Imagen clínica
Resolución de los linfangioleiomiomas torácicos y abdominales en una paciente con linfangioleiomiomatosis tratada con sirolimus
Resolution of Thoracic and Abdominal Lymphangioleiomyomas in a Patient With Lymphangioleiomyomatosis Treated With Sirolimus
Read
8995
Timeswas read the article
2041
Total PDF
6954
Total HTML
Share statistics
array:24 [ "pii" => "S0300289615001027" "issn" => "03002896" "doi" => "10.1016/j.arbres.2015.02.013" "estado" => "S300" "fechaPublicacion" => "2016-06-01" "aid" => "1153" "copyright" => "SEPAR" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2016;52:329-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4113 "formatos" => array:3 [ "EPUB" => 103 "HTML" => 3371 "PDF" => 639 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S1579212916300416" "issn" => "15792129" "doi" => "10.1016/j.arbr.2016.04.002" "estado" => "S300" "fechaPublicacion" => "2016-06-01" "aid" => "1153" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2016;52:329-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1929 "formatos" => array:3 [ "EPUB" => 119 "HTML" => 1289 "PDF" => 521 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Resolution of Thoracic and Abdominal Lymphangioleiomyomas in a Patient With Lymphangioleiomyomatosis Treated With Sirolimus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "329" "paginaFinal" => "330" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Resolución de los linfangioleiomiomas torácicos y abdominales en una paciente con linfangioleiomiomatosis tratada con sirolimus" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1039 "Ancho" => 1500 "Tamanyo" => 201372 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest computed axial tomography (CAT) (A) showing a right paravertebral cystic lesion 3.2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.9<span class="elsevierStyleHsp" style=""></span>cm, consistent with retrocrural lymphangioleiomyoma. Abdominal CAT (B) showing tumor 6.8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3.9<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5.1<span class="elsevierStyleHsp" style=""></span>cm of retroperitoneal cystic appearance, located in the left para-aortic region, extending to the pelvis, consistent with abdominal lymphangioleiomyoma. Chest-abdominal CAT one year later (C and D) showing practically complete resolution of lesions.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Cabeza, María Ángeles Ruiz-Cobos, Álvaro Casanova" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "Cabeza" ] 1 => array:2 [ "nombre" => "María Ángeles" "apellidos" => "Ruiz-Cobos" ] 2 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Casanova" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289615001027" "doi" => "10.1016/j.arbres.2015.02.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615001027?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212916300416?idApp=UINPBA00003Z" "url" => "/15792129/0000005200000006/v1_201605260126/S1579212916300416/v1_201605260126/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0300289615001052" "issn" => "03002896" "doi" => "10.1016/j.arbres.2015.03.005" "estado" => "S300" "fechaPublicacion" => "2016-06-01" "aid" => "1156" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2016;52:331" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2368 "formatos" => array:3 [ "EPUB" => 106 "HTML" => 1707 "PDF" => 555 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen clínica</span>" "titulo" => "Ilustramos la dificultad en el diagnóstico y tratamiento del sarcoma pulmonar" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "331" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "An example of difficulty in diagnosising and treating lung sarcoma" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 679 "Ancho" => 1501 "Tamanyo" => 90902 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Radiografía de tórax: masa paracardiaca izquierda. B) Tomografía por emisión de positrones; masa inferior izquierda con aumento acusado del metabolismo glicídico que contacta con pleura posterior, espacio paravertebral y cisura mayor.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Quintana Cortés, Patricia Cruz Castellanos, Javier de Castro Carpeño" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Quintana Cortés" ] 1 => array:2 [ "nombre" => "Patricia" "apellidos" => "Cruz Castellanos" ] 2 => array:2 [ "nombre" => "Javier" "apellidos" => "de Castro Carpeño" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212916300313" "doi" => "10.1016/j.arbr.2016.03.025" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212916300313?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615001052?idApp=UINPBA00003Z" "url" => "/03002896/0000005200000006/v1_201605260144/S0300289615001052/v1_201605260144/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0300289616000089" "issn" => "03002896" "doi" => "10.1016/j.arbres.2015.12.001" "estado" => "S300" "fechaPublicacion" => "2016-06-01" "aid" => "1298" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Arch Bronconeumol. 2016;52:321-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 19894 "formatos" => array:3 [ "EPUB" => 149 "HTML" => 16376 "PDF" => 3369 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisión</span>" "titulo" => "Revisión de la enfermedad del pulmón de granjero" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "321" "paginaFinal" => "328" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Farmer's Lung Disease. A Review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figura 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1093 "Ancho" => 1650 "Tamanyo" => 160252 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Medidas de barrera. Diferentes modelos de mascarillas y filtros útiles en la evitación antigénica en la EPG.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Esteban Cano-Jiménez, Adelaida Acuña, María Isabel Botana, Teresa Hermida, María Guadalupe González, Virginia Leiro, Irene Martín, Sonia Paredes, Pilar Sanjuán" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Esteban" "apellidos" => "Cano-Jiménez" ] 1 => array:2 [ "nombre" => "Adelaida" "apellidos" => "Acuña" ] 2 => array:2 [ "nombre" => "María Isabel" "apellidos" => "Botana" ] 3 => array:2 [ "nombre" => "Teresa" "apellidos" => "Hermida" ] 4 => array:2 [ "nombre" => "María Guadalupe" "apellidos" => "González" ] 5 => array:2 [ "nombre" => "Virginia" "apellidos" => "Leiro" ] 6 => array:2 [ "nombre" => "Irene" "apellidos" => "Martín" ] 7 => array:2 [ "nombre" => "Sonia" "apellidos" => "Paredes" ] 8 => array:2 [ "nombre" => "Pilar" "apellidos" => "Sanjuán" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212916300246" "doi" => "10.1016/j.arbr.2016.03.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212916300246?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289616000089?idApp=UINPBA00003Z" "url" => "/03002896/0000005200000006/v1_201605260144/S0300289616000089/v1_201605260144/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen clínica</span>" "titulo" => "Resolución de los linfangioleiomiomas torácicos y abdominales en una paciente con linfangioleiomiomatosis tratada con sirolimus" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "329" "paginaFinal" => "330" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Luis Cabeza Osorio, María Ángeles Ruiz Cobos, Álvaro Casanova Espinosa" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Luis" "apellidos" => "Cabeza Osorio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "María Ángeles" "apellidos" => "Ruiz Cobos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "Álvaro" "apellidos" => "Casanova Espinosa" "email" => array:1 [ 0 => "acasanova1977@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario del Henares, Coslada, Madrid, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario del Henares, Coslada, Madrid, España" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Resolution of Thoracic and Abdominal Lymphangioleiomyomas in a Patient With Lymphangioleiomyomatosis Treated With Sirolimus" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1039 "Ancho" => 1500 "Tamanyo" => 188209 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tomografía axial computarizada (TAC) torácica (A) donde se observa una lesión quística paravertebral derecha de 3,2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1,9<span class="elsevierStyleHsp" style=""></span>cm, compatible con un linfangioleiomioma retrocrural. TAC abdominal (B) donde se aprecia una tumoración de 6,8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3,9<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5,1<span class="elsevierStyleHsp" style=""></span>cm de aspecto quístico retroperitoneal, de localización paraaórtica izquierda que se extiende hasta la pelvis, compatible con un linfangioleiomioma abdominal. TAC toraco-abdominal al año (C y D) donde se observa una resolución prácticamente completa de las lesiones descritas.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Mujer de 53 años diagnosticada en el año 2010 de linfangioleiomiomatosis (LAM), con afectación pulmonar difusa con múltiples quistes de paredes finas, linfangioleiomiomas quísticos retrocrurales derechos y múltiples tumoraciones de aspecto quístico retroperitoneales compatibles con linfangioleiomiomas abdominales, la de mayor tamaño de 6,8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3,9<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5,1<span class="elsevierStyleHsp" style=""></span>cm de diámetro (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a> A y B). La función pulmonar al diagnóstico mostraba una capacidad vital forzada (FVC) de 3.300<span class="elsevierStyleHsp" style=""></span>ml (98%), un volumen espiratorio forzado en el primer segundo (FEV<span class="elsevierStyleInf">1</span>) de 2.370<span class="elsevierStyleHsp" style=""></span>ml (82%) y un cociente FEV<span class="elsevierStyleInf">1</span>/FVC del 69%. La capacidad de difusión de monóxido de carbono (DLCO) era del 89%. Clínicamente, refería disnea de grandes esfuerzos y episodios intermitentes de dolor torácico y abdominal de predominio catamenial. Tras 2 años de seguimiento se observa un empeoramiento significativo de la función pulmonar siendo el FEV<span class="elsevierStyleInf">1</span> de 2.040<span class="elsevierStyleHsp" style=""></span>ml (71%) y la DLCO de un 72%, un aumento de la disnea basal y persistencia de la clínica catamenial. Dada la progresión clínica y funcional se inicia tratamiento con el inhibidor de m-TOR (del inglés <span class="elsevierStyleItalic">«mammalian target of rapamycin»</span>) sirolimus a dosis de 2<span class="elsevierStyleHsp" style=""></span>mg/día<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a>. Un año después del inicio del tratamiento se realiza un control radiológico evidenciándose una resolución prácticamente completa de los linfangioleiomiomas torácicos y abdominales<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>C y D). Se observa una mejoría clínica y estabilidad de la función pulmonar con un FEV<span class="elsevierStyleInf">1</span> de 1.980<span class="elsevierStyleHsp" style=""></span>ml (70%) y una DLCO del 82%. Esta imagen demuestra el efecto beneficioso de sirolimus en la reducción del tamaño de los linfangioleiomiomas torácicos y abdominales, y en la estabilización de la función pulmonar en pacientes con LAM.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1039 "Ancho" => 1500 "Tamanyo" => 188209 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tomografía axial computarizada (TAC) torácica (A) donde se observa una lesión quística paravertebral derecha de 3,2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1,9<span class="elsevierStyleHsp" style=""></span>cm, compatible con un linfangioleiomioma retrocrural. TAC abdominal (B) donde se aprecia una tumoración de 6,8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3,9<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5,1<span class="elsevierStyleHsp" style=""></span>cm de aspecto quístico retroperitoneal, de localización paraaórtica izquierda que se extiende hasta la pelvis, compatible con un linfangioleiomioma abdominal. TAC toraco-abdominal al año (C y D) donde se observa una resolución prácticamente completa de las lesiones descritas.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of sirolimus in lymphangioleiomyomatosis" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "National Institutes of Health Rare Lung Diseases Consortium; MILES Trial Group" "etal" => true "autores" => array:6 [ 0 => "F.X. McCormack" 1 => "Y. Inoue" 2 => "J. Moss" 3 => "L.G. Singer" 4 => "C. Strange" 5 => "K. Nakata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1100391" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2011" "volumen" => "364" "paginaInicial" => "1595" "paginaFinal" => "1606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21410393" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Everolimus treatment of abdominal lymphangioleiomyoma in five women with sporadic lymphangioleiomyomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.M. Mohammadieh" 1 => "S.D. Bowler" 2 => "E.J. Silverstone" 3 => "A.R. Glanville" 4 => "D.H. Yates" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med J Aust" "fecha" => "2013" "volumen" => "199" "paginaInicial" => "121" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23879512" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000005200000006/v1_201605260144/S0300289615001027/v1_201605260144/es/main.assets" "Apartado" => array:4 [ "identificador" => "45361" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imagen clínica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005200000006/v1_201605260144/S0300289615001027/v1_201605260144/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615001027?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 1 | 10 |
| 2024 October | 57 | 19 | 76 |
| 2024 September | 65 | 7 | 72 |
| 2024 August | 72 | 27 | 99 |
| 2024 July | 74 | 20 | 94 |
| 2024 June | 90 | 30 | 120 |
| 2024 May | 74 | 22 | 96 |
| 2024 April | 64 | 24 | 88 |
| 2024 March | 77 | 26 | 103 |
| 2024 February | 63 | 29 | 92 |
| 2023 October | 1 | 0 | 1 |
| 2023 September | 1 | 0 | 1 |
| 2023 April | 2 | 1 | 3 |
| 2023 March | 12 | 3 | 15 |
| 2023 February | 61 | 37 | 98 |
| 2023 January | 54 | 27 | 81 |
| 2022 December | 69 | 27 | 96 |
| 2022 November | 100 | 22 | 122 |
| 2022 October | 77 | 32 | 109 |
| 2022 September | 69 | 30 | 99 |
| 2022 August | 93 | 37 | 130 |
| 2022 July | 62 | 42 | 104 |
| 2022 June | 72 | 41 | 113 |
| 2022 May | 76 | 29 | 105 |
| 2022 April | 104 | 36 | 140 |
| 2022 March | 96 | 50 | 146 |
| 2022 February | 104 | 30 | 134 |
| 2022 January | 99 | 35 | 134 |
| 2021 December | 102 | 42 | 144 |
| 2021 November | 127 | 42 | 169 |
| 2021 October | 131 | 54 | 185 |
| 2021 September | 64 | 49 | 113 |
| 2021 August | 53 | 33 | 86 |
| 2021 July | 76 | 26 | 102 |
| 2021 June | 65 | 56 | 121 |
| 2021 May | 75 | 39 | 114 |
| 2021 April | 160 | 58 | 218 |
| 2021 March | 75 | 34 | 109 |
| 2021 February | 77 | 21 | 98 |
| 2021 January | 64 | 23 | 87 |
| 2020 December | 74 | 29 | 103 |
| 2020 November | 65 | 26 | 91 |
| 2020 October | 57 | 20 | 77 |
| 2020 September | 57 | 16 | 73 |
| 2020 August | 61 | 21 | 82 |
| 2020 July | 62 | 37 | 99 |
| 2020 June | 69 | 18 | 87 |
| 2020 May | 103 | 19 | 122 |
| 2020 April | 63 | 24 | 87 |
| 2020 March | 78 | 20 | 98 |
| 2020 February | 84 | 25 | 109 |
| 2020 January | 93 | 29 | 122 |
| 2019 December | 89 | 21 | 110 |
| 2019 November | 74 | 20 | 94 |
| 2019 October | 147 | 13 | 160 |
| 2019 September | 142 | 17 | 159 |
| 2019 August | 133 | 12 | 145 |
| 2019 July | 157 | 13 | 170 |
| 2019 June | 142 | 12 | 154 |
| 2019 May | 198 | 9 | 207 |
| 2019 April | 212 | 33 | 245 |
| 2019 March | 156 | 19 | 175 |
| 2019 February | 135 | 17 | 152 |
| 2019 January | 162 | 20 | 182 |
| 2018 December | 153 | 19 | 172 |
| 2018 November | 150 | 34 | 184 |
| 2018 October | 181 | 29 | 210 |
| 2018 September | 92 | 13 | 105 |
| 2018 June | 2 | 0 | 2 |
| 2018 May | 25 | 1 | 26 |
| 2018 April | 39 | 9 | 48 |
| 2018 March | 42 | 5 | 47 |
| 2018 February | 63 | 9 | 72 |
| 2018 January | 59 | 8 | 67 |
| 2017 December | 36 | 9 | 45 |
| 2017 November | 29 | 4 | 33 |
| 2017 October | 36 | 7 | 43 |
| 2017 September | 29 | 8 | 37 |
| 2017 August | 38 | 9 | 47 |
| 2017 July | 26 | 10 | 36 |
| 2017 June | 35 | 14 | 49 |
| 2017 May | 53 | 14 | 67 |
| 2017 April | 57 | 14 | 71 |
| 2017 March | 27 | 12 | 39 |
| 2017 February | 29 | 12 | 41 |
| 2017 January | 19 | 10 | 29 |
| 2016 December | 19 | 16 | 35 |
| 2016 November | 45 | 20 | 65 |
| 2016 October | 61 | 36 | 97 |
| 2016 September | 45 | 22 | 67 |
| 2016 August | 8 | 3 | 11 |
| 2016 July | 6 | 2 | 8 |
| 2016 June | 45 | 32 | 77 |
| 2016 May | 7 | 5 | 12 |
| 2016 April | 1 | 1 | 2 |
| 2016 February | 1 | 1 | 2 |
| 2016 January | 1 | 1 | 2 |
| 2015 December | 1 | 1 | 2 |
| 2015 November | 12 | 0 | 12 |
| 2015 October | 3 | 0 | 3 |
Show all
