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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La s&#237;lice&#44; en 1997&#44; fue incluida en el grupo 1 &#40;carcin&#243;geno demostrado en humanos&#41; de la International Agency for Research on Cancer &#40;IARC&#41;&#46; Sin embargo&#44; los resultados discrepantes de diferentes estudios hacen que persista el debate sobre su poder carcin&#243;geno&#44; y el inter&#233;s de este debate estriba en el gran n&#250;mero de trabajadores expuestos a la s&#237;lice&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizar las caracter&#237;sticas diferenciales en los casos incidentes de c&#225;ncer de pulm&#243;n entre individuos expuestos a la s&#237;lice y los no expuestos que podr&#237;an sugerir&#44; de manera indirecta&#44; alg&#250;n efecto carcinog&#233;nico de la s&#237;lice&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se recogen datos de historia laboral&#44; edad&#44; h&#225;bito tab&#225;quico&#44; espirometr&#237;a&#44; presencia de neumoconiosis y tipo histol&#243;gico de los casos de c&#225;ncer de pulm&#243;n primario&#44; en varones diagnosticados durante 22 meses consecutivos en el Instituto Nacional de Silicosis&#46; Se compararon estas variables en funci&#243;n de la exposici&#243;n a la s&#237;lice&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La comparaci&#243;n de las diferentes variables entre el grupo de pacientes con historia de exposici&#243;n a la s&#237;lice y el grupo sin exposici&#243;n demostr&#243; diferencias significativas en la edad &#40;63&#44;7 &#177; 8&#44;8 y 66&#44;7 &#177; 8&#44;6 a&#241;os&#44; respectivamente&#59; p&#60;0&#44;05&#41;&#44; el consumo de tabaco &#40;44&#44;1 &#177; 22&#44;4 y 48&#44;9 &#177; 22&#44;3 paquetesa&#241;o&#59; p&#60;0&#44;05&#41; y la presencia de un &#237;ndice de Tiffeneau por debajo del 70&#37; &#40;en el 78&#37; en expuestos frente al 55&#37; de los no expuestos&#59; p&#60;0&#44;05&#41;&#46; No se observaron diferencias en los tipos histol&#243;gicos ni en la presentaci&#243;n cl&#237;nica o radiol&#243;gica&#44; en relaci&#243;n con los antecedentes de exposici&#243;n a la s&#237;lice&#46; En el an&#225;lisis multivariante en funci&#243;n de la edad de aparici&#243;n de la enfermedad&#44; la exposici&#243;n a s&#237;lice se mantuvo como predictor independiente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los resultados de este estudio ponen de manifiesto que las caracter&#237;sticas clinicorradiol&#243;gicas y la distribuci&#243;n de las estirpes histol&#243;gicas en los pacientes con exposici&#243;n a la s&#237;lice no difieren de las de los pacientes sin exposici&#243;n&#46; Sin embargo&#44; en los individuos expuestos a la s&#237;lice durante su vida laboral&#44; el c&#225;ncer de pulm&#243;n se presenta a una edad m&#225;s temprana y en sujetos con un menor consumo de tabaco&#44; lo que podr&#237;a sugerir alg&#250;n efecto carcin&#243;geno de la s&#237;lice&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 1977 silica was listed as a group 1 carcinogen &#40;demonstrated in humans&#41; by the International Agency for Research on Cancer&#46; However&#44; conflicting results from various studies have kept debate alive as to its carcinogenic capacity&#46; The interest of this debate lies in the large number of workers exposed to silica&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To analyze the differential characteristics of lung cancer among silica exposed and silica non-exposed individuals&#44; to identify indirectly a possible carcinogenic effect of silica&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">For all males with a diagnosis of lung cancer over a period of 22 consecutive months at the National Silicosis Institute &#40;Oviedo&#44; Spain&#41;&#44; we recorded work history&#44; age&#44; smoking habits&#44; spirometry&#44; the presence of pneumoconiosis and histology&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparing the results for silica exposed and non-exposed individuals&#44; we found significant differences for age &#40;63&#46;7 &#177; 8&#46;8 and 66&#46;7 &#177; 8&#46;6 y&#44; respectively&#59; p&#60;0&#46;05&#41;&#44; smoking &#40;44&#46;1 &#177; 22&#46;4 and 48&#46;9 &#177; 22&#46;3 packs&#47;year&#59; p&#60;0&#46;05&#41; and a Tiffeneau index under 70&#37; &#40;in 78&#37; of exposed vs&#46; 55&#37; of non-exposed patients&#59; p&#60;0&#46;05&#41;&#46; No significant differences in histology&#44; signs and symptoms or radiographs were observed between the two groups&#46; In the multifactorial analysis in function of age of onset&#44; exposure to silica continued to be an independent predictor&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Our results show that the clinical and radio-logical signs and histology of patients exposed or non-exposed to silica did not differ&#46; However&#44; lung cancer appears earlier among individuals with work-related exposure to silica and lower rates of tobacco smoking&#44; suggesting some carcinogenic effect for silica&#46;</p>"
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Características del cáncer de pulmón en pacientes con exposición laboral a la sílice. Estudio comparativo entre individuos expuestos y no expuestos
Characteristics of lung cancer in patients exposed to silica at work. A comparison of exposed and non-exposed individuals
M.J. Barrenechea, C. Martínez
Corresponding author
cmartinez@hca.es

Correspondencia: Servicio de Neumología Ocupacional. Instituto Nacional de Silicosis. Hospital Central de Asturias. Dr. Bellmunt, s/n. 33006 Oviedo. España
, A. Paramá, G. Rego
Servicio de Neumología Ocupacional. Instituto Nacional de Silicosis. Oviedo. España
M.J. Ferreiroa, A. Tardónb
a Servicio de Neumología. Hospital Puerta de Hierro. Madrid. España
b Departamento de Medicina Preventiva y Salud Pública. Universidad de Oviedo. España
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La s&#237;lice&#44; en 1997&#44; fue incluida en el grupo 1 &#40;carcin&#243;geno demostrado en humanos&#41; de la International Agency for Research on Cancer &#40;IARC&#41;&#46; Sin embargo&#44; los resultados discrepantes de diferentes estudios hacen que persista el debate sobre su poder carcin&#243;geno&#44; y el inter&#233;s de este debate estriba en el gran n&#250;mero de trabajadores expuestos a la s&#237;lice&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizar las caracter&#237;sticas diferenciales en los casos incidentes de c&#225;ncer de pulm&#243;n entre individuos expuestos a la s&#237;lice y los no expuestos que podr&#237;an sugerir&#44; de manera indirecta&#44; alg&#250;n efecto carcinog&#233;nico de la s&#237;lice&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se recogen datos de historia laboral&#44; edad&#44; h&#225;bito tab&#225;quico&#44; espirometr&#237;a&#44; presencia de neumoconiosis y tipo histol&#243;gico de los casos de c&#225;ncer de pulm&#243;n primario&#44; en varones diagnosticados durante 22 meses consecutivos en el Instituto Nacional de Silicosis&#46; Se compararon estas variables en funci&#243;n de la exposici&#243;n a la s&#237;lice&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La comparaci&#243;n de las diferentes variables entre el grupo de pacientes con historia de exposici&#243;n a la s&#237;lice y el grupo sin exposici&#243;n demostr&#243; diferencias significativas en la edad &#40;63&#44;7 &#177; 8&#44;8 y 66&#44;7 &#177; 8&#44;6 a&#241;os&#44; respectivamente&#59; p&#60;0&#44;05&#41;&#44; el consumo de tabaco &#40;44&#44;1 &#177; 22&#44;4 y 48&#44;9 &#177; 22&#44;3 paquetesa&#241;o&#59; p&#60;0&#44;05&#41; y la presencia de un &#237;ndice de Tiffeneau por debajo del 70&#37; &#40;en el 78&#37; en expuestos frente al 55&#37; de los no expuestos&#59; p&#60;0&#44;05&#41;&#46; No se observaron diferencias en los tipos histol&#243;gicos ni en la presentaci&#243;n cl&#237;nica o radiol&#243;gica&#44; en relaci&#243;n con los antecedentes de exposici&#243;n a la s&#237;lice&#46; En el an&#225;lisis multivariante en funci&#243;n de la edad de aparici&#243;n de la enfermedad&#44; la exposici&#243;n a s&#237;lice se mantuvo como predictor independiente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los resultados de este estudio ponen de manifiesto que las caracter&#237;sticas clinicorradiol&#243;gicas y la distribuci&#243;n de las estirpes histol&#243;gicas en los pacientes con exposici&#243;n a la s&#237;lice no difieren de las de los pacientes sin exposici&#243;n&#46; Sin embargo&#44; en los individuos expuestos a la s&#237;lice durante su vida laboral&#44; el c&#225;ncer de pulm&#243;n se presenta a una edad m&#225;s temprana y en sujetos con un menor consumo de tabaco&#44; lo que podr&#237;a sugerir alg&#250;n efecto carcin&#243;geno de la s&#237;lice&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 1977 silica was listed as a group 1 carcinogen &#40;demonstrated in humans&#41; by the International Agency for Research on Cancer&#46; However&#44; conflicting results from various studies have kept debate alive as to its carcinogenic capacity&#46; The interest of this debate lies in the large number of workers exposed to silica&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To analyze the differential characteristics of lung cancer among silica exposed and silica non-exposed individuals&#44; to identify indirectly a possible carcinogenic effect of silica&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">For all males with a diagnosis of lung cancer over a period of 22 consecutive months at the National Silicosis Institute &#40;Oviedo&#44; Spain&#41;&#44; we recorded work history&#44; age&#44; smoking habits&#44; spirometry&#44; the presence of pneumoconiosis and histology&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparing the results for silica exposed and non-exposed individuals&#44; we found significant differences for age &#40;63&#46;7 &#177; 8&#46;8 and 66&#46;7 &#177; 8&#46;6 y&#44; respectively&#59; p&#60;0&#46;05&#41;&#44; smoking &#40;44&#46;1 &#177; 22&#46;4 and 48&#46;9 &#177; 22&#46;3 packs&#47;year&#59; p&#60;0&#46;05&#41; and a Tiffeneau index under 70&#37; &#40;in 78&#37; of exposed vs&#46; 55&#37; of non-exposed patients&#59; p&#60;0&#46;05&#41;&#46; No significant differences in histology&#44; signs and symptoms or radiographs were observed between the two groups&#46; In the multifactorial analysis in function of age of onset&#44; exposure to silica continued to be an independent predictor&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Our results show that the clinical and radio-logical signs and histology of patients exposed or non-exposed to silica did not differ&#46; However&#44; lung cancer appears earlier among individuals with work-related exposure to silica and lower rates of tobacco smoking&#44; suggesting some carcinogenic effect for silica&#46;</p>"
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Article information
ISSN: 03002896
Original language: Spanish
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