Biopsia de músculo liso bronquial mediante fibrobroncoscopia. Eficacia de la técnica en individuos con función pulmonar normal y en pacientes con EPOC
Fiber-optic bronchoscopic biopsy of bronchial smooth muscle. Efficacy of the technique in individuals with normal lung function and patients with COPD
a Servei de Pneumologia. Unitat d'Endoscòpia Respiratòria. Hospital del Mar. Barcelona. España
b Grup de Recerca de Pneumologia. URRA-IMIM. Universitat Autònoma de Barcelona (Profs. V.C. y J.M.B.), y CEXS-Universitat Pompeu Fabra (Prof. J.L.). Barcelona. España
c Fellow Predoctoral. Grup de Recerca de Pneumologia. URRA-IMIM. CEXS-Universitat Pompeu Fabra. Barcelona. España
d Servei d'Anatomia Patològica. Hospital del Mar. Barcelona. España
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Unitat d'Endoscòpia Respiratòria. Hospital del Mar. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Grup de Recerca de Pneumologia. URRA-IMIM. Universitat Autònoma de Barcelona (Profs. V.C. y J.M.B.), y CEXS-Universitat Pompeu Fabra (Prof. J.L.). Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Fellow Predoctoral. Grup de Recerca de Pneumologia. URRA-IMIM. CEXS-Universitat Pompeu Fabra. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servei d'Anatomia Patològica. Hospital del Mar. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servei de Pneumologia. Hospital del Mar. P.° Marítim, 25-29. 08003 Barcelona. España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Fiber-optic bronchoscopic biopsy of bronchial smooth muscle. Efficacy of the technique in individuals with normal lung function and patients with COPD" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-04-02" "fechaAceptado" => "2002-06-18" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190650" "palabras" => array:7 [ 0 => "Fibrobroncoscopia" 1 => "Músculo liso bronquial" 2 => "Remodelado" 3 => "EPOC" 4 => "Desmina" 5 => "Actina" 6 => "Miosina" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190649" "palabras" => array:7 [ 0 => "Fiberoptic bronchoscopy" 1 => "Bronchial smooth muscle" 2 => "Remodeling" 3 => "COPD" 4 => "Desmin" 5 => "Actin" 6 => "Myosin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento y Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El epitelio y el músculo liso de las vías aéreas de pacientes con enfermedad pulmonar obstructiva crónica (EPOC) o asma bronquial evidencian cambios estructurales asociados probablemente con un aumento de la expresión de moléculas inflamatorias y con factores de crecimiento celular. El estudio de la relación entre enfermedad y cambios en el músculo liso bronquial es difícil si se restringe a muestras necrópsicas o de toracotomía. El presente estudio fue diseñado para evaluar la probabilidad de obtener músculo liso bronquial mediante biopsia bronquial endoscópica, tanto en pacientes con EPOC como en individuos con función pulmonar normal, su relación con la histología del epitelio bronquial, y la potencial utilidad para estudiar episodios de remodelado del músculo de la vías aéreas.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyó a 42 pacientes a quienes se realizó una fibrobroncoscopia con finalidad diagnóstica. Se tomaron sistemáticamente biopsias bronquiales de los espolones de división lobares y segmentarios. La estructura epitelial se analizó mediante histología convencional. El músculo liso fue identificado mediante immunohistoquímica (anticuerpo antidesmina) y análisis por Western-blot (anticuerpos contra desmina, actina y miosina).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El 69% de las biopsias contenía músculo liso bronquial. La probabilidad de obtener músculo liso fue mayor en biopsias de bronquios segmentarios que lobares (el 72 frente al 30%; p<0,05), y no evidenció relación con la presencia de EPOC ni con los signos de inflamación epitelial. Los fragmentos permitieron la identificación electroforética de proteínas estructurales implicadas en los procesos de remodelado muscular (miosina, actina, desmina).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La biopsia bronquial endoscópica permite obtener muestras de músculo liso bronquial, especialmente cuando se realiza en los bronquios segmentarios, en un elevado porcentaje de pacientes. Es posible que esta técnica sea útil en futuros estudios que evalúen los procesos de remodelado del músculo liso de la vía aérea.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background and Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The epithelium and airway smooth muscles of patients with chronic obstructive pulmonary disease (COPD) or bronchial asthma undergo certain structural changes that are probably related to increased expression of inflammatory molecules and cell growth factors. Studying the relation between disease and changes in bronchial smooth muscle is difficult if investigation is restricted to samples from autopsies or thoracotomies. This study was designed to evaluate the probability of obtaining bronchial smooth muscle by endoscopic bronchial biopsy in patients with COPD and from individuals with normal lung function, the relation of disease to bronchial epithelial histology, and the potential usefulness of studying airway muscle remodeling events.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Forty-two patients undergoing diagnostic fiberoptic bronchoscopy were enrolled. Bronchial biopsies were taken systematically from the lobar and segmental dividing ridges. The epithelial structure was analyzed by conventional histology. The smooth muscle was identified by immunohistochemistry (anti-desmin antibody assay) and Western-blot analysis (anti-desmin, actin and myosin antibodies).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Sixty-nine percent of the biopsies contained bronchial smooth muscle. The probability of obtaining smooth muscle was higher in segmental than in lobar biopsies (72 vs 30%, p<0.05). This probability was unrelated to the presence of COPD or to signs of epithelial inflammation. The fragments allowed us to use electrophoresis to identify protein structures (myosin, actin, desmin) involved in muscle remodeling processes.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Endoscopic biopsy of the bronchi allows us to obtain bronchial smooth muscle samples in a large percentage of patients, particularly when performed on segmental bronchi. The technique may be useful for future studies examining the processes of airway smooth muscle remodeling.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Estudio subvencionado, en parte, por las becas ARMAR, FUCAP y SEPAR. Resultados preliminares presentados en el XXXIII Congreso Nacional SEPAR, 2000</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COPD: current concepts and future prospects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.S. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 8 | 12 |
| 2024 October | 46 | 26 | 72 |
| 2024 September | 48 | 29 | 77 |
| 2024 August | 75 | 38 | 113 |
| 2024 July | 65 | 33 | 98 |
| 2024 June | 67 | 28 | 95 |
| 2024 May | 52 | 35 | 87 |
| 2024 April | 26 | 28 | 54 |
| 2024 March | 45 | 35 | 80 |
| 2024 February | 32 | 35 | 67 |
| 2024 January | 0 | 2 | 2 |
| 2023 December | 0 | 6 | 6 |
| 2023 November | 0 | 2 | 2 |
| 2023 October | 0 | 6 | 6 |
| 2023 September | 0 | 3 | 3 |
| 2023 July | 0 | 8 | 8 |
| 2023 June | 0 | 18 | 18 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 12 | 13 | 25 |
| 2023 February | 66 | 18 | 84 |
| 2023 January | 49 | 36 | 85 |
| 2022 December | 53 | 37 | 90 |
| 2022 November | 71 | 30 | 101 |
| 2022 October | 48 | 32 | 80 |
| 2022 September | 76 | 31 | 107 |
| 2022 August | 63 | 55 | 118 |
| 2022 July | 55 | 33 | 88 |
| 2022 June | 72 | 59 | 131 |
| 2022 May | 80 | 37 | 117 |
| 2022 April | 61 | 34 | 95 |
| 2022 March | 62 | 47 | 109 |
| 2022 February | 53 | 24 | 77 |
| 2022 January | 54 | 35 | 89 |
| 2021 December | 97 | 76 | 173 |
| 2021 November | 66 | 62 | 128 |
| 2021 October | 130 | 57 | 187 |
| 2021 September | 54 | 53 | 107 |
| 2021 August | 36 | 44 | 80 |
| 2021 July | 39 | 33 | 72 |
| 2021 June | 39 | 47 | 86 |
| 2021 May | 50 | 39 | 89 |
| 2021 April | 81 | 75 | 156 |
| 2021 March | 82 | 56 | 138 |
| 2021 February | 79 | 41 | 120 |
| 2021 January | 60 | 41 | 101 |
| 2020 December | 62 | 22 | 84 |
| 2020 November | 80 | 20 | 100 |
| 2020 October | 61 | 12 | 73 |
| 2020 September | 79 | 10 | 89 |
| 2020 August | 39 | 12 | 51 |
| 2020 July | 65 | 22 | 87 |
| 2020 June | 52 | 15 | 67 |
| 2020 May | 57 | 15 | 72 |
| 2020 April | 62 | 16 | 78 |
| 2020 March | 56 | 28 | 84 |
| 2020 February | 61 | 20 | 81 |
| 2020 January | 60 | 28 | 88 |
| 2019 December | 53 | 19 | 72 |
| 2019 November | 54 | 7 | 61 |
| 2019 October | 38 | 9 | 47 |
| 2019 September | 43 | 16 | 59 |
| 2019 August | 52 | 8 | 60 |
| 2019 July | 55 | 29 | 84 |
| 2019 June | 66 | 16 | 82 |
| 2019 May | 53 | 32 | 85 |
| 2019 April | 69 | 13 | 82 |
| 2019 March | 39 | 16 | 55 |
| 2019 February | 44 | 10 | 54 |
| 2019 January | 26 | 6 | 32 |
| 2018 December | 35 | 19 | 54 |
| 2018 November | 56 | 22 | 78 |
| 2018 October | 70 | 12 | 82 |
| 2018 September | 36 | 9 | 45 |
| 2018 May | 14 | 2 | 16 |
| 2018 April | 18 | 5 | 23 |
| 2018 March | 17 | 8 | 25 |
| 2018 February | 8 | 10 | 18 |
| 2018 January | 9 | 9 | 18 |
| 2017 December | 10 | 14 | 24 |
| 2017 November | 15 | 10 | 25 |
| 2017 October | 29 | 11 | 40 |
| 2017 September | 20 | 11 | 31 |
| 2017 August | 15 | 11 | 26 |
| 2017 July | 34 | 15 | 49 |
| 2017 June | 30 | 17 | 47 |
| 2017 May | 33 | 6 | 39 |
| 2017 April | 24 | 14 | 38 |
| 2017 March | 32 | 12 | 44 |
| 2017 February | 9 | 6 | 15 |
| 2017 January | 11 | 6 | 17 |
| 2016 December | 33 | 9 | 42 |
| 2016 November | 24 | 14 | 38 |
| 2016 October | 26 | 15 | 41 |
| 2016 September | 27 | 16 | 43 |
| 2016 August | 21 | 7 | 28 |
| 2016 July | 20 | 6 | 26 |
| 2016 June | 25 | 10 | 35 |
| 2016 May | 21 | 5 | 26 |
| 2016 April | 13 | 0 | 13 |
| 2016 March | 9 | 3 | 12 |
| 2016 February | 15 | 3 | 18 |
| 2016 January | 26 | 14 | 40 |
| 2015 December | 28 | 10 | 38 |
| 2015 November | 31 | 8 | 39 |
| 2015 October | 139 | 1 | 140 |
| 2015 September | 161 | 0 | 161 |
| 2015 August | 108 | 0 | 108 |
| 2015 July | 114 | 0 | 114 |
| 2015 June | 133 | 0 | 133 |
| 2015 May | 229 | 0 | 229 |
| 2015 April | 149 | 0 | 149 |
| 2015 March | 133 | 0 | 133 |
| 2015 February | 110 | 0 | 110 |
| 2015 January | 108 | 0 | 108 |
| 2014 December | 105 | 0 | 105 |
| 2014 November | 166 | 0 | 166 |
| 2014 October | 227 | 0 | 227 |
| 2014 September | 127 | 0 | 127 |
| 2014 August | 112 | 0 | 112 |
| 2014 July | 94 | 0 | 94 |
| 2014 June | 141 | 0 | 141 |
| 2014 May | 200 | 0 | 200 |
| 2014 April | 146 | 0 | 146 |
| 2014 March | 127 | 0 | 127 |
| 2014 February | 104 | 0 | 104 |
| 2014 January | 62 | 0 | 62 |
| 2013 December | 86 | 0 | 86 |
| 2013 November | 106 | 0 | 106 |
| 2013 October | 107 | 0 | 107 |
| 2013 September | 82 | 0 | 82 |
| 2013 August | 96 | 0 | 96 |
| 2013 July | 81 | 0 | 81 |
| 2013 June | 87 | 0 | 87 |
| 2013 May | 95 | 0 | 95 |
| 2013 April | 69 | 0 | 69 |
| 2013 March | 13 | 0 | 13 |
| 2000 January | 4505 | 0 | 4505 |
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