | 47 | 10 | 57 |
2015 October | 8 | 1 | 9 |
2015 September | 1 | 0 | 1 |
2015 June | 1 | 0 | 1 |