Investigación en infecciones respiratorias: una perspectiva desde el Área Tuberculosis e Infecciones Respiratorias (TIR)
Respiratory Infections Research: a Perspective From the Tuberculosis and Respiratory Infections Area (TIR)
M. Jesús Cremades, M. Luiza de Souza-Galvão, José M. García, Rosario Menéndez
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Comité Ejecutivo del Área Tuberculosis e Infecciones Respiratorias
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Jesús Cremades, M. Luiza de Souza-Galvão, José M. García, Rosario Menéndez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Jesús Cremades" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Luiza de Souza-Galvão" ] 2 => array:2 [ "nombre" => "José M." "apellidos" => "García" ] 3 => array:4 [ "nombre" => "Rosario" "apellidos" => "Menéndez" "email" => array:1 [ 0 => "rmenend@separ.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Comité Ejecutivo del Área Tuberculosis e Infecciones Respiratorias" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Respiratory Infections Research: a Perspective From the Tuberculosis and Respiratory Infections Area (TIR)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec240593" "palabras" => array:6 [ 0 => "Infecciones respiratorias" 1 => "Neumonía" 2 => "Tuberculosis" 3 => "EPOC" 4 => "Bronquiectasias" 5 => "Fibrosis quística" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec240592" "palabras" => array:6 [ 0 => "Respiratory infections" 1 => "Pneumonia" 2 => "Tuberculosis" 3 => "COPD" 4 => "Bronchiectasis" 5 => "Cystic fibrosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Se revisó la producción científica del Área TIR de SEPAR durante 2008. En neumonías se destacaron los estudios de la proteína C reactiva, la procalcitonina y las citocinas como marcadores predictores del fracaso terapéutico y la investigación de la predisposición genética del huésped —polimorfismos de la lectina asociada a manosa— en el pronóstico. En referencia a la tuberculosis, entre las diversas actividades del año SEPAR «Tuberculosis y la solidaridad», se incluyó la publicación de la nueva normativa SEPAR para el «Diagnóstico y tratamiento de la tuberculosis». Los estudios en tuberculosis han versado sobre la infección tuberculosa, las nuevas técnicas in vitro de detección de interferón gamma, comités de diagnóstico de tuberculosis no bacilífera y pautas de tratamiento sin rifampicina e isoniacida. En la enfermedad pulmonar obstructiva crónica (EPOC) hemos destacado los nuevos aspectos en la indicación del tratamiento antibiótico publicados en el Documento de Consenso para el Tratamiento antimicrobiano de la agudización de la EPOC y en la Guía clínica SEPAR-ALAT. En el campo de la fibrosis quística (FQ), resaltamos 3 trabajos: <span class="elsevierStyleItalic">a)</span> relación entre la colonización-infección crónica por <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> y la hiperreactividad bronquial; <span class="elsevierStyleItalic">b)</span> respuestas séricas de inmunoglobulinas frente a <span class="elsevierStyleItalic">Aspergillus fumigatus</span> y <span class="elsevierStyleItalic">Candida albicans</span> en la colonización del aparato respiratorio inferior y su significado clínico, y <span class="elsevierStyleItalic">c)</span> prevalencia de micobacterias ambientales en estos pacientes. En el capítulo bronquiectasias destacó un estudio sobre la relación entre la inflamación sistémica y parámetros de gravedad, y finalmente se revisaron las principales aportaciones de la nueva normativa SEPAR sobre diagnóstico y tratamiento de las bronquiectasias.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The scientific production of the TIR Area of SEPAR during 2008 is reviewed. In pneumonias, studies on C-reactive protein, procalcitonin and the cytokines as predictive markers of treatment failure are noteworthy, as well as research into the genetic predisposition of the host (polymorphisms of mannose binding lectin) in the prognosis. Among the different activities on tuberculosis in the SEPAR «Tuberculosis and Solidarity» year, was the publication of the new SEPAR guidelines for the «Diagnosis and Treatment of Tuberculosis». The studies into tuberculosis have been on, the tuberculosis infection, the new in vitro techniques for detecting interferon gamma, new non-bacillary tuberculosis diagnostic committees, and treatment schemes without rifampicin and isoniazid. In COPD,we have highlighted new aspects in the indications for antibiotic treatment in the Consensus Document for the antibiotic treatment of acute exacerbations of COPD, and in the SEPAR-ALAT Clinical Guidelines. In the field of cystic fibrosis (CF), we highlight 3 studies: <span class="elsevierStyleItalic">a)</span> association between colonising- <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> induced chronic infection and bronchial hyperreactivity; <span class="elsevierStyleItalic">b)</span> serum immunoglobulins response to <span class="elsevierStyleItalic">Aspergillus fumigatus</span> and Ca<span class="elsevierStyleItalic">ndida albicans</span> in the colonising of the lower respiratory tract and its clinical significance; and <span class="elsevierStyleItalic">c)</span> prevalence of environmental mycobacteria in these patients. In the chapter on bronchiectasis, a study on the relationship between systemic inflammation and severity parameters is highlighted, and finally, the main contributions of the new SEPAR guidelines on the diagnosis and treatment of bronchiectasis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Soler Porcar N. Marcadores biológicos en las agudizaciones de la enfermedad pulmonar obstructiva crónica (EPOC): ¿nos ayudan en la decisión de utilizar antibióticos? Arch Bronconeumol. 2008; en prensa." ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 3 | 6 |
| 2024 October | 32 | 14 | 46 |
| 2024 September | 29 | 15 | 44 |
| 2024 August | 45 | 30 | 75 |
| 2024 July | 32 | 19 | 51 |
| 2024 June | 59 | 22 | 81 |
| 2024 May | 47 | 21 | 68 |
| 2024 April | 25 | 22 | 47 |
| 2024 March | 34 | 23 | 57 |
| 2024 February | 26 | 31 | 57 |
| 2023 March | 6 | 2 | 8 |
| 2023 February | 19 | 30 | 49 |
| 2023 January | 22 | 22 | 44 |
| 2022 December | 31 | 29 | 60 |
| 2022 November | 24 | 24 | 48 |
| 2022 October | 30 | 29 | 59 |
| 2022 September | 27 | 29 | 56 |
| 2022 August | 26 | 39 | 65 |
| 2022 July | 29 | 39 | 68 |
| 2022 June | 26 | 36 | 62 |
| 2022 May | 31 | 31 | 62 |
| 2022 April | 31 | 32 | 63 |
| 2022 March | 34 | 39 | 73 |
| 2022 February | 27 | 26 | 53 |
| 2022 January | 22 | 31 | 53 |
| 2021 December | 17 | 43 | 60 |
| 2021 November | 25 | 40 | 65 |
| 2021 October | 22 | 43 | 65 |
| 2021 September | 25 | 61 | 86 |
| 2021 August | 12 | 38 | 50 |
| 2021 July | 11 | 32 | 43 |
| 2021 June | 22 | 42 | 64 |
| 2021 May | 17 | 26 | 43 |
| 2021 April | 51 | 117 | 168 |
| 2021 March | 17 | 34 | 51 |
| 2021 February | 34 | 21 | 55 |
| 2021 January | 25 | 14 | 39 |
| 2020 December | 20 | 22 | 42 |
| 2020 November | 12 | 24 | 36 |
| 2020 October | 14 | 18 | 32 |
| 2020 September | 9 | 13 | 22 |
| 2020 August | 29 | 19 | 48 |
| 2020 July | 14 | 19 | 33 |
| 2020 June | 12 | 7 | 19 |
| 2020 May | 22 | 20 | 42 |
| 2020 April | 20 | 25 | 45 |
| 2020 March | 28 | 19 | 47 |
| 2020 February | 16 | 24 | 40 |
| 2020 January | 21 | 20 | 41 |
| 2019 December | 9 | 21 | 30 |
| 2019 November | 15 | 15 | 30 |
| 2019 October | 14 | 9 | 23 |
| 2019 September | 3 | 11 | 14 |
| 2019 August | 24 | 18 | 42 |
| 2019 July | 17 | 18 | 35 |
| 2019 June | 6 | 16 | 22 |
| 2019 May | 15 | 17 | 32 |
| 2019 April | 30 | 31 | 61 |
| 2019 March | 16 | 12 | 28 |
| 2019 February | 20 | 16 | 36 |
| 2019 January | 13 | 18 | 31 |
| 2018 December | 15 | 14 | 29 |
| 2018 November | 39 | 18 | 57 |
| 2018 October | 34 | 16 | 50 |
| 2018 September | 26 | 8 | 34 |
| 2018 July | 0 | 1 | 1 |
| 2018 May | 6 | 1 | 7 |
| 2018 April | 11 | 6 | 17 |
| 2018 March | 5 | 7 | 12 |
| 2018 February | 5 | 8 | 13 |
| 2018 January | 9 | 6 | 15 |
| 2017 December | 4 | 12 | 16 |
| 2017 November | 5 | 7 | 12 |
| 2017 October | 10 | 9 | 19 |
| 2017 September | 4 | 10 | 14 |
| 2017 August | 10 | 10 | 20 |
| 2017 July | 3 | 6 | 9 |
| 2017 June | 13 | 26 | 39 |
| 2017 May | 11 | 7 | 18 |
| 2017 April | 6 | 9 | 15 |
| 2017 March | 4 | 6 | 10 |
| 2017 February | 5 | 8 | 13 |
| 2017 January | 4 | 13 | 17 |
| 2016 December | 22 | 11 | 33 |
| 2016 November | 26 | 14 | 40 |
| 2016 October | 29 | 23 | 52 |
| 2016 September | 6 | 10 | 16 |
| 2016 August | 16 | 10 | 26 |
| 2016 July | 24 | 14 | 38 |
| 2016 June | 17 | 14 | 31 |
| 2016 May | 9 | 4 | 13 |
| 2016 April | 8 | 1 | 9 |
| 2016 March | 12 | 2 | 14 |
| 2016 February | 7 | 3 | 10 |
| 2016 January | 17 | 15 | 32 |
| 2015 December | 15 | 11 | 26 |
| 2015 November | 21 | 6 | 27 |
| 2015 October | 28 | 1 | 29 |
| 2015 September | 27 | 0 | 27 |
| 2015 August | 24 | 0 | 24 |
| 2015 July | 28 | 0 | 28 |
| 2015 June | 17 | 0 | 17 |
| 2015 May | 24 | 0 | 24 |
| 2015 April | 21 | 0 | 21 |
| 2015 March | 22 | 0 | 22 |
| 2015 February | 11 | 0 | 11 |
| 2015 January | 14 | 0 | 14 |
| 2014 December | 14 | 0 | 14 |
| 2014 November | 21 | 0 | 21 |
| 2014 October | 27 | 0 | 27 |
| 2014 September | 24 | 0 | 24 |
| 2014 August | 23 | 0 | 23 |
| 2014 July | 21 | 0 | 21 |
| 2014 June | 23 | 0 | 23 |
| 2014 May | 23 | 0 | 23 |
| 2014 April | 21 | 0 | 21 |
| 2014 March | 31 | 0 | 31 |
| 2014 February | 22 | 0 | 22 |
| 2014 January | 18 | 0 | 18 |
| 2013 December | 20 | 0 | 20 |
| 2013 November | 23 | 0 | 23 |
| 2013 October | 25 | 0 | 25 |
| 2013 September | 16 | 0 | 16 |
| 2013 August | 38 | 0 | 38 |
| 2013 July | 26 | 0 | 26 |
| 2013 June | 14 | 0 | 14 |
| 2013 May | 15 | 0 | 15 |
| 2013 April | 9 | 0 | 9 |
| 2013 March | 6 | 0 | 6 |
| 2000 January | 921 | 0 | 921 |
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