¿Cómo evaluar el riesgo de asma bronquial en lactantes y preescolares?

array:23 ["pii" => "S0300289606706883" "issn" => "03002896" "doi" => "10.1157/13092416" "estado" => "S300" "fechaPublicacion" => "2006-09-01" "aid" => "70688" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Arch Bronconeumol. 2006;42:453-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 13927 "formatos" => array:3 [ "EPUB" => 96 "HTML" => 12704 "PDF" => 1127 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289606706895" "issn" => "03002896" "doi" => "10.1157/13092417" "estado" => "S300" "fechaPublicacion" => "2006-09-01" "aid" => "70689" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:457-74" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 21022 "formatos" => array:3 [ "EPUB" => 83 "HTML" => 19826 "PDF" => 1113 ] ] "es" => array:8 [ "idiomaDefecto" => true "cabecera" => "Normativa separ" "titulo" => "Normativa del asma ocupacional" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "457" "paginaFinal" => "474" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ramon Orriols Martínez, Khalil Abu Shams, Enrique Alday Figueroa, María Jesús Cruz Carmona, Juan Bautista Galdiz Iturri, Isabel Isidro Montes, Xavier Muñoz Gall, Santiago Quirce Gancedo, Joaquín Sastre Domínguez" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Ramon" "apellidos" => "Orriols Martínez" ] 1 => array:2 [ "nombre" => "Khalil" "apellidos" => "Abu Shams" ] 2 => array:2 [ "nombre" => "Enrique" "apellidos" => "Alday Figueroa" ] 3 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Cruz Carmona" ] 4 => array:2 [ "nombre" => "Juan Bautista" "apellidos" => "Galdiz Iturri" ] 5 => array:2 [ "nombre" => "Isabel" "apellidos" => "Isidro Montes" ] 6 => array:2 [ "nombre" => "Xavier" "apellidos" => "Muñoz Gall" ] 7 => array:2 [ "nombre" => "Santiago" "apellidos" => "Quirce Gancedo" ] 8 => array:2 [ "nombre" => "Joaquín" "apellidos" => "Sastre Domínguez" ] 9 => array:1 [ "colaborador" => "Grupo de Trabajo de la Sociedad Española de Neumología Y Cirugía Torácica (SEPAR)" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289606706895?idApp=UINPBA00003Z" "url" => "/03002896/0000004200000009/v1_201305141822/S0300289606706895/v1_201305141822/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289606706871" "issn" => "03002896" "doi" => "10.1157/13092415" "estado" => "S300" "fechaPublicacion" => "2006-09-01" "aid" => "70687" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:446-52" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8335 "formatos" => array:3 [ "EPUB" => 84 "HTML" => 7263 "PDF" => 988 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "Originales" "titulo" => "Estudio multicéntrico epidemiológico-clínico de cáncer de pulmón en España (estudio EpicliCP-2003)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "446" "paginaFinal" => "452" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The EpicliCP-2003 Study: a Multicenter Epidemiological and Clinical Study of Lung Cancer in Spain" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Julio Sánchez de Cos Escuín, Luis Miravet Sorribes, José Abal Arca, Ana Núñez Ares, Jesús Hernández Hernández, Ana M. Castañar Jover, Francisco Javier Muñoz Gutiérrez, Luis García Arangüena, Miguel Ángel Alonso, M. del Carmen Montero Martínez, Jesús Allende González, Ignacio Sánchez Hernández" "autores" => array:12 [ 0 => array:2 [ "nombre" => "Julio" "apellidos" => "Sánchez de Cos Escuín" ] 1 => array:2 [ "nombre" => "Luis" "apellidos" => "Miravet Sorribes" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Abal Arca" ] 3 => array:2 [ "nombre" => "Ana" "apellidos" => "Núñez Ares" ] 4 => array:2 [ "nombre" => "Jesús" "apellidos" => "Hernández Hernández" ] 5 => array:2 [ "nombre" => "Ana M." "apellidos" => "Castañar Jover" ] 6 => array:2 [ "nombre" => "Francisco" "apellidos" => "Javier Muñoz Gutiérrez" ] 7 => array:2 [ "nombre" => "Luis" "apellidos" => "García Arangüena" ] 8 => array:2 [ "nombre" => "Miguel" "apellidos" => "Ángel Alonso" ] 9 => array:2 [ "nombre" => "M." "apellidos" => "del Carmen Montero Martínez" ] 10 => array:2 [ "nombre" => "Jesús" "apellidos" => "Allende González" ] 11 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Sánchez Hernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289606706871?idApp=UINPBA00003Z" "url" => "/03002896/0000004200000009/v1_201305141822/S0300289606706871/v1_201305141822/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "Revisión" "titulo" => "¿Cómo evaluar el riesgo de asma bronquial en lactantes y preescolares?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "453" "paginaFinal" => "456" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José A. Castro-Rodríguez" "autores" => array:1 [ 0 => array:4 [ "nombre" => "José A." "apellidos" => "Castro-Rodríguez" "email" => array:1 [ 0 => "jacastro17@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Medicina Respiratoria Infantil. Universidad de Santiago de Chile. Santiago de Chile. Chile" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. J.A. Castro-Rodríguez. Avda. San Carlos de Apoquindo 856. Las Condes. Santiago de Chile. Chile." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Assessing the Risk of Asthma in Infants and Pre-School Children" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-12-29" "fechaAceptado" => "2006-01-10" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153155" "palabras" => array:5 [ 0 => "Sibilancias" 1 => "Fenotipos" 2 => "Asma" 3 => "Algoritmo predictor de asma" 4 => "Niños" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec153156" "palabras" => array:5 [ 0 => "Wheezing" 1 => "Phenotypes" 2 => "Asthma" 3 => "Asthma predictive index" 4 => "Children" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "El asma infantil es una enfermedad inflamatoria heterogénea con diferentes fenotipos (con sibilancias transitorias, no atópicos, atópicos y obesos) y diferente expresión clínica y multifactorial, pero que siguen una vía común, caracterizada por cuadros recurrentes de obstrucción de la vía aérea. Se ha demostrado que la inmensa mayoría de asmáticos comienza su enfermedad en los primeros años de vida, que la inflamación y la remodelación de la vía aérea están ya presentes en escolares asmáticos e incluso que hay inflamación en lactantes con sibilancias persistentes. El problema consiste en identificar tempranamente qué lactante con sibilancias recurrentes tiene riesgo de presentar posteriormente asma persistente. Se postula el uso del Algoritmo Predictor de Asma (Asthma Predictive Index), que es una herramienta simple, validada en estudios longitudinales y que nos permite identificar tempranamente ese fenotipo de lactantes sibilantes (cuya función pulmonar presenta su principal deterioro irreversible en los primeros años de vida) con riesgo de desarrollar asma." ] "en" => array:1 [ "resumen" => "Childhood asthma is a heterogeneous inflammatory disease with several wheezing phenotypes (transient, atopic, nonatopic, and obese) and various clinical expressions of multifactorial origin. All forms, however, follow a similar course characterized by recurrent episodes of airway obstruction. Studies have shown that the onset of disease occurs early in life for the great majority of asthmatics, that airway inflammation and remodeling are present in schoolchildren with asthma, and that even infants with persistent wheezing present airway inflammation. The difficulty lies in the early identification of infants with recurrent wheezing who are at risk of suffering persistent asthma later in life. The Asthma Predictive Index, a simple tool validated in a longitudinal study, has been suggested for early identification of infants with recurrent wheezing who are at risk of developing asthma and whose lung function has undergone major irreversible damage during the first years of life." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical phenotypes of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.H. Bel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "44" "paginaFinal" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14749605" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchoalveolar lavage findings suggest two different forms of childhood asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.C. Stevenson" 1 => "G. Turner" 2 => "L.G. Heaney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "1997" "volumen" => "27" "paginaInicial" => "1027" "paginaFinal" => "1035" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9678834" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistent wheezing in very young children is associated with lower respiratory inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.E. Krawiec" 1 => "J.Y. Westcott" 2 => "H.W. Chu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.6.2005116" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "1338" "paginaFinal" => "1343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11371398" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophilic inflammation in the bronchial mucosa of children with bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Pohunek" 1 => "W.R. Roche" 2 => "J. Turzikova" 3 => "J. Kudrmann" 4 => "J.O. Warner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Resp J" "fecha" => "1997" "volumen" => "10" "numero" => "Suppl 25" "paginaInicial" => "160" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early thickening of the reticular basement membrane in children with difficult asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.N. Payne" 1 => "A.V. Rogers" 2 => "E. Adelroth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200205-414OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "78" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12502479" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of inhaled corticosteroids in pediatric asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H. Bisgaard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol Suppl" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "27" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9316099" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacological interventions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Pedersen" 1 => "S. Szefler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "1998" "volumen" => "12" "paginaInicial" => "40S" "paginaFinal" => "45S" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early treatment of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Haahtela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "74" "paginaFinal" => "81" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10422752" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wheezing during the first year of life in infants from low-income population: a descriptive study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Mallol" 1 => "R. Andrade" 2 => "F. Auger" 3 => "J. Rodríguez" 4 => "R. Alvarado" 5 => "L. Figueroa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Allergol Immunopathol (Madr)" "fecha" => "2005" "volumen" => "33" "paginaInicial" => "257" "paginaFinal" => "263" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma and wheezing in the first six years of life. Group Health Medical Associates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F.D. Martinez" 1 => "A.L. Wright" 2 => "L.M. Taussig" 3 => "C.J. Holberg" 4 => "M. Halonen" 5 => "W.J. Morgan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199501193320301" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1995" "volumen" => "332" "paginaInicial" => "133" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7800004" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.A. Castro-Rodríguez" 1 => "C.J. Holberg" 2 => "W.J. Morgan" 3 => "A.L. Wright" 4 => "F.D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.6.2006140" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "1344" "paginaFinal" => "1349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11371399" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Italian Study on Asthma in Young Adults study group" "etal" => false "autores" => array:6 [ 0 => "R. De Marco" 1 => "F. Locatelli" 2 => "I. Cerveri" 3 => "M. Bugiani" 4 => "A. Marinoni" 5 => "G. Giammanco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2002" "volumen" => "110" "paginaInicial" => "228" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12170262" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors in infants with lower respiratory tract diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.M. López" 1 => "H. Sepúlveda" 2 => "I. Valdés" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Chil Pediatr" "fecha" => "1994" "volumen" => "65" "paginaInicial" => "154" "paginaFinal" => "157" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.J. Morgan" 1 => "D.A. Stern" 2 => "D.L. Sherrill" 3 => "S. Guerra" 4 => "C.J. Holberg" 5 => "T.W. Guilbert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200504-525OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "172" "paginaInicial" => "1253" "paginaFinal" => "1258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16109980" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.T. Stein" 1 => "C.J. Holberg" 2 => "W.J. Morgan" 3 => "A.L. Wright" 4 => "E. Lombardi" 5 => "L. Taussig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1997" "volumen" => "52" "paginaInicial" => "946" "paginaFinal" => "952" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9487341" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient early wheeze is not associated with impaired lung function in 7-yr-old children" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Multicentre Allergy Study Group" "etal" => true "autores" => array:6 [ 0 => "S. Lau" 1 => "S. Illi" 2 => "C. Sommerfeld" 3 => "B. Niggemann" 4 => "K. Volkel" 5 => "C. Madloch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "834" "paginaFinal" => "841" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12765430" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of wheezing disorders and asthma in preschool children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F.D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pediatrics" "fecha" => "2002" "volumen" => "109" "numero" => "2 Suppl" "paginaInicial" => "362" "paginaFinal" => "367" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11826251" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interrupter resistance and wheezing phenotypes at 4 years of age" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Brussee" 1 => "H.A. Smit" 2 => "L.P. Koopman" 3 => "A.H. Wijga" 4 => "M. Kerkhof" 5 => "K. Corver" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200306-800OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2004" "volumen" => "169" "paginaInicial" => "209" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14597483" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Issues relating to children born prematurely" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.P. Speer" 1 => "M. Silverman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "1998" "volumen" => "27" "paginaInicial" => "13S" "paginaFinal" => "16S" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Siblings, day-care attendance, and the risk of asthma and wheezing during childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.M. Ball" 1 => "J.A. Castro-Rodríguez" 2 => "K.A. Griffith" 3 => "C.J. Holberg" 4 => "F.D. Martínez" 5 => "A.L. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM200008243430803" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2000" "volumen" => "343" "paginaInicial" => "538" "paginaFinal" => "543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10954761" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children’s Respiratory Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.T. Stein" 1 => "C.J. Holberg" 2 => "D. Sherrill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "1999" "volumen" => "149" "paginaInicial" => "1030" "paginaFinal" => "1037" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10355379" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.T. Stein" 1 => "D. Sherrill" 2 => "W.J. Morgan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(98)10321-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1999" "volumen" => "354" "paginaInicial" => "541" "paginaFinal" => "545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10470697" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory symptoms, asthma, exercise test, spirometry, and atopy in schoolchildren from a Lima shanty town" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.E. Penny" 1 => "S. Murad" 2 => "S.S. Madrid" 3 => "T.S. Herrera" 4 => "A. Piñeiro" 5 => "D.E. Cáceres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "607" "paginaFinal" => "612" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11462062" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How much asthma is really attributable to atopy?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Pearce" 1 => "J. Pekkanen" 2 => "R. Richard Beasley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "268" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10325905" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A different pattern of risk factors for atopic and non-atopic wheezing in 9-12-year-old children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. García-Marcos" 1 => "J.A. Castro-Rodríguez" 2 => "M.M. Suárez-Varela" 3 => "J.B. Garrido" 4 => "G.G. Hernández" 5 => "A.M. Gimeno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Allergy Immunol" "fecha" => "2005" "volumen" => "16" "paginaInicial" => "471" "paginaFinal" => "477" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A community-based study of the epidemiology of asthma. Incidence rates 1964:1983" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.W. Yunginger" 1 => "C.E. Reed" 2 => "E.J. O’Connell" 3 => "L.J. Melton" 4 => "W.M. O’Fallon" 5 => "M.D. Silverstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Rev Resp Dis" "fecha" => "1992" "volumen" => "146" "paginaInicial" => "888" "paginaFinal" => "894" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A longitudinal, population-based, cohort study of childhood asthma followed to adulthood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.R. Sears" 1 => "J.M. Greene" 2 => "A.R. Willan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa022363" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2003" "volumen" => "349" "paginaInicial" => "1414" "paginaFinal" => "1422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14534334" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors in childhood as predictors of asthma in adult life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Jenkins" 1 => "J.L. Hopper" 2 => "G. Bowes" 3 => "J.B. Carlin" 4 => "L.B. Flander" 5 => "G.G. Giles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1994" "volumen" => "309" "paginaInicial" => "90" "paginaFinal" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8038673" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Melbourne asthma study: 1964-1999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.D. Phelan" 1 => "C.F. Robertson" 2 => "A. Olinsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2002" "volumen" => "109" "paginaInicial" => "189" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11842286" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of childhood asthma in mid-adult life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Oswald" 1 => "P.D. Phelan" 2 => "A. Lanigan" 3 => "M. Hibbert" 4 => "G. Bowers" 5 => "A. Olinsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "1994" "volumen" => "309" "paginaInicial" => "95" "paginaFinal" => "96" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Specific airway resistance in 3-year-old children: a prospective cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Lowe" 1 => "C.S. Murray" 2 => "A. Custovic" 3 => "B.M. Simpson" 4 => "P.M. Kissen" 5 => "A. Woodcock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(02)08781-0" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2002" "volumen" => "359" "paginaInicial" => "1904" "paginaFinal" => "1908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12057553" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship among asthma, serum IgE and skin test reactivity to inhaled allergens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.R. Freidhoff" 1 => "D.G. Marsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Arch Allergy Immunol" "fecha" => "1993" "volumen" => "100" "paginaInicial" => "355" "paginaFinal" => "361" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8481654" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.R. Sears" 1 => "B. Burrows" 2 => "E.M. Flawndry" 3 => "G.P. Herbison" 4 => "C.J. Hewitt" 5 => "M.D. Holdaway" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199110103251504" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1991" "volumen" => "325" "paginaInicial" => "1067" "paginaFinal" => "1071" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1891008" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of asthma with serum IgE levels and skin test reactivity to allergens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Burrows" 1 => "F.D. Martínez" 2 => "M. Halonen" 3 => "R.A. Barbee" 4 => "G. Cline" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198902023200502" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "320" "paginaInicial" => "271" "paginaFinal" => "277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2911321" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Longitudinal changes in atopy during a 4-year period, relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian school children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Peat" 1 => "C.M. Salome" 2 => "A.J. Woolcock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1990" "volumen" => "85" "paginaInicial" => "65" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2299108" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pattern of atopic sensitization is associated with the development of asthma in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Illi" 1 => "E. Von Mutius" 2 => "S. Lau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2001" "volumen" => "108" "paginaInicial" => "709" "paginaFinal" => "714" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Total serum IgE and its association with asthma symptoms and allergic sensitization among children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.L. Sherrill" 1 => "R.T. Stein" 2 => "M. Halonen" 3 => "C.J. Holberg" 4 => "A. Wright" 5 => "F.D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1999" "volumen" => "104" "paginaInicial" => "28" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10400836" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for an intensive care unit admission in children with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Belessis" 1 => "S. Dixon" 2 => "A. Thomsen" 3 => "B. Duffy" 4 => "W. Rawlinson" 5 => "R. Henry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.10443" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2004" "volumen" => "37" "paginaInicial" => "201" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14966813" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma mortality in the Danish child population: risk factors and causes of asthma death" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.M. Jorgensen" 1 => "V.B. Jensen" 2 => "S. Bulow" 3 => "T.L. Dahm" 4 => "P. Prahl" 5 => "K. Juel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.10305" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2003" "volumen" => "36" "paginaInicial" => "142" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12833494" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Guerra" 1 => "A.L. Wright" 2 => "W.J. Morgan" 3 => "D.L. Sherrill" 4 => "C.J. Holberg" 5 => "F.D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200309-1224OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2004" "volumen" => "170" "paginaInicial" => "78" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028559" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age-related differences in perceived asthma control in childhood: guidelines and reality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.E. Kuehni" 1 => "U. Frey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "880" "paginaFinal" => "889" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12412679" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recognizing early asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F.D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Allergy" "fecha" => "1999" "volumen" => "54" "numero" => "Suppl 49" "paginaInicial" => "24" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15841673" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A clinical index to define risk of asthma in young children with recurrent wheezing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.A. Castro-Rodríguez" 1 => "A.L. Wright" 2 => "L.M. Taussig" 3 => "F.D. Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.162.4.9912111" "Revista" => array:6 [ "tituloSerie" => "Am J Resp Crit Care Med" "fecha" => "2000" "volumen" => "162" "paginaInicial" => "1403" "paginaFinal" => "1406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11029352" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000004200000009/v1_201305141822/S0300289606706883/v1_201305141822/es/main.assets" "Apartado" => array:4 [ "identificador" => "9299" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisiones" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000004200000009/v1_201305141822/S0300289606706883/v1_201305141822/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289606706883?idApp=UINPBA00003Z"]