Correspondencia: Servicio de Neumología Ocupacional. Instituto Nacional de Silicosis. Hospital Central de Asturias. Dr. Bellmunt, s/n. 33006 Oviedo. España
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Hueto, J. Boldú, P. Cebollero, J.A. Cascante, J. Abu-Shams, V.M. Eguía, N. Esandi" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Hueto" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Boldú" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Cebollero" ] 3 => array:2 [ "nombre" => "J.A." "apellidos" => "Cascante" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Abu-Shams" ] 5 => array:2 [ "nombre" => "V.M." "apellidos" => "Eguía" ] 6 => array:2 [ "nombre" => "N." "apellidos" => "Esandi" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289602752903?idApp=UINPBA00003Z" "url" => "/03002896/0000003800000012/v1_201307081546/S0300289602752903/v1_201307081546/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Características del cáncer de pulmón en pacientes con exposición laboral a la sílice. Estudio comparativo entre individuos expuestos y no expuestos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "561" "paginaFinal" => "567" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "M.J. Barrenechea, C. Martínez, A. Paramá, G. Rego" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Barrenechea" ] 1 => array:4 [ "nombre" => "C." "apellidos" => "Martínez" "email" => array:1 [ 0 => "cmartinez@hca.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Paramá" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Rego" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología Ocupacional. Instituto Nacional de Silicosis. Oviedo. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Neumología Ocupacional. Instituto Nacional de Silicosis. Hospital Central de Asturias. Dr. Bellmunt, s/n. 33006 Oviedo. España" ] ] ] 1 => array:3 [ "autoresLista" => "M.J. Ferreiro, A. Tardón" "autores" => array:2 [ 0 => array:3 [ "nombre" => "M.J." "apellidos" => "Ferreiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Tardón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Puerta de Hierro. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Preventiva y Salud Pública. Universidad de Oviedo. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Characteristics of lung cancer in patients exposed to silica at work. A comparison of exposed and non-exposed individuals" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-06-25" "fechaAceptado" => "2002-10-06" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190643" "palabras" => array:4 [ 0 => "Cáncer de pulmón" 1 => "Sílice" 2 => "Carcinógeno" 3 => "Silicosis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190644" "palabras" => array:4 [ 0 => "Lung cancer" 1 => "Silica" 2 => "Carcinogen" 3 => "Silicosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La sílice, en 1997, fue incluida en el grupo 1 (carcinógeno demostrado en humanos) de la International Agency for Research on Cancer (IARC). Sin embargo, los resultados discrepantes de diferentes estudios hacen que persista el debate sobre su poder carcinógeno, y el interés de este debate estriba en el gran número de trabajadores expuestos a la sílice.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizar las características diferenciales en los casos incidentes de cáncer de pulmón entre individuos expuestos a la sílice y los no expuestos que podrían sugerir, de manera indirecta, algún efecto carcinogénico de la sílice.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se recogen datos de historia laboral, edad, hábito tabáquico, espirometría, presencia de neumoconiosis y tipo histológico de los casos de cáncer de pulmón primario, en varones diagnosticados durante 22 meses consecutivos en el Instituto Nacional de Silicosis. Se compararon estas variables en función de la exposición a la sílice.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La comparación de las diferentes variables entre el grupo de pacientes con historia de exposición a la sílice y el grupo sin exposición demostró diferencias significativas en la edad (63,7 ± 8,8 y 66,7 ± 8,6 años, respectivamente; p<0,05), el consumo de tabaco (44,1 ± 22,4 y 48,9 ± 22,3 paquetesaño; p<0,05) y la presencia de un índice de Tiffeneau por debajo del 70% (en el 78% en expuestos frente al 55% de los no expuestos; p<0,05). No se observaron diferencias en los tipos histológicos ni en la presentación clínica o radiológica, en relación con los antecedentes de exposición a la sílice. En el análisis multivariante en función de la edad de aparición de la enfermedad, la exposición a sílice se mantuvo como predictor independiente.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los resultados de este estudio ponen de manifiesto que las características clinicorradiológicas y la distribución de las estirpes histológicas en los pacientes con exposición a la sílice no difieren de las de los pacientes sin exposición. Sin embargo, en los individuos expuestos a la sílice durante su vida laboral, el cáncer de pulmón se presenta a una edad más temprana y en sujetos con un menor consumo de tabaco, lo que podría sugerir algún efecto carcinógeno de la sílice.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 1977 silica was listed as a group 1 carcinogen (demonstrated in humans) by the International Agency for Research on Cancer. However, conflicting results from various studies have kept debate alive as to its carcinogenic capacity. The interest of this debate lies in the large number of workers exposed to silica.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To analyze the differential characteristics of lung cancer among silica exposed and silica non-exposed individuals, to identify indirectly a possible carcinogenic effect of silica.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">For all males with a diagnosis of lung cancer over a period of 22 consecutive months at the National Silicosis Institute (Oviedo, Spain), we recorded work history, age, smoking habits, spirometry, the presence of pneumoconiosis and histology.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparing the results for silica exposed and non-exposed individuals, we found significant differences for age (63.7 ± 8.8 and 66.7 ± 8.6 y, respectively; p<0.05), smoking (44.1 ± 22.4 and 48.9 ± 22.3 packs/year; p<0.05) and a Tiffeneau index under 70% (in 78% of exposed vs. 55% of non-exposed patients; p<0.05). No significant differences in histology, signs and symptoms or radiographs were observed between the two groups. In the multifactorial analysis in function of age of onset, exposure to silica continued to be an independent predictor.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Our results show that the clinical and radio-logical signs and histology of patients exposed or non-exposed to silica did not differ. However, lung cancer appears earlier among individuals with work-related exposure to silica and lower rates of tobacco smoking, suggesting some carcinogenic effect for silica.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 4 | 7 |
2024 October | 30 | 38 | 68 |
2024 September | 44 | 30 | 74 |
2024 August | 51 | 49 | 100 |
2024 July | 33 | 36 | 69 |
2024 June | 40 | 67 | 107 |
2024 May | 43 | 40 | 83 |
2024 April | 18 | 22 | 40 |
2024 March | 31 | 41 | 72 |
2024 February | 29 | 43 | 72 |
2024 January | 0 | 1 | 1 |
2023 December | 0 | 5 | 5 |
2023 November | 0 | 12 | 12 |
2023 October | 0 | 6 | 6 |
2023 September | 0 | 3 | 3 |
2023 August | 0 | 4 | 4 |
2023 July | 0 | 23 | 23 |
2023 June | 0 | 12 | 12 |
2023 May | 0 | 1 | 1 |
2023 April | 0 | 4 | 4 |
2023 March | 4 | 3 | 7 |
2023 February | 16 | 30 | 46 |
2023 January | 30 | 30 | 60 |
2022 December | 45 | 28 | 73 |
2022 November | 29 | 30 | 59 |
2022 October | 33 | 36 | 69 |
2022 September | 22 | 21 | 43 |
2022 August | 30 | 55 | 85 |
2022 July | 28 | 33 | 61 |
2022 June | 29 | 49 | 78 |
2022 May | 31 | 44 | 75 |
2022 April | 31 | 77 | 108 |
2022 March | 30 | 72 | 102 |
2022 February | 36 | 40 | 76 |
2022 January | 21 | 67 | 88 |
2021 December | 18 | 54 | 72 |
2021 November | 31 | 73 | 104 |
2021 October | 39 | 73 | 112 |
2021 September | 38 | 85 | 123 |
2021 August | 25 | 74 | 99 |
2021 July | 21 | 57 | 78 |
2021 June | 38 | 83 | 121 |
2021 May | 16 | 72 | 88 |
2021 April | 30 | 123 | 153 |
2021 March | 36 | 75 | 111 |
2021 February | 37 | 34 | 71 |
2021 January | 21 | 52 | 73 |
2020 December | 40 | 43 | 83 |
2020 November | 24 | 61 | 85 |
2020 October | 17 | 36 | 53 |
2020 September | 17 | 24 | 41 |
2020 August | 28 | 29 | 57 |
2020 July | 40 | 52 | 92 |
2020 June | 14 | 50 | 64 |
2020 May | 31 | 37 | 68 |
2020 April | 28 | 30 | 58 |
2020 March | 17 | 38 | 55 |
2020 February | 34 | 37 | 71 |
2020 January | 30 | 33 | 63 |
2019 December | 30 | 38 | 68 |
2019 November | 15 | 21 | 36 |
2019 October | 10 | 30 | 40 |
2019 September | 13 | 24 | 37 |
2019 August | 18 | 8 | 26 |
2019 July | 11 | 27 | 38 |
2019 June | 22 | 14 | 36 |
2019 May | 22 | 60 | 82 |
2019 April | 31 | 61 | 92 |
2019 March | 21 | 23 | 44 |
2019 February | 11 | 10 | 21 |
2019 January | 11 | 22 | 33 |
2018 December | 19 | 25 | 44 |
2018 November | 15 | 21 | 36 |
2018 October | 24 | 18 | 42 |
2018 September | 26 | 10 | 36 |
2018 July | 1 | 0 | 1 |
2018 May | 6 | 1 | 7 |
2018 April | 6 | 7 | 13 |
2018 March | 7 | 8 | 15 |
2018 February | 6 | 12 | 18 |
2018 January | 7 | 9 | 16 |
2017 December | 13 | 18 | 31 |
2017 November | 4 | 10 | 14 |
2017 October | 10 | 9 | 19 |
2017 September | 8 | 11 | 19 |
2017 August | 7 | 9 | 16 |
2017 July | 11 | 10 | 21 |
2017 June | 15 | 21 | 36 |
2017 May | 7 | 8 | 15 |
2017 April | 7 | 7 | 14 |
2017 March | 6 | 20 | 26 |
2017 February | 2 | 10 | 12 |
2017 January | 6 | 8 | 14 |
2016 December | 14 | 10 | 24 |
2016 November | 24 | 23 | 47 |
2016 October | 16 | 20 | 36 |
2016 September | 12 | 11 | 23 |
2016 August | 13 | 6 | 19 |
2016 July | 12 | 7 | 19 |
2016 June | 17 | 7 | 24 |
2016 May | 14 | 5 | 19 |
2016 April | 7 | 2 | 9 |
2016 March | 7 | 4 | 11 |
2016 February | 14 | 3 | 17 |
2016 January | 27 | 16 | 43 |
2015 December | 30 | 14 | 44 |
2015 November | 34 | 21 | 55 |
2015 October | 167 | 1 | 168 |
2015 September | 155 | 0 | 155 |
2015 August | 148 | 0 | 148 |
2015 July | 153 | 0 | 153 |
2015 June | 139 | 0 | 139 |
2015 May | 162 | 0 | 162 |
2015 April | 115 | 0 | 115 |
2015 March | 147 | 0 | 147 |
2015 February | 125 | 0 | 125 |
2015 January | 74 | 0 | 74 |
2014 December | 90 | 0 | 90 |
2014 November | 144 | 0 | 144 |
2014 October | 172 | 0 | 172 |
2014 September | 159 | 0 | 159 |
2014 August | 102 | 0 | 102 |
2014 July | 118 | 0 | 118 |
2014 June | 177 | 0 | 177 |
2014 May | 171 | 0 | 171 |
2014 April | 163 | 0 | 163 |
2014 March | 144 | 0 | 144 |
2014 February | 99 | 0 | 99 |
2014 January | 96 | 0 | 96 |
2013 December | 62 | 0 | 62 |
2013 November | 118 | 0 | 118 |
2013 October | 101 | 0 | 101 |
2013 September | 89 | 0 | 89 |
2013 August | 62 | 0 | 62 |
2013 July | 86 | 0 | 86 |
2013 June | 60 | 0 | 60 |
2013 May | 83 | 0 | 83 |
2013 April | 39 | 0 | 39 |
2013 March | 11 | 0 | 11 |
2000 January | 5882 | 0 | 5882 |