Toxicidad pulmonar por talidomida
Lung toxicity due to thalidomide
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Guijarro, A. Cantó" "autores" => array:2 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Guijarro" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Cantó" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028960275271X?idApp=UINPBA00003Z" "url" => "/03002896/0000003800000010/v1_201307081551/S030028960275271X/v1_201307081551/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Toxicidad pulmonar por talidomida" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "492" "paginaFinal" => "494" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "F. Carrión Valero" "autores" => array:1 [ 0 => array:3 [ "nombre" => "F." "apellidos" => "Carrión Valero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neumología Hospital Clínico Universitario. Facultad de Medicina. Universitat de València. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Servicio de Neumología. Hospital Clínico Universitario.Avda. Blasco Ibáñez, 17. 46010 Valencia" ] ] ] 1 => array:3 [ "autoresLista" => "V. Bertomeu González" "autores" => array:1 [ 0 => array:3 [ "nombre" => "V." "apellidos" => "Bertomeu González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicios de Cardiología. Hospital Clínico Universitario. Facultad de Medicina. Universitat de València. Valencia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Lung toxicity due to thalidomide" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-01-24" "fechaAceptado" => "2002-03-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190667" "palabras" => array:3 [ 0 => "Talidomida" 1 => "Toxicidad pulmonar" 2 => "Mieloma múl-tiple" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190668" "palabras" => array:3 [ 0 => "Thalidomide" 1 => "Lung toxicity" 2 => "Multiple myeloma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La talidomida es un fármaco bien conocido por sus efectos secundarios, aunque la toxicidad pulmonar no ha sido comunicada. Presentamos el caso de un varón de 65 años, diagnosticado de mieloma múltiple IgG kappa en estadio IA, que en el día 37 del tratamiento con talidomida presentó de forma aguda tos, malestar general, disnea de reposo y sudación. La presión arterial era 90/60<span class="elsevierStyleHsp" style=""></span>mmHg y no tenía fie-bre. En la radiografía de tórax había un patrón intersticial alveolar en el hemitórax derecho, y en la gasometría arterial una insuficiencia respiratoria parcial (pH 7,40, PaCO<span class="elsevierStyleInf">2</span>40<span class="elsevierStyleHsp" style=""></span>mmHg, PaO<span class="elsevierStyleInf">2</span>47<span class="elsevierStyleHsp" style=""></span>mmHg). El análisis de sangre evidenció alteraciones propias de su mieloma múltiple y las determinaciones microbiológicas fueron negativas (esputo, hemocultivos y detección de antígenos de <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> y <span class="elsevierStyleItalic">Legionella pneumophilaen orina</span>). Tras la retirada del fármaco y recibir oxigenoterapia y corticoides intravenosos, el paciente evolucionó bien. Una radiografía de tórax realizada 4 días después fue normal y en la gasometría arterial desa-pareció la insuficiencia respiratoria</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Como conclusión, cabe mencionar que la toxicidad pulmonar grave deberá ser incluida entre los efectos adversos potenciales de la talidomida</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Although the side effects of thalidomide are well known, lung toxicity has not been reported. We describe the case of a 65-year-old man with multiple myeloma (IgG kappa) in stage IA who, on the thirty-seventh day of treatment with thalidomide, developed acute coughing, general malaise, dyspnea at rest and sudoresis. Blood pressure was 90/60<span class="elsevierStyleHsp" style=""></span>mm Hg and temperature was normal. An interstitial and alveolar pattern was visible on the right side of a chest film and arterial blood gases indicated partial respiratory insufficiency (pH 7.40, PaCO,<span class="elsevierStyleInf">2</span>40<span class="elsevierStyleHsp" style=""></span>mmHg, PaO<span class="elsevierStyleInf">2</span>47<span class="elsevierStyleHsp" style=""></span>mmHg). Blood analysis showed alterations expected for multiple myeloma and microbiology was negative (sputum and blood cultures and urinary antigen detection for <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> and <span class="elsevierStyleItalic">Legionella pneumophila</span>). After thalidomide was withdrawn and oxygen and intravenous corticoids were administered, outcome was good. A chest film 4 days later was normal and arterial blood gases showed that respiratory insufficiency had disappeared</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We conclude that severe lung toxicity should be included among the potential adverse effects of thalidomide</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide victims win review of compensation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Christie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Bmj" "fecha" => "1994" "volumen" => "308" "paginaInicial" => "739" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11644521" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dark remedy: the impact of thalidomide and its revival as a vital medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.M. Tansey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2001" "volumen" => "345" "paginaInicial" => "226" "paginaFinal" => "227" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.P. Sampaio" 1 => "E.N. Sarno" 2 => "R. Galilly" 3 => "Z.A. Cohn" 4 => "G. Kaplan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1991" "volumen" => "173" "paginaInicial" => "699" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1997652" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antitumor activity of thalidomide in refractary múltiple myeloma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Singhal" 1 => "J. Eehta" 2 => "R. Desikan" 3 => "D. Ayers" 4 => "P. Roberson" 5 => "P. Eddlemon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "1965" "paginaFinal" => "1971" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide. A revival story" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Raje" 1 => "K. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199911183412110" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "1606" "paginaFinal" => "1609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10564693" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.C III Rosenow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dis Mon" "fecha" => "1994" "volumen" => "40" "paginaInicial" => "253" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8174459" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physician knowledge, attitudes, and behavior related to reporting adverse drug events" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.S. Rogers" 1 => "E. Israel" 2 => "C.R. Smith" 3 => "D. Levine" 4 => "A.M. McBean" 5 => "C. Valiente" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1988" "volumen" => "148" "paginaInicial" => "1596" "paginaFinal" => "1600" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3382304" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Parman" 1 => "M.J. Wiley" 2 => "P.G. Wells" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/8466" "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "1999" "volumen" => "5" "paginaInicial" => "582" "paginaFinal" => "585" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10229238" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide back-under strict control" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Marwick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Jama" "fecha" => "1997" "volumen" => "278" "paginaInicial" => "1135" "paginaFinal" => "1137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9326459" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.P. Sampaio" 1 => "G. Kaplan" 2 => "A. Miranda" 3 => "J.A. Nery" 4 => "C.P. Miguel" 5 => "S.M. Viana" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1993" "volumen" => "168" "paginaInicial" => "408" "paginaFinal" => "414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8335978" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide in gastrointestinal disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Bousvaros" 1 => "B. Mueller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drugs" "fecha" => "2001" "volumen" => "61" "paginaInicial" => "777" "paginaFinal" => "7787" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11398909" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide in dermatology. New indications for an old drug" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Calderon" 1 => "M. Anzilotti" 2 => "R. Phelps" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "1997" "volumen" => "36" "paginaInicial" => "881" "paginaFinal" => "887" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9466191" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Talidomida y enfermedad del injerto contra el huésped: bases de una nueva indicación y efectos secundarios" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. López Gil" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1992" "volumen" => "99" "paginaInicial" => "545" "paginaFinal" => "548" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The place of thalidomide in the treatment of inflamatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.J. Stevens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lupus" "fecha" => "1996" "volumen" => "5" "paginaInicial" => "257" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8869894" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of thalidomide on experimental tumors and metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.I. Minchinton" 1 => "K.H. Fryer" 2 => "K.R. Wendt" 3 => "K.A. Clow" 4 => "M.M. Hayes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anticancer Drugs" "fecha" => "1996" "volumen" => "7" "paginaInicial" => "339" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8792009" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide in cancer: potencial uses and limitations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Singhal" 1 => "J. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BioDrugs" "fecha" => "2001" "volumen" => "15" "paginaInicial" => "163" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11437682" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide is an inhibitor of angiogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. D'Amato" 1 => "M.S. Loughman" 2 => "E. Flynn" 3 => "J. Folkman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1994" "volumen" => "91" "paginaInicial" => "4082" "paginaFinal" => "4085" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7513432" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bone marrow angiogenesis and mast cell density increase simultaneosly with progression of human multiple myeloma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Ribatti" 1 => "A. Vacca" 2 => "B. Nico" 3 => "F. Quondamatteo" 4 => "R. Ria" 5 => "M. Minischetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6690070" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1999" "volumen" => "79" "paginaInicial" => "451" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10027312" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of thalidomide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.L. Crawford" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bmj" "fecha" => "1994" "volumen" => "308" "paginaInicial" => "1437" "paginaFinal" => "1438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8019266" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide neuropathy incidence and clinicoelectrophysiologic findings in 42 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Ochonsky" 1 => "J. Verroust" 2 => "S. Bastuji-Garin" 3 => "R. Gheradi" 4 => "J. Revuz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1994" "volumen" => "130" "paginaInicial" => "66" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8285742" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse reactions to thalidomide in patients infected with human immunodeficiency virus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Haslett" 1 => "J. Tramontana" 2 => "M. Burroughs" 3 => "M. Hempstead" 4 => "G. Kaplan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "1223" "paginaFinal" => "1227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9195087" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thalidomide-induced amenorrhea: two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Passeron" 1 => "J.P. Lacour" 2 => "D. Murr" 3 => "J.P. Ortonne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2001" "volumen" => "144" "paginaInicial" => "1292" "paginaFinal" => "1293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11422077" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deep venous thrombosis and thalidomide therapy for multiple myeloma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Osman" 1 => "R. Comenzo" 2 => "S.V. Rajkumar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM200106213442516" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2001" "volumen" => "344" "paginaInicial" => "1951" "paginaFinal" => "1952" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11419443" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased risk of deep-vein thrombosis in patients with myeloma receiving thalidomide and chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Zangari" 1 => "E. Anaissie" 2 => "B. Barlogie" 3 => "A. Badros" 4 => "R. Desikan" 5 => "A.V. Gopal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2001" "volumen" => "98" "paginaInicial" => "1614" "paginaFinal" => "1615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11520815" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxicidad pulmonar en el tratamiento del cáncer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. De Castro" 1 => "Y. Viches" 2 => "M. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1995" "volumen" => "105" "paginaInicial" => "661" "paginaFinal" => "668" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxicidad pulmonar por maprotilina: a propósito de un caso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Gullón" 1 => "R. Fernández" 2 => "I.J. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10932348" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxicidad pulmonar por fármacos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Carrión Valero" 1 => "J. Marín Pardo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1999" "volumen" => "35" "paginaInicial" => "550" "paginaFinal" => "559" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10687040" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003800000010/v1_201307081551/S0300289602752721/v1_201307081551/es/main.assets" "Apartado" => array:4 [ "identificador" => "9217" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Notas clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003800000010/v1_201307081551/S0300289602752721/v1_201307081551/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289602752721?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 1 | 5 |
| 2024 October | 51 | 38 | 89 |
| 2024 September | 67 | 32 | 99 |
| 2024 August | 82 | 40 | 122 |
| 2024 July | 56 | 33 | 89 |
| 2024 June | 72 | 33 | 105 |
| 2024 May | 55 | 41 | 96 |
| 2024 April | 35 | 28 | 63 |
| 2024 March | 60 | 42 | 102 |
| 2024 February | 29 | 34 | 63 |
| 2024 January | 0 | 7 | 7 |
| 2023 December | 0 | 4 | 4 |
| 2023 November | 0 | 6 | 6 |
| 2023 October | 0 | 4 | 4 |
| 2023 September | 0 | 13 | 13 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 6 | 6 |
| 2023 June | 0 | 14 | 14 |
| 2023 April | 0 | 1 | 1 |
| 2023 March | 12 | 11 | 23 |
| 2023 February | 50 | 36 | 86 |
| 2023 January | 26 | 32 | 58 |
| 2022 December | 28 | 50 | 78 |
| 2022 November | 47 | 39 | 86 |
| 2022 October | 39 | 65 | 104 |
| 2022 September | 23 | 71 | 94 |
| 2022 August | 40 | 70 | 110 |
| 2022 July | 26 | 52 | 78 |
| 2022 June | 27 | 48 | 75 |
| 2022 May | 41 | 60 | 101 |
| 2022 April | 54 | 46 | 100 |
| 2022 March | 48 | 56 | 104 |
| 2022 February | 27 | 30 | 57 |
| 2022 January | 37 | 43 | 80 |
| 2021 December | 31 | 48 | 79 |
| 2021 November | 45 | 55 | 100 |
| 2021 October | 94 | 53 | 147 |
| 2021 September | 44 | 66 | 110 |
| 2021 August | 46 | 54 | 100 |
| 2021 July | 60 | 34 | 94 |
| 2021 June | 36 | 42 | 78 |
| 2021 May | 32 | 41 | 73 |
| 2021 April | 76 | 62 | 138 |
| 2021 March | 113 | 29 | 142 |
| 2021 February | 97 | 23 | 120 |
| 2021 January | 74 | 15 | 89 |
| 2020 December | 54 | 25 | 79 |
| 2020 November | 43 | 26 | 69 |
| 2020 October | 36 | 18 | 54 |
| 2020 September | 29 | 21 | 50 |
| 2020 August | 41 | 12 | 53 |
| 2020 July | 40 | 30 | 70 |
| 2020 June | 42 | 16 | 58 |
| 2020 May | 46 | 48 | 94 |
| 2020 April | 53 | 13 | 66 |
| 2020 March | 38 | 31 | 69 |
| 2020 February | 36 | 32 | 68 |
| 2020 January | 42 | 40 | 82 |
| 2019 December | 40 | 26 | 66 |
| 2019 November | 15 | 25 | 40 |
| 2019 October | 44 | 29 | 73 |
| 2019 September | 20 | 29 | 49 |
| 2019 August | 35 | 12 | 47 |
| 2019 July | 46 | 49 | 95 |
| 2019 June | 54 | 31 | 85 |
| 2019 May | 62 | 30 | 92 |
| 2019 April | 42 | 37 | 79 |
| 2019 March | 21 | 14 | 35 |
| 2019 February | 11 | 11 | 22 |
| 2019 January | 32 | 8 | 40 |
| 2018 December | 12 | 23 | 35 |
| 2018 November | 26 | 27 | 53 |
| 2018 October | 47 | 17 | 64 |
| 2018 September | 21 | 10 | 31 |
| 2018 May | 24 | 3 | 27 |
| 2018 April | 26 | 2 | 28 |
| 2018 March | 12 | 13 | 25 |
| 2018 February | 12 | 11 | 23 |
| 2018 January | 6 | 7 | 13 |
| 2017 December | 15 | 22 | 37 |
| 2017 November | 23 | 16 | 39 |
| 2017 October | 23 | 10 | 33 |
| 2017 September | 18 | 9 | 27 |
| 2017 August | 19 | 14 | 33 |
| 2017 July | 17 | 13 | 30 |
| 2017 June | 45 | 17 | 62 |
| 2017 May | 25 | 12 | 37 |
| 2017 April | 18 | 7 | 25 |
| 2017 March | 11 | 13 | 24 |
| 2017 February | 10 | 9 | 19 |
| 2017 January | 12 | 8 | 20 |
| 2016 December | 24 | 14 | 38 |
| 2016 November | 28 | 22 | 50 |
| 2016 October | 28 | 33 | 61 |
| 2016 September | 26 | 24 | 50 |
| 2016 August | 26 | 12 | 38 |
| 2016 July | 42 | 9 | 51 |
| 2016 June | 31 | 12 | 43 |
| 2016 May | 26 | 8 | 34 |
| 2016 April | 23 | 0 | 23 |
| 2016 March | 24 | 3 | 27 |
| 2016 February | 17 | 3 | 20 |
| 2016 January | 33 | 17 | 50 |
| 2015 December | 40 | 16 | 56 |
| 2015 November | 39 | 13 | 52 |
| 2015 October | 107 | 1 | 108 |
| 2015 September | 73 | 0 | 73 |
| 2015 August | 88 | 0 | 88 |
| 2015 July | 64 | 0 | 64 |
| 2015 June | 65 | 0 | 65 |
| 2015 May | 106 | 0 | 106 |
| 2015 April | 73 | 0 | 73 |
| 2015 March | 73 | 0 | 73 |
| 2015 February | 49 | 0 | 49 |
| 2015 January | 76 | 0 | 76 |
| 2014 December | 67 | 0 | 67 |
| 2014 November | 58 | 0 | 58 |
| 2014 October | 86 | 0 | 86 |
| 2014 September | 55 | 0 | 55 |
| 2014 August | 49 | 0 | 49 |
| 2014 July | 43 | 0 | 43 |
| 2014 June | 72 | 0 | 72 |
| 2014 May | 70 | 0 | 70 |
| 2014 April | 54 | 0 | 54 |
| 2014 March | 68 | 0 | 68 |
| 2014 February | 63 | 0 | 63 |
| 2014 January | 45 | 0 | 45 |
| 2013 December | 49 | 0 | 49 |
| 2013 November | 56 | 0 | 56 |
| 2013 October | 50 | 0 | 50 |
| 2013 September | 61 | 0 | 61 |
| 2013 August | 62 | 0 | 62 |
| 2013 July | 71 | 0 | 71 |
| 2013 June | 49 | 0 | 49 |
| 2013 May | 49 | 0 | 49 |
| 2013 April | 22 | 0 | 22 |
| 2013 March | 10 | 0 | 10 |
| 2000 January | 2412 | 0 | 2412 |
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