Síndrome antisintetasa y afección pulmonar intersticial. Descripción de 6 casos
Antisynthetase syndrome and interstitial lung involvement. Report of 6 cases
R. Santiago Villalobos
, J.L. López-Campos Bodineau, E. Rodríguez Becerra, E. Laserna Martínez, E. Luque Crespo, G. Borja Urbano
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Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Hospital Universitario Virgen del Rocío. Sevilla
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Borja Urbano" "autores" => array:6 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Santiago Villalobos" "email" => array:1 [ 0 => "rsantiago_villalobos@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J.L." "apellidos" => "López-Campos Bodineau" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Rodríguez Becerra" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Laserna Martínez" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Luque Crespo" ] 5 => array:2 [ "nombre" => "G." "apellidos" => "Borja Urbano" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Hospital Universitario Virgen del Rocío. Sevilla" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Bami, 27, 4° D. 41013 Sevilla" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Antisynthetase syndrome and interstitial lung involvement. Report of 6 cases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-12-27" "fechaAceptado" => "2002-03-19" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190663" "palabras" => array:3 [ 0 => "Enfermedad pulmonar intersticial" 1 => "Síndrome antisintetasa" 2 => "Enfermedad sistémica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190664" "palabras" => array:3 [ 0 => "Interstitial lung disease" 1 => "Antisynthetase syndrome" 2 => "Systemic disease" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentamos los casos de 6 pacientes, 4 varones y 2 mujeres, diagnosticados de síndrome antisintetasa con afección pulmonar. La edad media era de 60 años. El síntoma guía desde el punto de vista respiratorio fue la disnea progresiva, presente en 4 pacientes. De los otros dos pacientes, uno tenía hemoptisis y el otro estaba asintomático. Respecto a la clínica sistémica, 2 pacientes presentaban fenómeno de Raynaud, 3 artritis de manos y 4 afección muscular. La radiografía del tórax revelaba la presencia de infiltrados intersticiales lineales de distinto grado en todos los casos menos en un paciente, quien además padecía una silicosis. La exploración funcional respiratoria demostró una alteración ventilatoria restrictiva en 4 casos, de carácter obstructivo en un paciente afectado de EPOC y normal en otro. El anticuerpo antisintetasa (ACAS) detectado fue el anti-Jo1 en 4 casos y el anti-PL12 en otro. En el sexto caso no se determinó la naturaleza del ACAS. La evolución de los enfermos fue favorable en todos los casos menos en uno. La determinación de los ACAS es de utilidad dentro del estudio de las neumopatías intersticiales idiopáticas</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The cases of 6 patients (4 men, 2 women) with antisynthetase syndrome are reported. The mean age was 60 years and the most frequent symptom was increasing dyspnea (4 patients). One of the remaining 2 patients had hemoptysis and the last was asymptomatic. Systemic symptoms included Raynaud's phenomenon (2 patients), arthritis in hands (3) and muscle impairment (4). Chest films showed linear interstitial infiltrates of varying severity in 5 patients; the patient without such infiltrates also suffered silicosis. Functional assessment showed restrictive impairment in 4 patients; of the remaining 2 patients, 1 had chronic obstructive pulmonary disease and 1 had normal function. The antisynthetase antibody (ASAB) detected was anti-Jo-1 in 4 cases, anti-PL-12 in 1 case, and unidentified in 1 case. The course of disease was satisfactory for 5 patients. ASAB analysis is useful for studying idiopathic interstitial lung disease</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aminoacyl-tRNA histidil (Jo-1) synthetase autoantibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.J. Maddison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Autoantibodies. Elsevier Science" "paginaInicial" => "31" "paginaFinal" => "35" "serieFecha" => "1996" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aminoacyl-tRNA (other than histidil) synthetase autoantibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "I.N. Targoff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Autoantibodies. Elsevier Science" "paginaInicial" => "36" "paginaFinal" => "46" "serieFecha" => "1996" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis: charaterization of the Jo-1 antibody system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Nishikai" 1 => "M. Reichlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Anthritis Rheum" "fecha" => "1980" "volumen" => "23" "paginaInicial" => "881" "paginaFinal" => "888" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-Jo-1 antibody: a marker for myositis with interstitial lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Bernstein" 1 => "S.H. Morgan" 2 => "J. Chapman" 3 => "C.C. Bunn" 4 => "M.B. Mathews" 5 => "M. Turner-Warwick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Bmj (Clin Res Ed)" "fecha" => "1984" "volumen" => "289" "paginaInicial" => "151" "paginaFinal" => "152" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymiositis pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Marguerie" 1 => "C.C. Bunn" 2 => "H.L. Beynon" 3 => "R.M. Bernstein" 4 => "J.M. Hughes" 5 => "A.K. So" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Q J Med" "fecha" => "1990" "volumen" => "77" "paginaInicial" => "1019" "paginaFinal" => "1038" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2267280" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.A. Love" 1 => "R.L. Reff" 2 => "D.D. Fraser" 3 => "I.N. Targoff" 4 => "M. Dalakas" 5 => "P.H. Plotz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "1991" "volumen" => "70" "paginaInicial" => "360" "paginaFinal" => "374" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification and prognosis of inflammatory muscle disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F.W. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "1994" "volumen" => "20" "paginaInicial" => "811" "paginaFinal" => "826" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7855323" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Síndrome antisintetasa. Presentación de 3 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "C. Campos Fernández" 1 => "J. Calvo Catalá" 2 => "M.I. González-Cruz Cervellera" 3 => "J.V. Parra Ródenas" 4 => "M. García Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Esp Reumatol" "fecha" => "1998" "volumen" => "25" "paginaInicial" => "106" "paginaFinal" => "108" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.N. Targoff" 1 => "F.C. Arnett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1990" "volumen" => "88" "paginaInicial" => "241" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2178410" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti PL-12 and pulmonary fibrosis in a patient ten years after silica/silicate dust exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Osterode" 1 => "H. Rudiger" 2 => "W. Graninger" 3 => "D.H. Petzl" 4 => "K. Rappersberger" 5 => "G. Dekan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "1998" "volumen" => "16" "paginaInicial" => "622" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9779317" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple clinical and biological autoinmune manifestations in 50 workers after occupational exposure to silica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Sánchez Román" 1 => "I. Wichmann" 2 => "J. Salaberri" 3 => "J.M. Valera" 4 => "A. Núñez- Roldán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "1993" "volumen" => "52" "paginaInicial" => "534" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8394065" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of polymiositis with anti-histidyl-t-rNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Serratrice" 1 => "B. Granel" 2 => "X. Pache" 3 => "P. Disdier" 4 => "C. De Roux-Serratrice" 5 => "J.F. Pellissier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2001" "volumen" => "20" "paginaInicial" => "379" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11642524" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.W. Friedman" 1 => "I.N. Targoff" 2 => "F.C. Arnett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "1996" "volumen" => "26" "paginaInicial" => "459" "paginaFinal" => "467" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8870113" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug therapy of the idiopathic inflammatory myopathies: Predictors of response to prednisone, azathioprine and methotrexate and a comparison of their efficacy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. Joffe" 1 => "L.A. Love" 2 => "R.L. Leff" 3 => "D.D. Fraser" 4 => "I.N. Targoff" 5 => "J.E. Hicks" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1993" "volumen" => "94" "paginaInicial" => "379" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8386437" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Isolation of a novel antibody, which precipitates ribonucleoprotein complex containing threonine tRNA from a patient with polymyositis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Okada" 1 => "R. Mukai" 2 => "F. Harada" 3 => "T. Kabashima" 4 => "Y. Nakao" 5 => "K. Yamane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Biochem" "fecha" => "1984" "volumen" => "139" "paginaInicial" => "425" "paginaFinal" => "429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6559690" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoantibodies against alanyl-tRNA synthetase and tRNAAla coexist and are associated with myositis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.C. Bunn" 1 => "R.M. Bernstein" 2 => "M.B. Mathews" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1986" "volumen" => "163" "paginaInicial" => "1281" "paginaFinal" => "1291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3701255" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoantibodies to glycyl-transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Hirakata" 1 => "A. Suwa" 2 => "Y. Takeda" 3 => "Y. Matsuoka" 4 => "S. Irimajiri" 5 => "I.N. Targoff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1996" "volumen" => "39" "paginaInicial" => "146" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8546723" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of polymyositis with anti-OJ (isoleucyl-transfer RNA synthetase) antibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Suwa" 1 => "M. Hirakata" 2 => "S. Satoh" 3 => "T. Ezaki" 4 => "T. Mimori" 5 => "S. Inada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "755" "paginaFinal" => "756" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10609083" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Hirakata" 1 => "A. Suwa" 2 => "S. Nagai" 3 => "M.A. Kron" 4 => "E.P. Trieu" 5 => "a.l. Mimori T et" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1999" "volumen" => "162" "paginaInicial" => "2315" "paginaFinal" => "2330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9973509" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003800000010/v1_201307081551/S0300289602752733/v1_201307081551/es/main.assets" "Apartado" => array:4 [ "identificador" => "9217" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Notas clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003800000010/v1_201307081551/S0300289602752733/v1_201307081551/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289602752733?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 23 | 28 |
| 2024 October | 41 | 131 | 172 |
| 2024 September | 52 | 135 | 187 |
| 2024 August | 57 | 93 | 150 |
| 2024 July | 64 | 104 | 168 |
| 2024 June | 56 | 108 | 164 |
| 2024 May | 47 | 73 | 120 |
| 2024 April | 38 | 70 | 108 |
| 2024 March | 42 | 83 | 125 |
| 2024 February | 33 | 64 | 97 |
| 2024 January | 0 | 7 | 7 |
| 2023 December | 0 | 11 | 11 |
| 2023 November | 0 | 12 | 12 |
| 2023 October | 0 | 5 | 5 |
| 2023 August | 8 | 1 | 9 |
| 2023 July | 0 | 17 | 17 |
| 2023 June | 0 | 18 | 18 |
| 2023 May | 0 | 3 | 3 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 6 | 37 | 43 |
| 2023 February | 30 | 86 | 116 |
| 2023 January | 35 | 91 | 126 |
| 2022 December | 36 | 126 | 162 |
| 2022 November | 41 | 143 | 184 |
| 2022 October | 36 | 184 | 220 |
| 2022 September | 35 | 135 | 170 |
| 2022 August | 36 | 143 | 179 |
| 2022 July | 28 | 200 | 228 |
| 2022 June | 23 | 229 | 252 |
| 2022 May | 35 | 172 | 207 |
| 2022 April | 30 | 205 | 235 |
| 2022 March | 47 | 199 | 246 |
| 2022 February | 31 | 205 | 236 |
| 2022 January | 35 | 199 | 234 |
| 2021 December | 33 | 190 | 223 |
| 2021 November | 50 | 208 | 258 |
| 2021 October | 37 | 242 | 279 |
| 2021 September | 30 | 196 | 226 |
| 2021 August | 32 | 225 | 257 |
| 2021 July | 23 | 212 | 235 |
| 2021 June | 34 | 279 | 313 |
| 2021 May | 29 | 218 | 247 |
| 2021 April | 53 | 433 | 486 |
| 2021 March | 74 | 311 | 385 |
| 2021 February | 48 | 181 | 229 |
| 2021 January | 42 | 184 | 226 |
| 2020 December | 39 | 168 | 207 |
| 2020 November | 26 | 233 | 259 |
| 2020 October | 48 | 170 | 218 |
| 2020 September | 33 | 131 | 164 |
| 2020 August | 47 | 139 | 186 |
| 2020 July | 29 | 155 | 184 |
| 2020 June | 29 | 126 | 155 |
| 2020 May | 20 | 149 | 169 |
| 2020 April | 31 | 147 | 178 |
| 2020 March | 41 | 247 | 288 |
| 2020 February | 32 | 298 | 330 |
| 2020 January | 39 | 306 | 345 |
| 2019 December | 42 | 264 | 306 |
| 2019 November | 44 | 271 | 315 |
| 2019 October | 69 | 425 | 494 |
| 2019 September | 59 | 266 | 325 |
| 2019 August | 43 | 194 | 237 |
| 2019 July | 66 | 278 | 344 |
| 2019 June | 57 | 270 | 327 |
| 2019 May | 100 | 349 | 449 |
| 2019 April | 94 | 337 | 431 |
| 2019 March | 34 | 305 | 339 |
| 2019 February | 17 | 234 | 251 |
| 2019 January | 29 | 285 | 314 |
| 2018 December | 27 | 278 | 305 |
| 2018 November | 36 | 283 | 319 |
| 2018 October | 57 | 181 | 238 |
| 2018 September | 76 | 358 | 434 |
| 2018 August | 3 | 0 | 3 |
| 2018 July | 1 | 0 | 1 |
| 2018 June | 1 | 0 | 1 |
| 2018 May | 37 | 3 | 40 |
| 2018 April | 33 | 14 | 47 |
| 2018 March | 16 | 17 | 33 |
| 2018 February | 7 | 13 | 20 |
| 2018 January | 7 | 12 | 19 |
| 2017 December | 10 | 74 | 84 |
| 2017 November | 10 | 245 | 255 |
| 2017 October | 13 | 230 | 243 |
| 2017 September | 30 | 270 | 300 |
| 2017 August | 9 | 246 | 255 |
| 2017 July | 11 | 252 | 263 |
| 2017 June | 26 | 330 | 356 |
| 2017 May | 30 | 321 | 351 |
| 2017 April | 10 | 235 | 245 |
| 2017 March | 27 | 321 | 348 |
| 2017 February | 10 | 250 | 260 |
| 2017 January | 8 | 99 | 107 |
| 2016 December | 10 | 186 | 196 |
| 2016 November | 29 | 228 | 257 |
| 2016 October | 15 | 232 | 247 |
| 2016 September | 80 | 294 | 374 |
| 2016 August | 255 | 340 | 595 |
| 2016 July | 119 | 130 | 249 |
| 2016 June | 60 | 60 | 120 |
| 2016 May | 44 | 36 | 80 |
| 2016 April | 15 | 1 | 16 |
| 2016 March | 9 | 9 | 18 |
| 2016 February | 6 | 3 | 9 |
| 2016 January | 55 | 65 | 120 |
| 2015 December | 40 | 34 | 74 |
| 2015 November | 45 | 22 | 67 |
| 2015 October | 812 | 2 | 814 |
| 2015 September | 868 | 0 | 868 |
| 2015 August | 1099 | 0 | 1099 |
| 2015 July | 1024 | 0 | 1024 |
| 2015 June | 840 | 0 | 840 |
| 2015 May | 907 | 0 | 907 |
| 2015 April | 764 | 0 | 764 |
| 2015 March | 855 | 0 | 855 |
| 2015 February | 724 | 0 | 724 |
| 2015 January | 609 | 0 | 609 |
| 2014 December | 577 | 0 | 577 |
| 2014 November | 666 | 0 | 666 |
| 2014 October | 734 | 0 | 734 |
| 2014 September | 521 | 0 | 521 |
| 2014 August | 542 | 0 | 542 |
| 2014 July | 469 | 0 | 469 |
| 2014 June | 558 | 0 | 558 |
| 2014 May | 566 | 0 | 566 |
| 2014 April | 499 | 0 | 499 |
| 2014 March | 567 | 0 | 567 |
| 2014 February | 482 | 0 | 482 |
| 2014 January | 436 | 0 | 436 |
| 2013 December | 253 | 0 | 253 |
| 2013 November | 221 | 0 | 221 |
| 2013 October | 235 | 0 | 235 |
| 2013 September | 231 | 0 | 231 |
| 2013 August | 240 | 0 | 240 |
| 2013 July | 154 | 0 | 154 |
| 2013 June | 98 | 0 | 98 |
| 2013 May | 97 | 0 | 97 |
| 2013 April | 82 | 0 | 82 |
| 2013 March | 23 | 0 | 23 |
| 2000 January | 7092 | 0 | 7092 |
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