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Carta al Director
Hemorragia alveolar oculta en paciente con sarcoma de Kaposi broncopulmonar
Occult alveolar hemorrhage in patient with bronchopulmonary Kaposi sarcoma
Ingrid Martinez Ramireza,
Corresponding author
ijmartinezr@unal.edu.co

Autor para correspondencia.
, Adan Jose Luquezb, Plutarco Garcia Herrerosc
a Fellow de Neumología, Universidad Nacional de Colombia, Bogotá, Colombia
b Medicina Interna, Universidad Nacional de Colombia, Bogotá, Colombia
c Unidad de Neumología, Instituto Nacional de Cancerología, Bogotá, Colombia
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Hemorragia alveolar oculta en paciente con sarcoma de Kaposi</span><p id="par0005" class="elsevierStylePara elsevierViewall">Se trata de un var&#243;n de 23 a&#241;os con infecci&#243;n por virus de inmunodeficiencia humana &#40;VIH&#41; y antecedente de sarcoma de Kaposi en paladar&#44; tratado con radioterapia y antirretrovirales hace 2 a&#241;os&#46; Consulta por la aparici&#243;n de lesiones viol&#225;ceas en piel de cara&#44; disnea y dolor pleur&#237;tico con recuento de linfocitos T CD4 de 149 c&#233;lulas&#47;mm<span class="elsevierStyleSup">3</span> y carga viral 52&#46;092 copias&#47;ml&#46; La tomograf&#237;a de t&#243;rax de alta resoluci&#243;n &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41; revel&#243; n&#243;dulos bilaterales con bordes irregulares y &#225;reas de vidrio esmerilado&#44; engrosamiento peribroncovascular y derrame pleural izquierdo&#46; La broncoscopia mostr&#243; una lesi&#243;n elevada de la mucosa en segmento apical de l&#243;bulo superior derecho y el lavado broncoalveolar &#40;LBA&#41;&#44; abundantes hemosider&#243;fagos que confirman la presencia de hemorragia alveolar&#46; La inmunohistoqu&#237;mica fue positiva para herpes virus tipo 8 &#40;VHH-8&#41;&#46; Se inici&#243; tratamiento con doxorrubicina liposomal&#44; y cambio de terapia antirretroviral con sobrevida de 8 meses hasta la fecha&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">El sarcoma de Kaposi con compromiso pulmonar ocurre en el 6-32&#37; de los pacientes con s&#237;ndrome de inmunodeficiencia adquirida &#40;sida&#41;&#44; que cursan con lesiones cut&#225;neas<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#44; y en el 47-75&#37; de los pacientes <span class="elsevierStyleItalic">postmortem</span><a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Las lesiones comprometen el par&#233;nquima pulmonar&#44; el &#225;rbol bronquial&#44; la pleura&#44; la pared tor&#225;cica y los ganglios linf&#225;ticos mediastinales<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a>&#44; y se asocian a un conteo de linfocitos T CD4<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100 c&#233;lulas&#47;mm<span class="elsevierStyleSup">3</span>&#46; Las coinfecciones son causa de muerte en el 80&#37; de los casos e incluyen citomegalovirus&#44; complejo <span class="elsevierStyleItalic">Mycobacterium avium</span>&#44; <span class="elsevierStyleItalic">Pneumocistis jirovecii</span>&#44; neumon&#237;a bacteriana e infecci&#243;n por herpes simplex<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La tomograf&#237;a de t&#243;rax revela n&#243;dulos mal definidos bilaterales y sim&#233;tricos en una distribuci&#243;n peribroncovascular &#40;lesiones en llama&#41;&#46; Otros hallazgos incluyen engrosamiento septal peribroncovascular e interlobular&#44; consolidaci&#243;n progresiva del espacio a&#233;reo y opacidades en vidrio esmerilado<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Las lesiones en paladar son un fuerte predictor de compromiso broncopulmonar<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; En la broncoscopia las lesiones t&#237;picas son placas de color rojo o viol&#225;ceo &#171;en cereza&#187; en el &#225;rbol bronquial<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; que se asocian a la detecci&#243;n del VHH-8 en LBA&#44; el cual es altamente espec&#237;fico &#40;95-98&#44;9&#37;&#41; con sensibilidad variable del 58-100&#37;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">La hemorragia alveolar oculta se describi&#243; 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Article information
ISSN: 03002896
Original language: Spanish
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2020 February 72 26 98
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2019 December 78 25 103
2019 November 49 19 68
2019 October 58 22 80
2019 September 82 13 95
2019 August 49 25 74
2019 July 51 25 76
2019 June 57 14 71
2019 May 88 39 127
2019 April 89 37 126
2019 March 53 27 80
2019 February 53 19 72
2019 January 50 14 64
2018 December 49 26 75
2018 November 59 27 86
2018 October 74 24 98
2018 September 54 19 73
2018 July 6 0 6
2018 June 1 0 1
2018 May 33 1 34
2018 April 54 4 58
2018 March 72 4 76
2018 February 48 6 54
2018 January 47 1 48
2017 December 44 13 57
2017 November 34 7 41
2017 October 28 7 35
2017 September 46 12 58
2017 August 43 16 59
2017 July 31 26 57
2017 June 40 24 64
2017 May 50 19 69
2017 April 25 25 50
2017 March 31 20 51
2017 February 41 18 59
2017 January 39 7 46
2016 December 38 13 51
2016 November 71 18 89
2016 October 80 18 98
2016 September 83 20 103
2016 August 68 23 91
2016 July 68 14 82
2016 June 81 23 104
2016 May 61 13 74
2016 April 32 2 34
2016 March 32 3 35
2016 February 44 4 48
2016 January 54 20 74
2015 December 67 21 88
2015 November 82 26 108
2015 October 124 5 129
2015 September 1 0 1
2015 August 3 0 3
2015 July 18 0 18
2015 June 6 0 6
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